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1. HOM-Damping Studies in a Multi-Cell Elliptical Superconducting RF Cavity for the Multi-Turn Energy Recovery Linac PERLE

Author: Barbagallo, C., Duchesne, P., Kaabi, W., Olry, G., Zomer, F., Rimmer, R. A., Wang, H., Apsimon, R., and Setiniyaz, S.
Subjects: Physics - Accelerator Physics
Abstract: Higher order mode (HOM) damping is a crucial issue for the next generation of high-current energy recovery linacs (ERLs). Beam-induced HOMs can store sufficient energy in the superconducting RF (SRF) cavities, giving rise to beam instabilities and increasing the heat load at cryogenic temperatures. To limit these effects, using HOM couplers on the cutoff tubes of SRF cavities becomes crucial to absorb beam-induced wakefields consisting of all cavity eigenmodes. The study presented here focuses on a 5-cell 801.58 MHz elliptical SRF cavity designed for the multi-turn energy recovery linac PERLE (Powerful Energy Recovery Linac for Experiments). Several coaxial coupler designs are analyzed and optimized to enhance the damping of monopole and dipole HOMs of the 5-cell cavity. The broadband performance of HOM damping is also confirmed by the time-domain wakefield and the frequency-domain simulations. In addition, the thermal behavior of the HOM couplers is investigated. A comparison between various HOM-damping schemes is carried out to guarantee an efficient HOM power extraction from the cavity., Comment: Proceedings of the International Workshop on Energy Recovery Linacs (ERL 22), Cornell University, Ithaca, NY, USA, 3-6 Oct. 2022
Published: 2024

2. Beam Breakup Instability Studies of Powerful Energy Recovery Linac for Experiments

Author: Setiniyaz, Sadiq, Apsimon, R., Williams, P. H., Barbagallo, C., Bogacz, S. A., Bodenstei, R. M., and Deitrick, K.
Subjects: Physics - Accelerator Physics
Abstract: The maximum achievable beam current in an Energy Recovery Linac (ERL) is often constrained by Beam Breakup (BBU) instability. Our previous research highlighted that filling patterns have a substantial impact on BBU instabilities in multi-pass ERLs. In this study, we extend our investigation to the 8-cavity model of the Powerful ERL for Experiment (PERLE). We evaluate its requirements for damping cavity Higher Order Modes (HOMs) and propose optimal filling patterns and bunch timing strategies. Our findings reveal a significant new insight: while filling patterns are crucial, the timing of bunches also plays a critical role in mitigating HOM beam loading and BBU instability. This previously underestimated factor is essential for effective BBU control. We estimated the PERLE threshold current using both analytical and numerical models, incorporating the designed PERLE HOM dampers. During manufacturing, HOM frequencies are expected to vary slightly, with an assumed RMS frequency jitter of 0.001 between cavities for the same HOM. Introducing this jitter into our models, we found that the dampers effectively suppressed BBU instability, achieving a threshold current an order of magnitude higher than the design requirement. Our results offer new insights into ERL BBU beam dynamics and have important implications for the design of future ERLs.
Published: 2024

3. Interim report for the International Muon Collider Collaboration (IMCC)

Author: Accettura, C., Adrian, S., Agarwal, R., Ahdida, C., Aimé, C., Aksoy, A., Alberghi, G. L., Alden, S., Amapane, N., Amorim, D., Andreetto, P., Anulli, F., Appleby, R., Apresyan, A., Asadi, P., Mahmoud, M. Attia, Auchmann, B., Back, J., Badea, A., Bae, K. J., Bahng, E. J., Balconi, L., Balli, F., Bandiera, L., Barbagallo, C., Barlow, R., Bartoli, C., Bartosik, N., Barzi, E., Batsch, F., Bauce, M., Begel, M., Berg, J. S., Bersani, A., Bertarelli, A., Bertinelli, F., Bertolin, A., Bhat, P., Bianchi, C., Bianco, M., Bishop, W., Black, K., Boattini, F., Bogacz, A., Bonesini, M., Bordini, B., de Sousa, P. Borges, Bottaro, S., Bottura, L., Boyd, S., Breschi, M., Broggi, F., Brunoldi, M., Buffat, X., Buonincontri, L., Burrows, P. N., Burt, G. C., Buttazzo, D., Caiffi, B., Calatroni, S., Calviani, M., Calzaferri, S., Calzolari, D., Cantone, C., Capdevilla, R., Carli, C., Carrelli, C., Casaburo, F., Casarsa, M., Castelli, L., Catanesi, M. G., Cavallucci, L., Cavoto, G., Celiberto, F. G., Celona, L., Cemmi, A., Ceravolo, S., Cerri, A., Cerutti, F., Cesarini, G., Cesarotti, C., Chancé, A., Charitonidis, N., Chiesa, M., Chiggiato, P., Ciccarella, V. L., Puviani, P. Cioli, Colaleo, A., Colao, F., Collamati, F., Costa, M., Craig, N., Curtin, D., D'Angelo, L., Da Molin, G., Damerau, H., Dasu, S., de Blas, J., De Curtis, S., De Gersem, H., Del Moro, T., Delahaye, J. -P., Denisov, D., Denizli, H., Dermisek, R., Valdor, P. Desiré, Desponds, C., Di Luzio, L., Di Meco, E., Di Petrillo, K. F., Di Sarcina, I., Diociaiuti, E., Dorigo, T., Dreimanis, K., Pree, T. du, Edgecock, T., Fabbri, S., Fabbrichesi, M., Farinon, S., Ferrand, G., Somoza, J. A. Ferreira, Fieg, M., Filthaut, F., Fox, P., Franceschini, R., Ximenes, R. Franqueira, Gallinaro, M., Garcia-Sciveres, M., Garcia-Tabares, L., Gargiulo, R., Garion, C., Garzelli, M. V., Gast, M., Gerber, C. E., Giambastiani, L., Gianelle, A., Gianfelice-Wendt, E., Gibson, S., Gilardoni, S., Giove, D. A., Giovinco, V., Giraldin, C., Glioti, A., Gorzawski, A., Greco, M., Grojean, C., Grudiev, A., Gschwendtner, E., Gueli, E., Guilhaudin, N., Han, C., Han, T., Hauptman, J. M., Herndon, M., Hillier, A. D., Hillman, M., Holmes, T. R., Homiller, S., Jana, S., Jindariani, S., Johannesson, S., Johnson, B., Jones, O. R., Jurj, P. -B., Kahn, Y., Kamath, R., Kario, A., Karpov, I., Kelliher, D., Kilian, W., Kitano, R., Kling, F., Kolehmainen, A., Kong, K. C., Kosse, J., Krintiras, G., Krizka, K., Kumar, N., Kvikne, E., Kyle, R., Laface, E., Lane, K., Latina, A., Lechner, A., Lee, J., Lee, L., Lee, S. W., Lefevre, T., Leonardi, E., Lerner, G., Li, P., Li, Q., Li, T., Li, W., Voti, R. Li, Lindroos, M., Lipton, R., Liu, D., Liu, M., Liu, Z., Lombardi, A., Lomte, S., Long, K., Longo, L., Lorenzo, J., Losito, R., Low, I., Lu, X., Lucchesi, D., Luo, T., Lupato, A., Métral, E., Mękała, K., Ma, Y., Mańczak, J. M., Machida, S., Madlener, T., Magaletti, L., Maggi, M., Durand, H. Mainaud, Maltoni, F., Mandurrino, M., Marchand, C., Mariani, F., Marin, S., Mariotto, S., Martin-Haugh, S., Masullo, M. R., Mauro, G. S., Mazzolari, A., Mele, B., Meloni, F., Meng, X., Mentink, M., Miceli, R., Milas, N., Mohammadi, A., Moll, D., Montella, A., Morandin, M., Morrone, M., Mulder, T., Musenich, R., Nardecchia, M., Nardi, F., Neuffer, D., Newbold, D., Novelli, D., Olvegård, M., Onel, Y., Orestano, D., Osborne, J., Otten, S., Torres, Y. M. Oviedo, Paesani, D., Griso, S. Pagan, Pagani, D., Pal, K., Palmer, M., Pampaloni, A., Panci, P., Pani, P., Papaphilippou, Y., Paparella, R., Paradisi, P., Passeri, A., Pastrone, N., Pellecchia, A., Piccinini, F., Piekarz, H., Pieloni, T., Plouin, J., Portone, A., Potamianos, K., Potdevin, J., Prestemon, S., Puig, T., Qiang, J., Quettier, L., Rabemananjara, T. R., Radicioni, E., Radogna, R., Rago, I. C., Ratkus, A., Resseguie, E., Reuter, J., Ribani, P. L., Riccardi, C., Ricciardi, S., Robens, T., Robert, Y., Roger, C., Rojo, J., Romagnoni, M., Ronald, K., Rosser, B., Rossi, C., Rossi, L., Rozanov, L., Ruhdorfer, M., Ruiz, R., Queiroz, F. S., Saini, S., Sala, F., Salierno, C., Salmi, T., Salvini, P., Salvioni, E., Sammut, N., Santini, C., Saputi, A., Sarra, I., Scarantino, G., Schneider-Muntau, H., Schulte, D., Scifo, J., Sen, T., Senatore, C., Senol, A., Sertore, D., Sestini, L., Rêgo, R. C. Silva, Simone, F. M., Skoufaris, K., Sorbello, G., Sorbi, M., Sorti, S., Soubirou, L., Spataro, D., Stamerra, A., Stapnes, S., Stark, G., Statera, M., Stechauner, B. M., Su, S., Su, W., Sun, X., Sytov, A., Tang, J., Taylor, R., Kate, H. Ten, Testoni, P., Thiele, L. S., Garcia, R. Tomas, Mugglestone, M. Topp, Torims, T., Torre, R., Tortora, L. T., Trifinopoulos, S., Udongwo, S. -A., Vai, I., Valente, R. U., van Rienen, U., van Weelderen, R., Vanwelde, M., Velev, G., Venditti, R., Vendrasco, A., Verna, A., Verweij, A., Verwilligen, P., Villamzar, Y., Vittorio, L., Vitulo, P., Vojskovic, I., Wang, D., Wang, L. -T., Wang, X., Wendt, M., Widorski, M., Wozniak, M., Wu, Y., Wulzer, A., Xie, K., Yang, Y., Yap, Y. C., Yonehara, K., Yoo, H. D., You, Z., Zanetti, M., Zaza, A., Zhang, L., Zhu, R., Zlobin, A., Zuliani, D., and Zurita, J. F.
Subjects: Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract: The International Muon Collider Collaboration (IMCC) [1] was established in 2020 following the recommendations of the European Strategy for Particle Physics (ESPP) and the implementation of the European Strategy for Particle Physics-Accelerator R&D Roadmap by the Laboratory Directors Group [2], hereinafter referred to as the the European LDG roadmap. The Muon Collider Study (MuC) covers the accelerator complex, detectors and physics for a future muon collider. In 2023, European Commission support was obtained for a design study of a muon collider (MuCol) [3]. This project started on 1st March 2023, with work-packages aligned with the overall muon collider studies. In preparation of and during the 2021-22 U.S. Snowmass process, the muon collider project parameters, technical studies and physics performance studies were performed and presented in great detail. Recently, the P5 panel [4] in the U.S. recommended a muon collider R&D, proposed to join the IMCC and envisages that the U.S. should prepare to host a muon collider, calling this their "muon shot". In the past, the U.S. Muon Accelerator Programme (MAP) [5] has been instrumental in studies of concepts and technologies for a muon collider., Comment: This document summarises the International Muon Collider Collaboration (IMCC) progress and status of the Muon Collider R&D programme
Published: 2024

4. Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional‐Based Italian Database

Author: Tikhonoff, V, Casiglia, E, Virdis, A, Grassi, G, Angeli, F, Arca, M, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Masi, S, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Temporelli, P, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Tikhonoff V., Casiglia E., Virdis A., Grassi G., Angeli F., Arca M., Barbagallo C. M., Bombelli M., Cappelli F., Cianci R., Cicero A. F. G., Cirillo M., Cirillo P., Dell'oro R., D'elia L., Desideri G., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Mallamaci F., Maloberti A., Masi S., Masulli M., Mazza A., Mengozzi A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Reboldi G., Rivasi G., Russo E., Salvetti M., Temporelli P. L., Tocci G., Ungar A., Verdecchia P., Viazzi F., Volpe M., Borghi C., Tikhonoff, V, Casiglia, E, Virdis, A, Grassi, G, Angeli, F, Arca, M, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Masi, S, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Temporelli, P, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Tikhonoff V., Casiglia E., Virdis A., Grassi G., Angeli F., Arca M., Barbagallo C. M., Bombelli M., Cappelli F., Cianci R., Cicero A. F. G., Cirillo M., Cirillo P., Dell'oro R., D'elia L., Desideri G., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Mallamaci F., Maloberti A., Masi S., Masulli M., Mazza A., Mengozzi A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Reboldi G., Rivasi G., Russo E., Salvetti M., Temporelli P. L., Tocci G., Ungar A., Verdecchia P., Viazzi F., Volpe M., and Borghi C.
Abstract: BACKGROUND: Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, the exact level at which risk begins to rise is unclear. The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension has conceived a protocol aimed at searching for the prognostic cutoff value of triglycerides in predicting cardiovascular events in a large regional-based Italian cohort. METHODS AND RESULTS: Among 14 189 subjects aged 18 to 95 years followed-up for 11.2 (5.3–13.2) years, the prognostic cutoff value of triglycerides, able to discriminate combined cardiovascular events, was identified by means of receiver operating characteristic curve. The conventional (150 mg/dL) and the prognostic cutoff values of triglycerides were used as independent predictors in separate multivariable Cox regression models adjusted for age, sex, body mass index, total and high-density lipoprotein cholesterol, serum uric acid, arterial hypertension, diabetes, chronic renal disease, smoking habit, and use of an-tihypertensive and lipid-lowering drugs. During 139 375 person-years of follow-up, 1601 participants experienced cardiovascular events. Receiver operating characteristic curve showed that 89 mg/dL (95% CI, 75.8–103.3, sensitivity 76.6, specificity 34.1, P<0.0001) was the prognostic cutoff value for cardiovascular events. Both cutoff values of triglycerides, the conventional and the newly identified, were accepted as multivariate predictors in separate Cox analyses, the hazard ratios being 1.211 (95% CI, 1.063–1.378, P=0.004) and 1.150 (95% CI, 1.021–1.295, P=0.02), respectively. CONCLUSIONS: Lower (89 mg/dL) than conventional (150 mg/dL) prognostic cutoff value of triglycerides for cardiovascular events does exist and is associated with increased cardiovascular risk in an Italian cohort.
Published: 2024

5. Beam dynamics driven design of powerful energy recovery linac for experiments

Author: Bogacz, S. A., primary, André, K. D. J., additional, Brüning, O., additional, Holzer, B. J., additional, Hounsell, B. R., additional, Klein, M., additional, Militsyn, B. L., additional, Williams, P. H., additional, Segurana, G. Pérez, additional, Bailey, I., additional, Apsimon, R., additional, Setiniyaz, S., additional, Abukeshek, R., additional, Barbagallo, C., additional, Abdillah, M. Ben, additional, Bruni, C., additional, Duchesne, P., additional, Duthil, P., additional, Fomin, A., additional, Guyot, C., additional, Kaabi, W., additional, Michaud, J., additional, Olry, G., additional, Perrot, L., additional, Reynet, D., additional, Roux, R., additional, Stocchi, A., additional, Wurth, S., additional, Abualrob, H., additional, Baylac, M., additional, Bouly, F., additional, and Jacquot, B., additional
Published: 2024
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6. Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (Urrah Project)

Author: D'Elia, L, Masulli, M, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D'Elia, Lanfranco, Masulli, Maria, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Galletti, Ferruccio, D'Elia, L, Masulli, M, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D'Elia, Lanfranco, Masulli, Maria, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Galletti, Ferruccio
Abstract: Purpose: Recently, a novel index (triglyceride-glucose index-TyG) was considered a surrogate marker of insulin resistance (IR); in addition, it was estimated to be a better expression of IR than widely used tools. Few and heterogeneous data are available on the relationship between this index and mortality risk in non-Asian populations. Therefore, we estimated the predictive role of baseline TyG on the incidence of all-cause and cardiovascular (CV) mortality in a large sample of the general population. Moreover, in consideration of the well-recognized role of serum uric acid (SUA) on CV risk and the close correlation between SUA and IR, we also evaluated the combined effect of TyG and SUA on mortality risk. Methods: The analysis included 16,649 participants from the URRAH cohort. The risk of all-cause and CV mortality was evaluated by the Kaplan-Meier estimator and Cox multivariate analysis. Results: During a median follow-up of 144 months, 2569 deaths occurred. We stratified the sample by the optimal cut-off point for all-cause (4.62) and CV mortality (4.53). In the multivariate Cox regression analyses, participants with TyG above cut-off had a significantly higher risk of all-cause and CV mortality, than those with TyG below the cut-off. Moreover, the simultaneous presence of high levels of TyG and SUA was associated with a higher mortality risk than none or only one of the two factors. Conclusions: The results of this study indicate that these TyG (a low-cost and simple non-invasive marker) thresholds are predictive of an increased risk of mortality in a large and homogeneous general population. In addition, these results show a synergic effect of TyG and SUA on the risk of mortality.
Published: 2024

7. Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project

Author: D’Elia, L, Masulli, M, Cirillo, P, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Dell’Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D’Elia, Lanfranco, Masulli, Maria, Cirillo, Pietro, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Dell’Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Galletti, Ferruccio, D’Elia, L, Masulli, M, Cirillo, P, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Dell’Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D’Elia, Lanfranco, Masulli, Maria, Cirillo, Pietro, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Dell’Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Galletti, Ferruccio
Abstract: Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.35 Units. Therefore, given that no SUA/sCr ratio threshold for CV risk has been identified for patients with diabetes, we aimed to assess the relationship between this index and CV mortality and to validate this threshold in the URRAH subpopulation with diabetes; the URRAH participants with diabetes were studied (n = 2230). The risk of CV mortality was evaluated by the Kaplan–Meier estimator and Cox multivariate analysis. During a median follow-up of 9.2 years, 380 CV deaths occurred. A non-linear inverse association between baseline SUA/sCr ratio and risk of CV mortality was detected. In the whole sample, SUA/sCr ratio > 5.35 Units was not a significant predictor of CV mortality in diabetic patients. However, after stratification by kidney function, values > 5.35 Units were associated with a significantly higher mortality rate only in normal kidney function, while, in participants with overt kidney dysfunction, values of SUA/sCr ratio > 7.50 Units were associated with higher CV mortality. The SUA/sCr ratio threshold, previously proposed by the URRAH Study Group, is predictive of an increased risk of CV mortality in people with diabetes and preserved kidney function. While, in consideration of the strong association among kidney function, SUA, and CV mortality, a different cut-point was detected for diabetics with impaired kidney function. These data highlight the different predictive roles of SUA (and its interaction with kidney function) in CV risk, pointing out the difference in metabolic- and kidney-dependent SUA levels also in diabetic
Published: 2024

8. Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project

Author: Maloberti, Alessandro, Giannattasio, C., Bombelli, M., Desideri, G., Cicero, A. F. G., Muiesan, M. L., Rosei, E. A., Salvetti, M., Ungar, A., Rivasi, G., Pontremoli, R., Viazzi, F., Facchetti, R., Ferri, C., Bernardino, B., Galletti, F., D’Elia, L., Palatini, P., Casiglia, E., Tikhonoff, V., Barbagallo, C. M., Verdecchia, P., Masi, S., Mallamaci, F., Cirillo, M., Rattazzi, M., Pauletto, P., Cirillo, P., Gesualdo, L., Mazza, A., Volpe, M., Tocci, G., Iaccarino, G., Nazzaro, P., Lippa, L., Parati, G., Dell’Oro, R., Quarti-Trevano, F., Grassi, G., Virdis, A., and Borghi, C.
Published: 2020
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9. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author: Muiesan, M, Agabiti Rosei, C, Paini, A, Casiglia, E, Cirillo, M, Grassi, G, Iaccarino, G, Mallamaci, F, Maloberti, A, Mazza, A, Mengozzi, A, Palatini, P, Parati, G, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Borghi, C, Angeli, F, Barbagallo, C, Bombelli, M, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, P, Dell'Oro, R, Medica, C, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Lippa, L, Masi, S, Masulli, M, Nazzaro, P, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Muiesan M. L., Agabiti Rosei C., Paini A., Casiglia E., Cirillo M., Grassi G., Iaccarino G., Mallamaci F., Maloberti A., Mazza A., Mengozzi A., Palatini P., Parati G., Reboldi G., Rivasi G., Russo E., Salvetti M., Tikhonoff V., Tocci G., Borghi C., Angeli F., Barbagallo C. M., Bombelli M., Cianci R., Ciccarelli M., Cicero A. F. G., Cirillo P., Dell'Oro R., Medica C., D'Elia L., Desideri G., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Lippa L., Masi S., Masulli M., Nazzaro P., Pontremoli R., Quarti-Trevano F., Rattazzi M., Ungar A., Verdecchia P., Viazzi F., Virdis A., Volpe M., Muiesan, M, Agabiti Rosei, C, Paini, A, Casiglia, E, Cirillo, M, Grassi, G, Iaccarino, G, Mallamaci, F, Maloberti, A, Mazza, A, Mengozzi, A, Palatini, P, Parati, G, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Borghi, C, Angeli, F, Barbagallo, C, Bombelli, M, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, P, Dell'Oro, R, Medica, C, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Lippa, L, Masi, S, Masulli, M, Nazzaro, P, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Muiesan M. L., Agabiti Rosei C., Paini A., Casiglia E., Cirillo M., Grassi G., Iaccarino G., Mallamaci F., Maloberti A., Mazza A., Mengozzi A., Palatini P., Parati G., Reboldi G., Rivasi G., Russo E., Salvetti M., Tikhonoff V., Tocci G., Borghi C., Angeli F., Barbagallo C. M., Bombelli M., Cianci R., Ciccarelli M., Cicero A. F. G., Cirillo P., Dell'Oro R., Medica C., D'Elia L., Desideri G., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Lippa L., Masi S., Masulli M., Nazzaro P., Pontremoli R., Quarti-Trevano F., Rattazzi M., Ungar A., Verdecchia P., Viazzi F., Virdis A., and Volpe M.
Abstract: Unlabelled: A relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study. Aim: of this study was to investigate the association between SUA and left ventricular mass index (LVMI) and whether SUA and LVMI or their combination may predict the incidence of CV death. Methods: Subjects with echocardiographic measurement of LVMI included in the URRAH study (n=10733) were part of this analysis. LV hypertrophy (LVH) was defined as LVMI > 95 g/m2 in women and 115 g/m2 in men. Results: A significant association between SUA and LVMI was observed in multiple regression analysis in men: beta 0,095, F 5.47, P< 0.001 and women: beta 0,069, F 4.36, P<0.001. During follow-up 319 CV deaths occurred. Kaplan-Meier curves showed a significantly poorer survival rate in subjects with higher SUA (> 5.6 mg/dl in men and 5.1 mg/dl in women) and LVH (log-rank chi-square 298.105; P<0.0001). At multivariate Cox regression analysis in women LVH alone and the combination of higher SUA and LVH but not hyperuricemia alone, were associated with a higher risk of CV death, while in men hyperuricemia without LVH, LVH without hyperuricemia and their combination were all associated with a higher incidence of CV death. Conclusions: Our findings demonstrate that SUA is independently associated with LVMI and suggest that the combination of hyperuricemia with LVH is an independent and powerful predictor for CV death both in men and women.
Published: 2023

10. O-062 MicroRNAs in Blastocoel Fluid: a molecular signature for predicting human embryo implantation potential

Author: Battaglia, R, primary, Caponnetto, A, additional, Ferrara, C, additional, Fazzio, A, additional, Barbagallo, C, additional, Barbagallo, D, additional, Vento, M E, additional, Carli, L, additional, Kasapi, E, additional, Palini, S, additional, Sierka, W, additional, Valerio, D, additional, Longobardi, S, additional, D’Hooghe, T, additional, and Di Pietro, C, additional
Published: 2023
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11. ApoE Polymorphism in a Small Mediterranean Island: Relationships with Plasma Lipids, Lipoproteins and LDL Particle Size

Author: Barbagallo, C. M., Polizzi, F., Severino, M., Rizzo, M., Vivona, N., Onorato, F., Caldarella, R., Cefalù, A. B., Noto, D., Notarbartolo, A., and Averna, M. R.
Published: 2001

12. Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study

Author: Tikhonoff, V, Casiglia, E, Spinella, P, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Tikhonoff V., Casiglia E., Spinella P., Barbagallo C. M., Bombelli M., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Mallamaci F., Maloberti A., Masi S., Mazza A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Rivasi G., Salvetti M., Tocci G., Ungar A., Verdecchia P., Viazzi F., Virdis A., Volpe M., Grassi G., Borghi C., Tikhonoff, V, Casiglia, E, Spinella, P, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Tikhonoff V., Casiglia E., Spinella P., Barbagallo C. M., Bombelli M., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Mallamaci F., Maloberti A., Masi S., Mazza A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Rivasi G., Salvetti M., Tocci G., Ungar A., Verdecchia P., Viazzi F., Virdis A., Volpe M., Grassi G., and Borghi C.
Abstract: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal) cerebrovascular (CBV) events in the whole database. The URic acid Right for heArt Health study is a nationwide, multicenter, observational cohort study involving data on subjects aged 18–95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 120.7 ± 61.8 months. A total of 14,588 subjects were included in the analysis. A prognostic cut-off value of SUA able to discriminate combined CBV events (>4.79 mg/dL or >284.91 µmol/L) was identified by means of receiver operating characteristic curve in the whole database. Multivariate Cox regression analysis adjusted for confounders (age, sex, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, body mass index, low-density lipoprotein cholesterol, and use of diuretics) identified an independent association between SUA and combined CBV events in the whole database (HR 1.249, 95% confidence interval, 1.041–1.497, p = 0.016). The results of the present study confirm that SUA is an independent risk marker for CBV events after adjusting for potential confounding variables, including arterial hypertension, and demonstrate that >4.79 mg/dL is a valid prognostic cut-off value.
Published: 2022

13. Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project

Author: Masulli, M, D'Elia, L, Angeli, F, Barbagallo, C, Bilancio, G, Bombelli, M, Bruno, B, Casiglia, E, Cianci, R, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Borghi, C, Galletti, F, Masulli M., D'Elia L., Angeli F., Barbagallo C. M., Bilancio G., Bombelli M., Bruno B., Casiglia E., Cianci R., Cicero A. F. G., Cirillo M., Cirillo P., Dell'Oro R., Desideri G., Ferri C., Gesualdo L., Giannattasio C., Grassi G., Iaccarino G., Lippa L., Mallamaci F., Maloberti A., Masi S., Mazza A., Mengozzi A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Reboldi G., Rivasi G., Salvetti M., Tikhonoff V., Tocci G., Ungar A., Verdecchia P., Viazzi F., Virdis A., Volpe M., Borghi C., Galletti F., Masulli, M, D'Elia, L, Angeli, F, Barbagallo, C, Bilancio, G, Bombelli, M, Bruno, B, Casiglia, E, Cianci, R, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Virdis, A, Volpe, M, Borghi, C, Galletti, F, Masulli M., D'Elia L., Angeli F., Barbagallo C. M., Bilancio G., Bombelli M., Bruno B., Casiglia E., Cianci R., Cicero A. F. G., Cirillo M., Cirillo P., Dell'Oro R., Desideri G., Ferri C., Gesualdo L., Giannattasio C., Grassi G., Iaccarino G., Lippa L., Mallamaci F., Maloberti A., Masi S., Mazza A., Mengozzi A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Reboldi G., Rivasi G., Salvetti M., Tikhonoff V., Tocci G., Ungar A., Verdecchia P., Viazzi F., Virdis A., Volpe M., Borghi C., and Galletti F.
Abstract: Background and aim: The URRAH (URic acid Right for heArt Health) Study has identified cut-off values of serum uric acid (SUA) predictive of total mortality at 4.7 mg/dl, and cardiovascular (CV) mortality at 5.6 mg/dl. Our aim was to validate these SUA thresholds in people with diabetes. Methods and results: The URRAH subpopulation of people with diabetes was studied. All-cause and CV deaths were evaluated at the end of follow-up. A total of 2570 diabetic subjects were studied. During a median follow-up of 107 months, 744 deaths occurred. In the multivariate Cox regression analyses adjusted for several confounders, subjects with SUA ≥5.6 mg/dl had higher risk of total (HR: 1.23, 95%CI: 1.04–1.47) and CV mortality (HR:1.31, 95%CI:1.03–1.66), than those with SUA <5.6 mg/dl. Increased all-cause mortality risk was shown in participants with SUA ≥4.7 mg/dl vs SUA below 4.7 mg/dl, but not statistically significant after adjustment for all confounders. Conclusions: SUA thresholds previously proposed by the URRAH study group are predictive of total and CV mortality also in people with diabetes. The threshold of 5.6 mg/dl can predict both total and CV mortality, and so is candidate to be a clinical cut-off for the definition of hyperuricemia in patients with diabetes.
Published: 2022

14. The association of uric acid with mortality modifies at old age: Data from the uric acid right for heart health (URRAH) study

Author: Ungar, A, Rivasi, G, Di Bari, M, Virdis, A, Casiglia, E, Masi, S, Mengozzi, A, Barbagallo, C, Bombelli, M, Bruno, B, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Ciccarelli, M, Lippa, L, Mallamaci, F, Maloberti, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Salvetti, M, Tikhonoff, V, Tocci, G, Cianci, R, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Ungar A., Rivasi G., Di Bari M., Virdis A., Casiglia E., Masi S., Mengozzi A., Barbagallo C. M., Bombelli M., Bruno B., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Ciccarelli M., Lippa L., Mallamaci F., Maloberti A., Mazza A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Salvetti M., Tikhonoff V., Tocci G., Cianci R., Verdecchia P., Viazzi F., Volpe M., Grassi G., Borghi C., Ungar, A, Rivasi, G, Di Bari, M, Virdis, A, Casiglia, E, Masi, S, Mengozzi, A, Barbagallo, C, Bombelli, M, Bruno, B, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Ciccarelli, M, Lippa, L, Mallamaci, F, Maloberti, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Salvetti, M, Tikhonoff, V, Tocci, G, Cianci, R, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Ungar A., Rivasi G., Di Bari M., Virdis A., Casiglia E., Masi S., Mengozzi A., Barbagallo C. M., Bombelli M., Bruno B., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Ferri C., Galletti F., Gesualdo L., Giannattasio C., Iaccarino G., Ciccarelli M., Lippa L., Mallamaci F., Maloberti A., Mazza A., Muiesan M. L., Nazzaro P., Palatini P., Parati G., Pontremoli R., Quarti-Trevano F., Rattazzi M., Salvetti M., Tikhonoff V., Tocci G., Cianci R., Verdecchia P., Viazzi F., Volpe M., Grassi G., and Borghi C.
Abstract: Objectives: In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for heart health (URRAH) study. Methods: Eight thousand URRAH participants aged 65R were included in the analysis. The predictive role of SUA was assessed using Cox regression models stratified according to the cut-off age of 75. SUA was tested as continuous and categorical variable (age-specific quartiles). The prognostic threshold of SUA for mortality was analysed using receiver operating characteristic curves. Results: Among participants aged 65–74, multivariate Cox regression analysis adjusted for CV risk factors and comorbidities identified an independent association of SUA with both all-cause mortality (hazard ratio [HR] 1.169, 95% confidence interval [CI] 1.107–1.235) and CV mortality (HR 1.146, 95% CI 1.064–1.235). The cut-off value of 4.8mg/dl discriminated mortality status. In participants aged 75R, we observed a J-shaped relationship of SUA with all-cause and CV mortality, with risk increasing at extreme SUA levels. Conclusions: These results confirmed the predictive role of SUA for all-cause and CV mortality in older adults, while revealing considerable age-related differences. Mortality risk increased at higher SUA levels in participants aged 65–74, with a prognostic threshold of 4.8mg/dl. The relationship between SUA and mortality was J-shaped in oldest participants. Large interventional studies are needed to clarify the benefits and possible risks of urate-lowering treatments in older adults.
Published: 2022

15. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author: Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, Borghi, Claudio, Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio
Abstract: The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.
Published: 2023

16. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author: Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Virdis, Agostino, Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Virdis, Agostino
Abstract: High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan–Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12–1.40], p < 0.001) and CVM (1.31 [1.11–1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12–1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02–1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23–1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99–1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.
Published: 2023

17. Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level

Author: Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio
Abstract: Background and aims: Whether the association between very high HDL-cholesterol levels and cardiovascular mortality (CVM) is modulated by some facilitating factors is unclear. Aim of the study was to investigate whether the risk of CVM associated with very high HDL-cholesterol is increased in subjects with hyperuricemia. Methods and results: Multivariable Cox analyses were made in 18,072 participants from the multicentre URRAH study stratified by sex and HDL-cholesterol category. During a median follow-up of 11.4 years there were 1307 cases of CVM. In multivariable Cox models a J-shaped association was found in the whole population, with the highest risk being present in the high HDL-cholesterol group [>80 mg/dL, adjusted hazard ratio (HR), 1.28; 95%CI, 1.02–1.61; p = 0.031)]. However, a sex-specific analysis revealed that this association was present only in women (HR, 1.34; 95%CI, 1.02–1.77; p = 0.034) but not in men. The risk of CVM related to high HDL-cholesterol was much greater in the women with high uric acid (>0.30 mmol/L, HR 1.61; 95%CI, 1.08–2.39) than in those with low uric acid (HR, 1.17; 95%CI, 0.80–1.72, p for interaction = 0.016). In women older than 70 years with hyperuricemia the risk related to high HDL-cholesterol was 1.83 (95%CI, 1.19–2.80, p < 0.005). Inclusion of BMI in the models weakened the strength of the associations. Conclusion: Our data indicate that very high HDL-cholesterol levels in women are associated with CVM in a J-shaped fashion. The risk of CVM is increased by concomitant hyperuricemia suggesting that a proinflammatory/oxidative state can enhance the detrimental cardiovascular effects associated with high HDL-cholesterol.
Published: 2023

18. Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Author: Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, and Borghi, Claudio
Abstract: Objective:In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events.Methods:Among 20 724 participants followed-up for 126 ± 64 months, after detecting cut-off by the receiver operating characteristic curves, we calculated by Cox models adjusted for confounders having CV events as dependent variable the hazard ratio (HR) of SUA/sCr > cut-off. We also verified if the role of cut-off varied with increasing SUA/sCr.Results:A plausible prognostic cut-off of SUA/sCr was found and was the same in the whole database, in men and in women (>5.35). The HR of SUA/sCr > cut-off was 1.159 (95% confidence interval [CI] 1.092-1.131, P < 0.03) in all, 1.161 (95% CI 1.021-1.335, P < 0.02) in men, and 1.444 (95% CI 1.012-1.113, P < 0.03) in women. In increasing quintiles of SUA/sCr the cut-offs were >3.08, >4.87, >5.35, >6.22 and >7.58, respectively. The HRs significantly increased from the 3rd to the 5th quintile (1.21, 95% CI 1.032-1.467, P = 0.018; 1.294, 95% CI 1.101-1.521, P = 0.002; and 1.642, 95% CI 1.405-1.919, P < 0.0001; respectively), that is, over 5.35, whereas the 2nd quintile was not significantly different from the 1st (reference).Conclusion:Having SUA/sCr >5.35 is an independent CV risk indicator both in men and women. The cut-off is dynamic and significantly increases with increasing SUA/sCr.
Published: 2023

19. Corrigendum to: High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid

Author: Palatini, P, Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Cicero, AFG, Barbagallo, CM, Muiesan, ML, Palatini, P, Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Cicero, AFG, Barbagallo, CM, and Muiesan, ML
Published: 2023

20. The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk

Author: Pugliese, N, Mengozzi, A, Virdis, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Parati, G, Palatini, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Masi, S, Borghi, C, Pugliese N. R., Mengozzi A., Virdis A., Casiglia E., Tikhonoff V., Cicero A. F. G., Ungar A., Rivasi G., Salvetti M., Barbagallo C. M., Bombelli M., Dell'Oro R., Bruno B., Lippa L., D'Elia L., Verdecchia P., Mallamaci F., Cirillo M., Rattazzi M., Cirillo P., Gesualdo L., Mazza A., Giannattasio C., Maloberti A., Volpe M., Tocci G., Georgiopoulos G., Iaccarino G., Nazzaro P., Parati G., Palatini P., Galletti F., Ferri C., Desideri G., Viazzi F., Pontremoli R., Muiesan M. L., Grassi G., Masi S., Borghi C., Pugliese, N, Mengozzi, A, Virdis, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Parati, G, Palatini, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Masi, S, Borghi, C, Pugliese N. R., Mengozzi A., Virdis A., Casiglia E., Tikhonoff V., Cicero A. F. G., Ungar A., Rivasi G., Salvetti M., Barbagallo C. M., Bombelli M., Dell'Oro R., Bruno B., Lippa L., D'Elia L., Verdecchia P., Mallamaci F., Cirillo M., Rattazzi M., Cirillo P., Gesualdo L., Mazza A., Giannattasio C., Maloberti A., Volpe M., Tocci G., Georgiopoulos G., Iaccarino G., Nazzaro P., Parati G., Palatini P., Galletti F., Ferri C., Desideri G., Viazzi F., Pontremoli R., Muiesan M. L., Grassi G., Masi S., and Borghi C.
Abstract: Introduction: Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis. Aim: We assessed the prognostic role of SUA in patients with and without MS. Methods: We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure. Results: A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previously validated cardiovascular SUA cut-off to predict CVM (> 5.1 mg/dL in women and 5.6 mg/dL in men), elevated SUA levels were significantly associated to a worse outcome in patients with and without MS (all p < 0.0001) and provided a significant net reclassification improvement of 7.1% over the diagnosis of MS for CVM (p = 0.004). Cox regression analyses identified an independent association between SUA and CVM (Hazard Ratio: 1.79 [95% CI, 1.15–2.79]; p < 0.0001) after the adjustment for MS, its single components and renal function. Three specific combinations of the MS components were associated with higher CVM when increasing SUA levels were reported, and systemic hypertension was the only individual component ever-present (all p < 0.0001). Conclusion: Increasing SUA levels are associated with a higher CVM risk irrespective of the presence of MS: a cardiovascular SUA threshold may improve risk stratification. Graphic abstract: [Figure not available: see fulltext.]
Published: 2021

21. Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study

Author: Maloberti, A, Bombelli, M, Facchetti, R, Barbagallo, C, Bernardino, B, Rosei, E, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Ferri, C, Galletti, F, Giannattasio, C, Loreto, G, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti A., Bombelli M., Facchetti R., Barbagallo C. M., Bernardino B., Rosei E. A., Casiglia E., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Dell'Oro R., Ferri C., Galletti F., Giannattasio C., Loreto G., Iaccarino G., Lippa L., Mallamaci F., Masi S., Mazza A., Muiesan M. L., Nazzaro P., Parati G., Palatini P., Pauletto P., Pontremoli R., Quarti-Trevano F., Rattazzi M., Rivasi G., Salvetti M., Tikhonoff V., Tocci G., Ungar A., Verdecchia P., Viazzi F., Volpe M., Virdis A., Grassi G., Borghi C., Maloberti, A, Bombelli, M, Facchetti, R, Barbagallo, C, Bernardino, B, Rosei, E, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Ferri, C, Galletti, F, Giannattasio, C, Loreto, G, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti A., Bombelli M., Facchetti R., Barbagallo C. M., Bernardino B., Rosei E. A., Casiglia E., Cicero A. F. G., Cirillo M., Cirillo P., Desideri G., D'elia L., Dell'Oro R., Ferri C., Galletti F., Giannattasio C., Loreto G., Iaccarino G., Lippa L., Mallamaci F., Masi S., Mazza A., Muiesan M. L., Nazzaro P., Parati G., Palatini P., Pauletto P., Pontremoli R., Quarti-Trevano F., Rattazzi M., Rivasi G., Salvetti M., Tikhonoff V., Tocci G., Ungar A., Verdecchia P., Viazzi F., Volpe M., Virdis A., Grassi G., and Borghi C.
Abstract: Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on the role of diuretic-related hyperuricemia are still scanty. The present study was designed to collect information on the relationship between diuretic-related hyperuricemia and cardiovascular events. Methods: The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122.3±66.9 months. Patients were classified into four groups according to the diuretic use (yes vs. no) and serum uric acid (SUA) levels (higher vs. lower than the median value of 4.8 mg/dl). All-cause death, cardiovascular deaths and first cardiovascular event were considered as outcomes. Results: Seventeen thousand, seven hundred and fortyseven individuals were included in the analysis. Mean age was 57.1±15.2 years, men were 45.3% and SBP and DBP amounted to 144.1±24.6 and 85.2±13.2 mmHg. 17.2% of individuals take diuretics of whom 58% had SUA higher than median value. Patients with hyperuricemia without diuretic use served as reference group. In multivariate adjusted analysis (sex, age, SBP, BMI, glucose, total cholesterol, and glomerular filtration rate) individuals with hyperuricemia and diuretic use exhibit a similar risk for the three outcomes as compared with the reference group. Conclusion: Our study showed that diuretic-related hyperuricemia carry a similar risk of cardiovascular events and all-cause mortality when compared with individuals that present hyperuricemia in absence of diuretic therapy.
Published: 2021

22. Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project

Author: Maloberti, A, Giannattasio, C, Bombelli, M, Desideri, G, Cicero, A, Muiesan, M, Rosei, E, Salvetti, M, Ungar, A, Rivasi, G, Pontremoli, R, Viazzi, F, Facchetti, R, Ferri, C, Bernardino, B, Galletti, F, D'Elia, L, Palatini, P, Casiglia, E, Tikhonoff, V, Barbagallo, C, Verdecchia, P, Masi, S, Mallamaci, F, Cirillo, M, Rattazzi, M, Pauletto, P, Cirillo, P, Gesualdo, L, Mazza, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Lippa, L, Parati, G, Dell'Oro, R, Quarti-Trevano, F, Grassi, G, Virdis, A, Borghi, C, Maloberti, Alessandro, Cicero, A F G, Muiesan, M L, Rosei, E A, Barbagallo, C M, Maloberti, A, Giannattasio, C, Bombelli, M, Desideri, G, Cicero, A, Muiesan, M, Rosei, E, Salvetti, M, Ungar, A, Rivasi, G, Pontremoli, R, Viazzi, F, Facchetti, R, Ferri, C, Bernardino, B, Galletti, F, D'Elia, L, Palatini, P, Casiglia, E, Tikhonoff, V, Barbagallo, C, Verdecchia, P, Masi, S, Mallamaci, F, Cirillo, M, Rattazzi, M, Pauletto, P, Cirillo, P, Gesualdo, L, Mazza, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Lippa, L, Parati, G, Dell'Oro, R, Quarti-Trevano, F, Grassi, G, Virdis, A, Borghi, C, Maloberti, Alessandro, Cicero, A F G, Muiesan, M L, Rosei, E A, and Barbagallo, C M
Abstract: The latest European Guidelines of Arterial Hypertension have officially introduced uric acid evaluation among the cardiovascular risk factors that should be evaluated in order to stratify patient’s risk. In fact, it has been extensively evaluated and demonstrated to be an independent predictor not only of all-cause and cardiovascular mortality, but also of myocardial infraction, stroke and heart failure. Despite the large number of studies on this topic, an important open question that still need to be answered is the identification of a cardiovascular uric acid cut-off value. The actual hyperuricemia cut-off (> 6 mg/dL in women and 7 mg/dL in men) is principally based on the saturation point of uric acid but previous evidence suggests that the negative impact of cardiovascular system could occur also at lower levels. In this context, the Working Group on uric acid and CV risk of the Italian Society of Hypertension has designed the Uric acid Right for heArt Health project. The primary objective of this project is to define the level of uricemia above which the independent risk of CV disease may increase in a significantly manner. In this review we will summarize the first results obtained and describe the further planned analysis.
Published: 2020

23. PROGNOSTIC CUTOFF OF TRIGLYCERIDES PREDICTING CARDIOVASCULAR OUTCOME IN A LARGE REGIONAL-BASED ITALIAN DATABASE

Author: Tikhonoff, V, Casiglia, E, Virdis, A, Barbagallo, C, Cirillo, M, Desideri, G, Ferri, C, Galletti, F, Grassi, G, Giannattasio, C, Iaccarino, G, Mazza, A, Muiesan, M, Palatini, P, Parati, G, Pontremoli, R, Verdecchia, P, Volpe, M, Ungar, A, Borghi, C, Tikhonoff, Valerie, Casiglia, Edoardo, Virdis, Agostino, Barbagallo, Carlo, Cirillo, Massimo, Desideri, Giambattista, Ferri, Claudio, Galletti, Ferruccio, Grassi, Guido, Giannattasio, Cristina, Iaccarino, Guido, Mazza, Alberto, Muiesan, Maria Lorenza, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Verdecchia, Paolo, Volpe, Massimo, Ungar, Andrea, Borghi, Caludio, Tikhonoff, V, Casiglia, E, Virdis, A, Barbagallo, C, Cirillo, M, Desideri, G, Ferri, C, Galletti, F, Grassi, G, Giannattasio, C, Iaccarino, G, Mazza, A, Muiesan, M, Palatini, P, Parati, G, Pontremoli, R, Verdecchia, P, Volpe, M, Ungar, A, Borghi, C, Tikhonoff, Valerie, Casiglia, Edoardo, Virdis, Agostino, Barbagallo, Carlo, Cirillo, Massimo, Desideri, Giambattista, Ferri, Claudio, Galletti, Ferruccio, Grassi, Guido, Giannattasio, Cristina, Iaccarino, Guido, Mazza, Alberto, Muiesan, Maria Lorenza, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Verdecchia, Paolo, Volpe, Massimo, Ungar, Andrea, and Borghi, Caludio
Abstract: Objective: Searching for a prognostic cut-off value of triglycerides (TG) in predicting cardiovascular (CV) outcome in a large regional-based Italian database of men and women. Design and method: A nationwide multicentre database collects data on subjects aged 18 to 95 years recruited on a regional community basis from all the territory of Italy with at least 1 measure of TG and a mean follow-up of 110.1 ± 64.3 months. A total of 18,784 subjects were included in the analysis. CV outcome was defined on the basis of ICD10 codes and double-checked with general practitioners and hospital files. Multivariate dichotomic Cox regression models having CV outcome as dependent variable, adjusted for age, sex, serum uric acid, body mass index, total and HDL-cholesterol, arterial hypertension, diabetes, chronic renal disease, smoking habit, use of antihypertensive and lipid lowering drugs were preliminarily used to search for an association between TG log-transformed as a continuous variable and CV event. The conventional cut-off value of TG (150 mg/d) and the prognostic cut-off value of TG identified by means of receiver operating characteristics (ROC) curves, both able to discriminate between subjects developing a CV event, were used as independent predictors in further multivariate Cox models adjusted for the confounders listed above. Results: During 172,329 person-years of follow-up, 1910 participants experienced CV events (11.1 per 1000 age-adjusted person-years). In Cox analysis, TG as a continuous variable was a significant predictor of CV event [odds ratio, OR, 1.189 (1.060-1.334), p = 0.003]. ROC curve showed that > 105 mg/dl (95%CI 75.8-129.3, sensitivity 61.7, specificity 48.8, p < 0.0001) was the prognostic cut-off value for CV event. The conventional cut-off (150 mg/dl) and that identified by ROC curve (105 mg/dl) were both accepted as multivariate predictors in separate Cox analyses, the hazard ratios being 1.157 (95%CI 1.037-1.290, p = 0.009) and 1.137 (95%C
Published: 2022

24. SERUM URIC ACID, LEFT VENTRICULAR MASS AND CARDIOVASCULAR DEATH. THE URIC ACID RIGHT FOR HEART HEALTH (URRAH) STUDY

Author: Muiesan, M, Salvetti, M, Paini, A, Rosei, C, Virdis, A, Casiglia, E, Tikhonoff, V, Barbagallo, C, Cirillo, M, Desideri, G, Ferri, C, Galletti, F, Giannattasio, C, Iaccarino, G, Mallamaci, F, Masi, S, Mazza, A, Palatini, P, Pontremoli, R, Verdecchia, P, Volpe, M, Grassi, G, Borghi, C, Muiesan, Maria Lorenza, Salvetti, Massimo, Paini, Anna, Rosei, Claudia Agabiti, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Barbagallo, Carlo Maria, Desideri, Giovanbattista, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Masi, Stefano, Mazza, Alberto, Palatini, Paolo, Pontremoli, Roberto, Verdecchia, Paolo, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Muiesan, M, Salvetti, M, Paini, A, Rosei, C, Virdis, A, Casiglia, E, Tikhonoff, V, Barbagallo, C, Cirillo, M, Desideri, G, Ferri, C, Galletti, F, Giannattasio, C, Iaccarino, G, Mallamaci, F, Masi, S, Mazza, A, Palatini, P, Pontremoli, R, Verdecchia, P, Volpe, M, Grassi, G, Borghi, C, Muiesan, Maria Lorenza, Salvetti, Massimo, Paini, Anna, Rosei, Claudia Agabiti, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Barbagallo, Carlo Maria, Desideri, Giovanbattista, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Masi, Stefano, Mazza, Alberto, Palatini, Paolo, Pontremoli, Roberto, Verdecchia, Paolo, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
Abstract: Objective: A relationship between serum uric acid(UA)and CV events has been documented in the URRAH study.The association between UA and left ventricular mass index(LVMI)has been investigated with heterogeneous results.Aim of this study was to investigate the association between UA and LVMI and whether UA and LVMI or they combination may predict the incidence of death for CV disease(CVM)in a large Italian cohort in the frame of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension(SIIA). Design and method: URRAH study is a nationwide,multicentre,observational cohort study involving data on subjects aged 18to95years,recruited on a community basis from all regions of Italy under the patronage of the SIIA.CVM was defined as death due to fatal myocardial infarction,stroke,sudden cardiac death,or heart failure.Multivariate Cox regression models having CVM as dependent variables,adjusted for age,sex,BMI, SBP,glycemia,total cholesterol,triglycerides,HDL-cholesterol,smoking and estimated glomerular filtration rate(eGFR)were used to search for an association between UAandLVMI as a continuous variable and CVM.LVH was defined asLVMI> 95 g/m2 in women and 115 g/m2 in men. Results: 10733 subjects(mean age,54years;51þmale)with echocardiographic LVMI measurements were included in the analysis study.A significant association between UA and LVMI was confirmed in multiple regression analysis in both sexes(men:beta0,095,F5.47,P < 0.001;women:beta0,069,F4.36,P < 0.001).During follow-up(median 130months),319subjects died for a CVevent,including myocardial infarction, angina pectoris, congestive heart failure and cerebrovascular disease.Previously identified sex specific cut off values(5.6 mg/dl men,5.1 mg/dl women)and LVH were used to define 4 different groups(normal UA and LVMI,increased UA and no LVH,normal UA and LVH,increased UA and LVH).Kaplan-Meier curves showed a significantly poorer survival rate in the group with higher UA and LV
Published: 2022

25. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project

Author: Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo Maria, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo Maria, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
Abstract: Background: Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database. Methods: Clinical data of 26,971 individuals were analyzed. Factors associated with the presence of hyperuricemia defined on the basis of previously determined URRAH cutoffs for cardiovascular and all-cause mortality were evaluated through multivariate analysis. Chronic kidney disease was defined as eGFR < 60 ml/min per 1.73 m2 and/or abnormal urinary albumin excretion diagnosed as: (i) microalbuminuria if urinary albumin concentration was > 30 and ≤ 300 mg/L, or if urinary albumin-to-creatinine ratio (ACR) was > 3.4 mg/mmol and ≤ 34 mg/mmol; (ii) macroalbuminuria if urinary albumin concentration was > 300 mg/L, or if ACR was > 34 mg/mmol. Results: Mean age was 58 ± 15 years (51% males, 62% with hypertension and 12% with diabetes), mean eGFR was 81 ml/min per 1.73m22with a prevalence of eGFR < 60 and micro- or macroalbuminuria of 16, 15 and 4%, respectively. Serum uric acid showed a trend towards higher values along with decreasing renal function. Both the prevalence of gout and the frequency of allopurinol use increased significantly with the reduction of eGFR and the increase in albuminuria. Hyperuricemia was independently related to male gender, eGFR strata, and signs of insulin resistance such as body mass index (BMI) and triglycerides. Conclusions: The lower the eGFR the higher th
Published: 2022

26. High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid

Author: Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Parati, Gianfranco, Virdis, Agostino, Reboldi, Gianpaolo, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Parati, Gianfranco, Virdis, Agostino, Reboldi, Gianpaolo, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio
Abstract: Aims: Whether the association between uric acid (UA) and cardiovascular disease is influenced by some facilitating factors is unclear. The aim of this study was to investigate whether the risk of cardiovascular mortality (CVM) associated with elevated UA was modulated by the level of resting heart rate (HR). Methods and results: Multivariable Cox analyses were made in 19 128 participants from the multicentre Uric acid Right for heArt Health study. During a median follow-up of 11.2 years, there were 1381 cases of CVM. In multivariable Cox models both UA and HR, either considered as continuous or categorical variables were independent predictors of CVM both improving risk discrimination (P ≤ 0.003) and reclassification (P < 0.0001) over a multivariable model. However, the risk of CVM related to high UA (≥5.5 mg/dL, top tertile) was much lower in the subjects with HR
Published: 2022

27. Comparison of two polygenic risk score to identify non-monogenic primary hypocholesterolemias in a large cohort of Italian hypocholesterolemic subjects: Polygenic hypocholesterolemias

Author: Cefalu A. B., Spina R., Noto D., Rabacchi C., Giammanco A., Simone M. L., Brucato F., Scrimali C., Gueli-Alletti M. G., Barbagallo C. M., Tarugi P., Averna M, Cefalu A.B., Spina R., Noto D., Rabacchi C., Giammanco A., Simone M.L., Brucato F., Scrimali C., Gueli-Alletti M.G., Barbagallo C.M., Tarugi P., and Averna M
Subjects: Polygenic risk score, Mutation, Hypobetalipoproteinemia
Abstract: Background: Primary Hypobetalipoproteinemias (HBL) are a group of dominant and recessive monogenic genetic disorders caused by mutations in APOB, PCSK9, ANGPTL3, MTTP, Sar1b genes and characterized by plasma levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (apoB) below the 5th percentile of the distribution in a given population. Mutations in the candidate genes account only for a small proportion of subjects with HBL suggesting a role for a polygenic contribution to the low cholesterol phenotype. Objective: To explore the complex genetic architecture of HBL we compared two polygenic risk scores in order to assess the role of the polygenic burden and the differences in the clinical phenotype between monogenic and polygenic HBL; we studied a cohort of 170 subjects with primary HBL referred over a 25-year period to 2 Italian reference centers have been studied. Methods: The genetic analyses have been based on: Sanger sequencing, in-house NGS customized panel and two scores, PRS1 and PRS2 for the polygenic burden. Results: Sixty 60 (35%) and 63 (37%) subjects had a monogenic and polygenic HBL respectively. LDL-C plasma levels were significantly lower in monogenic HBL (30.87 ± 3.12 mg/dl) compared with the non-monogenic HBL (42.80 ± 2.18 mg/dl) (p
Published: 2022

28. Pristine Quality Networked Music Performance System for the Web

Author: Sacchetto, M., primary, Severi, L., additional, Rottondi, C., additional, Shtrepi, L., additional, Masoero, M.C., additional, Barbagallo, C., additional, Valle, A., additional, and Servetti, A., additional
Published: 2022
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29. The Clinical Approach to the Patients with Low HDL and Elevated Plasma Triglyceride

Author: Averna, M. R., Barbagallo, C. M., Notarbartolo, A., Catapano, A. L., editor, Gotto, A. M., Jr., editor, Smith, Louis C., editor, and Paoletti, Rodolfo, editor
Published: 1993
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30. Lipid and apolipoprotein in cord blood

Author: Averna, M. R., Barbagallo, C. M., Amato, S., Di Paola, G., Marino, G., Labisi, M., Dimita, U., Notarbartolo, A., Descovich, Giancarlo, editor, Gaddi, Antonio, editor, Magri, Gianluigi, editor, and Lenzi, Sergio, editor
Published: 1990
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31. Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study

Author: Muiesan, M, Salvetti, M, Virdis, A, Masi, S, Casiglia, E, Tikhonoff, V, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D’Eliak, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Mazza, A, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Rattazzi, M, Rivasi, G, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Muiesan, Maria L., Salvetti, Massimo, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valérie, Barbagallo, Carlo M., Bombelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Eliak, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Rattazzi, Marcello, Rivasi, Giulia, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Muiesan, M, Salvetti, M, Virdis, A, Masi, S, Casiglia, E, Tikhonoff, V, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D’Eliak, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Mallamaci, F, Maloberti, A, Mazza, A, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Rattazzi, M, Rivasi, G, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Muiesan, Maria L., Salvetti, Massimo, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valérie, Barbagallo, Carlo M., Bombelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Eliak, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Rattazzi, Marcello, Rivasi, Giulia, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
Abstract: OBJECTIVE: To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal and morbid heart failure in a large Italian cohort in the frame of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension. METHODS: The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, cohort study involving data on individuals aged 18-95 years, recruited on a community basis from all regions of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 128 ± 65 months. Incident heart failure was defined on the basis of International Classification of Diseases Tenth Revision codes and double-checked with general practitioners and hospital files. Multivariate Cox regression models having fatal and morbid heart failure as dependent variables, adjusted for sex, age, SBP, diabetes, estimated glomerular filtration rate, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol, previous diagnosis of heart failure and use of diuretics as possible confounders, were used to search for an association between SUA as a continuous variable and heart failure. By means of receiver operating characteristic curves, two prognostic cut-off values (one for all heart failure and one for fatal heart failure) were identified as able to discriminate between individuals doomed to develop the event. These cut-off values were used as independent predictors to divide individuals according to prognostic cut-off values in a multivariate Cox models, adjusted for confounders. RESULTS: A total of 21 386 individuals were included in the analysis. In Cox analyses, SUA as a continuous variable was a significant predictor of all [hazard ratio 1.29 (1.23-1.359), P < 0.0001] and fatal [hazard ratio 1.268 (1.121-1.35), P < 0.0001] incident heart failure. Cut-off values of SUA able to discriminate all and fatal heart failure status were identified by mean of receiver operating characteristic cur
Published: 2021

32. Serum Uric Acid and Kidney Disease Measures Independently Predict Cardiovascular and Total Mortality: The Uric Acid Right for Heart Health (URRAH) Project

Author: Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Quarti Trevano, F, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo M, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria L, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Quarti Trevano, Fosca A L, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Quarti Trevano, F, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo M, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria L, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Quarti Trevano, Fosca A L, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
Abstract: Background: Serum uric acid predicts the onset and progression of kidney disease, and the occurrence of cardiovascular and all-cause mortality. Nevertheless, it is unclear which is the appropriate definition of hyperuricemia in presence of chronic kidney disease (CKD). Our goal was to study the independent impact of uric acid and CKD on mortality.Methods: We retrospectively investigated 21,963 patients from the URRAH study database. Hyperuricemia was defined on the basis of outcome specific cut-offs separately identified by ROC curves according to eGFR strata. The primary endpoints were cardiovascular and all-cause mortality.Results: After a mean follow-up of 9.8 year, there were 1,582 (7.20%) cardiovascular events and 3,130 (14.25%) deaths for all causes. The incidence of cardiovascular and all-cause mortality increased in parallel with reduction of eGFR strata and with progressively higher uric acid quartiles. During 215,618 person-years of follow-up, the incidence rate for cardiovascular mortality, stratified based on eGFR (>90, between 60 and 90 and <60 ml/min) was significantly higher in patients with hyperuricemia and albuminuria (3.8, 22.1 and 19.1, respectively) as compared to those with only one risk factor or none (0.4, 2.8 and 3.1, respectively). Serum uric acid and eGFR significantly interact in determining cardiovascular and all-cause mortality. For each SUA increase of 1 mg/dl the risk for mortality increased by 10% even after adjustment for potential confounding factors included eGFR and the presence of albuminuria.Conclusions: hyperuricemia is a risk factor for cardiovascular and all-cause mortality additively to eGFR strata and albuminuria, in patients at cardiovascular risk.
Published: 2021

33. Lipid and Apoprotein Profile in Renal Transplant Recipients

Author: Barbagallo, C. M., Averna, M. R., Sparacino, V., Caputo, F, Labisi, M, Marino, G, Mancino, C, Calabrese, S, Notarbartolo, A, Andreucci, Vittorio E., editor, and Dal Canton, Antonio, editor
Published: 1991
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34. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries

Author: Taddei, C. (Cristina), Jackson, R. (Rod), Zhou, B. (Bin), Bixby, H. (Honor), Danaei, G. (Goodarz), Di Cesare, M. (Mariachiara), Kuulasmaa, K. (Kari), Hajifathalian, K. (Kaveh), Bentham, J. (James), Bennett, J. E. (James E.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Dallongeville, J. (Jean), DeBacquer, D. (Dirk), Giampaoli, S. (Simona), Gudnason, V. (Vilmundur), Khang, Y.-H. (Young-Ho), Laatikainen, T. (Tiina), Mann, J. I. (Jim, I), Marques-Vidal, P. (Pedro), Mensah, G. A. (George A.), Mueller-Nurasyid, M. (Martina), Ninomiya, T. (Toshiharu), Petkeviciene, J. (Janina), Rodriguez-Artalejo, F. (Fernando), Servais, J. (Jennifer), Soderberg, S. (Stefan), Stavreski, B. (Bill), Wilsgaard, T. (Tom), Zdrojewski, T. (Tomasz), Zhao, D. (Dong), Stevens, G. A. (Gretchen A.), Savin, S. (Stefan), Cowan, M. J. (Melanie J.), Riley, L. M. (Leanne M.), Ezzati, M. (Majid), Adams, R. J. (Robert J.), Ahrens, W. (Wolfgang), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Anderssen, S. A. (Sigmund A.), Ariansen, I. (Inger), Arveiler, D. (Dominique), Aspelund, T. (Thor), Auvinen, J. (Juha), Avdicova, M. (Maria), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Bata, I. (Iqbal), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Bernotiene, G. (Gailute), Bi, Y. (Yufang), Bienek, A. (Asako), Bjorkelund, C. (Cecilia), Bo, S. (Simona), Boehm, B. O. (Bernhard O.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Bruno, G. (Graziella), Busch, M. A. (Markus A.), Cabrera de Leon, A. (Antonio), Capuano, V. (Vincenzo), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Censi, L. (Laura), Chen, F. (Fangfang), Chen, S. (Shuohua), Chirlaque, M.-D. (Maria-Dolores), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Cooper, C. (Cyrus), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A. B. (Ana B.), Cui, L. (Liufu), D'Arrigo, G. (Graziella), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Dennison, E. (Elaine), Deschamps, V. (Valerie), Di Castelnuovo, A. (Augusto), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Doering, A. (Angela), Drygas, W. (Wojciech), Du, Y. (Yong), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), Elosua, R. (Roberto), Eriksson, J. G. (Johan G.), Evans, A. (Alun), Faeh, D. (David), Felix-Redondo, F. J. (Francisco J.), Fernandez-Berges, D. (Daniel), Ferrari, M. (Marika), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gianfagna, F. (Francesco), Gill, T. K. (Tiffany K.), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonzalez Gross, M. (Marcela), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grosso, G. (Giuseppe), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guallar-Castillon, P. (Pilar), Gudmundsson, E. F. (Elias F.), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gutzwiller, F. (Felix), Hardy, R. (Rebecca), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A. J. (Alison J.), He, J. (Jiang), He, Y. (Yuna), Herrala, S. (Sauli), Hihtaniemi, I. T. (Ilpo Tapani), Hobbs, M. (Michael), Hopman, W. M. (Wilma M.), Maria Huerta, J. (Josi), Huybrechts, I. (Inge), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ikeda, N. (Nayu), Iwasaki, M. (Masanori), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jennings, G. (Garry), Jeong, S.-L. (Seung-Lyeal), Jiang, C. Q. (Chao Qiang), Joffres, M. (Michel), Jokelainen, J. J. (Jari J.), Jonas, J. B. (Jost B.), Jozwiak, J. (Jacek), Kajantie, E. O. (Eero O.), Kauhanen, J. (Jussi), Keil, U. (Ulrich), Keinanen-Kiukaanniemi, S. (Sirkka), Kersting, M. (Mathilde), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kolle, E. (Elin), Korpelainen, R. (Raija), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Krokstad, S. (Steinar), Kujala, U. M. (Urho M.), Kurjata, P. (Pawel), Lam, T. H. (Tai Hing), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L. E. (Lars E.), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lin, X. (Xu), Lind, L. (Lars), Lissner, L. (Lauren), Liu, J. (Jing), Lopez-Garcia, E. (Esther), Lorbeer, R. (Roberto), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Manzato, E. (Enzo), Mathiesen, E. B. (Ellisiv B.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McLean, S. B. (Scott B.), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Metcalf, P. (Patricia), Mi, J. (Jie), Miller, J. C. (Jody C.), Moreno, L. A. (Luis A.), Morin, S. N. (Suzanne N.), Mossakowska, M. (Malgorzata), Muiesan, M. L. (Maria L.), Mursu, J. (Jaakko), Nakamura, H. (Harunobu), Namesna, J. (Jana), Nauck, M. (Matthias), Maria Navarrete-Munoz, E. (Eva), Neal, W. A. (William A.), Nenko, I. (Ilona), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Noale, M. (Marianna), Norie, S. (Sawada), Noto, D. (Davide), O'Neill, T. (Terence), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olafsson, O. (Orn), Paccaud, F. M. (Fred Michel), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Panza, F. (Francesco), Parnell, W. R. (Winsome R.), Peltonen, M. (Markku), Peters, A. (Annette), Petersmann, A. (Astrid), Pigeot, I. (Iris), Pilotto, L. (Lorenza), Piwonska, A. (Aleksandra), Plans-Rubio, P. (Pedro), Porta, M. (Miquel), Price, J. F. (Jacqueline F.), Puder, J. J. (Jardena J.), Puhakka, S. E. (Soile E.), Radisauskas, R. (Ricardas), Raitakari, O. (Olli), Ramos, R. (Rafel), Redon, J. (Josep), Rigo, F. (Fernando), del Cristo Rodriguez-Perez, M. (Maria), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Roy, J. G. (Joel G. R.), Ruidavets, J.-B. (Jean-Bernard), Rutkowski, M. (Marcin), Salanave, B. (Benoit), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sans, S. (Susana), Saramies, J. L. (Jouko L.), Saum, K.-U. (Kai-Uwe), Scheidt-Nave, C. (Christa), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C. O. (Carsten O.), Schoettker, B. (Ben), Sebert, S. (Sylvain), Sen, A. (Abhijit), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shiri, R. (Rahman), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Stathopoulou, M. G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stokwiszewski, J. (Jakub), Sundstrom, J. (Johan), Suriyawongpaisal, P. (Paibul), Tamosiunas, A. (Abdonas), Tan, E. J. (Eng Joo), Taylor, A. (Anne), Tell, G. (Grethe), Thijs, L. (Lutgarde), Tolonen, H. K. (Hanna K.), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Tsugane, S. (Shoichiro), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tzourio, C. (Christophe), Uusitalo, H. M. (Hannu M. T.), Van Herck, K. (Koen), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Veronesi, G. (Giovanni), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wagner, A. (Aline), Wagner, A. (Anne), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wei, W. (Wenbin), Whincup, P. H. (Peter H.), Wiecek, A. (Andrzej), Willeit, J. (Johann), Willeit, P. (Peter), Wojtyniak, B. (Bogdan), Wong, A. (Andrew), Woodward, M. (Mark), Wu, F. C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Zambon, S. (Sabina), and Zhao, W. (Wenhua)
Subjects: blood lipids, HDL cholesterol, LDL cholesterol, total cholesterol, nutritional and metabolic diseases, lipids (amino acids, peptides, and proteins), multi-country study
Abstract: Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
Published: 2020

35. Repositioning of the global epicentre of non-optimal cholesterol

Author: Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R. M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R. T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M. K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M. L. (Maria Laura Caminia), Martinez, A. R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, T. (Trudy), Riley, L. M. (Leanne M.), Cowan, M. J. (Melanie J.), Savin, S. (Stefan), Bennett, J. E. (James E.), Stevens, G. A. (Gretchen A.), Paciorek, C. J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A. P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B. G. (Borge G.), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gomez, L. (Leandra), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. J. (Robert J.), Agdeppa, I. A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahluwalia, T. S. (Tarunveer S.), Ahmad, N. A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S. H. (Soheir H.), Ahrens, W. (Wolfgang), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M. M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amarapurkar, D. N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Anjana, R. M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R. E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K. K. (Krishna K.), Aspelund, T. (Thor), Assuncao, M. C. (Maria Cecilia F.), Auvinen, J. (Juha), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M. B. (Marius B.), Bjorkelund, C. (Cecilia), Bloch, K. V. (Katia, V), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B. O. (Bernhard O.), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M. A. (Markus A.), de Leon, A. C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capanzana, M. V. (Mario, V), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F. F. (Felipe F.), Censi, L. (Laura), Chadjigeorgiou, C. A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.-D. (Maria-Dolores), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S. C. (Susana C.), Cooper, C. (Cyrus), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A. B. (Ana B.), Csilla, S. (Semanova), Cui, L. (Liufu), Cureau, F. V. (Felipe, V), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P. D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A. D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Helene), Dennison, E. (Elaine), Deschamps, V. (Valerie), Dhimal, M. (Meghnath), Di Castelnuovo, A. F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C. A. (Charmaine A.), Duda, R. B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Eriksson, J. G. (Johan G.), Escobedo-de la Pena, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M. R. (Mohammad Reza), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Foger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J. M. (Johanna M.), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T. K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Goncalves, H. (Helen), Gonzalez-Chica, D. A. (David A.), Gonzalez-Gross, M. (Marcela), Gonzalez-Rivas, J. P. (Juan P.), Gonzalez-Villalpando, C. (Clicerio), Gonzalez-Villalpando, M.-E. (Maria-Elena), Gonzalez, A. R. (Angel R.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-Castillon, P. (Pilar), Guan, O. P. (Ong Peng), Gudmundsson, E. F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I. R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R. H. (Rachakulla Hari), Hashemi-Shahri, S. M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A. J. (Alison J.), He, J. (Jiang), He, Y. (Yuna), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A. G. (Allan G.), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W. M. (Wilma M.), Horimoto, A. R. (Andrea R. V. R.), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Htike, M. M. (Maung Maung Than), Huerta, J. M. (Jose Maria), Huhtaniemi, I. T. (Ilpo Tapani), Huisman, M. (Martijn), Hunsberger, M. L. (Monica L.), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (Mohsen M.), Wong, N. I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M. A. (M. Arfan), Iotova, V. (Violeta), Irazola, V. E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), Ismail, A. A. (Aziz Al-Safi), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jaddou, H. Y. (Hashem Y.), Jafar, T. (Tazeen), James, K. (Kenneth), Jamrozik, K. (Konrad), Janszky, I. (Imre), Janus, E. (Edward), Järvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G. B. (Gorm B.), Jeong, S.-l. (Seung-lyeal), Jha, A. K. (Anjani Kumar), Jiang, C. Q. (Chao Qiang), Jimenez, R. O. (Ramon O.), Jockel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J. J. (Jari J.), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Jozwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. O. (Eero O.), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kamstrup, P. R. (Pia R.), Karki, K. B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H. C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I. V. (Iliana, V), Kolle, E. (Elin), Kolsteren, P. (Patrick), Konig, J. (Jurgen), Korpelainen, R. (Raija), . (), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U. M. (Urho M.), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F. Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T. H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T. S. (Tint Swe), Laugsand, L. E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimaki, T. (Terho), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M. F. (M. Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Lind, L. (Lars), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P. A. (Paulo A.), Lozano, J. E. (Jose Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G. L. (George L. L.), Machado-Rodrigues, A. M. (Aristides M.), Machi, S. (Suka), Madar, A. A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Rao, K. M. (Kodavanti Mallikharjuna), Manios, Y. (Yannis), Mann, J. I. (Jim, I), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L. P. (Luis P.), Mathiesen, E. B. (Ellisiv B.), Matsha, T. E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McLean, S. B. (Scott B.), McNulty, B. A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A. (AmirHoushang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I. I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H. E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J. C. (Jody C.), Minderico, C. S. (Claudia S.), Mini, G. K. (G. K.), Miquel, J. F. (Juan Francisco), Miranda, J. J. (J. Jaime), Mirjalili, M. R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P. A. (Pietro A.), Moghaddam, S. S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M. (MostafaK), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), MohdYusoff, M. F. (Muhammad Fadhli), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Mollehave, L. T. (Line T.), Mller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Mondo, C. K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Morin, S. N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K. P. (Kelias P.), Muiesan, M. L. (Maria L.), Muller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Nauck, M. (Matthias), Neal, W. A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noto, D. (Davide), Al Nsour, M. (Mohannad), Nuhoglu, I. (Irfan), O'Neill, T. W. (Terence W.), O'Reilly, D. (Dermot), Ochoa-Aviles, A. M. (Angelica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, O. (Orn), Olie, V. (Valerie), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ong, S. (SokKing), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P. J. (Pedro J.), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Ostovar, A. (Afshin), Otero, J. A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W. R. (Winsome R.), Patel, N. D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S. V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pichardo, R. N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, L. (Lorenza), Piwonska, A. (Aleksandra), Pizarro, A. N. (Andreia N.), Plans-Rubio, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J. F. (Jacqueline F.), Providencia, R. (Rui), Puder, J. J. (Jardena J.), Puhakka, S. E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S. R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Perez, M. d. (Maria del Cristo), Rodriguez-Villamizar, L. A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E. L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J. G. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B. S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A. R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasias, A. M. (Alba M.), Santos, D. A. (Diana A.), Santos, M. (MariaPaula), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B. D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (Christa), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C. O. (Carsten O.), Schottker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A. A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S. G. (Sadaf G.), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S. A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjostrom, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M. B. (Marieke B.), Soderberg, S. (Stefan), Soemantri, A. (Agustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M. H. (Mohammad Hossein), Sonestedt, E. (Emily), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J. A. (Jan A.), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stessman, J. (Jochanan), Stevanovic, R. (Ranko), Stieber, J. (Jutta), Stockl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Suarez-Medina, R. (Ramon), Sun, C.-A. (Chien-An), Sundstrom, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Sylva, R. C. (Rene Charles), Szklo, M. (Moyses), Tai, E. S. (E. Shyong), Tamosiunas, A. (Abdonas), Tan, E. (EngJoo), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G. S. (Grethe S.), Tello, T. (Tania), Thankappan, K. R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Toft, U. (Ulla), Tolonen, H. K. (Hanna K.), Tolstrup, J. S. (Janne S.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Tormo, M. J. (Maria Jose), Tornaritis, M. J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O. T. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van Dam, R. (RobM), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), Rossem, L. (Lenievan), Van Schoor, N. M. (Natasja M.), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Perez, P. (Patricia), Vasan, S. K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernandez, S. J. (Silvia J.), Veronesi, G. (Giovanni), MoniqueVerschuren, W. M. (W. M.), Victora, C. G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W. M. (Wan Mohamad Wan), WanMohamud, W. N. (Wan Nazaimoon), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S. G. (S. Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R. A. (Roy A.), Wong, A. (Andrew), Wong, T. Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F. C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T. P. (Toh Peng), Yiallouros, P. K. (Panayiotis K.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad Faudzi), Zainuddin, A. A. (Ahmad A.), Zakavi, S. R. (Seyed Rasoul), Zali, M. R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), KoZaw, K. (Ko), Zdrojewski, T. (Tomasz), Vrkic, T. Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J. Z. (Julio Zuniga), Gregg, E. W. (Edward W.), Ezzati, M. (Majid), Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R. M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R. T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M. K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M. L. (Maria Laura Caminia), Martinez, A. R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, T. (Trudy), Riley, L. M. (Leanne M.), Cowan, M. J. (Melanie J.), Savin, S. (Stefan), Bennett, J. E. (James E.), Stevens, G. A. (Gretchen A.), Paciorek, C. J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A. P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B. G. (Borge G.), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gomez, L. (Leandra), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. J. (Robert J.), Agdeppa, I. A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahluwalia, T. S. (Tarunveer S.), Ahmad, N. A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S. H. (Soheir H.), Ahrens, W. (Wolfgang), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M. M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amarapurkar, D. N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Anjana, R. M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R. E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K. K. (Krishna K.), Aspelund, T. (Thor), Assuncao, M. C. (Maria Cecilia F.), Auvinen, J. (Juha), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M. B. (Marius B.), Bjorkelund, C. (Cecilia), Bloch, K. V. (Katia, V), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B. O. (Bernhard O.), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M. A. (Markus A.), de Leon, A. C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capanzana, M. V. (Mario, V), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F. F. (Felipe F.), Censi, L. (Laura), Chadjigeorgiou, C. A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.-D. (Maria-Dolores), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S. C. (Susana C.), Cooper, C. (Cyrus), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A. B. (Ana B.), Csilla, S. (Semanova), Cui, L. (Liufu), Cureau, F. V. (Felipe, V), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P. D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A. D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Helene), Dennison, E. (Elaine), Deschamps, V. (Valerie), Dhimal, M. (Meghnath), Di Castelnuovo, A. F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C. A. (Charmaine A.), Duda, R. B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Eriksson, J. G. (Johan G.), Escobedo-de la Pena, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M. R. (Mohammad Reza), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Foger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J. M. (Johanna M.), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T. K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Goncalves, H. (Helen), Gonzalez-Chica, D. A. (David A.), Gonzalez-Gross, M. (Marcela), Gonzalez-Rivas, J. P. (Juan P.), Gonzalez-Villalpando, C. (Clicerio), Gonzalez-Villalpando, M.-E. (Maria-Elena), Gonzalez, A. R. (Angel R.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-Castillon, P. (Pilar), Guan, O. P. (Ong Peng), Gudmundsson, E. F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I. R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R. H. (Rachakulla Hari), Hashemi-Shahri, S. M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A. J. (Alison J.), He, J. (Jiang), He, Y. (Yuna), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A. G. (Allan G.), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W. M. (Wilma M.), Horimoto, A. R. (Andrea R. V. R.), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Htike, M. M. (Maung Maung Than), Huerta, J. M. (Jose Maria), Huhtaniemi, I. T. (Ilpo Tapani), Huisman, M. (Martijn), Hunsberger, M. L. (Monica L.), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (Mohsen M.), Wong, N. I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M. A. (M. Arfan), Iotova, V. (Violeta), Irazola, V. E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), Ismail, A. A. (Aziz Al-Safi), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jaddou, H. Y. (Hashem Y.), Jafar, T. (Tazeen), James, K. (Kenneth), Jamrozik, K. (Konrad), Janszky, I. (Imre), Janus, E. (Edward), Järvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G. B. (Gorm B.), Jeong, S.-l. (Seung-lyeal), Jha, A. K. (Anjani Kumar), Jiang, C. Q. (Chao Qiang), Jimenez, R. O. (Ramon O.), Jockel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J. J. (Jari J.), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Jozwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. O. (Eero O.), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kamstrup, P. R. (Pia R.), Karki, K. B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H. C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I. V. (Iliana, V), Kolle, E. (Elin), Kolsteren, P. (Patrick), Konig, J. (Jurgen), Korpelainen, R. (Raija), . (), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U. M. (Urho M.), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F. Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T. H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T. S. (Tint Swe), Laugsand, L. E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimaki, T. (Terho), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M. F. (M. Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Lind, L. (Lars), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P. A. (Paulo A.), Lozano, J. E. (Jose Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G. L. (George L. L.), Machado-Rodrigues, A. M. (Aristides M.), Machi, S. (Suka), Madar, A. A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Rao, K. M. (Kodavanti Mallikharjuna), Manios, Y. (Yannis), Mann, J. I. (Jim, I), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L. P. (Luis P.), Mathiesen, E. B. (Ellisiv B.), Matsha, T. E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McLean, S. B. (Scott B.), McNulty, B. A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A. (AmirHoushang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I. I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H. E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J. C. (Jody C.), Minderico, C. S. (Claudia S.), Mini, G. K. (G. K.), Miquel, J. F. (Juan Francisco), Miranda, J. J. (J. Jaime), Mirjalili, M. R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P. A. (Pietro A.), Moghaddam, S. S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M. (MostafaK), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), MohdYusoff, M. F. (Muhammad Fadhli), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Mollehave, L. T. (Line T.), Mller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Mondo, C. K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Morin, S. N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K. P. (Kelias P.), Muiesan, M. L. (Maria L.), Muller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Nauck, M. (Matthias), Neal, W. A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noto, D. (Davide), Al Nsour, M. (Mohannad), Nuhoglu, I. (Irfan), O'Neill, T. W. (Terence W.), O'Reilly, D. (Dermot), Ochoa-Aviles, A. M. (Angelica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, O. (Orn), Olie, V. (Valerie), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ong, S. (SokKing), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P. J. (Pedro J.), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Ostovar, A. (Afshin), Otero, J. A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W. R. (Winsome R.), Patel, N. D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S. V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pichardo, R. N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, L. (Lorenza), Piwonska, A. (Aleksandra), Pizarro, A. N. (Andreia N.), Plans-Rubio, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J. F. (Jacqueline F.), Providencia, R. (Rui), Puder, J. J. (Jardena J.), Puhakka, S. E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S. R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Perez, M. d. (Maria del Cristo), Rodriguez-Villamizar, L. A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E. L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J. G. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B. S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A. R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasias, A. M. (Alba M.), Santos, D. A. (Diana A.), Santos, M. (MariaPaula), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B. D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (Christa), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C. O. (Carsten O.), Schottker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A. A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S. G. (Sadaf G.), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S. A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjostrom, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M. B. (Marieke B.), Soderberg, S. (Stefan), Soemantri, A. (Agustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M. H. (Mohammad Hossein), Sonestedt, E. (Emily), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J. A. (Jan A.), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stessman, J. (Jochanan), Stevanovic, R. (Ranko), Stieber, J. (Jutta), Stockl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Suarez-Medina, R. (Ramon), Sun, C.-A. (Chien-An), Sundstrom, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Sylva, R. C. (Rene Charles), Szklo, M. (Moyses), Tai, E. S. (E. Shyong), Tamosiunas, A. (Abdonas), Tan, E. (EngJoo), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G. S. (Grethe S.), Tello, T. (Tania), Thankappan, K. R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Toft, U. (Ulla), Tolonen, H. K. (Hanna K.), Tolstrup, J. S. (Janne S.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Tormo, M. J. (Maria Jose), Tornaritis, M. J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O. T. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van Dam, R. (RobM), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), Rossem, L. (Lenievan), Van Schoor, N. M. (Natasja M.), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Perez, P. (Patricia), Vasan, S. K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernandez, S. J. (Silvia J.), Veronesi, G. (Giovanni), MoniqueVerschuren, W. M. (W. M.), Victora, C. G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W. M. (Wan Mohamad Wan), WanMohamud, W. N. (Wan Nazaimoon), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S. G. (S. Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R. A. (Roy A.), Wong, A. (Andrew), Wong, T. Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F. C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T. P. (Toh Peng), Yiallouros, P. K. (Panayiotis K.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad Faudzi), Zainuddin, A. A. (Ahmad A.), Zakavi, S. R. (Seyed Rasoul), Zali, M. R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), KoZaw, K. (Ko), Zdrojewski, T. (Tomasz), Vrkic, T. Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J. Z. (Julio Zuniga), Gregg, E. W. (Edward W.), and Ezzati, M. (Majid)
Abstract: High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world³ and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions t
Published: 2020

36. Identification of the Uric Acid Thresholds Predicting an Increased Total and Cardiovascular Mortality Over 20 Years

Author: Virdis, A, Masi, S, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Parati, G, Palatini, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Virdis, A, Masi, S, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Parati, G, Palatini, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio
Abstract: Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed the threshold of SUA that increases the risk of total mortality and cardiovascular mortality (CVM). The URRAH study (Uric Acid Right for Heart Health) is a multicentre retrospective, observational study, which collected data from several large population-based longitudinal studies in Italy and subjects recruited in the hypertension clinics of the Italian Society of Hypertension. Total mortality was defined as mortality for any cause, CVM as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure. A total of 22 714 subjects were included in the analysis. Multivariate Cox regression analyses identified an independent association between SUA and total mortality (hazard ratio, 1.53 [95% CI, 1.21-1.93]) or CVM (hazard ratio, 2.08 [95% CI, 1.146-2.97]; P<0.001). Cutoff values of SUA able to discriminate total mortality (4.7 mg/dL [95% CI, 4.3-5.1 mg/dL]) and CVM status (5.6 mg/dL [95% CI, 4.99-6.21 mg/dL]) were identified. The information on SUA levels provided a significant net reclassification improvement of 0.26 and of 0.27 over the Heart Score risk chart for total mortality and CVM, respectively (P<0.001). Sex-specific cutoff values for total mortality and CVM were also identified and validated. In conclusion, SUA levels increasing the risk of total mortality and CVM are significantly lower than those used for the definition of hyperuricemia in clinical practice. Our data provide evidence of a cardiovascular SUA threshold that might contribute in clinical practice to improve identification of patients at higher risk of CVM.
Published: 2020

37. Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

Author: Casiglia, E, Tikhonoff, V, Virdis, A, Masi, S, Barbagallo, C, Bombelli, M, Bruno, B, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Masi, Stefano, Barbagallo, Carlo M, Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Casiglia, E, Tikhonoff, V, Virdis, A, Masi, S, Barbagallo, C, Bombelli, M, Bruno, B, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Grassi, G, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Masi, Stefano, Barbagallo, Carlo M, Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
Abstract: Objective:The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.Methods:The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.Results:A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.Conclusion:The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.
Published: 2020

38. The C(-260)>T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction

Author: Longobardo, M. T., Cefalù, A. B., Pezzino, F., Noto, D., Emmanuele, G., Barbagallo, C. M., Fiore, B., Monastero, R., Castello, A., Molini, V., Notarbartolo, A., Travali, S., and Averna, M. R.
Published: 2003
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39. Italian familial defective apolipoprotein B patients share a unique haplotype with other Caucasian patients

Author: Cefalù, A. B., Barbagallo, C. M., Sesti, E., Caldarella, R., Polizzi, F., Marino, G., Noto, D., Rolleri, M., Travali, S., Scalisi, G., Notarbartolo, A., Corsini, A., Bertolini, S., and Averna, M. R.
Published: 2001
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40. Liver is not the unique site of synthesis of Β2-glycoprotein I (apolipoprotein H): evidence for an intestinal localization

Author: Averna, M., Paravizzini, G., Lanteri, E., Petralia, S., Cavallaro, S., Travali, S., Marino, G., Cavera, G., Barbagallo, C. M., Notarbartolo, A., Magro, G., and Grasso, S.
Published: 1997
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41. Upregulated microRNAs in membranous glomerulonephropathy are associated with significant downregulation of IL6 and MYC mRNAs

Author: Barbagallo, C, Passanisi, R, Mirabella, F, Cirnigliaro, M, Costanzo, A, Lauretta, G, Barbagallo, D, Bianchi, C, Pagni, F, Castorina, S, Granata, A, Di Pietro, C, Ragusa, M, Malatino, L, Purrello, M, Barbagallo, Cristina, Passanisi, Roberta, Mirabella, Federica, Cirnigliaro, Matilde, Costanzo, Arianna, Lauretta, Giovanni, Barbagallo, Davide, Bianchi, Cristina, Pagni, Fabio, Castorina, Sergio, Granata, Antonio, Di Pietro, Cinzia, Ragusa, Marco, Malatino, Lorenzo S, Purrello, Michele, Barbagallo, C, Passanisi, R, Mirabella, F, Cirnigliaro, M, Costanzo, A, Lauretta, G, Barbagallo, D, Bianchi, C, Pagni, F, Castorina, S, Granata, A, Di Pietro, C, Ragusa, M, Malatino, L, Purrello, M, Barbagallo, Cristina, Passanisi, Roberta, Mirabella, Federica, Cirnigliaro, Matilde, Costanzo, Arianna, Lauretta, Giovanni, Barbagallo, Davide, Bianchi, Cristina, Pagni, Fabio, Castorina, Sergio, Granata, Antonio, Di Pietro, Cinzia, Ragusa, Marco, Malatino, Lorenzo S, and Purrello, Michele
Abstract: Membranous glomerulonephropathy (MGN) is a glomerulopathy characterized by subepithelial deposits of immune complexes on the extracapillary side of the glomerular basement membrane. Insertion of C5b-9 (complement membrane-attack complex) into the membrane leads to functional impairment of the glomerular capillary wall. Knowledge of the molecular pathogenesis of MGN is actually scanty. MicroRNA (miRNA) profiling in MGN and unaffected tissues was performed by TaqMan Low-Density Arrays. Expression of miRNAs and miRNA targets was evaluated in Real-Time polymerase chain reaction (PCR). In vitro transient silencing of miRNAs was achieved through transfection with miRNA inhibitors. Ten miRNAs (let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, miR-107, miR-129-3p, miR-423-5p, miR-516-3p, miR-532-3p, and miR-1275) were differentially expressed (DE) in MGN biopsies compared to unaffected controls. Interleukin 6 (IL6) and MYC messenger RNAs (mRNAs; targets of DE miRNAs) were significantly downregulated in biopsies from MGN patients, and upregulated in A498 cells following let-7a-5p or let-7c-5p transient silencing. Gene ontology analysis showed that DE miRNAs regulate pathways associated with MGN pathogenesis, including cell cycle, proliferation, and apoptosis. A significant correlation between DE miRNAs and mRNAs and clinical parameters (i.e., antiphospholipid antibodies, serum creatinine, estimated glomerular filtration, proteinuria, and serum cholesterol) has been detected. Based on our data, we propose that DE miRNAs and their downstream network may be involved in MGN pathogenesis and could be considered as potential diagnostic biomarkers of MGN
Published: 2019

42. Factor VII activity is an independent predictor of cardiovascular mortality in elderly women of a Sicilian population: results of an 11-years follow up: 101

Author: Noto, D., Barbagallo, C. M., Cefalu, A. B., Cavera, G., Sapienza, M., Notarbartolo, A., Davì, G., and Averna, M. R.
Published: 2003

43. Leukocyte count, diabetes mellitus and age are strong predictors of stroke in a rural population of southern Italy: an eight years follow-up: 91

Author: Cefalù, A. B., Noto, D., Barbagallo, C. M., Cavera, G., Caimi, G., Marino, G., Lo Coco, L., Caldarella, T., Notarbartolo, A., and Averna, M. R.
Published: 2003

44. Low-density-lipoprotein peak particle size in a Mediterranean population

Author: Rizzo, M, Barbagallo, C. M., Severino, M., Polizzi, F., Onorato, F., Noto, D., Cefalù, A. B., Pace, A., Marino, G., Notarbartolo, A., and Averna, R. M.
Published: 2003

45. miRNAs in the vitreous humor of patients affected by idiopathic epiretinal membrane and macular hole

Author: Russo A, Ragusa M, Barbagallo C, Longo A, Avitabile T, Uva MG, Bonfiglio V, Toro M, Caltabiano R, Mariotti C, Boscia F, Romano MR, Di Pietro C, Barbagallo D, Purrello M, Reibaldi M, Russo, Andrea, Ragusa, Marco, Barbagallo, Cristina, Longo, Antonio, Avitabile, Teresio, Uva, Maurizio G, Bonfiglio, Vincenza, Toro, Mario D, Caltabiano, Rosario, Mariotti, Cesare, Boscia, Francesco, Romano, Mario R, Di Pietro, Cinzia, Barbagallo, Davide, Purrello, Michele, Reibaldi, Michele, Russo, A, Ragusa, M, Barbagallo, C, Longo, A, Avitabile, T, Uva, Mg, Bonfiglio, V, Toro, M, Caltabiano, R, Mariotti, C, Boscia, F, Romano, Mr, Di Pietro, C, Barbagallo, D, Purrello, M, and Reibaldi, M
Subjects: Male, Multidisciplinary, lcsh:R, lcsh:Medicine, Correction, Down-Regulation, Epiretinal Membrane, Middle Aged, Retinal Perforations, Vitreous Body, MicroRNAs, Vitrectomy, Humans, lcsh:Q, Female, Prospective Studies, lcsh:Science, Transcriptome, miRNA, macular hole
Abstract: The aim of the present study was to assess the expression of miRNAs in the Vitreous Humor (VH) of patients with Macular Hole (MH) and Epiretinal Membrane (ERM) compared to a control group.In this prospective, comparative study, 2-ml of VH was extracted from the core of the vitreous chamber in consecutive patients who underwent standard vitrectomy for ERM and MH. RNA was extracted and TaqMan® Low Density Arrays (TLDAs) were used to profile the transcriptome of 754 miRNAs. Results were validated by single TaqMan® assays. Finally, we created a biological network of differentially expressed miRNA targets and their nearest neighbors.Overall 10 eyes with MH, 16 eyes with idiopathic ERM and 6 controls were enrolled in the study. Profiling data identified 5 miRNAs differentially expressed in patients affected by MH and ERM with respect to controls. Four were downregulated (miR-19b, miR-24, miR-155, miR-451) and 1 was downregulated (miR-29a); TaqMan® assays of the VH of patients affected by MH and ERM, with respect to controls, showed that the most differentially expressed were miR-19b (FC -9.13, p:0.00004), mir-24 (FC -7.52, p:0.004) and miR-142-3p (FC -5.32, p:0.011). Our network data showed that deregulation of differentially expressed miRNAs induces an alteration of several pathways associated with genes involved in both MH and ERM.The present study suggests that disregulation of miR-19b, miR-24 and miR-142-3p, might be related to the alterations that characterize patients affected by MH and ERM.
Published: 2017

46. Real-time spatial compound sonography of Achilles tendon in patients with heterozygous familial hypercholesterolaemia and normal physical examination

Author: Bartolotta, T. V., Taibbi, A., Malizia, G., Mamone, G., Barbagallo, C., Midiri, M., and Lagalla, R.
Published: 2007
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47. III° Convegno nazionale AIRA

Author: Cirnigliaro M, 42., Barbagallo, C, Gulisano, M, Domini, Cn, Barone, R, Barbagallo, D, Ragusa, M, Di Pietro, C, Rizzo, R, and Purrello, M
Published: 2018

48. miRNAs as New Potential Biomarkers for Autism Spectrum Disorder in serum and saliva

Author: Cirnigliaro, M, Barbagallo, C, Gulisano, M, Domini, Cn, Barone, R, Barbagallo, D, Ragusa, M, Di Pietro, C, Rizzo, R, and Purrello, M
Published: 2018

49. Identification Of P.Leu167Del Apoe Gene Mutation By Next Generation Sequencing In A Large Hypercholesterolemic Family

Author: Scrimali, C., primary, Spina, R., additional, Ingrassia, V., additional, Cefalù, A.B., additional, Brucato, F., additional, Misiano, G., additional, Valenti, V., additional, Noto, D., additional, Altieri, G.I., additional, Fayer, F., additional, Giammanco, A., additional, Barbagallo, C., additional, and Averna, M., additional
Published: 2019
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50. The Clinical Approach to the Patients with Low HDL and Elevated Plasma Triglyceride

Author: Averna, M. R., primary, Barbagallo, C. M., additional, and Notarbartolo, A., additional
Published: 1993
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