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Prevention and treatment of arterial hypertension is of great importance. Improvement of existing medicines through the use of alternative routes of administration can enhance the pharmacotherapeutic characteristics of active pharmaceutical ingredients (APIs). Transdermal therapeutic systems (TTS) allow for delivery of a drug through intact skin into the systemic circulation, while minimizing side effects. The development of transdermal formulations of antihypertensive drugs, Lisinopril dihydrate in particular, has practical and scientific significance. Optimization of the algorithm for the development of transdermal drugs involves in vitro preformulation studies of the membrane permeability of APIs and the identification of factors that affect this process.

The development of small and medium-sized businesses, shaping the market structure of the economy, ensures the growth of production of goods and services, their saturation of the market, and solves a number of social problems. Under certain prerequisites, small and medium-sized businesses can become a driver of sustainable economic development and an increase in the “stratum” of the middle class, which predetermines its state support. Despite the importance of SMEs for the national economy, this sector of the economy remains the most vulnerable and subject to the influence of the external environment. For example, many small companies, which traditionally have weak immunity to negative market fluctuations, barely withstood the impact of the COVID-19 pandemic. As part of the study, an assessment of the influence of external factors on the volume of activities of small and medium-sized businesses in the Siberian Federal District was given, monitoring and timely response to changes in which will allow managing to provide timely support for small businesses.

The reuse of industrial zones is becoming one of the determinants of sustainable urban development, which ensures the effective use of urban areas, taking into account the principle of their integrated development. However, the modern urbanized environment has serious environmental problems, which limits the active use of the redevelopment tool. The conducted research of the implemented redevelopment projects showed that their main share is accounted for the construction of apartments and housing, multinational complexes, creative spaces and offices. The results of the cluster analysis of the territories of Russia allowed the authors to identify the most promising regions for redevelopment.