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1. A control chart based on data depth for monitoring the variability in a multivariate process.

Author

Barale, M. S. and Shirke, D. T.

Subjects
*COVARIANCE matrices, *PERFORMANCE theory, *QUALITY control charts
Abstract

Majority of the existing statistical procedures for monitoring the covariance matrix of the multivariate processes are based on normality or other distributional assumption. In order to isolate the change in the process variation, these procedures are less powerful due to distributional assumptions. In this article, we study the control charts for monitoring covariance matrix critically. We provide a distribution-free two-sample test for multivariate scale problem called as modified rank test based on data depth. A control chart is proposed based on the data depth based modified rank test. A modified rank test based on data depth is the extension of the modified rank test for univariate two-sample location and scale problem. Data depth based center outward ranking is used for defining test statistic. The performance study of the proposed control charts reveals that the proposed control chart is a better alternative to traditional control charts for variability when a distribution of the process is not known but some historical in-control data is available. The control chart is illustrated with the real-life CSTR process data. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi C. A., Larcher A., Capitanio U., Mari A., Antonelli A., Artibani W., Barale M., Bertini R., Bove P., Brunocilla E., Da Pozzo L., Di Maida F., Fiori C., Gontero P., Li Marzi V., Longo N., Mirone V., Montanari E., Porpiglia F., Schiavina R., Schips L., Simeone C., Siracusano S., Terrone C., Trombetta C., Volpe A., Montorsi F., Ficarra V., Carini M., Minervini A., Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi C. A., Larcher A., Capitanio U., Mari A., Antonelli A., Artibani W., Barale M., Bertini R., Bove P., Brunocilla E., Da Pozzo L., Di Maida F., Fiori C., Gontero P., Li Marzi V., Longo N., Mirone V., Montanari E., Porpiglia F., Schiavina R., Schips L., Simeone C., Siracusano S., Terrone C., Trombetta C., Volpe A., Montorsi F., Ficarra V., Carini M., and Minervini A.

Abstract

Background: Partial nephrectomy (PN) has a non-negligible perioperative morbidity. Comparative evidence of the available surgical techniques is limited. Objective: To compare the perioperative outcomes of open, laparoscopic, and robotic PN. Methods: Data of 2331 patients treated with PN for cT1 renal tumors were extracted from the RECORd2 database, a prospective multicenter project. Multivariable regression models assessed the relationship between surgical technique and surgical margins, warm ischemia time, postoperative complications, and acute kidney injury (AKI). The probability of achieving a modified trifecta (negative margins, warm ischemia time <25 min, and no Clavien–Dindo ≥2 complications) was examined for each surgical approach. Results: Minimally invasive techniques had lower rate of Clavien–Dindo ≥2 complications than that of open surgery (odds ratio [OR] for robotic surgery: 0.27; 95% confidence interval [95% CI]: 0.15–0.47, p < 0.0001; OR for laparoscopy: 0.52; 95% CI: 0.34–0.78; p = 0.002). The probability of receiving ischemia was highest for robotic PN (p < 0.001). Among on-clamp PN, laparoscopy had longer ischemia than open (estimate: 1.09; 95% CI: –0.00 to 2.18; p = 0.050) and robotic (estimate: 1.36; 95% CI: 0.31–2.40; p = 0.011) surgery. When compared with open PN, the risk of AKI was roughly halved for patients treated by robotic and laparoscopic surgery (both p < 0.0001). Positive margins rate did not differ between the groups (all p ≥ 0.1). The likelihood to achieve a modified trifecta was not affected by surgical technique in the overall population (all p ≥ 0.075). In Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score < 10 lesions, robotic surgery had higher probability of achieving a modified trifecta than open PN (OR: 1.66; 95% CI: 1.09–2.53; p = 0.018) and laparoscopy (OR: 1.34; 95% CI: 0.94–1.90; p = 0.11). Conclusions: In PADUA < 10 renal tumors, robotic PN allows for higher rates of trifecta than

Published
2021

7. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Celia, A., Cindolo, L., Costantini, E., Daja, J., Falsaperla, M., Furlan, M., Morgia, G., Porreca, A., Roscigno, M., Selli, C., Simonato, A., Tellini, R., Vespasiani, G., Villari, D., Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., and Bravi CA, Larcher A, Capitanio U, Mari A, Antonelli A, Artibani W, Barale M, Bertini R, Bove P, Brunocilla E, Da Pozzo L, Di Maida F, Fiori C, Gontero P, Li Marzi V, Longo N, Mirone V, Montanari E, Porpiglia F, Schiavina R, Schips L, Simeone C, Siracusano S, Terrone C, Trombetta C, Volpe A, Montorsi F, Ficarra V, Carini M, Minervini A

Subjects
Male, medicine.medical_specialty, Urology, medicine.medical_treatment, 030232 urology & nephrology, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Robotic Surgical Procedures, Ischemia, Medicine, Humans, Minimally Invasive Surgical Procedures, Prospective Studies, Perioperative Period, Aged, medicine.diagnostic_test, business.industry, renal carcinoma, Odds ratio, Perioperative, Middle Aged, medicine.disease, Confidence interval, Kidney Neoplasms, Surgery, Settore MED/24, 030220 oncology & carcinogenesis, Female, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, business, Perioperative outcome
Abstract

Background: Partial nephrectomy (PN) has a non-negligible perioperative morbidity. Comparative evidence of the available surgical techniques is limited. Objective: To compare the perioperative outcomes of open, laparoscopic, and robotic PN. Methods: Data of 2331 patients treated with PN for cT1 renal tumors were extracted from the RECORd2 database, a prospective multicenter project. Multivariable regression models assessed the relationship between surgical technique and surgical margins, warm ischemia time, postoperative complications, and acute kidney injury (AKI). The probability of achieving a modified trifecta (negative margins, warm ischemia time

Published
2021

11. Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project)

Author

Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, Villari, D, Mari A., Campi R., Schiavina R., Amparore D., Antonelli A., Artibani W., Barale M., Bertini R., Borghesi M., Bove P., Brunocilla E., Capitanio U., Da Pozzo L., Daja J., Gontero P., Larcher A., Li Marzi V., Longo N., Mirone V., Montanari E., Pisano F., Porpiglia F., Simeone C., Siracusano S., Tellini R., Trombetta C., Volpe A., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Celia A., Costantini E., Di Maida F., Falsaperla M., Fiori C., Furlan M., Marson F., Montorsi F., Morgia G., Porreca A., Roscigno M., Schips L., Selli C., Simonato A., Terrone C., Vespasiani G., Villari D., Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, Villari, D, Mari A., Campi R., Schiavina R., Amparore D., Antonelli A., Artibani W., Barale M., Bertini R., Borghesi M., Bove P., Brunocilla E., Capitanio U., Da Pozzo L., Daja J., Gontero P., Larcher A., Li Marzi V., Longo N., Mirone V., Montanari E., Pisano F., Porpiglia F., Simeone C., Siracusano S., Tellini R., Trombetta C., Volpe A., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Celia A., Costantini E., Di Maida F., Falsaperla M., Fiori C., Furlan M., Marson F., Montorsi F., Morgia G., Porreca A., Roscigno M., Schips L., Selli C., Simonato A., Terrone C., Vespasiani G., and Villari D.

Abstract

Objective: To identify meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy (PN). Patients and Methods: We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumours, between 2013 and 2016, at 26 Italian urological centres (RECORd 2 project). A multivariable logistic regression for surgical complications was performed. A nomogram was created from the multivariable model. Internal validation processes were performed using bootstrapping with 1000 repetitions. Results: Overall, 2584 patients who underwent PN were evaluated for the final analyses. The median (interquartile [IQR]) American Society of Anesthesiologists (ASA) score was 2 (2–3). In all, 72.4% of patients had clinical T1a (cT1a) stage tumours. The median (IQR) Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score was 7 (6–8). Overall, 34.3%, 27.7%, 38% of patients underwent open PN (OPN), laparoscopic PN (LPN), and robot-assisted PN (RAPN). Overall and major postoperative surgical complications were recorded in 10.2% and 2.5% of patients, respectively. At multivariable analysis, age, ASA score, cT2 vs cT1a stage, PADUA score, preoperative anaemia, OPN and LPN vs RAPN, were significant predictive factors of postoperative surgical complications. We used these variables to construct a nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%. Conclusion: Several clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.

Published
2019

12. Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project)

Author

Mari, A., Campi, R., Schiavina, R., Amparore, D., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Borghesi, M., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Daja, J., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Pisano, F., Porpiglia, F., Simeone, C., Siracusano, S., Tellini, R., Trombetta, C., Volpe, A., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Celia, A., Costantini, E., Di Maida, F., Falsaperla, M., Fiori, C., Furlan, M., Marson, F., Montorsi, F., Morgia, G., Porreca, A., Roscigno, M., Schips, L., Selli, C., Simonato, A., Terrone, C., Vespasiani, G., Villari, D., Mari A, Campi R, Schiavina R, Amparore D, Antonelli A, Artibani W, Barale M, Bertini R, Borghesi M, Bove P, Brunocilla E, Capitanio U, Da Pozzo L, Daja J, Gontero P, Larcher A, Li Marzi V, Longo N, Mirone V, Montanari E, Pisano F, Porpiglia F, Simeone C, Siracusano S, Tellini R, Trombetta C, Volpe A, Ficarra V, Carini M, Minervini A, Mari, Andrea, Campi, Riccardo, Schiavina, Riccardo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Barale, Maurizio, Bertini, Roberto, Borghesi, Marco, Bove, Pierluigi, Brunocilla, Eugenio, Capitanio, Umberto, Da Pozzo, Luigi, Daja, Julian, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Mirone, Vincenzo, Montanari, Emanuele, Pisano, Francesca, Porpiglia, Francesco, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Trombetta, Carlo, Volpe, Alessandro, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, Mari, A., Campi, R., Schiavina, R., Amparore, D., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Borghesi, M., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Daja, J., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Pisano, F., Porpiglia, F., Simeone, C., Siracusano, S., Tellini, R., Trombetta, C., Volpe, A., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Celia, A., Costantini, E., Di Maida, F., Falsaperla, M., Fiori, C., Furlan, M., Marson, F., Montorsi, F., Morgia, G., Porreca, A., Roscigno, M., Schips, L., Selli, C., Simonato, A., Terrone, C., Vespasiani, G., Villari, D., Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, and Villari, D

Subjects
partial nephrectomy, complications, Male, medicine.medical_specialty, renal cell carcinoma, nephron-sparing surgery, nomogram, robot-assisted partial nephrectomy, medicine.medical_treatment, Urology, 030232 urology & nephrology, complication, Logistic regression, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Interquartile range, Renal cell carcinoma, complications, nephron-sparing surgery, nomogram, partial nephrectomy, renal cell carcinoma, robot-assisted partial nephrectomy, Medicine, Humans, In patient, Prospective Studies, Stage (cooking), Aged, business.industry, Nomogram, postoperative surgical complications, partial nephrectomy, RECORd 2 project, Kidney Neoplasm, Nomogram, Middle Aged, medicine.disease, Kidney Neoplasms, Surgery, Editorial Commentary, Nomograms, Settore MED/24, 030220 oncology & carcinogenesis, partial nephrectomy, complications, Observational study, Female, Postoperative Complication, business, Human
Abstract

Objective To identify meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy (PN). Patients and methods We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumours, between 2013 and 2016, at 26 Italian urological centres (RECORd 2 project). A multivariable logistic regression for surgical complications was performed. A nomogram was created from the multivariable model. Internal validation processes were performed using bootstrapping with 1000 repetitions. Results Overall, 2584 patients who underwent PN were evaluated for the final analyses. The median (interquartile [IQR]) American Society of Anesthesiologists (ASA) score was 2 (2-3). In all, 72.4% of patients had clinical T1a (cT1a) stage tumours. The median (IQR) Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score was 7 (6-8). Overall, 34.3%, 27.7%, 38% of patients underwent open PN (OPN), laparoscopic PN (LPN), and robot-assisted PN (RAPN). Overall and major postoperative surgical complications were recorded in 10.2% and 2.5% of patients, respectively. At multivariable analysis, age, ASA score, cT2 vs cT1a stage, PADUA score, preoperative anaemia, OPN and LPN vs RAPN, were significant predictive factors of postoperative surgical complications. We used these variables to construct a nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%. Conclusion Several clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.

Published
2019

14. Perioperative and mid-term oncological and functional outcomes after partial nephrectomy for entirely endophytic renal tumors: a prospective multicenter observational study (the RECORD 2 project)

Author

Di Maida, F., primary, Mari, A., additional, Antonelli, A., additional, Barale, M., additional, Bove, P., additional, Brunocilla, E., additional, Lambertini, L., additional, Capitanio, U., additional, Fiori, C., additional, Gallioli, A., additional, Grosso, A.A., additional, Gontero, P., additional, Longo, N., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Schiavina, R., additional, Li Marzi, V., additional, Tellini, R., additional, Trombetta, C., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2021
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15. A nomogram for the prediction of significant long-term renal function loss after robot-assisted partial nephrectomy for localized renal tumors: A prospective multicenter observational study (RECORd2 project)

Author

Mari, A., primary, Tellini, R., additional, Di Maida, F., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Bove, P., additional, Brunocilla, E., additional, Campi, R., additional, Capitanio, U., additional, Gontero, P., additional, Longo, N., additional, Montanari, E., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Schiavina, R., additional, Serni, S., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2021
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16. Perioperative and mid-term oncological and functional outcomes after partial nephrectomy for entirely endophytic renal tumors: A prospective multicenter observational study (the RECORD2 Project)

Author

Mari, A., primary, Di Maida, F., additional, Antonelli, A., additional, Barale, M., additional, Bove, P., additional, Brunocilla, E., additional, Campi, R., additional, Capitanio, U., additional, Fiori, C., additional, Gallioli, A., additional, Grosso, A.A., additional, Gontero, P., additional, Longo, N., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Schiavina, R., additional, Li Marzi, V., additional, Tellini, R., additional, Trombetta, C., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2021
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21. Treatment of Acromegalic Osteopathy in Real-life Clinical Practice: The BAAC (Bone Active Drugs in Acromegaly) Study

Author

Mazziotti, G, Battista, C, Maffezzoni, F, Chiloiro, Sabrina, Ferrante, E, Prencipe, N, Grasso, L, Gatto, F, Olivetti, R, Arosio, M, Barale, M, Bianchi, Antonio, Cellini, M, Chiodini, I, De Marinis Grasso, Laura, Del Sindaco, G, Di Somma, C, Ferlin, A, Ghigo, E, Giampietro, Antonella, Grottoli, S, Lavezzi, E, Mantovani, G, Morenghi, E, Pivonello, R, Porcelli, T, Procopio, M, Pugliese, F, Scillitani, A, Lania, Ag., Chiloiro S (ORCID:0000-0001-9241-2392), Bianchi A, De Marinis Laura (ORCID:0000-0001-9916-0669), Giampietro A, Mazziotti, G, Battista, C, Maffezzoni, F, Chiloiro, Sabrina, Ferrante, E, Prencipe, N, Grasso, L, Gatto, F, Olivetti, R, Arosio, M, Barale, M, Bianchi, Antonio, Cellini, M, Chiodini, I, De Marinis Grasso, Laura, Del Sindaco, G, Di Somma, C, Ferlin, A, Ghigo, E, Giampietro, Antonella, Grottoli, S, Lavezzi, E, Mantovani, G, Morenghi, E, Pivonello, R, Porcelli, T, Procopio, M, Pugliese, F, Scillitani, A, Lania, Ag., Chiloiro S (ORCID:0000-0001-9241-2392), Bianchi A, De Marinis Laura (ORCID:0000-0001-9916-0669), and Giampietro A

Abstract

Background: Vertebral fractures (VFs) are a frequent complication of acromegaly, but no studies have been so far published on effectiveness of antiosteoporotic drugs in this clinical setting. Objective: To evaluate whether in real-life clinical practice bone active drugs may reduce the risk of VFs in patients with active or controlled acromegaly. Study design: Retrospective, longitudinal study including 9 tertiary care endocrine units. Patients and methods: Two hundred and forty-eight patients with acromegaly (104 males; mean age 56.00 ± 13.60 years) were evaluated for prevalent and incident VFs by quantitative morphometric approach. Bone active agents were used in 52 patients (20.97%) and the median period of follow-up was 48 months (range 12-132). Results: During the follow-up, 65 patients (26.21%) developed incident VFs in relationship with pre-existing VFs (odds ratio [OR] 3.75; P < .001), duration of active acromegaly (OR 1.01; P = .04), active acromegaly at the study entry (OR 2.48; P = .007), and treated hypoadrenalism (OR 2.50; P = .005). In the entire population, treatment with bone active drugs did not have a significant effect on incident VFs (P = .82). However, in a sensitive analysis restricted to patients with active acromegaly at study entry (111 cases), treatment with bone active drugs was associated with a lower risk of incident VFs (OR 0.11; P = .004), independently of prevalent VFs (OR 7.65; P < .001) and treated hypoadrenalism (OR 3.86; P = .007). Conclusions: Bone active drugs may prevent VFs in patients with active acromegaly.

Published
2020

25. The healthier the patient, the longer the ischemia: Surgical implications for partial nephrectomy in the RECORd2 project

Author

Bravi, C.A., primary, Larcher, A., additional, Capitanio, U., additional, Montorsi, F., additional, Bertini, R., additional, Antonelli, A., additional, Siracusano, S., additional, Barale, M., additional, Gontero, P., additional, Bove, P., additional, Brunocilla, E., additional, Schiavina, R., additional, Da Pozzo, L., additional, Longo, N., additional, Montanari, E., additional, Porpiglia, F., additional, Simeone, C., additional, Volpe, A., additional, Ficarra, V., additional, Li Marzi, V., additional, Di Maida, F., additional, Mari, A., additional, Carini, M., additional, and Minervini, A., additional

Published
2020
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27. Natural history of widespread high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: Should we rebiopsy them all?

Author

Oderda, M., primary, Rosazza, M., additional, Agnello, M., additional, Barale, M., additional, Calleris, G., additional, Ceruti, C., additional, Daniele, L., additional, Delsedime, L., additional, Falcone, M., additional, Faletti, R., additional, Filippini, C., additional, Giordano, A., additional, Marquis, A., additional, Marra, G., additional, Pacchioni, D., additional, and Gontero, P., additional

Published
2020
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28. Transperineal free-hand mpMRI targeted prostate biopsies under local anesthesia: A preliminary analysis of learning curves

Author

Calleris, G., primary, Marra, G., additional, Zhuang, J., additional, Beltrami, M., additional, Zhao, X., additional, Marquis, A., additional, Kan, Y., additional, Oderda, M., additional, Greco, A., additional, Zitella, A., additional, Bisconti, A., additional, Huang, H., additional, Faletti, R., additional, Zhang, Q., additional, Molinaro, L., additional, Falcone, M., additional, Cappuccelli, S., additional, Wang, W., additional, Barale, M., additional, Giordano, A., additional, Agnello, M., additional, Guo, H., additional, and Gontero, P., additional

Published
2020
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33. Denial and oncological pathology: Case report of a massive testicular cancer.

Author

Pizzuto, G, Barale, M, Sedigh, O, and Frea, B

Subjects
*TESTICULAR cancer, *PATHOLOGY, *LYMPHADENECTOMY, *DIAGNOSIS, *TESTIS, *CASTRATION
Abstract

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. The surgical treatment is either radical orchiectomy or radical orchiectomy plus retroperitoneal lymph node dissection. Case presentation: The case presented concerns a 48-year-old male with a history of left testicular trauma and subsequent hypotrophy. Over the next 4 years, the patient developed a testicle size increase up to 15 cm in diameter. At diagnosis, he had retroperitoneal lymphadenopathy. The patient was, after surgery, referred to the oncology department. Conclusion: The awareness of the male population respect to testicular cancer and its screening methods (e.g. self-examination) is essential to make the diagnosis at an early stage. It is also essential to psychologically support patients undergoing surgical and/or pharmacological therapy due to risk of determining anxiety or depression compared to the whole population. [ABSTRACT FROM AUTHOR]

Published
2021
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35. In-office MRI-targeted transperineal freehand prostate biopsies under local anaesthesia: Are they feasible?

Author

Marquis, A., primary, Marra, G., additional, Oderda, M., additional, D’Agate, D., additional, Tappero, S., additional, Calleris, G., additional, Zitella, A., additional, Greco, A., additional, Bisconti, A., additional, Falcone, M., additional, Barale, M., additional, Agnello, M., additional, Giordano, A., additional, Faletti, R., additional, Bergamasco, L., additional, Molinaro, L., additional, and Gontero, P., additional

Published
2019
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36. Postoperative outcomes and two-year renal function in patients with limited life expectancy treated with partial nephrectomy for renal tumors: Analysis of predictors and comparison with patients with longer life expectancy (the record 2 project)

Author

Mari, A., primary, Nazzani, S., additional, Tellini, R., additional, Gontero, P., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Bertini, R., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Mirone, V., additional, Montanari, E., additional, Porpiglia, F., additional, Schiavina, R., additional, Serni, S., additional, Simeone, C., additional, Trombetta, C., additional, Volpe, A., additional, Artibani, W., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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37. Is systematic sampling of the prostate still necessary in the MRI/TRUS fusion biopsy era? Results from a multicenter retrospective cohort

Author

Oderda, M., primary, Marra, G., additional, Albissini, S., additional, Altobelli, E., additional, Baco, E., additional, Beatrici, V., additional, Dellabella, M., additional, Descotes, J., additional, Eldred-Evans, D., additional, Fasolis, G., additional, Ferriero, M., additional, Fiard, G., additional, Giacobbe, A., additional, Kumar, P., additional, Lacetera, V., additional, Mozer, P., additional, Muto, G., additional, Papalia, R., additional, Peltier, A., additional, Piechaud, T., additional, Pierangeli, T., additional, Simone, G., additional, Calleris, G., additional, Bisconti, A., additional, Marquis, A., additional, Giordano, A., additional, Zitella, A., additional, Greco, A., additional, Agnello, M., additional, Falcone, M., additional, Barale, M., additional, Roche, J., additional, Roupret, M., additional, and Gontero, P., additional

Published
2019
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38. Feasibility and complications of in-office transperineal free-hand prostate biopsies under local anesthesia: A single center prospective study

Author

Marquis, A., primary, Marra, G., additional, Oderda, M., additional, Tappero, S., additional, D’Agate, D., additional, Calleris, G., additional, Zitella, A., additional, Greco, A., additional, Falcone, M., additional, Bisconti, A., additional, Barale, M., additional, Agnello, M., additional, Giordano, A., additional, Faletti, R., additional, Bergamasco, L., additional, Molinaro, L., additional, and Gontero, P., additional

Published
2019
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39. A surgical nomogram for predicting the risk of positive surgical margins in patients treated with partial nephrectomy for renal cell carcinoma: The RECORd2 project

Author

Tellini, R., primary, Schiavina, R., additional, Antonelli, A., additional, Barale, M., additional, Borghesi, M., additional, Bossa, R., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Di Maida, F., additional, Gontero, P., additional, Longo, N., additional, Montanari, E., additional, Porpiglia, F., additional, Serni, S., additional, Simeone, C., additional, Siracusano, S., additional, Trombetta, C., additional, Volpe, A., additional, Ficarra, V., additional, Mari, A., additional, and Minervini, A., additional

Published
2019
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40. Perioperative morbidity of open, laparoscopic and robotic partial nephrectomy: A prospective multicenter observational study (RECORd2)

Author

Bravi, C., primary, Larcher, A., additional, Capitanio, U., additional, Montorsi, F., additional, Antonelli, A., additional, Barale, M., additional, Bertini, R., additional, Bove, P., additional, Brunocilla, E., additional, Da Pozzo, L., additional, Di Maida, F., additional, Gontero, P., additional, Li Marzi, V., additional, Longo, N., additional, Montanari, E., additional, Porpiglia, F., additional, Schiavina, R., additional, Simeone, C., additional, Siracusano, S., additional, Volpe, A., additional, Ficarra, V., additional, Carini, M., additional, Mari, A., additional, and Minervini, A., additional

Published
2019
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41. Perioperative complications after partial nephrectomy for complex renal tumors: A prospective multicenter observational study (RECORd 2 project)

Author

Di Maida, F., primary, Tellini, R., additional, Mari, A., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Gontero, P., additional, Mirone, V., additional, Montanari, E., additional, Montorsi, F., additional, Porpiglia, F., additional, Schiavina, R., additional, Serni, S., additional, Simeone, C., additional, Trombetta, C., additional, Volpe, A., additional, Artibani, W., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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42. Ischemia time during partial nephrectomy has a different impact on renal function loss according to preoperative risk of acute kidney injury. Results from a prospective multicenter observational study (the RECORD2 project)

Author

Bravi, C., primary, Capitanio, U., additional, Mari, A., additional, Larcher, A., additional, Antonelli, A., additional, Artibani, W., additional, Barale, M., additional, Bertini, R., additional, Bove, P., additional, Brunocilla, E., additional, Da Pozzo, L., additional, Di Maida, F., additional, Tellini, R., additional, Fiori, C., additional, Gontero, P., additional, Li Marzi, V., additional, Longo, N., additional, Mirone, V., additional, Montanari, E., additional, Porpiglia, F., additional, Schiavina, R., additional, Schips, L., additional, Simeone, C., additional, Siracusano, S., additional, Terrone, C., additional, Trombetta, C., additional, Volpe, A., additional, Montorsi, F., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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43. Choosing the right patient for salvage radical prostatectomy: Oncological outcomes compared between eau guidelines-compliant and non-compliant patients

Author

Calleris, G., primary, Gontero, P., additional, Alessio, P., additional, Marra, G., additional, Oderda, M., additional, Pisano, F., additional, Battaglia, A., additional, Filippini, C., additional, Munegato, S., additional, Munoz, F., additional, Palazzetti, A., additional, Bisconti, A., additional, Marquis, A., additional, Giordano, A., additional, Zitella, A., additional, Greco, A., additional, Agnello, M., additional, Falcone, M., additional, Barale, M., additional, Ricardi, U., additional, Linares, E., additional, Sanchez-Salas, R., additional, Challacombe, B., additional, Cathcart, P., additional, Dasgupta, P., additional, Goonewardene, S., additional, Popert, R., additional, Cahill, D., additional, Gillatt, D., additional, Persad, R., additional, Palou, J., additional, Joniau, S., additional, Piechaud, T., additional, Smelzo, S., additional, De La Taille, A., additional, Roupret, M., additional, Albisinni, S., additional, Van Velthoven, R., additional, Morlacco, A., additional, Vidit, S., additional, Gandaglia, G., additional, Mottrie, A., additional, Smith, J., additional, Joshi, S., additional, Fiscus, G., additional, Berger, A., additional, Aron, M., additional, Abreu, A., additional, Gilles, I., additional, Van Der Poel, H., additional, Tilki, D., additional, Lawrentschuk, N., additional, Murphy, D., additional, Leung, G., additional, Davis, J., additional, and Karnes, R., additional

Published
2019
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45. Clinical and surgical predictors of medical and surgical postoperative complications in patients with limited life expectancy treated with partial nephrectomy for renal tumors: Insight from the RECORD2 project

Author

Mari, A., primary, Tellini, R., additional, Gontero, P., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Bertini, R., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Mirone, V., additional, Montanari, E., additional, Pisano, F., additional, Porpiglia, F., additional, Schiavina, R., additional, Serni, S., additional, Simeone, C., additional, Trombetta, C., additional, Volpe, A., additional, Artibani, W., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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46. A prospective multicenter evaluation of predictive factors for positive surgical margins after partial nephrectomy for renal cell carcinoma: The RECORD2 project

Author

Mari, A., primary, Di Maida, F., additional, Schiavina, R., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Borghesi, M., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Gontero, P., additional, Larcher, A., additional, Longo, N., additional, Montanari, E., additional, Porpiglia, F., additional, Serni, S., additional, Simeone, C., additional, Siracusano, S., additional, Trombetta, C., additional, Volpe, A., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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47. Perioperative complications after partial nephrectomy for complex (PADUA score ≥ 10) renal tumors: A prospective multicenter observational study (the RECORD2 Project)

Author

Mari, A., primary, Tellini, R., additional, Campi, R., additional, Amparore, D., additional, Antonelli, A., additional, Barale, M., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Gontero, P., additional, Mirone, V., additional, Montanari, E., additional, Montorsi, F., additional, Porpiglia, F., additional, Schiavina, R., additional, Serni, S., additional, Simeone, C., additional, Trombetta, C., additional, Volpe, A., additional, Artibani, W., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2019
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48. SC61 - Perioperative and mid-term oncological and functional outcomes after partial nephrectomy for entirely endophytic renal tumors: a prospective multicenter observational study (the RECORD 2 project)

Author

Di Maida, F., Mari, A., Antonelli, A., Barale, M., Bove, P., Brunocilla, E., Lambertini, L., Capitanio, U., Fiori, C., Gallioli, A., Grosso, A.A., Gontero, P., Longo, N., Montorsi, F., Porpiglia, F., Porreca, A., Rocco, B., Schiavina, R., Li Marzi, V., Tellini, R., Trombetta, C., Ficarra, V., Carini, M., and Minervini, A.

Published
2021
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50. A test based on data depth for testing location-scale of the two multivariate populations.

Author

Barale, M. S. and Shirke, D. T.

Subjects
*PERMUTATIONS, *BIOMETRY
Abstract

In the present article, a two-sample test for testing location and/or scale parameter of two multivariate populations is proposed. Baumgartner et al. [A nonparametric test for the general two-sample problem. Biometrics. 1998:1129–1135] proposed a univariate rank test for a general alternative. Murakami [Modified Baumgartner statistics for the two-sample and multisample problems: a numerical comparison. J Stat Comput Simul. 2012;82(5):711–728] modified this univariate rank test with the help of expectations and variances of ordered ranks. With the help of these tests, we have proposed a new rank test for testing location and/or scale parameters of two multivariate populations. Concept of data depth and permutation test are used to define the test procedure. The proposed test is compared with the existing tests for testing location and/or scale parameters of two multivariate populations by using extensive simulated size and power study. The simulation study reveals that the proposed test outperforms the existing tests for majority of the cases. The test procedure is illustrated with well-known Turtles data. [ABSTRACT FROM AUTHOR]

Published
2021
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