Search

Your search keyword '"Baraibar Churio, Arantxa"' showing total 7 results
Start Over Author "Baraibar Churio, Arantxa"
7 results on '"Baraibar Churio, Arantxa"'

1. Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells

Author

Bobadilla Muñoz, Miriam, primary, Orbe, Josune, additional, Abizanda, Gloria, additional, Machado, Florencio J. D., additional, Vilas, Amaia, additional, Ullate-Agote, Asier, additional, Extramiana, Leire, additional, Baraibar Churio, Arantxa, additional, Aranguren, Xabier L., additional, Cantero, Gloria, additional, Sáinz Amillo, Neira, additional, Rodríguez, José Antonio, additional, Ramos García, Luis, additional, Romero Riojas, Juan Pablo, additional, Vallejo-Illarramendi, Ainara, additional, Paradas, Carmen, additional, López de Munain, Adolfo, additional, Páramo, José Antonio, additional, Prósper, Felipe, additional, and Pérez-Ruiz, Ana, additional

Published
2023
Full Text
View/download PDF

2. Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells

Author

Red de Terapia Celular (España), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Cáncer (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), European Commission, Ministerio de Sanidad (España), Junta de Andalucía, Bobadilla Muñoz, Miriam, Orbe, Josune, Abizanda, Gloria, Machado, Florencio J. D., Vilas, Amaia, Ullate-Agote, Asier, Extramiana, Leire, Baraibar Churio, Arantxa, Aranguren, Xabier L., Cantero, Gloria, Sáinz Amillo, Neira, Rodríguez, José Antonio, Ramos García, Luis, Romero Riojas, Juan Pablo, Vallejo-Illarramendi, Ainara, Paradas, Carmen, López de Munain, Adolfo, Páramo, José Antonio, Prósper, Felipe, Pérez-Ruiz, Ana, Red de Terapia Celular (España), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Cáncer (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), European Commission, Ministerio de Sanidad (España), Junta de Andalucía, Bobadilla Muñoz, Miriam, Orbe, Josune, Abizanda, Gloria, Machado, Florencio J. D., Vilas, Amaia, Ullate-Agote, Asier, Extramiana, Leire, Baraibar Churio, Arantxa, Aranguren, Xabier L., Cantero, Gloria, Sáinz Amillo, Neira, Rodríguez, José Antonio, Ramos García, Luis, Romero Riojas, Juan Pablo, Vallejo-Illarramendi, Ainara, Paradas, Carmen, López de Munain, Adolfo, Páramo, José Antonio, Prósper, Felipe, and Pérez-Ruiz, Ana

Abstract

Aged muscles accumulate satellite cells with a striking decline response to damage. Although intrinsic defects in satellite cells themselves are the major contributors to aging-associated stem cell dysfunction, increasing evidence suggests that changes in the muscle-stem cell local microenvironment also contribute to aging. Here, we demonstrate that loss of the matrix metalloproteinase-10 (MMP-10) in young mice alters the composition of the muscle extracellular matrix (ECM), and specifically disrupts the extracellular matrix of the satellite cell niche. This situation causes premature features of aging in the satellite cells, contributing to their functional decline and a predisposition to enter senescence under proliferative pressure. Similarly, reduction of MMP-10 levels in young satellite cells from wild type animals induces a senescence response, while addition of the protease delays this program. Significantly, the effect of MMP-10 on satellite cell aging can be extended to another context of muscle wasting, muscular dystrophy. Systemic treatment of mdx dystrophic mice with MMP-10 prevents the muscle deterioration phenotype and reduces cellular damage in the satellite cells, which are normally under replicative pressure. Most importantly, MMP-10 conserves its protective effect in the satellite cell-derived myoblasts isolated from a Duchenne muscular dystrophy patient by decreasing the accumulation of damaged DNA. Hence, MMP-10 provides a previously unrecognized therapeutic opportunity to delay satellite cell aging and overcome satellite cell dysfunction in dystrophic muscles.

Published
2023

5. Local Preirradiation of Infarcted Cardiac Tissue Substantially Enhances Cell Engraftment

Author

Abizanda, Gloria, primary, López-Muneta, Leyre, additional, Linares, Javier, additional, Ramos, Luis I., additional, Baraibar-Churio, Arantxa, additional, Bobadilla, Miriam, additional, Iglesias, Elena, additional, Coppiello, Giulia, additional, Ripalda-Cemboráin, Purificación, additional, Aranguren, Xabier L., additional, Prósper, Felipe, additional, Pérez-Ruiz, Ana, additional, and Carvajal-Vergara, Xonia, additional

Published
2021
Full Text
View/download PDF

7. A quantitative method for the detection of muscle functional active and passive behavior recovery in models of damage-regeneration.

Author

Grasa, Jorge, Pérez-Ruíz, Ana, Muñoz, María Jesús, Soteras, Fernando, Bobadilla Muñoz, Miriam, Baraibar Churio, Arantxa, Prósper, Felipe, and Calvo, Begoña

Abstract

Unlike other organs, skeletal muscle is endowed with a remarkable potential for regeneration that depends on the presence of satellite cells. Histological and functional (force generation) recoveries after muscle damage are not parallel processes. The aim of this study is to examine the in vivo contractile properties and in vitro passive stress–stretch behavior of muscle during degeneration–regeneration processes. Notexin was injected into rat tibialis anterior muscle, and functional recovery and histological changes were compared. We found that histological improvement of damaged muscle is delayed in comparison with its capacity to generate force. The elastic properties of muscle were not altered in agreement with the unchanged cross-linking index, probably as a consequence of the unaltered deposition of total collagen during degeneration–regeneration processes together with the maintenance of the ratio of collagens type I and III. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results