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4 results on '"Barabino, Gf"'

1. Medical History, Drug Exposure and the Risk of Psoriasis

Author

Naldi, L, Chatenoud, L, Belloni, A, PESERICO STECCHINI NEGRI DE SALVI, Andrea, Balato, N, Virgili, Ar, Bruni, Pl, Ingordo, V, LO SCOCCO, G, Solaroli, C, Schena, D, DI LANDRO, A, Pezzarossa, E, Arcangeli, F, Gianni, C, Betti, R, Carli, P, Farris, A, Barabino, Gf, LA VECCHIA, C, Parazzini, F., and BELLONI FORTINA, Anna

Subjects
Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Case-control study, Dermatology, medicine.disease, Surgery, Psoriasis, medicine, Medical history, Risk factor, business, media_common
Abstract

Background/Aims: To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Methods: Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. Results: The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5–1.3) in hypertensive subjects, 1.1 (95% CI 0.6–2.0) in diabetics and 1.1 (95% CI 0.7–1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1–0.8). Conclusion: Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.

Published
2008
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2. Medical history, drug exposure and the risk of psoriasis. Evidence from an Italian case-control study

Author

Naldi, L, Chatenoud, L, Belloni, A, Peserico, A, Balato, N, Virgili, Anna, Bruni, Pl, Ingordo, V, Lo Scocco, G, Solaroli, C, Schena, D, Di Landro, A, Pezzarossa, E, Arcangeli, F, Gianni, C, Betti, R, Carli, P, Farris, A, Barabino, Gf, La Vecchia, C, Parazzini, F., Naldi, L, Chatenoud, L, Belloni, A, Peserico, A, Balato, Nicola, Virgili, Ar, Bruni, Pl, Ingordo, V, Lo Scocco, G, Solaroli, C, Schena, D, Di Landro, A, Pezzarossa, E, Arcangeli, F, Gianni, C, Betti, R, Carli, P, Farris, A, Barabino, Gf, La Vecchia, C, and Parazzini, F.

Subjects
Adult, Male, drug exposure, case-control study, Histamine Antagonists, psoriasis, Middle Aged, Prognosis, Age Distribution, Italy, Risk Factors, Confidence Intervals, Prevalence, Humans, Psoriasis, Female, Sex Distribution, Aged, Follow-Up Studies, Retrospective Studies
Abstract

To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis.Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited.The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5-1.3) in hypertensive subjects, 1.1 (95% CI 0.6-2.0) in diabetics and 1.1 (95% CI 0.7-1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1-0.8).Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.

Published
2008

3. Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study.

Author

Naldi L, Chatenoud L, Linder D, Belloni Fortina A, Peserico A, Virgili AR, Bruni PL, Ingordo V, Lo Scocco G, Solaroli C, Schena D, Barba A, Di Landro A, Pezzarossa E, Arcangeli F, Gianni C, Betti R, Carli P, Farris A, Barabino GF, and La Vecchia C

Subjects
Adult, Case-Control Studies, Female, Humans, Italy, Male, Middle Aged, Risk Factors, Body Mass Index, Psoriasis etiology, Smoking adverse effects, Stress, Psychological complications
Abstract

We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI >/= 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values >/=115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.

Published
2005
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4. Lepromatous vasculitis successfully treated by plasma exchange (PE).

Author

Ruzzenenti MR, Bruni R, Florio G, De Luigi MC, Lercari G, Barabino GF, Nunzi E, and Valbonesi M

Subjects
Humans, Leprosy, Lepromatous immunology, Middle Aged, Vasculitis immunology, Leprosy, Lepromatous complications, Leprosy, Lepromatous therapy, Plasma Exchange, Vasculitis etiology, Vasculitis therapy
Abstract

Vascular involvement is presently considered a "common pathway" in a number of diseases that is mediated by circulating immune complexes (CIC). CIC are found in the circulation when the disease is active and in single patients their level may parallel disease activity. Lepromatous leprosis is characterized by the presence of CIC and deposits of immunoglobulins and complement in vascular lesions of the different organs and an Arthus-like mechanism is considered as the basis for the clinical picture. The same mechanism is considered to play an essential pathophysiologic role in Lucio's phenomenon, which is characterized by lymphohistiocytic vascular infiltrates with or without thrombosis and secondary cutaneous infarction. Lepromatous vascular involvement is mediated by CIC whose antigen composition is known, the same as it is with HCV mediated cryoglobulinemia, HBV positive panarteritis nodosa, rheumatoid vasculitis, or Wagner's granulomatosis, which are usually treated by PE [1-3]. PE has been employed for lepromatous vasculitis since 1979 [4] and other cases have been successfully treated afterwards [5,6]. We report on another patient successfully treated by plasma exchange.

Published
2001
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