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2. Crohn´s disease is an independent risk factor for liver fibrosis in patients with inflammatory bowel disease and non-alcoholic fatty liver disease

Author

Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Gargallo-Puyuelo, Carla J., Gallego Llera, Beatriz, Refaie, Engy, Callau, Pilar, Mendi, Carolina, Baptista, Pedro M., Hernández Ainsa, María, Arroyo-Villarino, María Teresa, López de la Cruz, Julia, Martínez-García, Javier, Alfambra, Erika, Simón Marco, Miguel Ángel, Ampuero, Javier, and Gomollón, Fernando

Published
2024
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3. Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs

Author

Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Nocito-Colon, Maria Mercedes Lourdes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, del Rio-Nechaevsky, Marcela, Ramirez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, and Baptista, Pedro M.

Published
2023
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6. Liver Tissue Engineering

Author

Pla-Palacín, Iris, Sánchez-Romero, Natalia, Morini, Sara, Rubio-Soto, Daniela, Baptista, Pedro M., Eberli, Daniel, editor, Lee, Sang Jin, editor, and Traweger, Andreas, editor

Published
2021
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7. Crohn´s disease is an independent risk factor for liver fibrosis in patients with inflammatory bowel disease and non-alcoholic fatty liver disease

Author

Diputación General de Aragón, Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Gargallo-Puyuelo, Carla J., Gallego Llera, Beatriz, Refaie, Engy, Callau, Pilar, Mendi, Carolina, Baptista, Pedro M., Hernández Ainsa, María, Arroyo-Villarino, María Teresa, López de la Cruz, Julia, Martínez-García, Javier, Alfambra, Erika, Simón Marco, Miguel Ángel, Ampuero, Javier, Gomollón, Fernando, Diputación General de Aragón, Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Gargallo-Puyuelo, Carla J., Gallego Llera, Beatriz, Refaie, Engy, Callau, Pilar, Mendi, Carolina, Baptista, Pedro M., Hernández Ainsa, María, Arroyo-Villarino, María Teresa, López de la Cruz, Julia, Martínez-García, Javier, Alfambra, Erika, Simón Marco, Miguel Ángel, Ampuero, Javier, and Gomollón, Fernando

Abstract

[Background and aims] Controversial data have been reported regarding the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) in Inflammatory Bowel Disease (IBD) population and IBD-related risk factors. The aim of the study was to assess the prevalence and risk factors associated with NAFLD and liver fibrosis in IBD participants compared with non-IBD controls., [Methods] Cross-sectional, case-control study including 741 IBD cases and 170 non-IBD controls, matched by sex and age. All participants underwent liver ultrasound, transient elastography and laboratory tests. A logistic regression multivariable analysis was performed adjusting for classic metabolic risk factors and history of systemic steroid use., [Results] The prevalence of NAFLD and significant liver fibrosis was 45 % and 10 % in IBD group, and 40 % and 2.9 % in non-IBD group (p = 0.255 and 0.062, respectively). Longer IBD duration (aOR 1.02 95% CI (1.001–1.04)) and older age at IBD diagnosis (aOR 1.02 95 % CI (1.001–1.04)) were independent risk factors for NAFLD in IBD group. Crohn´s Disease was an independent risk factor for significant liver fibrosis in participants with IBD and NAFLD (aOR 3.97 95 % CI (1.78–8.96)). NAFLD occurred at lower BMI levels in IBD group with NAFLD compared to non-IBD group with NAFLD (aOR 0.92 95 % CI (0.87–0.98))., [Conclusions] Although we found no differences in the prevalence of NAFLD and liver fibrosis between IBD group and non-IBD group, our findings suggest that liver fibrosis progression should be closely monitored in patients with concomitant CD and NAFLD, more in particular in those with long standing active disease.

Published
2024

9. Tissue Organoids: Liver

Author

Solanas, Estela, Pla-Palacín, Iris, Sainz-Arnal, Pilar, Almeida, Manuel, Lue, Alberto, Serrano, Trinidad, Baptista, Pedro M., Teicher, Beverly A., Series editor, Soker, Shay, editor, and Skardal, Aleksander, editor

Published
2018
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10. Naturally-Derived Biomaterials for Tissue Engineering Applications

Author

Brovold, Matthew, Almeida, Joana I., Pla-Palacín, Iris, Sainz-Arnal, Pilar, Sánchez-Romero, Natalia, Rivas, Jesus J., Almeida, Helen, Dachary, Pablo Royo, Serrano-Aulló, Trinidad, Soker, Shay, Baptista, Pedro M., COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, Rezaei, Nima, Series Editor, Chun, Heung Jae, editor, Park, Kwideok, editor, Kim, Chun-Ho, editor, and Khang, Gilson, editor

Published
2018
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11. Liver Tissue Engineering

Author

Pla-Palacín, Iris, primary, Sánchez-Romero, Natalia, additional, Morini, Sara, additional, Rubio-Soto, Daniela, additional, and Baptista, Pedro M., additional

Published
2021
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12. Liver Tissue Engineering

Author

Pla-Palacín, Iris, primary, Sánchez-Romero, Natalia, additional, Morini, Sara, additional, Rubio-Soto, Daniela, additional, and Baptista, Pedro M., additional

Published
2020
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15. Cell transplantation-based regenerative medicine in liver diseases

Author

Cardinale, Vincenzo, primary, Lanthier, Nicolas, additional, Baptista, Pedro M., additional, Carpino, Guido, additional, Carnevale, Gianluca, additional, Orlando, Giuseppe, additional, Angelico, Roberta, additional, Manzia, Tommaso Maria, additional, Schuppan, Detlef, additional, Pinzani, Massimo, additional, Alvaro, Domenico, additional, Ciccocioppo, Rachele, additional, and Uygun, Basak E., additional

Published
2023
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16. Bioengineering of Liver Tissue

Author

Sainz-Arnal, Pilar, primary, Pla-Palacín, Iris, additional, Sánchez-Romero, Natalia, additional, Almeida, Manuel, additional, Morini, Sara, additional, Solanas, Estela, additional, Lue, Alberto, additional, Serrano-Aulló, Trinidad, additional, and Baptista, Pedro M., additional

Published
2019
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17. Integrated mapping and gene analysis in regions showing loss of heterozygosity in human breast cancer in the short arm of chromosome 1

Author

Baptista, Pedro M. R. V.

Subjects
616.99
Abstract

A flow-sorted chromosome 1 cosmid library was used to produce a cosmid pocket map spanning two regions in chromosome 1p - approximately 10 Mb in 1p31.1 and 1.7 Mb in 1p13.1. Loss of heterozygosity (LOH) in human breast cancer has been described at these regions. In chromosome 1p13.1 a more detailed physical map consisting of overlapping genomic inserts contained within bacterial recombinant clones was constructed. To the present moment no genomic sequence is yet available at this chromosomal region. For the identification of novel genes, exon trapping and cDNA selection were performed, on 9 overlapping clones from the physical map. The resulting putative exons/transcripts were analysed and compared with non-redundant, cDNA and protein databases. The DNA sequence of seven clones was identical to human cDNA clones. Two highly significant similarities of translations of these clones were found with a human alpha-mannosidase and a rat prostaglandin associated regulatory protein. Both genes were located in a smallest region of overlapping deletion in tumour DNA from patients with breast cancer. Analysis of the coding sequence of the genes using genomic DNA from patients with breast cancer showing LOH at this region will be presented in the thesis.

Published
2000

18. Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs

Author

Diputación General de Aragón, Gobierno de Aragón, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Fundación Inocente Inocente, Asociación Española Contra el Cáncer, Aspanoa, Asociación Carrera de la Mujer Ciudad de Monzón, Martínez-Domínguez, Samuel J., García-Mateo, Sandrfa, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Lourdes Nocito-Colon, Maria Mercedes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, Rio-Nechaevsky, Marcela del, Ramírez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, Baptista, Pedro M., Diputación General de Aragón, Gobierno de Aragón, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Fundación Inocente Inocente, Asociación Española Contra el Cáncer, Aspanoa, Asociación Carrera de la Mujer Ciudad de Monzón, Martínez-Domínguez, Samuel J., García-Mateo, Sandrfa, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Lourdes Nocito-Colon, Maria Mercedes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, Rio-Nechaevsky, Marcela del, Ramírez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, and Baptista, Pedro M.

Abstract

Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy.

Published
2023

19. Liver Tissue Engineering

Author

Morini, Sara, primary, Sánchez-Romero, Natalia, additional, Palacín, Iris Plá, additional, Arnal, Pilar Sainz, additional, Almeida, Manuel, additional, Verscheijden, Laurens, additional, Almeida, Joana I., additional, Lue, Alberto, additional, Llorente, Sara, additional, Almeida, Helen, additional, Dachary, Pablo Royo, additional, Gil, Agustín García, additional, Serrano-Aulló, Trinidad, additional, and Baptista, Pedro M., additional

Published
2018
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20. Contributors

Author

Agarwal, Rachit, primary, Ahlstrom, Jon D., additional, Ahmad, Rafiq, additional, Alarcon, Emilio I., additional, Almarza, Alejandro J., additional, Almeida-Porada, Graça, additional, Almeida, Manuel, additional, Alvarado-Velez, Melissa, additional, Anderson, James M., additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Balkan, Wayne, additional, Ballios, Brian G., additional, Baptista, Pedro M., additional, Baumann, M. Douglas, additional, Bedi, Supinder S., additional, Bellamkonda, Ravi V., additional, Bergmann, Nicole M., additional, Blau, Helen M., additional, Boerckel, Joel D., additional, Bratt-Leal, Andres M., additional, Brown, James C., additional, Brubaker, Scott, additional, Brunette, Isabelle, additional, Calderon, Gisele A., additional, Caplan, Arnold I., additional, Castner, David G., additional, Chang, Cynthia, additional, Chawla, Aditya, additional, Chen, Xuguang, additional, Cohen, Paul, additional, Cooke, Michael J., additional, Copus, Joshua S., additional, Correlo, Vitor M., additional, Cox, Charles S., additional, Dahl, Abritee, additional, Day, Richard M., additional, De Coppi, Paolo, additional, Dodla, Mahesh C., additional, Elisseeff, Jennifer H., additional, Emamaullee, Juliet A., additional, Esa, Adam, additional, Fang, Yunlan, additional, Faust, Heather J., additional, Fisher, John P., additional, Fisher, Matthew B., additional, Francois, Elvis L., additional, García, Andrés J., additional, Gavrilov, Svetlana, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmiti, Christopher V., additional, Gillispie, Gregory J., additional, Gilpin, Sarah E., additional, Godbey, W.T., additional, Gray, Andrea, additional, Green, Ronald M., additional, Griffith, May, additional, Guldberg, Robert E., additional, Guo, Qiongyu, additional, Gurtner, Geoffrey C., additional, Hacker, Michael C., additional, Hanna, Issa A., additional, Hare, Joshua M., additional, Hatzistergos, Konstantinos E., additional, Herber, Ralf-Peter, additional, Hilborn, Jöns, additional, Humes, H. David, additional, Hunsberger, Joshua G., additional, Iwasa, Kenjiro, additional, Jackson, John D., additional, Jackson, Margaret L., additional, Jang, Hae Lin, additional, Jansen, John A., additional, Johnston, Josephine, additional, Jorns, Carl, additional, Kang, Huijun, additional, Kaplan, David L., additional, Kaplan, David S., additional, Katz, Adam J., additional, Kelley, Matthew W., additional, Kennedy, Kelsey, additional, Khademhosseini, Ali, additional, Khang, Gilson, additional, Kim, Jinho, additional, Klein, Rachel H., additional, Klimanskaya, Irina, additional, Knoepfler, Paul S., additional, Ko, In Kap, additional, Kolambkar, Yash M., additional, Krieghoff, Jan, additional, Kucko, Nathan W., additional, Kumar, Manoj, additional, Kurtzberg, Joanne, additional, Kwilas, Anna, additional, Landry, Donald W., additional, Langhans, Mark T., additional, Lanza, Robert, additional, Lanzoni, Giacomo, additional, Lee, Sang Jin, additional, Leeuwenburgh, Sander C.G., additional, Leong, Kam W., additional, Liang, Rui, additional, Liaudanskaya, Volha, additional, Lin, Hang, additional, Longaker, Michael T., additional, Lorenz, Hermann P., additional, Loring, Jeanne F., additional, Lu, Shi-Jiang, additional, Lue, Alberto, additional, Ma, Peter X., additional, Magalhaes, Renata S., additional, Mandla, Serena, additional, Marshall, Clement D., additional, Martins-Green, Manuela, additional, Mason, Devon E., additional, Mau, Jonquil R., additional, McFarland, Richard, additional, McHale, Melissa K., additional, Melville, James C., additional, Meyers, Jason R., additional, Mikos, Antonios G., additional, Miller, Jordan S., additional, Mittermiller, Paul A., additional, Miyachi, Hideki, additional, Miyamoto, Shinka, additional, Monteiro, Nelson, additional, Moore, Alessandra L., additional, Morini, Sara, additional, Moser, Philipp T., additional, Mukhatyar, Vivek J., additional, Murdock, Mark, additional, Nagiel, Aaron, additional, Naughton, Gail K., additional, Nauta, Allison, additional, Navarro, Javier, additional, Newton, Jared M., additional, Nori, Aparna, additional, Okano, Teruo, additional, Oliveira, Joaquim M., additional, Ott, Harald C., additional, Padmanabhan, Jagannath, additional, Page, Kristin M., additional, Pallickaveedu Rajan Asari, Anil Kumar, additional, Papaioannou, Virginia E., additional, Park, Jihoon, additional, Payne, Samantha L., additional, Pelled, Gadi, additional, Pepper, Andrew, additional, Perumal, Elumalai, additional, Petreaca, Melissa, additional, Pino, Christopher J., additional, Pirosa, Alessandro, additional, Pla-Palacín, Iris, additional, Pokrywczynska, Marta, additional, Porada, Christopher D., additional, Porter, Blaise D., additional, Radisic, Milica, additional, Rambhia, Kunal J., additional, Raquel Maia, F., additional, Ratner, Buddy D., additional, Reddi, A.H., additional, Reis, Rui L., additional, Ricles, Laura, additional, Ricordi, Camillo, additional, Rizwan, Muhammad, additional, Robinson, Rebecca, additional, Rodrigues, Melanie, additional, Rothrauff, Benjamin B., additional, Sadri-Ardekani, Hooman, additional, Sainz-Arnal, Pilar, additional, Sambathkumar, Rangarajan, additional, Sánchez-Romero, Natalia, additional, Scarritt, Michelle, additional, Schneider, Christopher M., additional, Schwartz, Steven D., additional, Selem, Sarah, additional, Serrano-Aulló, Trinidad, additional, Shapiro, A.M. James, additional, Sheyn, Dmitriy, additional, Shimizu, Tatsuya, additional, Shinoka, Toshiharu, additional, Shoichet, Molly S., additional, Shoji, Toshihiro, additional, Shupe, Thomas, additional, Sikora, Andrew G., additional, Simpson, Fiona, additional, Skardal, Aleksander, additional, Skuk, Daniel, additional, Smith, Brandon T., additional, Sohn, Jihee, additional, Soker, Shay, additional, Solanas, Estela, additional, Song, Jeong Eun, additional, Sood, Disha, additional, Stocum, David L., additional, Strom, Stephen C., additional, Sun, Jessica M., additional, Takahashi, Hironobu, additional, Tremblay, Jacques P., additional, Tripathy, Nirmalya, additional, Tse, John W., additional, Tuan, Rocky S., additional, Verfaillie, Catherine M., additional, Vunjak-Novakovic, Gordana, additional, Wagner, William R., additional, Wang, Yanling, additional, Watson, Emma, additional, West, Jennifer L., additional, Williams, David F., additional, Williams, James K., additional, Wong, Mark E., additional, Woo, Savio L-Y., additional, Wood, Fiona M., additional, Xu, Lei, additional, Yakubovich, Doron C., additional, Yang, Yafeng, additional, Yaszemski, Michael J., additional, Yelick, Pamela C., additional, Yim, Evelyn K.F., additional, Yong, Carolyn, additional, Yoo, James J., additional, Young, Simon, additional, Yucel, Nora, additional, Zacharias, Rachel L., additional, Zhang, Yuanyuan, additional, Zhang, Ai, additional, Zhang, Jin, additional, and Zhu, Yang, additional

Published
2018
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25. Tissue Organoids: Liver

Author

Solanas, Estela, primary, Pla-Palacín, Iris, additional, Sainz-Arnal, Pilar, additional, Almeida, Manuel, additional, Lue, Alberto, additional, Serrano, Trinidad, additional, and Baptista, Pedro M., additional

Published
2017
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27. High level of polarized engraftment of porcine intrahepatic cholangiocyte organoids in decellularized liver scaffolds

Author

Krüger, Melanie, primary, Samsom, Roos‐Anne, additional, Oosterhoff, Loes A., additional, van Wolferen, Monique E., additional, Kooistra, Hans S., additional, Geijsen, Niels, additional, Penning, Louis C., additional, Kock, Linda M., additional, Sainz‐Arnal, Pilar, additional, Baptista, Pedro M., additional, and Spee, Bart, additional

Published
2022
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28. High level of polarized engraftment of porcine intrahepatic cholangiocyte organoids in decellularized liver scaffolds

Author

Krüger, Melanie, Samsom, Roos Anne, Oosterhoff, Loes A., van Wolferen, Monique E., Kooistra, Hans S., Geijsen, Niels, Penning, Louis C., Kock, Linda M., Sainz-Arnal, Pilar, Baptista, Pedro M., Spee, Bart, Krüger, Melanie, Samsom, Roos Anne, Oosterhoff, Loes A., van Wolferen, Monique E., Kooistra, Hans S., Geijsen, Niels, Penning, Louis C., Kock, Linda M., Sainz-Arnal, Pilar, Baptista, Pedro M., and Spee, Bart

Abstract

In Europe alone, each year 5500 people require a life-saving liver transplantation, but 18% die before receiving one due to the shortage of donor organs. Whole organ engineering, utilizing decellularized liver scaffolds repopulated with autologous cells, is an attractive alternative to increase the pool of available organs for transplantation. The development of this technology is hampered by a lack of a suitable large-animal model representative of the human physiology and a reliable and continuous cell source. We have generated porcine intrahepatic cholangiocyte organoids from adult stem cells and demonstrate that these cultures remained stable over multiple passages whilst retaining the ability to differentiate into hepatocyte- and cholangiocyte-like cells. Recellularization onto porcine scaffolds was efficient and the organoids homogeneously differentiated, even showing polarization. Our porcine intrahepatic cholangiocyte system, combined with porcine liver scaffold paves the way for developing whole liver engineering in a relevant large-animal model.

Published
2022

36. Contributors

Author

Almeida-Porada, Graça, primary, Asatrian, Greg, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baptista, Pedro M., additional, Best, Cameron, additional, Bitar, Khalil N., additional, Breuer, Christopher K., additional, Brown, Bryan N., additional, Canadas, Raphaël F., additional, Caplan, Arnold I., additional, Cervelló, Irene, additional, Chen, William C.W., additional, Chen, Dong F., additional, Childers, Martin K., additional, Cho, Kin-Sang, additional, Conti, Claudio J., additional, Crespo-Barreda, A., additional, Del Río, Marcela, additional, Della Verde, Giacomo, additional, Dhal, Abritee, additional, Donnenberg, Albert, additional, Encabo-Berzosa, M.M., additional, Giménez, Ignacio, additional, Goddard, Melissa A., additional, González-Pastor, R., additional, Gottardi, Riccardo, additional, Guan, Xuan, additional, Guerrero-Aspizua, Sara, additional, Guo, Chenying, additional, Hardy, Winters, additional, Herman, Ira M., additional, Hwang, Catalina K., additional, Iglesias, M., additional, Ignacio, Glicerio, additional, James, Aaron W., additional, Khanh Vu, Thi H., additional, Kikyo, Nobuaki, additional, Kurtzberg, Joanne, additional, Kuster, Gabriela M., additional, Lanas, Angel, additional, Langhans, Mark T., additional, Larcher, Fernando, additional, Lee, Avione Y., additional, Lee, Yong-Ung, additional, Liao, Ronglih, additional, Liou, Jr-Jiun, additional, Mack, David L., additional, Mahler, Nathan, additional, Marques, Alexandra P., additional, Marra, Kacey G., additional, Martin-Duque, P., additional, Meade, Patricia, additional, Medrano, Jose Vicente, additional, Moran, Emma, additional, Oliveira, Joaquim M., additional, Ortíz-Teba, P., additional, Péault, Bruno, additional, Pfister, Otmar, additional, Pina, Sandra, additional, Porada, Christopher D., additional, Reis, Rui L., additional, Rubin, J. Peter, additional, Sabin, Keith, additional, Sánchez-Romero, Natalia, additional, Santamaria, Alvaro, additional, Serrano, J.L., additional, Sheets, Anthony R., additional, Simón, Carlos, additional, Soker, Shay, additional, Soo, Chia, additional, Sun, Jessica M., additional, Talib, Mays, additional, Tara, Shuhei, additional, Ting, Kang, additional, Tuan, Rocky S., additional, Valentin, Jolene E., additional, Vyas, Dipen, additional, Wang, Bo, additional, Wertheim, Jason A., additional, Yu, Honghua, additional, Zakhem, Elie, additional, Zapatero-Solana, Elisabeth, additional, Zhang, Nan, additional, and Zhang, Yuanyuan, additional

Published
2016
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39. Safety and Efficacy of BCG Re-Vaccination in Reducing COVID-19 Morbidity in Healthcare Workers: A Double-Blind, Randomised, Controlled, Phase 3 Trial

Author

Upton, Caryn Megan, primary, van Wijk, Rob C., additional, Mockeliunas, Laurynas, additional, Simonsson, Ulrika S. H., additional, McHarry, Kirsten, additional, van den Hoogen, Gerben, additional, Muller, Chantal, additional, von Delft, Arne, additional, van der Westhuizen, H, additional, van Crevel, reinout, additional, Walzl, Gerhard, additional, Baptista, Pedro M., additional, Peter, Jonny, additional, Diacon, Andreas H., additional, and Consortium, BCG CORONA, additional

Published
2022
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40. Contributors

Author

Abolbashari, Mehran, primary, Ahn, Jaimo, additional, Akel, Salem, additional, Allickson, Julie G., additional, Almeida-Porada, Graça, additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Au, Patrick, additional, Aufiero, Danielle, additional, Baptista, Pedro M., additional, Bartel, Ronnda L., additional, Bartholomew, Amelia, additional, Baum, Elona, additional, Bemden, Angie Botto-van, additional, Bitar, Khalil N., additional, Boxer, Lynne, additional, Brown, Matthew P., additional, Brown, Heather L., additional, Bryant, Stephanie J., additional, Carvalho, Pedro P., additional, Chandra, Prafulla, additional, Chapman, John R., additional, Das, Shreyasi, additional, Deegan, Daniel B., additional, Dhal, Abritee, additional, Donnenberg, Albert D., additional, Durdy, Matthew B., additional, Durfor, Charles N., additional, Edelman, Elazer R., additional, Fink, Donald, additional, Fischkoff, Steven, additional, Frey-Vasconcells, Joyce L., additional, Führmann, Tobias, additional, Gacchina Johnson, Carmen, additional, Gadish, Or, additional, Gambhir, Sanjiv S., additional, Gee, Adrian P., additional, Gomes, Manuela E., additional, Hankenson, Kurt D., additional, Hariri, Robert J., additional, Hatcher, Heather C., additional, Heidaran, Mohammad, additional, Huss, Ralf, additional, Hyde, John, additional, Ikada, Yoshito, additional, Jain, Deepak, additional, Jain, Paul A., additional, Jokerst, Jesse V., additional, Jungebluth, Philipp, additional, Kandyba, Eve, additional, Kaplan, David S., additional, Karandish, Safa, additional, Kasper, F. Kurtis, additional, Kelkar, Sneha S., additional, Kenyon, Norma, additional, Kobielak, Krzysztof, additional, Kramer, Jesse, additional, Lee, Sang Jin, additional, Lee, Mark H., additional, Leung, Yvonne, additional, Lim, Mei Ling, additional, Littman, Neil J., additional, Macchiarini, Paolo, additional, Malik, Nafees N., additional, Mann, Brenda K., additional, Marra, Kacey G., additional, Marx, Robert E., additional, Mastrangelo, Lina, additional, McCright, Brent, additional, McFarland, Richard, additional, Mendicino, Michael, additional, Mikos, Antonios G., additional, Mitrousis, Nikolaos, additional, Mohs, Aaron M., additional, Moore, Thomas, additional, Moran, Emma C., additional, Niles, Walter, additional, Niu, Guoguang, additional, Nomi, Masashi, additional, Nunez, Tamara, additional, Perry, Robert, additional, Pfotenhauer, Robert P., additional, Porada, Christopher D., additional, Premenand, Kavitha, additional, Prestwich, Glenn D., additional, Raghavan, Shreya, additional, Rao, Mahendra, additional, Ratcliffe, Anthony, additional, Rego, Stephen, additional, Reis, Rui L., additional, Rich, Ivan N., additional, Rodrigues, Márcia T., additional, Rubin, J. Peter, additional, Sampson, Steven, additional, Sapoznik, Etai, additional, Sharp, John G., additional, Shoichet, Molly S., additional, Skuk, Daniel, additional, Snyder, Evan Y., additional, Soker, Shay, additional, Somara, Sita, additional, Spencer, Tom, additional, Stewart, Suzanne, additional, Sundivakkam, Premenand, additional, Szilagyi, Erszebet, additional, Tatara, Alexander M., additional, Tobe, Brian, additional, Tremblay, Jacques P., additional, Trounson, Alan O., additional, Tuladhar, Anup, additional, Tull, Lori, additional, Valentin, Jolene E., additional, Vyas, Dipen, additional, Wang, Zhan, additional, Winquist, Alicia, additional, Witten, Celia, additional, Wong, Mark E.K., additional, Yoo, James J., additional, Yoon, Diana, additional, Zakhem, Elie, additional, and Zambon, Joao Paulo, additional

Published
2015
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43. List of Contributors

Author

Afroze, Syeda H., primary, Alpini, Gianfranco, additional, Anderson, Eric C., additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baiguera, Silvia, additional, Baiocchi, Leonardo, additional, Baptista, Pedro M., additional, Bejarano-Pineda, Lorena, additional, Benedetti, Enrico, additional, Beraldi, Rosanna, additional, Berdichevski, Alexandra, additional, Bhuyan, Mohammod, additional, Bishop, Alex G., additional, Bitar, Khalil N., additional, Blose, Kory J., additional, Brasile, Lauren, additional, Braza, Faouzi, additional, Breuer, Christopher K., additional, Brouard, Sophie, additional, Brown, Bryan N., additional, Burke, George W., additional, Butler, Peter E., additional, Butler, Colin R., additional, Calderon, Damelys, additional, Cancedda, Ranieri, additional, Cantero Peral, Susana, additional, Carbone, Marco, additional, Castanares-Zapatero, Diego, additional, Castro Santa, Edward, additional, Chatenoud, Lucienne, additional, Chawla, Reema, additional, Chen, Linda, additional, Chiono, Valeria, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Ciccarelli, Olga, additional, Collienne, Christine, additional, Corradini, Francesca, additional, Cortiella, Joaquin, additional, Cravedi, Paolo, additional, Cypel, Marcelo, additional, Da Sacco, Stefano, additional, Date, Hiroshi, additional, Davies, Paige S., additional, De Coppi, Paolo, additional, De Luca, Michele, additional, Dean, Ethan W., additional, Degauque, Nicolas, additional, Domínguez-Bendala, Juan, additional, Dubernard, Jean Michel, additional, ElBackly, Rania M., additional, English, Karen, additional, Fändrich, Fred, additional, Farney, Alan C., additional, Faulk, Denver M., additional, García-Arrarás, José E., additional, Gianello, Pierre, additional, Giangreco, Adam, additional, Glaser, Shannon S., additional, Gobble, Ryan, additional, Goldstein, Aaron S., additional, Grant, Christa N., additional, Grikscheit, Tracy C., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guillot, Pascale V., additional, Hamilton, Nicholas, additional, Hantson, Philippe, additional, Hemal, Sij, additional, Hematti, Peiman, additional, Hynds, Robert E., additional, Inverardi, Luca, additional, Jacquet, Luc M., additional, Janes, Sam M., additional, Jell, Gavin, additional, Jensen, Kendal, additional, Jochmans, Ina, additional, Kanai, Nobuo, additional, Katari, Ravi, additional, Keshavjee, Shaf, additional, Kim, Jaehyup, additional, Kim, Yeonhee, additional, King, Nancy M.P., additional, Kobayashi, Eiji, additional, Koshiba, Takaaki, additional, Krawiec, Jeffrey T., additional, Kurobe, Hirotsugu, additional, Lai, Quirino, additional, Lanzoni, Giacomo, additional, Laterre, Pierre-François, additional, Lerut, Jan P., additional, Lerut, Toni, additional, Li, Ou, additional, Macchiarini, Paolo, additional, Maghsoudlou, Panagiotis, additional, Mamode, Nizam, additional, Manzia, Tommaso M., additional, Martinez-Fernandez, Almudena, additional, Martovetsky, Gleb, additional, Mastrogiacomo, Maddalena, additional, Masuda, Shigeo, additional, McQuilling, John P., additional, Mehra, Mandeep R., additional, Menasché, Philippe, additional, Meng, Fanyin, additional, Mironi-Harpaz, Iris, additional, Mirzazadeh, Majid, additional, Moiemen, Naiem S., additional, Moran, Emma, additional, Muiesan, Paolo, additional, Nardo, Tiziana, additional, Nelson, Timothy J, additional, Netti, Paolo A., additional, Neuberger, James M., additional, Nigam, Sanjay K., additional, Ohe, Hidenori, additional, Okano, Teruo, additional, Opara, Emmanuel C., additional, Orgill, Dennis P., additional, Otte, Jean-Bernard, additional, Ozer, Sinan, additional, Pareta, Rajesh A., additional, Patel, Timil, additional, Pellegrini, Graziella, additional, Peloso, Andrea, additional, Perin, Laura, additional, Petruzzo, Palmina, additional, Pinheiro, Rafael S., additional, Pirenne, Jacques, additional, Poindexter, Lauren K., additional, Pucéat, Michel, additional, Pugliese, Alberto, additional, Raghavan, Shreya, additional, Rahal, Kinan, additional, Rama, Paolo, additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Reyna-Soriano, Daniel, additional, Rico Juri, Juan M., additional, Ricordi, Camillo, additional, Roberts, Keith J., additional, Rocco, Kevin A., additional, Rodriguez-Devora, Jorge I., additional, Rogers, Jeffrey, additional, Rudnick, David A., additional, Ruggenenti, Piero, additional, Sageshima, Junichiro, additional, Salvatori, Marcus, additional, Samavedi, Satyavrata, additional, Sannino, Alessandro, additional, Scalera, Irene, additional, Sedaghati, Tina, additional, Sedrakyan, Sargis, additional, Seifalian, Alexander M., additional, Seifalian, Amelia, additional, Seliktar, Dror, additional, Selvaggi, Gennaro, additional, Shapira-Schweitzer, Keren, additional, Shinoka, Toshiharu, additional, Shupe, Thomas, additional, Smith, Nicholas R., additional, Soulillou, Jean-Paul, additional, Spinelli, Valentina, additional, Sutherland, David E.R., additional, Tara, Shuhei, additional, Teratani, Takumi, additional, Terzic, Andre, additional, Thomas, Sunu S., additional, Tisone, Giuseppe, additional, Totonelli, Giorgia, additional, Tzakis, Andreas, additional, Tzvetanov, Ivo G., additional, Udelsman, Brooks V., additional, Uygun, Basak E., additional, Vacanti, Joseph P., additional, Van Caenegem, Olivier, additional, Van Dyke, Mark, additional, Van Raemdonck, Dirk E., additional, Vorp, David A., additional, Vyas, Dipen, additional, Wang, Kun, additional, Weinbaum, Justin S., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wittebole, Xavier, additional, Wong, Melissa H., additional, Wood, Kathryn J., additional, Xu, Tao, additional, Yamato, Masayuki, additional, You, Sylvaine, additional, Yuan, Yuyu, additional, Zambon, Joao Paulo, additional, Zattoni, Michela, additional, and Zhu, Lei, additional

Published
2014
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46. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do

Author

Ribitsch, Iris, Baptista, Pedro M, Lange-Consiglio, Anna, Melotti, Luca, Patruno, Marco, Jenner, Florien, Schnabl-Feichter, Eva, Dutton, Luke C, Connolly, David J, van Steenbeek, Frank G, Dudhia, Jayesh, Penning, Louis C, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-1, CS_Genetics, CS_STEM, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-1, CS_Genetics, and CS_STEM

Subjects
pig, 0301 basic medicine, sheep, medicine.medical_specialty, Informed choice, large animal models, sheep, pig, horse, dog, regenerative medicine, tissue engineering, naturally occurring disease, Histology, naturally occurring disease, lcsh:Biotechnology, Large animal models, Biomedical Engineering, regenerative medicine, Bioengineering, Review, 02 engineering and technology, Disease, Horse, Regenerative medicine, 03 medical and health sciences, Resource (project management), lcsh:TP248.13-248.65, Dog, Medicine, Tissue engineering, Intensive care medicine, Research question, naturallyoccurring disease, Biología y Biomedicina, Pig, Sheep, business.industry, Bioengineering and Biotechnology, 021001 nanoscience & nanotechnology, horse, Clinical trial, 030104 developmental biology, large animal models, tissue engineering, dog, Naturally occurring disease, Animal studies, 0210 nano-technology, business, Biotechnology, Large animal
Abstract

Proceedings of: TERMIS EU 2019, 27th-31st May 2019, Rhodes, Greece. Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an increasing drive toward clinical translation of breakthrough technologies. However, the progression of promising preclinical data to achieve successful clinical market authorisation remains a bottleneck. One hurdle for progress to the clinic is the transition from small animal research to advanced preclinical studies in large animals to test safety and efficacy of products. Notwithstanding this, to draw meaningful and reliable conclusions from animal experiments it is critical that the species and disease model of choice is relevant to answer the research question as well as the clinical problem. Selecting the most appropriate animal model requires in-depth knowledge of specific species and breeds to ascertain the adequacy of the model and outcome measures that closely mirror the clinical situation. Traditional reductionist approaches in animal experiments, which often do not sufficiently reflect the studied disease, are still the norm and can result in a disconnect in outcomes observed between animal studies and clinical trials. To address these concerns a reconsideration in approach will be required. This should include a stepwise approach using in vitro and ex vivo experiments as well as in silico modeling to minimize the need for in vivo studies for screening and early development studies, followed by large animal models which more closely resemble human disease. Naturally occurring, or spontaneous diseases in large animals remain a largely untapped resource, and given the similarities in pathophysiology to humans they not only allow for studying new treatment strategies but also disease etiology and prevention. Naturally occurring disease models, particularly for longer lived large animal species, allow for studying disorders at an age when the disease is most prevalent. As these diseases are usually also a concern in the chosen veterinary species they would be beneficiaries of newly developed therapies. Improved awareness of the progress in animal models is mutually beneficial for animals, researchers, human and veterinary patients. In this overview we describe advantages and disadvantages of various animal models including domesticated and companion animals used in regenerative medicine and tissue engineering to provide an informed choice of disease-relevant animal models. We would like to thank Niklas Dresen, Institute of Veterinary Anatomy, University Leipzig as well as John Breteler, Elfriede Cremer, Bernhard Cremer, and Elisabeth Schieder for the provided graphical support and Michaela Hauser for formatting the references. PB acknowledges the funded projects PI15/00563 and PI18/00529 from ISCIII, Spain.

Published
2020
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48. Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells.

Author

Schneeberger, Kerstin, Sánchez-Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G, Oosterhoff, Loes A, Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E, van Tienderen, Gilles, Lieshout, Ruby, Colemonts-Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M A, van der Laan, Luc J W, Penning, Louis C, Fuchs, Sabine A, Clevers, Hans, De Kock, Joery, Baptista, Pedro M, Spee, Bart, Schneeberger, Kerstin, Sánchez-Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G, Oosterhoff, Loes A, Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E, van Tienderen, Gilles, Lieshout, Ruby, Colemonts-Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M A, van der Laan, Luc J W, Penning, Louis C, Fuchs, Sabine A, Clevers, Hans, De Kock, Joery, Baptista, Pedro M, and Spee, Bart

Abstract

The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)-positive adult stem cells represent an exciting new cell source for liver regeneration; however, culturing large numbers of organoids with current protocols is tedious and the level of hepatic differentiation is limited. Here, we established a new method for the expansion of large quantities of human liver organoids in spinner flasks. Due to improved oxygenation in the spinner flasks, organoids rapidly proliferated and reached an average 40-fold cell expansion after two weeks, compared to 6-fold expansion in static cultures. The organoids repopulated decellularized liver discs and formed liver-like tissue. After differentiation in spinner flasks, mature hepatocyte markers were highly upregulated compared to static organoid cultures, and cytochrome p450 activity reached levels equivalent to hepatocytes. CONCLUSION: We established a highly efficient method for culturing large numbers of LGR5-positive stem cells in the form of organoids, which paves the way for the application of organoids for tissue engineering and liver transplantation.

Published
2020

49. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do

Author

Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-1, CS_Genetics, Ribitsch, Iris, Baptista, Pedro M, Lange-Consiglio, Anna, Melotti, Luca, Patruno, Marco, Jenner, Florien, Schnabl-Feichter, Eva, Dutton, Luke C, Connolly, David J, van Steenbeek, Frank G, Dudhia, Jayesh, Penning, Louis C, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-1, CS_Genetics, Ribitsch, Iris, Baptista, Pedro M, Lange-Consiglio, Anna, Melotti, Luca, Patruno, Marco, Jenner, Florien, Schnabl-Feichter, Eva, Dutton, Luke C, Connolly, David J, van Steenbeek, Frank G, Dudhia, Jayesh, and Penning, Louis C

Published
2020

50. Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells.

Author

Onderzoek, dCSCA RMSC-1, Sub General Pharmacology, dCSCA AVR, Biochemisch laboratorium, Faculteit Diergeneeskunde, Schneeberger, Kerstin, Sánchez-Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G, Oosterhoff, Loes A, Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E, van Tienderen, Gilles, Lieshout, Ruby, Colemonts-Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M A, van der Laan, Luc J W, Penning, Louis C, Fuchs, Sabine A, Clevers, Hans, De Kock, Joery, Baptista, Pedro M, Spee, Bart, Onderzoek, dCSCA RMSC-1, Sub General Pharmacology, dCSCA AVR, Biochemisch laboratorium, Faculteit Diergeneeskunde, Schneeberger, Kerstin, Sánchez-Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G, Oosterhoff, Loes A, Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E, van Tienderen, Gilles, Lieshout, Ruby, Colemonts-Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M A, van der Laan, Luc J W, Penning, Louis C, Fuchs, Sabine A, Clevers, Hans, De Kock, Joery, Baptista, Pedro M, and Spee, Bart

Published
2020

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