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Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. Inflammation is a complex and pervasive physiological and pathological process. The physiological and pathological mechanisms of inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 and other research focus diseases are not clear yet, and they are considered to be related to inflammation. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and the latest research results on the improvement of curcumin pharmacokinetics. It is beneficial to the further study of curcumin and provides new ideas and insights for the development of curcumin anti-inflammatory preparations.

Ligustri Lucidi Fructus (LLF) is one of the usual Chinese herbs that has long been used with high therapeutic and condition value. LLF is used for the treatment of dizziness and tinnitus, soreness and weakness of the waist and knees, premature greying of the hair, the darkness of the eyes, internal heat and thirst, bone steam and hot flashes and other symptoms.This review reviews botany, traditional uses, processing, phytochemistry, quality control, pharmacology, toxicity and pharmacokinetics to better understand its therapeutic potential.The literature on LLF was obtained from Google Scholar and Baidu Scholar, PubMed, ScienceDirect, SciFinder, Web of Science, China National Knowledge Infrastructure (CNKI), WAN FANG DATA and libraries. Some local books, official websites, PhD or MS's dissertations were also included. Phytochemical constituents' structures were drawn by ChemDraw software.So far, Multiple chemical components were isolated and identified from LLF, mainly including terpenoids and flavonoids. Modern studies have shown that LLF extracts and compounds have a wide range of pharmacological effects, including antitumor, liver protection, blood glucose, lipid-lowering, immune regulation, and other aspects.LLF occupies an important position in the traditional medical system. It is cost-effective and is a significant plant with therapeutic applications in modern medicine. However, further in-depth studies are needed to determine the medical use of this plant and its chemical composition, pharmacological activity, quality control, toxicity and pharmacokinetics.

Fueter’s theorem (1934) asserts that every holomorphic intrinsic function of one complex variable induces an axial quaternionic monogenic function. Sce (Atti Accad Naz Lincei Rend Cl Sci Fis Mat Nat 23:220–225, 1957) generalizes Fueter’s theorem to the Euclidean spaces $${{\mathbb {R}}}^{n+1}$$ for n being odd positive integers. By using pointwise differential computation he asserted that every holomorphic intrinsic function of one complex variable induces an axial Clifford monogenic function for the cases n being odd. Qian (Rend Mat Acc Lincei 8:111–117, 1997) extended Sce’s result to both n being odd and even cases by using the corresponding Fourier multiplier operator when the required integrability is guaranteed, and the Kelvin inversion if not. For n being odd, Qian’s generalization coincides with Sce’s result based on the pointwise differential operator. In this paper, we unify these results in the distribution sense.

Vascular dementia (VD) is one of the leading causes of neurological disorder following Alzheimer's disease. The present study evaluated the possible role of asiaticoside in the treatment of rats with VD and its inhibitory effects on autophagy in hippocampal tissues. Double ligation was used for permanent occlusion of the arteries, and spatial memory was assessed using the T‑maze test. Western blotting was used for determination of protein expression levels and H&E staining for histological analysis. Treatment of rats with VD with asiaticoside significantly alleviated the impairment in spontaneously altered behaviors and significantly reduced escape latency. VD mediated a decrease in distance travelled, swim time and number of platform crossings, whereas this was alleviated by asiaticoside. Furthermore, VD‑mediated hippocampal tissue damage was significantly alleviated by asiaticoside treatment (P

In this paper we first prove an important formula for the fractional Laplacian, and then we use it to invert the Fueter mapping theorem for axially monogenic functions of degree k. In fact, we prove that for every axially monogenic function of degree k f ( x ) = [ A ( x 0 , | x _ | ) + x _ | x _ | B ( x 0 , | x _ | ) ] P k ( x _ ) , x ∈ R n + 1 , there exists a holomorphic intrinsic function f k in C such that f ( x ) = τ k ( f k ) ( x ) : = ( − Δ ) k + ( n − 1 ) / 2 ( f → k ( x ) P k ( x _ ) ) , where n can be any positive integer, k can be any non-negative integer, f → k is the slice monogenic function induced by f k , and P k ( x _ ) is an inner spherical monogenic polynomial of degree k. Using the maps τ k , k = 0 , 1 , 2 , … , we obtain a decomposition of a monogenic function for any value of the dimension n.

Vascular dementia (VD) is one of the leading causes of neurological disorders following Alzheimer's disease. The present study evaluated asiaticoside for possible role in treatment of VD in the rat model and inhibition of autophagy in hippocampus tissues. Asiaticoside treatment of the VD rats significantly (P

In this paper, we obtain the necessary and sufficient condition of the pre-compact sets in the variable exponent Lebesgue spaces, which is also called the Riesz-Kolmogorov theorem. The main novelty appearing in this approach is the constructive approximation which does not rely on the boundedness of the Hardy-Littlewood maximal operator in the considered spaces such that we do not need the log-Holder continuous conditions on the variable exponent. As applications, we establish the boundedness of Riemann-Liouville integral operators and prove the compactness of truncated Riemann-Liouville integral operators in the variable exponent Lebesgue spaces. Moreover, applying the Riesz-Kolmogorov theorem established in this paper, we obtain the existence and the uniqueness of solutions to a Cauchy type problem for fractional differential equations in variable exponent Lebesgue spaces.

The well known Fueter theorem allows to construct quaternionic regular functions or monogenic functions with values in a Clifford algebra defined on open sets of Euclidean space R n + 1 , starting from a holomorphic function in one complex variable or, more in general, from a slice hyperholomorphic function. Recently, the inversion of this theorem has been obtained for odd values of the dimension n . The present work extends the result to all dimensions n by using the Fourier multiplier method. More precisely, we show that for any axially monogenic function f defined in a suitable open set in R n + 1 , where n is a positive integer, we can find a slice hyperholomorphic function f → such that f = Δ ( n − 1 ) / 2 f → . Both the even and the odd dimensions are treated with the same, viz., the Fourier multiplier, method. For the odd dimensional cases the result obtained by the Fourier multiplier method coincides with the existing result obtained through the pointwise differential method.

In the article, the boundedness of vector-valued sublinear operators in Herz--Morrey spaces with variable exponents $M\dot{K}^{\alpha(\cdot),\lambda}_{q,p(\cdot)}(\mathbb{R}^{n})$ are obtained. Then Herz--Morrey type Besov and Triebel-Lizorkin spaces with variable exponents are introduced. Finally, we prove the equivalent quasi-norms on these spaces by Peetre's maximal operators.

This paper focuses on Taobao cheater detection. At present the phenomenon of fake trading is widespread in Taobao, which makes it difficult for consumers to distinguish between true and fake product reviews. To solve this problem, we collect a total number of 50,285 historical review data from 100 cheaters and 100 real buyers to create a dataset. By using these data, we extract 8 features from three dimensions that are reviewer, commodity, and review. Then we use the SVM algorithm to construct the classification model and choose the RFB kernel function, which has a better performance to identify the cheater. The precision of the final classification model we built to identify the cheater reaches up to 89%. The experimental result shows that extracting features from the historical review data can recognize the cheaters effectively. It can be applied to the recognition of the cheaters in Taobao.

This paper, based on the proposal of crypto-functions of existential there in Dong (2016a), mainly focuses on the motive of crypto-functions in existential there. The constraints of genre on existential there in terms of indirect realization relationship between genre and lexicogrammar are firstly discussed in an attempt to locate its motive path. Then such a path is followed to explore the distribution frequencies of existential there in each genre in COCA for the intention of shedding light on the motive of crypto-functions of existential there. It is found that existential there enjoys the highest distribution frequencies, among other genres, in academic genre characteristic of hierarchical knowledge structures, and that existential there structures conducive to the verticality of the discourse in academic genre help form a semantic network about Existents, i. e. NPs and in the meantime result in the crypto-function of existential there.

This paper, based on the exploration of crypto-functions of formal markers in English (Dong, 2016), preliminarily attempts to explicate the motive of their crypto-functions in systemic functional framework through a diachronic approach. The study firstly claims that formal markers can be treated as one of multiple linguistic expressions deployed for constructing the experiential phenomenon. Then the study assumes that the motive of crypto-functions of formal markers can be revealed from the diachronic conventionalization of multiple linguistic expressions towards formal markers in their process of experience construction. And such an assumption has then been tested with the distribution frequencies of formal markers in Corpus of Historical American English (COHA). It is found that, with the diachronic increase of the distribution frequencies of formal markers in COHA, the diachronic conventionalization of multiple linguistic expressions towards formal markers does exist, and that such a conventionalization is then attributed to language chunk composed of formal markers together with other following elements and renders formal markers prefabricate potential, thus resulting in their crypto-functions.

This paper focuses on developing a novel algorithm which dynamically optimizes the controllers of doubly fed induction generator (DFIG) driven by a wind turbine (WT) to increase DFIG transient performance in all wind speed conditions. Particle swarm optimization (PSO) is proposed to optimize parameters of PI controllers of DFIG's rotor side/grid side converters (RSC/GSC) at different wind speeds in order to maximize the damping ratios of the system eigenvalues in small signal stability analysis. Based on the optimal values and the wind speed data set, an artificial neural network (ANN) is designed, trained, and it has the ability to quickly forecast the optimal values of parameters. Adaptive PI controllers (including ANN) are designed which dynamically change PI gain values according to different wind speeds. Simulation is done via PSCAD software for a single machine connected to an infinite bus (SMIB) system. The results show that the DFIG of ANN-based adaptive PI control could significantly contribute in the transient performance improvement in a wide wind speed range.

In the process of environmental design and creation, the design sketch holds a very important position in that it not only illuminates the design's idea and concept but also shows the design's visual effects to the client. In the field of environmental design, computer aided design has made significant improvement. Many types of specialized design software for environmental performance of the drawings and post artistic processing have been implemented. Additionally, with the use of this software, working efficiency has greatly increased and drawings have become more specific and more specialized. By analyzing the application of photoshop image processing software in environmental design and comparing and contrasting traditional hand drawing and drawing with modern technology, this essay will further explore the way for computer technology to play a bigger role in environmental design.

Wind energy is becoming the most viable renewable energy source mainly because of the growing concerns over carbon emissions and uncertainties in fossil fuel supplies and the government policy impetus. The increasing penetration of wind power in distribution systems may significantly affect voltage stability of the systems, particularly during wind turbine cut-in and cut-off disturbances. Currently, doubly fed induction generator wind turbine (DFIG-WT) is the most popular wind turbine. This paper investigates the issues of voltage stability improvement and grid-loss reduction of distribution systems which include DFIG-WTs under unbalanced heavy loading conditions. Simulation studies are carried out in IEEE 34-bus test system using DIgSILENT software to examine these issues during steady-state and transient operations of the system. Optimal locations of the WTs are determined based on this analysis. A new index (system unbalanced voltage variance) is proposed to evaluate system unbalanced voltage. The dynamic impacts between WTs and motor loads are also examined.