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Neuromorphic computing is an emerging area with prospects to break the energy efficiency bottleneck of artificial intelligence (AI). A crucial challenge for neuromorphic computing is understanding the working principles of artificial synaptic devices. As an emerging class of synaptic devices, organic electrochemical transistors (OECTs) have attracted significant interest due to ultralow voltage operation, analog conductance tuning, mechanical flexibility, and biocompatibility. However, little work has been focused on the first-principal modeling of the synaptic behaviors of OECTs. The simulation of OECT synaptic behaviors is of great importance to understanding the OECT working principles as neuromorphic devices and optimizing ultralow power consumption neuromorphic computing devices. Here, we develop a two-dimensional transient drift-diffusion model based on modified Shockley equations for poly(3,4-ethylenedioxythiophene) (PEDOT)-based OECTs. We reproduced the typical transistor characteristics of these OECTs including the unique non-monotonic transconductance-gate bias curve and frequency dependency of transconductance. Furthermore, typical synaptic phenomena, such as excitatory/inhibitory postsynaptic current (EPSC/IPSC), paired-pulse facilitation/depression (PPF/PPD), and short-term plasticity (STP), are also demonstrated. This work is crucial in guiding the experimental exploration of neuromorphic computing devices and has the potential to serve as a platform for future OECT device simulation based on a wide range of semiconducting materials.

Blood vessels that deliver nutrients and oxygen over the entire body is essential for bone homeostasis. Especially, for the bone recovery, long-term in vivo vascular imaging is desirable. Here, we propose an optical and ultrasonic transparent bone window, which allows repeated, chronic monitoring of bone angiogenesis in mouse tibia defect. A metal ring with an outer diameter of 2 mm and an inner diameter of 1 mm is bonded with a silicone-based polydimethylsiloxane (PDMS) film and cover the bone surface, which can effectively eliminate the inflammation caused by repeated wound opening before imaging. We make a bone defect model in mouse tibia, and employ an optical resolution photoacoustic microscopy (ORPAM) to provide a high-resolution, label-free, long-term, in vivo observation of the bone vascularization during the bone defect healing. The results suggest that the artificial bone window can remain stable for inspection and play positive role for bone repair.

Osteogenesis and angiogenesis are essential for bone homeostasis and repair. Newly formed vessels convey osteogenic progenitors during bone regeneration. However, the lack of continuous and label-free visualization of the bone microvasculature has resulted in little understanding of the neovascular dynamics. Here, we take advantage of optical-resolution photoacoustic microscopy (ORPAM) for label-free, intravital, long-term observation of the bone vascular dynamics, including angiogenesis, remodeling and quantified angiogenic effect of locally-applied vascular endothelial growth factor (VEGF) in the murine tibial defect model. We employed ex vivo confocal microscopy and micro-computed tomography (micro-CT) imaging to verify the positive role of VEGF treatment. VEGF treatment increased the concentration of total hemoglobin, vascular branching, and vascular density, which correlated with more osteoprogenitors and increased bone formation within the defect. These data demonstrated ORPAM as a useful imaging tool that detected functional capillaries to understand hemodynamics, and revealed the effectiveness of locally delivered therapeutic agents with sufficient sensitivity, contributing to the understanding of spatiotemporal regulatory mechanisms on blood vessels during bone regeneration.

Stochastic resonance is like a nonlinear filter to detect the weak bearing fault-induced impulses that submerged in strong noises. Signal-to-noise ratio (SNR) is often used as the index to evaluate the SR output, but the fault characteristic frequency (FCF) must be known in order to calculate SNR. A novel bearing fault diagnosis method called synthetic quantitative index-based adaptive underdamped stochastic resonance (SQI-AUSR) is proposed. The synthetic quantitative index (SQI) is composed of power spectrum kurtosis, kurtosis, margin index, and correlation coefficient. The SQI is independent of FCF, which avoids the limitation that the calculation of SNR must know the FCF. Numeric simulations and two case studies of bearing faults are carried out. The results show that (1) the SQI is more effective than other proposed indexes such as correlation coefficient and weight power spectrum kurtosis and (2) the proposed SQI-AUSR is effective for bearing fault diagnosis and is better than SNR-AOSR.

New advance in modelling of the machining process is of great significance to improve component performance and manufacturing efficiency. This includes the material constitutive model and the approach used to describe the field flow of the material in cutting. In this study, a 3D model of high speed machining (HSM) of Ti6Al4V titanium alloy is developed. The coupled Eulerian-Lagrangian (CEL) approach was used to simulate the proposed cutting model. This cutting model includes a proposed constitutive model considering the strain hardening, strain-rate, temperature and stress state (e.g., stress triaxiality and Lode parameter) in the material plasticity and damage. This machining model is able to simulate the phenomenon of material side flow, which results in a larger chip width when compared to the width of cut and the lateral burr formation. The phenomenon of material side flow is validated by experimental results. The distribution of plastic strain and stress state shows that the workpiece transforms from plane strain state in middle surface to plane stress state in lateral surface, which finally results in the formation of lateral burr.

In order to explore the transverse bending responses of carbon fiber-reinforced polymer (CFRP) square tubes filled with aluminum foam, the three-point bending tests were carried out on an INSTRON machine, the full-field deformation measurement was performed using a 3D-DIC test system, the numerical model was established by ABAQUS/Explicit, and the bending stiffness was calculated by the improved analytical model based on shear-deformable beam theory. The discrepancies of experimental data, numerical results, and analytical predictions were acceptable, which were within 5%. The failure modes and mechanical properties of the filled tubes were experimentally captured and numerically predicted. Due to the filling effect of aluminum foam, the ultimate load, bending stiffness, and energy absorption of the filled CFRP square tubes increased, comparing to those of the hollow CFRP square tubes. With the increase of the aluminum foam density, the ultimate load, bending stiffness, and energy absorption of the filled tubes increased, while the specific ultimate load, specific bending stiffness, and specific energy absorption decreased.

Microplastics (MPs) and sulfamethoxazole (SMX) are emerging contaminants that are ubiquitous in the soil environment. In this study, we investigated MPs polymer type and soil environmental factor effects on SMX adsorption behavior in the soil system. Our results showed that MPs dosage affected the soil particles' SMX adsorption rate and capacity (Qe). Adding 1 % polystyrene (PS) increased the SMX adsorption rate significantly. The value of K

Microplastics and veterinary antibiotics are both emerging environmental contaminants that could be co-occurrence in agricultural soils. However, it's still unclear how the microplastics affect the bioaccessibility of antibiotics in a real soil environment. An in-situ measurement using diffusive gradients in thin-films devices suitable for polar organic compounds (o-DGT) coupled with soil moisture sampling were used to reveal such effects. Sulfamethoxazole (SMX) that was selected as a representative antibiotic and polyethylene (PE) microplastic with an average diameter of 35 μm were amended to the paddy soil and saline soil for the study. The result indicated that SMX degradation in the paddy soil was higher than that in the saline soil, meanwhile, PE microplastic addition promoted SMX degradation in both soils. In the paddy soil, PE microplastic addition enhanced release of SMX from soil solid to soil solution but no effects on the bioaccessibile SMX. However, in the saline soil, the PE microplastic addition reduced both SMX in soil solution and bioaccessibile SMX significantly (p 0.05). The potential resupply ability of the labile SMX from soil solid to soil solution which was expressed as R value enhanced significantly in saline soil, while such a change was negligible in the paddy soil. This implied that long-term release risk of SMX in the PE microplastic contaminated saline soil could not be neglected. Therefore, co-occurrence of PE microplastic and SMX in the soils might increase uptake of SMX by biotas and such effects depended on soil properties.

Objective Patients with ankylosing spondylitis (AS) carry an increased burden of cardiovascular diseases (CVD), but features denoting the development of CVD in AS are unclear. This study aimed to evaluate the percentage and absolute number of lymphocytes and CD4+T cells in AS patients complicated with CVD (AS-CVD) and determine whether circulating T helper 17 (Th17) cells are associated with the development of CVD in AS. Method A total of 117 AS patients (46 had CVD and 71 had no CVD) were enrolled in this retrospective study. The percentage and absolute number of lymphocytes and CD4+T cells were determined by flow cytometry. Associations between CVD and clinical markers were analysed using logistic regression. Results The ratio of Th17/Treg cells (0.30 vs 0.19, P = 0.014) and the absolute number of Th17 cells (7.27 cells/μL vs 4.34 cells/μL, P Conclusion Our findings provide evidence for the association between Th17 cells and increased cardiovascular risk in AS. Th17 cells may contribute to accelerated atherogenesis and increased cardiovascular burden in AS and be valuable for early assessment and management of AS-CVD.

Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA). Here, we examine Tfr-like and Tfh-like cells and their subsets in RA and assess the correlations between these subsets with B cells and cytokines related to the pathogenesis of RA and their clinical significance.Methods: The study population consisted of 18 healthy controls and 47 RA patients (17 new onset, 57.00 ± 11.73 years; 30 treated RA patients, 57.56 ± 1.97 years). Disease activity scores in 28 joints were calculated. The positive rates of rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) were 82.9 and 89.4%, respectively. Cell subsets were analyzed using flow cytometry, and serum cytokine levels were measured using cytometric bead array.Results: Tfh-like and PD-1+ Tfh-like cells were elevated, and the distribution of Tfh-like cell subsets was altered with increased Tfh17-like and Tfh1/17-like cells in RA patients. The receiver operating characteristics curves for Tfh-like, Tfh17-like, Tfh1/17-like, and PD-1+ Tfh-like cells indicate improved RA diagnostic potential. RA patients had decreased regulatory T (Treg), Tfr-like, and memory Tfr-like (mTfr-like) cells and increased Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios. Tfh-like cells and their subsets, including Tfh1-like, Tfh2-like, Tfh1/17-like, and PD-1+ Tfh-like cells, were positively correlated with B cells. Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios were positively correlated with B cells in new-onset RA. Interleukin (IL)-2, IL-4, IL-17, interferon-γ, and tumor necrosis factor-α were positively correlated with Tfr-like and mTfr-like cells. IL-2 and IL-10 were positively correlated with Tfh-like and Tfh2-like cells. IL-4 was positively correlated with Tfh-like cells.Conclusions: Tfh-like and PD-1+ Tfh-like cells are increased, whereas Treg, Tfr-like, and mTfr-like cells are decreased in RA, leading to an imbalance in Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios. Tfh-like cells and a portion of their subsets as well as Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios are closely related to B cells. Dysfunction of cell subsets leads to abnormal levels of cytokines involved in the pathogenesis of RA. The altered distributions of Tfh-like cell subsets, especially Tfh1/17-like cells, represent potential therapeutic targets for treatment of RA.

Objective. To investigate the relationship between serum interleukin-2 (IL-2) levels and disease activity, absolute numbers of peripheral lymphocyte subsets, autoantibodies, and associated cytokines in patients with rheumatoid arthritis (RA). Methods. This study included 106 patients with RA, evaluated their disease activity (DAS28 score), and divided them into disease remission (DAS28≤2.6), low disease activity (DAS28≤3.2), and moderate-high disease activity (DAS28>3.2) groups. Flow cytometry was used to detect the absolute numbers of peripheral lymphocyte subpopulations and CD4+ T cell subsets in each group, and serum cytokine levels were measured using cytometric bead array. Results. Serum IL-2 levels in RA patients were positively correlated with disease activity and rheumatoid factor titers (p<0.001 and p=0.045, respectively), and multiple regression analysis revealed that serum IL-2 levels were an independent factor affecting disease activity. Serum IL-2 levels were positively correlated with Th17/Treg ratios (p=0.013). Compared with the remission group, peripheral lymphocyte and CD4+ T lymphocyte subsets in patients with active RA decreased to varying degrees; however, the numbers of peripheral natural killer (NK) cells were significantly higher in the moderate-high disease activity group than in the remission (p=0.046) and low disease activity (p=0.020) groups; the percentages of NK cells had the same trend. In addition, the number and percentage of NK cells were positively correlated with serum IL-2 levels (p=0.018 and p=0.006, respectively). Conclusions. In RA patients, serum IL-2 levels were not only correlated with patients’ disease activity and autoantibody levels but were also involved in their Th17/Treg immune imbalance. In addition, in patients with active RA, NK cell levels were abnormally elevated, possibly due to high serum levels of IL-2.

NaCl aqueous solution (15wt%) was used as the quenching medium to prepare amorphous Lithium-Zinc ferrite hollow microspheres (LiZn FHMs) based on self-reactive quenching technology. Investigations by scanning electro microscope, X-ray diffraction, electron diffraction of transmission electron microscope, and differential scanning calorimetry prove that LiZn FHMs are susceptible to amorphization. It is indicated that NaCl aqueous solution (15wt%) has ultra-fast quenching speed, and the growth rate of crystals on LiZn FHMs is so large that the formation and growth of the crystal nucleus are significantly restrained. This is the main reason for the formation of amorphous LiZn FHMs.

Nanocomposite polymers based on phosphonic acid functionalized carbon nanotubes (CNT-POH) and sulfonated poly(ether ether ketone) (SPEEK) have been fabricated and employed as highly efficient proton exchange membranes. CNT-POH were synthesized through the grafting of carbon nanotubes (CNT) with diethylphosphatoethyl triethoxysilane and subsequent acidification of phosphate to phosphonic acid ligands. Incorporating CNT-POH into SPEEK matrix improves the proton conductivity at different temperatures and relative humidity, which can be attributed to the homogeneous dispersion of highly hydrophilic phosphonic acid groups and the formation of proton transport channels in the membrane. The methanol permeability of the composite membranes is also decreased, owing to the increased tortuosity of the methanol transport channel. The CNT in SPEEK matrix also enhance the dimensional stability and mechanical property remarkably. Consequently, this phosphonic acid functionalized CNT/SPEEK composite membrane (SPEEK-POH) is a potential candidate for application in direct methanol fuel cells (DMFC).

In view that the MEMS gyroscope has low precision, the virtual gyro is used to improve the output precision of the MEMS gyro. By analyzing the factors affecting the fusion precision of virtual gyro, the essential relationship between gyro noise correlation and the fusion precision is obtained. In static, the influence of the noise characteristics and noise correlation coefficient on the output precision of MEMS gyro array is great; while in dynamic, the influence of the noise characteristics is small due to system modeling error and non-linear error, the influence of the angular rate modeling accuracy is great. Therefore, the Taylor model is used to extend the motion model described by classical Newtonian mechanics, and the angular motion model of different modeling series is established. This paper introduces the improved current statistical model, uses the modified Rayleigh function to describe the angular motion variable, establishes the zero-mean colored driving noise model, realizes the adaptive adjustment of the frequency and the driving noise intensity, and establishes the high-precision dynamic angular rate model of different modeling series. Finally, the improved interactive multi-model Kalman filter is used to fuse the output of the gyro in the MEMS gyro array. The simulation results show that the proposed method can improve the output precision of MEMS gyroscopes effectively and has certain engineering application value.

Background:The incidence of Ankylosing Spondylitis (AS) complicated with cardiovascular diseases (CVD) has increased in recent years [1]. However, identification of risk factors indicating the development of CAD in AS patients is lacking. Th17 cells are increasingly recognized to be important in atherogenesis [2]. However, the role of these cells in the pathogenesis of ankylosing spondylitis patients complicated with cardiovascular events remains elusive.Objectives:This study aimed to assess the level of circulating Th17 cells as well as other lymphocyte subsets such as Treg, Th, Ts, and NK cells in AS combined with CVD, and further to evaluate whether elevations in special PBMC subpopulations in AS patients indicate an increased risk of CVD.Methods:Samples were assessed from 141 AS patients hospitalized at the Second Hospital of Shanxi Medical University (60 AS patients combined with CVD and 81 AS patients without CVD) and 100 healthy controls. The absolute numbers of lymphocytes and CD4+ T cells in peripheral blood were determined using Flow Cytometer. The association between PBMC subpopulations and CVD development in AS patients were analyzed using multivariable logistic regression.Results:1. Compared with AS group, AS with CVD group exhibited significant increases in the number of Th17 cells (P=0.001) and Treg cells (P=0.046). The ratio of Th17/Treg was also increased (P=0.085).2. Analogous increases in the absolute number (P3. Compared to HCs, 141 AS patients showed significantly decreased Treg cells (P4. Logistic regression showed age (odds ratio: 1.09; 95% CI: 1.035-1.137), hypertension (odds ratio: 3.31; 95% CI: 1.152-9.528), diabetes (odds ratio: 8.03; 95% CI: 1.251-51.503), and elevated level of Th1 number (odds ratio: 1.01; 95% CI: 1.003-1.016) and DD (D-dimer) (odds ratio: 1.00; 95% CI: 1.000-1.002) were significantly correlated with the onset of CVD in AS patients.5. Smoke, increased Th17 level, and use of NSAIDS were also positively correlated with the onset of CVD although the P-values did not reach significant.Conclusion:Our data indicates aberrant expansion of Th17 cells in AS with CVD patients. Moreover, age, hypertension, diabetes, and increased level of Th1 in PBMC and DD are single independent risk factors for the presence of CVD in AS. The mechanisms of atherogenesis in AS may associate with the elevations in Th1 and Th17 cells. Imbalance of Th1/Th2 and Th17/Treg may be shared etiologic pathways of AS and CVD, providing attractive targets for the prevention and therapy of CVD development in AS patients.References:[1]Kim JH, Choi IA. Cardiovascular morbidity and mortality in patients with spondyloarthritis: A meta-analysis. Int J Rheum Dis (2020). doi: 10.1111/1756-185x.13970.[2]Saigusa R, Winkels H, Ley K. T cell subsets and functions in atherosclerosis. Nat Rev Cardiol. 2020 Jul;17(7):387-401. doi: 10.1038/s41569-020-0352-5.Figure 1.Compared with AS group, AS with CVD group exhibited significant increases in the number of Th17 cells (P=0.001) and Treg cells (P=0.046). The ratio of Th17/Treg was also increased (P=0.085). The absolute number (PDisclosure of Interests:None declared.

Redundant design can improve the performance of an inertial navigation system, and the configuration is an important factor in determining the accuracy and reliability of the redundant inertial navigation system. As well as the sensor quantity and the reliability of single sensors, the reliability of the redundant inertial navigation system also depends on the capability of the fault diagnosis, which has been neglected in much of the previous research. This paper verifies that configurations designed using the previous method cannot maintain optimal performance in fault diagnosis. To optimize the performance in fault detection and isolation through the configuration design, an evaluation function for fault detectability and isolability is proposed based on Kullback–Leibler divergence. On this basis, the inherent diagnosability analysis method is proposed, and the configuration design method is developed with the analysis results. Simulation experiments prove that the proposed diagnosability analysis method can find the defects in the fault detection and isolation, and the diagnosability can be assessed correctly. Configurations designed using the proposed methodensure the optimal accuracy and reliability of the system, and effectively improve the fault diagnosis ability, too.

Lithium–Zinc ferrite hollow microspheres (LiZn FHMs) doped with La and Mg were synthesized by Fe + Zn + Fe2O3 + O2 + Li2CO3 reactive system based on self-reactive quenching technology. Influence of La and Mg doping on the surface morphology, phase structure and microwave absorption properties of LiZn FHMs were investigated. The results show that the surface morphology of LiZn FHMs changes little and are still composed of unnoticeable multi-shape crystal grains, whether they are doped or not. The phases are mainly made up of Fe3O4, Fe2O3, Li0.435Zn0.195Fe2.37O4 and Li0.5Fe2.5O4 without doping. The phases remain unchangeable after Mg doping, while LaFeO3 appears in the phase components after La doping. When LiZn ferrites are without doping, their minimum reflectivity at 4 mm is −14 dB at 7.5 GHz, and the effective absorption frequency band less than −10 dB is 6.4–8.6 GHz, with the bandwidth of 2.2 GHz. Compared with that without doping, the minimum reflectivity increases after Mg doping, and the effective absorption frequency band less than −10 dB disappears. After La doping, the minimum reflectivity is −30.2 dB at 6.2 GHz, and the effective absorption frequency band is 4.7–7.7 GHz, with the bandwidth of 3 GHz. It is found from the present investigations that the microwave absorption properties are improved after La doping, and those of LiZn FHMs after Mg doping are reduced.

Short-wave infrared (SWIR) detectors combining AlAs/In0.53Ga0.47As/AlAs double barrier structure (DBS) with In0.53Ga0.47As absorption layer are fabricated by molecular beam epitaxy. By adding a p-charge layer, the dark current density of the detector is lowered by 3 orders of magnitude. The responsivity of the detector is tested at room temperature, which reaches 6000 A/W when the power of the incident light is 0.7 nW. The noise equivalent power (NEP) of the detector at 5 kHz is measured to be 3.77×10−14 W/Hz1/2 at room temperature.

Background:Rheumatoid arthritis (RA) is a systemic autoimmune disease. It is characterized by highly disabling polyarthritis, but extra-articular features are also common and portend a poor prognosis. Compared with the general population, the incidence and mortality of cardiovascular disease in RA are significantly increased. Chronic autoimmune inflammation is the common pathogenesis of RA and coronary heart disease(CAD). We’ve proved that lymphocyte subsets imbalance and high cytokines expression play an important role in the occurrence and development of RA diseases. However, the level of lymphocyte subsets and cytokines of RA patients with CAD are rarely reported[1-2].Objectives:To explore the clinical characteristic of lymphocyte subsets and cytokines of RA patients with CAD,and make comparisons with simple RA patients and healthy controls.Methods:The study included 96 patients with a diagnosis of RA according to the 1987 revised criteria of the ACR, including 54 RA patients with CAD and 42 RA patients without CAD and other cardiovascular disease, 40 healthy controls are also concluded. The absolute numbers of lymphocyte subsets and T subsets in peripheral blood were measured by Flow Cytometer (FCM). Serum levels of IL-2, IL-4, IL-6, IL-10, IL-17, INF-γ, and TNF-α were measured by flow microsphere capture chip technique (CBA) for 19 RA patients with CAD and 38 simple RA patients among 96 patients.We also collected relevant clinical information and made DAS28 score, and all patients are in the middle-high disease activity group (DAS28>3.2).Results:(1) There was no difference in DAS28 scores between the two groups(p=0.572). (2)Compared with RA patients without CAD, the absolute number of total T cell(P=0.035), total B cell (P=0.006), CD4+T cell(P=0.012), Th1 cell(P=0.037), Th17 cell(P=0.033) and CD4+CD25+FOXP3+ Treg(P=0.003) was lower than RA patients with CAD, the number of NK cell(P=0.685), CD8+T cell(P=0.322) and Th2 cell(P=0.770) had no obvious difference between them. (3)Compared with the healthy control, the absolute number of total T cell(P=0.014), total B cell (P=0.006), CD8+T cell(P=0.000) in RA with CAD was evidently lower, but there was no siginificant difference in absolute number of CD4+T cell(P=0.582), Th1 cell(P=0.052), Th2 cell(P=0.595), Th17 cell(P=0.148) and Treg(P=0.176) (Figure 1).(4) In RA patients with CAD,the level of cytokines IL-2(P=0.042), IL-4(P=0.043) and IL-17(P=0.012) was lower, while other cytokines had no difference (Table 1).Figure 1.The absolute number of lymphcytes of RA patients with CAD(n=54),RA patients without CAD (n=42) and healthy control (n=40). (*PTable 1.The expression level of cytokines of RA patients with CAD(n=19) and RA patients without CAD (n=38).Cytokines (pg/ml)RA and CAD group(A) (n = 19)RA group(B) (n = 38)PvalueA vs. BIL-25.50(1.96, 12.82)6.82(4.45, 14.44)0.042IL-44.93(1.67, 9.41)6.28(4.49, 11.88)0.043IL-623.69(10.93, 73.08)36.67(15.40, 72.50)0.636IL-107.76(4.54, 10.50)7.62(5.69, 19.91)0.223IL-1710.81(4.04, 20.25)20.68(13.88, 45.58)0.012IFN-γ6.10(3.27, 13.84)7.13(5.79, 15.83)0.115TNF-α10.49(2.50, 29.04)14.96(10.03, 30.39)0.097Conclusion:Our research shows that there is lymphocyte imbalance and immune disorder existing in RA patients with CAD. Both the number of lymphocyte subsets and cytokine levels decreased in these patients than pure RA patients. It suggests that this group may be in lower immune state, which providing guidance for further clinical treatment of RA patients with CAD.References:[1]Winchester R, Giles JT, Nativ S, et al. Association of Elevations of Specific T Cell and Monocyte Subpopulations in Rheumatoid Arthritis With Subclinical Coronary Artery Atherosclerosis. [J]. Arthritis Rheumatol, 2016,68(1): 92-102.[2]England BR, Thiele GM, Anderson DR, et al. Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications. [J]. BMJ, 2018 04 23;361.Disclosure of Interests:None declared

Resonant tunneling diode with an In 0.53 Ga 0.47 As absorption layer is designed for light detection at 1550 nm. The responsivity of the detector is simulated by solving the Tsu–Esaki equation. The simulation results show that the responsivity of the detector is nonconstant. It decreases with the increment of the power density of the incident light. Samples of the detector are fabricated by molecular beam epitaxy. The experimental results show that the responsivity increases while the power density of the incident light decreases which agree with the simulation results. The responsivity reaches 4.8×10 8 A/(W/μm 2 ) at room temperature and 5.0×10 9 A/(W/μm 2 ) at 77 K when the power density of the incident light is 1×10 −13 W/μm 2 .

Lithium–Zinc ferrite hollow microspheres (LiZn FHMs) doped with Ce and Mg were synthesized with Fe + Zn + Fe2O3 + O2 + Li2CO3 reactive system by using self-reactive quenching technology. Effect of Ce and Mg doping on the surface morphology, phase structure, and microwave absorption properties of LiZn FHMs were investigated in detail. The results indicate that the surface morphology of LiZn FHMs shows little variation after Ce and Mg doping and is still composed of unnoticeable multi-shape crystal. The phases are mainly composed of Fe3O4, Fe2O3, Li0.435Zn0.195Fe2.37O4 and Li0.5Fe2.5O4 without doping. The main phases remain unchanged with Mg doping, but CeO2 appears in the phase components with Ce doping. It can be concluded that the microwave absorption properties are improved by Ce doping due to the variation of the ferromagnetic resonance frequency. But those of Mg doping are reduced due to the introduction of non-magnetic Mg2+.

A new epidemic SIRS model with discrete delay on scale-free network is presented. We give the formula of the basic reproductive number for the model and prove that the disease dies out when the basic reproductive number is less than unity, while the disease is uniformly persistent when the basic reproductive number is more than unity. Numerical simulations are given to demonstrate the main results.

In allusion to the problem that the gear fault signal appears unsteadily, strong nonlinearity, and feature information is effected by noises, a method for vibration signal preprocessing based on weighted morphological un-decimated wavelet (MUDW) decomposition and correlated kurtosis is proposed. Firstly, the MUDW method is presented under the scheme of morphological un-decimated wavelet decomposition. On this basement, in order to increase feature information content, it combines approximate signals in various layers according to their feature contribution weights, which is measured by correlated kurtosis factor. Secondly, the initial indexes of MUDW are analyzed and a systematic method for optimal selection is presented. Finally, the validity of the method is testified by the data of measured gear fault vibration signal.

In this paper, the state extending and filtering robust control (SEFERC) is proposed and investigated. In the SEFERC, the uncertain nonlinear part of the MIMO is extend to the new state parameter and estimated by the nonlinear tracking filter. With the estimated value, by the direct feedback linearization (DFL) method and H∞ control method, the nonlinear system can be converted to the linear system and stabilized with the robust control theory. Taking the certain excitation and speed synthetic control system for example, simulation results show that the SEFERC can accelerate the convergence speed of the state variables and improve the excitation and speed control speed.

A novel epidemicSIRSmodel with distributed delay on complex network is discussed in this paper. The formula of the basis reproductive numberR0for the model is given, and it is proved that the disease dies out whenR0<1and the disease is uniformly persistent whenR0>1. In addition, a unique endemic equilibrium for theSIRSmodel exists whenR0>1, and a set of sufficient conditions on the global attractiveness of the endemic equilibrium for the system is given.

Resonant tunnelling diode photodetectors with a 600 nm In0.53Ga0.47As absorption layer were fabricated by molecular beam epitaxy. The current–voltage characteristics of devices with different mesa diameters were tested and the negative differential resistance was observed in all devices. The responsivity of the detector was measured to be 4.19 × 105 A/W at 77 K and 1.92 × 104 A/W at room temperature under incident light with a power of 3.1 nW.

It needs to put structure of boundary scan in the circuit board for improving the controllability and observability of the device in complex circuit board. At the same time when structure of boundary scan improves pcb-level circuit testability, it also increased the complexity of circuit design which needs to weigh the testability improvement and design complexity, two factors. In view of the combinatorial optimization problem of the design complexity and minimize, solving method based on chaos optimization algorithm is proposed. Through example validation, the algorithm were obtained good results on optimization effect and operation time. The fact proved that, the algorithm can be effectively applied in board-level circuit testability design optimization and improving pcb-level circuit testability.

We demonstrate that all parameters of optical lightwave can be simultaneously designed as keys in security system. This multi-dimensional property of key can significantly enlarge the key space and further enhance the security level of the system. The single-shot off-axis digital holography with orthogonal polarized reference waves is employed to perform polarization state recording on object wave. Two pieces of polarization holograms are calculated and fabricated to be arranged in reference arms to generate random amplitude and phase distribution respectively. When reconstruction, original information which is represented with QR code can be retrieved using Fresnel diffraction with decryption keys and read out noise-free. Numerical simulation results for this cryptosystem are presented. An analysis on the key sensitivity and fault tolerance properties are also provided.