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AIM: To study clinical reference value of retinal microvascular changes in patients with cerebral microbleeds(CMBs)and discuss its clinical significance. METHODS:From January 2012 to December 2013, 125 hospitalized patients were collected, including 81 cases were male, 44 cases were female, mean age 76.3±11.2 years old. For all patients, functions of liver and kidney, blood-lipoids, blood sugar and blood biochemical examination were tested, and fundus photography and cerebral MR was done. According to the fundus camera eyes, retinal arteriolar equivalent(RAE), retinal venular equivalent(RVE), retinal vein diameter ratio(AVR)and arteriovenous crossing sign(AVN)were identified, CMBs were classified with cerebral MRI. All the data were processed by SPSS statistical software. RESULTS: The central retinal arteriolar equivalent(CRAE), central retinal venular equivalent(CRVE)and AVR values in the eyes were found no statistical difference(PPCOCLUSION: The results show that retinal microvascular changes, especially small retinal vein arteriovenous cross width, and arteriovenous crossing phenomenon, in which CMBs will happen more likely. After sex, age, hypertension and hyperglycemia in patients with traditional cardiovascular risk factors being ruled out, the retinal microvascular changes are still relatively factors of CMB's occurrence.

AIM: To observe the effect of laser combined with lacrimal duct intubation on the treatment of lacrimal duct obstruction diseases.METHODS:Of 79 patients(96 eyes)with lacrimal duct obstruction diseases, 27 eyes(22 eyes with canaliculi lacrimalis or lacrimal duct shutting and 5 eyes with ductus nasolacrimalis)underwent laser combined lacrimal drainage tube implantation, 69 eyes(27 eyes with ductus nasolacrimalis and 42 eyes with chronic dacryocystitis)received laser combined with nasolacrimal duct stenting. Eye drops included dexamethasone and antibiotic medicine were given in a week after operation. The patients implanted lacrimal drainage tube removed the tube at 3-6 month after operation, the other removed nasolacrimal stenting at 4 weeks after operation, all of patients were followed-up 12 months.RESULTS:Seventy-nine eyes were cured in all of the 96 eyes, 10 eyes were better, 7 eyes were ineffective. All 96 eyes had not been seen pus after being rinsed. Total efficiency was 93% and significant efficiency was 82%.CONCLUSION: Laser combined with different silicone tube implantation according to the different site was a simple and effective way inthe treatment of lacrimal duct obstruction.