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Your search keyword '"Bao-Hui Jin"' showing total 6 results
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6 results on '"Bao-Hui Jin"'

1. A New Redox Reaction of Ascorbic Acid at Platinum Electrodes

Author

Bao-Xian Ye, Lin Lin, Cui-Hong Wang, Bao-hui Jin, and Ling-fang Liu

Subjects
Reaction mechanism, Reaction rate constant, Half-reaction, chemistry, Diffusion, Inorganic chemistry, chemistry.chemical_element, General Chemistry, Ascorbic acid, Platinum, Electrochemistry, Photochemistry, Redox
Abstract

A pair of new redox peaks of ascorbic acid at a platinum electrode was found and studied in detailed by spectroelectrochemistry and electrochemistry technologies. This is a quasi-reversible redox reaction with a one-electron transfer process. The intermediate of tertiary carbon free radical exists in this process. The appearance reaction rate constant and the diffusion coefficient were investigated. A possible reaction mechanism has been proposed.

Published
2002

2. Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo

Author

Hua Sui, Bao Hui Jin, Shu Fang Pan, Qi Li, Jie Wu, Hui Rong Zhu, Jianfeng Cai, Nikitin Alexander Yu, Zhong Ze Fan, Xuan Liu, and Li Hong Zhou

Subjects
Chemotherapy, Article Subject, business.industry, Colorectal cancer, medicine.medical_treatment, Cancer, Traditional Chinese medicine, Drug resistance, lcsh:Other systems of medicine, Pharmacology, medicine.disease, lcsh:RZ201-999, In vitro, Multiple drug resistance, Complementary and alternative medicine, In vivo, medicine, business, Research Article
Abstract

Zuo Jin Wan (ZJW), a typical traditional Chinese medicine (TCM) formula, has been identified to have anticancer activity in recent studies. In this study, we determined the underlying mechanism of ZJW in the reversal effect of multidrug resistance on colorectal cancerin vitroandin vivo. Our results showed that ZJW significantly enhanced the sensitivity of chemotherapeutic drugs in HCT116/L-OHP, SGC7901/DDP, and Bel/Fu MDR cells. Moreover, combination of chemotherapy with ZJW could reverse the drug resistance of HCT116/L-OHP cells, increase the sensitivity of HCT116/L-OHP cells to L-OHP, DDP, 5-Fu, and MMCin vitro, and inhibit the tumor growth in the colorectal MDR cancer xenograft model. ICP-MS results showed that ZJW could increase the concentration of chemotherapeutic drugs in HCT116/L-OHP cells in a dose-dependent manner. Furthermore, we showed that ZJW could reverse drug resistance of colorectal cancer cells by decreasing P-gp levelin vitroandin vivo, which has been represented as one of the major mechanisms that contribute to the MDR phenotype. Our study has provided the first direct evidence that ZJW plays an important role in reversing multidrug resistance of human colorectal cancer and may be considered as a useful target for cancer therapy.

Published
2013
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3. [Analyze the antibody level of enterovirus 71 about children cases of hand-foot-mouse disease outbreak]

Author

Kun, Ju, Lin-En, Jiang, Wei, Li, Hui-Qing, Ren, Xu-Hua, Jing, and Bao-Hui, Jin

Subjects
Male, Immunoglobulin M, Child, Preschool, Immunoglobulin G, Humans, Infant, Enzyme-Linked Immunosorbent Assay, Female, Hand, Foot and Mouth Disease, Enterovirus
Abstract

To analyze the Enterovirus 71 infectious status about probably cases of hand-foot-mouse disease (HFMD).Collect the blood samples of HFDM children probably cases and test the IgG, IgM antibody by ELISA, analyzed the age and gender distribution.We collected 159 blood samples of children probably cases who are 1 to 5 years old. The average EV71 IgG positive rate is 63.5%, which of IgM is 12.0%. The positive rate of EV71 IgG is decrease by aged. Male's EV71 IgM positive rate is higher than female's significantly.The pathogen of this case of HFMD outbreak is EV71. Male's EV7l infectious and incidence are higher than female's. The result of this investigation could provide information to HFMD disease control.

Published
2010

4. Simultaneous determination of 42 organic chemicals in bottled water by combining C18 extraction disk with GC-MS and LC/MS/MS technique

Author

Li-qi Xie, Feng Xiao, Bo Chen, Bao-hui Jin, and Pei-jin Chen

Subjects
Microbiology (medical), Analyte, Chromatography, Chemistry, Extraction (chemistry), Public Health, Environmental and Occupational Health, Analytical chemistry, Water, Bottled water, Contamination, Hydrogen-Ion Concentration, Mass spectrometry, Gas Chromatography-Mass Spectrometry, Infectious Diseases, Gas chromatography, Solid phase extraction, Gas chromatography–mass spectrometry, Waste Management and Disposal, Water Pollutants, Chemical, Water Science and Technology, Chromatography, Liquid, Environmental Monitoring
Abstract

A method for the determination of 42 hazard residues required by ‘Japan Positive List System’ in bottled water was described. Hazard compounds in bottled water were extracted with a solid phase extraction step using C18 disks. Determination was carried out by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography-tandem mass spectrometry (LC/MS/MS). The disk extraction has high throughput which is well adapted to isolate and enrich these compounds from large volumes of water. For the water sample spiked at three concentration levels (LOQ, 4 times LOQ and 8 times LOQ), the recoveries of all analytes ranged between 65% and 120% with a relative standard deviation

Published
2009

5. Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway.

Author

Hua Sui, Shu-Fang Pan, Yu Feng, Bao-Hui Jin, Xuan Liu, Li-Hong Zhou, Feng-Gang Hou, Wen-Hai Wang, Xiao-Ling Fu, Zhi-Fen Han, Jian-Lin Ren, Xiao-Lan Shi, Hui-Rong Zhu, and Qi Li

Subjects
APOPTOSIS, CARRIER proteins, CELL lines, CELL surface antigens, CELLULAR signal transduction, COLON tumors, DOSE-response relationship in biochemistry, DRUG resistance, FLOW cytometry, GENE expression, GLYCOPROTEINS, HERBAL medicine, IMMUNODIAGNOSIS, CHINESE medicine, PHOSPHORYLATION, POLYMERASE chain reaction, RECTUM tumors, TRANSFERASES, WESTERN immunoblotting, DNA-binding proteins, OXALIPLATIN, REVERSE transcriptase polymerase chain reaction, IN vitro studies
Abstract

Background: Zuo-Jin-Wan (ZJW), a traditional Chinese medicine formula, has been identified to be effective against drug resistance in cancer. In the present study, we investigated the effect of ZJW on acquired oxaliplatin-resistant and the PI3K/Akt/NF-κB pathway in vitro. Methods: We tested the dose--response relationship of ZJW on reversing drug-resistance by CCK-8 assay and flow cytometry analysis in vitro. The protein expression of P-gp, MRP-2, LRP, and ABCB1 mRNA expression level were evaluated by Western blot and quantitative RT-PCR. The activities of PI3K/Akt/NF-κB pathway were also examined with or without ZJW, including Akt, IκB, p65 and their phosphorylation expression. Results: We found that ZJW significantly enhanced the sensitivity of chemotherapeutic drugs and increased oxaliplatin (L-OHP)-induced cell apoptosis in a time- and dose-dependent manner. Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-κB, which is necessary in the activation of the PI3K/Akt/NF-κB pathway. The effect of ZJW in reversing drug-resistance and suppressing phosphorylation of Akt (Ser473) and NF-κB were weakened after treatment with a PI3K/Akt activator in HCT116/L-OHP cells. Conclusions: Our study has provided the first direct evidence that ZJW reverses drug-resistance in human colorectal cancer by blocking the PI3K/Akt/NF-κB signaling pathway, and could be considered as a useful drug for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2014
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6. Simultaneous determination of 42 organic chemicals in bottled water by combining C18 extraction disk with GC-MS and LC/MS/MS technique.

Author

Bao-hui Jin, Feng Xiao, Bo Chen, Pei-jin Chen, and Li-qi Xie

Subjects
*BOTTLED water, *ORGANIC compounds, *DRINKING water, *GAS chromatography, *MASS spectrometry, *SOLID phase extraction, *LIQUID chromatography, *HAZARDOUS substances, *SAFETY
Abstract

A method for the determination of 42 hazard residues required by 'Japan Positive List System' in bottled water was described. Hazard compounds in bottled water were extracted with a solid phase extraction step using C18 disks. Determination was carried out by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography-tandem mass spectrometry (LC/MS/MS). The disk extraction has high throughput which is well adapted to isolate and enrich these compounds from large volumes of water. For the water sample spiked at three concentration levels (LOQ, 4 times LOQ and 8 times LOQ), the recoveries of all analytes ranged between 65% and 120% with a relative standard deviation < 24% (n = 8). [ABSTRACT FROM AUTHOR]

Published
2010
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