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5. The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

Author

Di Bartolo Belinda A, Vanags Laura Z, Tan Joanne TM, Bao Shisan, Rye Kerry-Anne, Barter Philip J, and Bursill Christina A

Subjects
High-density lipoproteins, apolipoproteinA-I, apolipoproteinA-I mimetic peptides, vascular inflammation, rabbits, intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background High-density lipoproteins (HDL) and their main apolipoprotein, apoA-I, exhibit anti-inflammatory properties. The development of peptides that mimic HDL apolipoproteins offers a promising strategy to reduce inflammatory disease. This study aimed to compare the anti-inflammatory effects of ETC-642, an apoA-I mimetic peptide, with that of discoidal reconstituted HDL (rHDL), consisting of full-length apoA-I complexed with phosphatidylcholine, in rabbits with chronic vascular inflammation. Results New Zealand White rabbits (n = 10/group) were placed on chow supplemented with 0.2% (w/w) cholesterol for 6-weeks. The animals received two infusions of saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide) on the third and fifth days of the final week. The infusions of rHDL and ETC-642 were able to significantly reduce cholesterol-induced expression of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the thoracic aorta (p < 0.05). When isolated rabbit HDL was pre-incubated with human coronary artery endothelial cells (HCAECs), prior to stimulation with TNF-α, it was found that HDL from ETC-642 treated rabbits were more effective at inhibiting the TNF-α-induced increase in ICAM-1, VCAM-1 and p65 than HDL isolated from saline treated rabbits (p < 0.05). There were, however, no changes in HDL lipid composition between treatment groups. Conclusions Infusion of ETC-642 causes anti-inflammatory effects that are comparable to rHDL in an animal model of chronic vascular inflammation and highlights that apoA-I mimetic peptides present a viable strategy for the treatment of inflammatory disease.

Published
2011
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19. Epidemiology of Coronavirus Disease in Gansu Province, China, 2020

Author

Fan, Jingchun, Liu, Xiaodong, Pan, Weimin, Douglas, Mark W., and Bao, Shisan

Subjects
United States. Centers for Disease Control and Prevention -- Analysis -- International economic relations, Coronavirus infections -- Health aspects -- Analysis, Coronaviruses -- Analysis -- Health aspects, Epidemiology -- Analysis -- Health aspects, Health
Abstract

The outbreak of coronavirus disease (COVID-19) was first reported on December 31, 2019, in Wuhan, China (1). Within a few weeks, the virus had spread rapidly throughout China and within [...]

Published
2020
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38. Alterations in gray matter morphology and functional connectivity in adult patients with newly diagnosed, untreated hypothyroidism

Author

Su, Wenxiu, primary, Zhao, Lianping, additional, Bao, Shisan, additional, Qin, Rui, additional, Cao, Jiancang, additional, Tian, Jing, additional, Han, Yalan, additional, Zhang, Taotao, additional, Chen, Chen, additional, Shi, Qian, additional, Guo, Qian, additional, Shao, Feifei, additional, and Tian, Limin, additional

Published
2023
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