1,342 results on '"Bao, T."'
Search Results
2. Optimization of WLS fiber readout for the HERD calorimeter
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Liu, X., Quan, Z., Dong, Y. W., Xu, M., Wang, J. J., Wang, R. J., Wang, Z. G., Cui, X. Z., Bao, T. W., Liao, C. L., Han, J. F., and Chen, Y.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
A novel 3-D calorimeter, composed of about 7500 LYSO cubes, is the key and crucial detector of the High Energy cosmic-Radiation Detection (HERD) facility to be installed onboard the China Space Station. Energy deposition from cosmic ray in each LYSO cube is translated by multiple wavelength shifting (WLS) fibers for multi-range data acquisition and real-time triggering. In this study, various methods of surface finish and encapsulation of the LYSO cube were investigated to optimize the amplitude from the WLS fiber end with the aim of improving the signal-to-noise ratio of Intensified scientific CMOS (IsCMOS) collection. The LYSO cube with five rough surfaces and a specular reflector achieves the maximum amplitude at the low-range fiber end, which is increased by roughly 44% compared to the polished cube with PTFE wrapping. The non-uniformity of amplitude at different positions on the LYSO cube surface was measured by X-ray and the positional correlation factor was derived for the entire cube. A simulation based on HERD CALO was conducted, which revealed that both the LYSO cube with five rough surfaces and the cube with rough bottom face exhibit superior energy resolution for electrons compared to the other two configurations.
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- 2023
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3. Longitudinal Relationship Between Psychological Capital and Anxiety in College Students: The Mediating Effect of Emotion Reregulation Strategy and Moderating Effect of Parent-Child Relationship
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Liu Z, Bao T, Yang Z, Ruan Y, Gao C, and Wu J
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psychological capital ,emotion regulation strategies ,anxiety ,parent-child relationship ,Psychology ,BF1-990 ,Industrial psychology ,HF5548.7-5548.85 - Abstract
Zijun Liu,1,* Tianhao Bao,2 Zhilan Yang,2,* Ye Ruan,2 Changqing Gao,2 Jie Wu2 1The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Affiliated Mental Health Center of Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Wu, Affiliated Mental Health Center of Kunming Medical University, Kunming, Yunnan, 650224, People’s Republic of China, Email wujie@kmmu.edu.cn Tianhao Bao, Affiliated Mental Health Center of Kunming Medical University, Kunming, Yunnan, 650224, People’s Republic of China, Email Doctor@kmmu.edu.cnObjective: Based on Conservation of resources theory, process model of emotion regulation and attachment theory, the present study examined how psychological capital affects anxiety through the mediation of emotion regulation strategies and explored the moderating role of parent-child relationship.Methods: Using a longitudinal study method, 962 college students were surveyed twice at one-year intervals.Results: (1) College students’ emotion regulation strategies (including cognitive reappraisal and expressive suppression) partially mediated psychological capital and anxiety mood; (2) parent-child relationship moderated the pathways of psychological capital and expressive suppression on anxiety, respectively.Conclusion: College students with higher levels of parent-child relationship had stronger predictive effects of psychological capital and weaker predictive effects of expressive suppression on anxiety mood. The research findings clarify the combined effects of emotion regulation and parent-child relationships on anxiety among college students, providing valuable reference for the design and implementation of interventions to promote individual psychological well-being.Keywords: psychological capital, emotion regulation strategies, anxiety, parent-child relationship
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- 2024
4. Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study
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Nguyen, Hoa T., Nguyen, Bao T., Thai, Thi H. Nhung, Tran, An V., Nguyen, Tan T., Vo, Tam, Mai, Linh D., Tran, Thach S., Nguyen, Tuan V., and Ho-Pham, Lan T.
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- 2024
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5. Splice-Modulating Antisense Oligonucleotides as Therapeutics for Inherited Metabolic Diseases
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Chen, Suxiang, Heendeniya, Saumya Nishanga, Le, Bao T., Rahimizadeh, Kamal, Rabiee, Navid, Zahra, Qurat ul ain, and Veedu, Rakesh N.
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- 2024
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6. Machine Learning Tools to Assist the Synthesis of Antibacterial Carbon Dots
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Bian Z, Bao T, Sun X, Wang N, Mu Q, Jiang T, Yu Z, Ding J, Wang T, and Zhou Q
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carbon dots ,machine learning ,antibacterial ,minimum inhibitory concentration ,classification algorithms ,Medicine (General) ,R5-920 - Abstract
Zirui Bian,1,* Tianzhe Bao,2,* Xuequan Sun,3,4 Ning Wang,1 Qian Mu,5 Ting Jiang,6 Zhongxiang Yu,6 Junhang Ding,2 Ting Wang,7 Qihui Zhou2 1Department of Bone, Huangdao District Central Hospital, Qingdao, People’s Republic of China; 2Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, People’s Republic of China; 3Weifang Eye Institute, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, People’s Republic of China; 4Zhengda Guangming International Eye Research Center, Qingdao Zhengda Guangming Eye Hospital, Qingdao University, Qingdao, People’s Republic of China; 5Department of Biomaterials, LongScience Biological (Qingdao) Co, LTD, Qingdao, People’s Republic of China; 6Heart Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao University, Qingdao, People’s Republic of China; 7Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qihui Zhou; Junhang Ding, Tel +86-17660670299, Email qihuizhou@uor.edu.cn; dingjunhang@uor.edu.cnIntroduction: The emergence and rapid spread of multidrug-resistant bacteria (MRB) caused by the excessive use of antibiotics and the development of biofilms have been a growing threat to global public health. Nanoparticles as substitutes for antibiotics were proven to possess substantial abilities for tackling MRB infections via new antimicrobial mechanisms. Particularly, carbon dots (CDs) with unique (bio)physicochemical characteristics have been receiving considerable attention in combating MRB by damaging the bacterial wall, binding to DNA or enzymes, inducing hyperthermia locally, or forming reactive oxygen species.Methods: Herein, how the physicochemical features of various CDs affect their antimicrobial capacity is investigated with the assistance of machine learning (ML) tools.Results: The synthetic conditions and intrinsic properties of CDs from 121 samples are initially gathered to form the raw dataset, with Minimum inhibitory concentration (MIC) being the output. Four classification algorithms (KNN, SVM, RF, and XGBoost) are trained and validated with the input data. It is found that the ensemble learning methods turn out to be the best on our data. Also, ϵ-poly(L-lysine) CDs (PL-CDs) were developed to validate the practical application ability of the well-trained ML models in a laboratory with two ensemble models managing the prediction.Discussion: Thus, our results demonstrate that ML-based high-throughput theoretical calculation could be used to predict and decode the relationship between CD properties and the anti-bacterial effect, accelerating the development of high-performance nanoparticles and potential clinical translation. Keywords: carbon dots, machine learning, antibacterial, minimum inhibitory concentration, classification algorithms
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- 2024
7. Acupuncture as Add-on Therapy to SSRIs Can Improve Outcomes of Treatment for Anxious Depression: Subgroup Analysis of the AcuSDep Trial
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Zhao B, Li Z, Shi C, Liu Y, Sun Y, Li B, Zhang J, Gong Z, Wang Y, Ma X, Yang X, Jiang H, Fu Y, Wang X, Li Y, Liu H, Bao T, and Fei Y
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anxious depression ,non-anxious depression ,acupuncture ,ssris ,subgroup analysis ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Bingcong Zhao,1,2 Zhigang Li,3 Chuan Shi,4 Yan Liu,5 Yang Sun,3 Bin Li,1,2 Jie Zhang,6 Zhizhong Gong,7 Yuanzheng Wang,8 Xuehong Ma,9 Xinjing Yang,10 Huili Jiang,3 Yuanbo Fu,1,2 Xin Wang,1,2 Yang Li,6 Hengchia Liu,6 Tuya Bao,3 Yutong Fei11– 13 1Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, People’s Republic of China; 3School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Psychological Assessment Center, Peking University Sixth Hospital, Beijing, People’s Republic of China; 5Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 6Department of Psychosomatic Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 7Division of Medical Affairs, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 8Department of Integrative TCM and Western Medicine, Peking University First Hospital, Beijing, People’s Republic of China; 9Department of Acupuncture & Moxibustion, Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 10Department of Traditional Chinese Medicine, South China Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 11Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 12Institute of Excellence in Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 13Beijing GRADE Centre, Beijing, People’s Republic of ChinaCorrespondence: Tuya Bao, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People’s Republic of China, Email tuyab@263.net Yutong Fei, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People’s Republic of China, Email feiyt@bucm.edu.cnPurpose: Anxious depression (AD) is a common, distinct depression subtype. This exploratory subgroup analysis aimed to explore the effects of acupuncture as an add-on therapy of selective serotonin reuptake inhibitors (SSRIs) for patients with AD or non-anxious depression (NAD).Patients and Methods: Four hundred and sixty-five patients with moderate-to-severe depression from the AcuSDep pragmatic trial were included in analysis. Patients were randomly assigned to receive MA+SSRIs, EA+SSRIs, or SSRIs alone (1:1:1) for six weeks. AD was defined by using dimensional criteria. The measurement instruments included 17-items Hamilton Depression Scale (HAMD-17), Self-Rating Depression Scale (SDS), Clinical Global Impression (CGI), Rating Scale for Side Effects (SERS), and WHO Quality of Life-BREF (WHOQOL-BREF). Comparison between AD and NAD subgroups and comparisons between groups within either AD or NAD subgroups were conducted.Results: Eighty percent of the patients met the criteria for AD. The AD subgroup had poorer clinical manifestations and treatment outcomes compared to those of the NAD subgroup. For AD patients, the HAMD response rate, remission rate, early onset rate, and the score changes on each scale at most measurement points on the two acupuncture groups were significantly better than the SSRIs group. For NAD patients, the HAMD early onset rates of the two acupuncture groups were significantly better than the SSRIs group.Conclusion: For AD subtype patients, either MA or EA add-on SSRIs showed comprehensive improvements, with small-to-medium effect sizes. For NAD subtype patients, both the add-on acupuncture could accelerate the response to SSRIs treatment. The study contributed to the existing literature by providing insights into the potential benefits of acupuncture in combination with SSRIs, especially for patients with AD subtypes. Due to its limited nature as a post hoc subgroup analysis, prospectively designed, high-quality trials are warranted.Clinical Trials Registration: ChiCTR-TRC-08000297.Keywords: anxious depression, non-anxious depression, acupuncture, SSRIs, subgroup analysis
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- 2024
8. Association Between Peripheral Retinal Defocus and Myopia by Multispectral Refraction Topography in Chinese Children
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Bao T, Qin L, Hou G, Jiang H, Wang L, Wang Y, Wu J, Wang J, and Pang Y
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peripheral refractive errors ,myopia ,spherical equivalent ,logistic analysis ,ocular biometrics ,Ophthalmology ,RE1-994 - Abstract
Tong Bao,1,* Liru Qin,2,* Guimei Hou,1 Hongmei Jiang,1 Lifeng Wang,1 Ying Wang,1 Junhui Wu,1 Jinli Wang,3 Yunlei Pang4 1Department of Ophthalmological Examination, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China; 2Department of Ophthalmology, Inner Mongolia Baogang Hospital, Baotou, People’s Republic of China; 3Department of Cataract, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China; 4Department of Ophthalmic Plastic Surgery, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinli Wang, Department of Cataract, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China, Email chaojueyewjl66@163.com Yunlei Pang, Department of Ophthalmic Plastic Surgery, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China, Email 29483645@qq.comObjective: To investigate the association between the peripheral refractive errors of the fundus in different regions and moderate and high myopia.Methods: In this case-control study, 320 children and adolescents aged 6 to 18 years were recruited. Peripheral refractive errors were measured using multispectral retinal refractive topography (MRT). Spherical equivalent (SE) and cylinder errors were classified into low, moderate, and high categories based on the magnitude range. Logistic regression was performed to test the factors associated with myopia.Results: There were 152 participants with low myopia and 168 participants with moderate and high myopia included in the current study. Participants with moderate and high myopia were most likely to be older, with larger axial length (AL), lower SE, less time to watch electronic devices on the weekend, a higher difference between central refractive error and paracentral refractive error from the superior side of the retina (RDV-S), but a smaller difference between the central refractive error and paracentral refractive error from the inferior side of the retina (RDV-I) than those with low myopia (all P < 0.05). After logistic analysis, female sex (odds ratio [OR] = 4.14; 95% confidence interval [CI] = 2.16– 7.97, P < 0.001), AL (OR = 6.88, 95% CI = 4.33– 10.93, P < 0.001), and RDV-I (OR = 0.52, 95% CI = 0.32– 0.86, P = 0.010) were independent factors for moderate and high myopia.Conclusion: Our study demonstrated that the retina peripheral refraction of the eyes (RDV-I) was associated with moderate and high myopia, and RDV-S was only associated with high myopia.Keywords: peripheral refractive errors, myopia, spherical equivalent, logistic analysis, ocular biometrics
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- 2024
9. Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study
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Hoa T. Nguyen, Bao T. Nguyen, Thi H. Nhung Thai, An V. Tran, Tan T. Nguyen, Tam Vo, Linh D. Mai, Thach S. Tran, Tuan V. Nguyen, and Lan T. Ho-Pham
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Medicine ,Science - Abstract
Abstract The epidemiology of vertebral fractures (VF) in underrepresented populations is not well-documented. This cohort study was part of a longitudinal osteoporosis research project with the aim of determining the prevalence, incidence, and risk factors for VF. 401 individuals (155 men) aged 50 years and older without a clinical diagnosis of VF were took radiographs at baseline and 2 years later. VF were ascertained using the Genant's semi-quantitative method. Bone mineral density (BMD) of femoral neck and lumbar spine were measured by dual-energy X-ray absorptiometry (Hologic Inc). The association between VF and risk factors was analyzed by the multiple logistic regression. The 95% confidence interval for prevalence and incidence was estimated by exact Poisson test. At baseline, the prevalence of VF was 12.2% (n = 49, 95% CI 9.0–16.2%) and increased with advancing age with one-fifth of those aged 70 and older having a VF. During the follow-up period, we observed 6 new VF, making the incidence of 6.6/1000 person-years (n = 6, 95% CI 2.4–14.3). The risk of prevalent VF was associated with male gender (OR: 2.67; 95% CI 1.28–5.87) and T-score at the femoral neck (OR per one SD decrease: 1.1; 1.03–1.17). These data indicate that VF is common among adults, and that lower femoral neck BMD was a risk factor for VF.
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- 2024
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10. An efficient framework for outfit compatibility prediction towards occasion
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Vo, Anh H., Le, Tung B. T., Pham, Huy V., and Nguyen, Bao T.
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- 2023
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11. Evaluation of Chemically Modified Nucleic Acid Analogues for Splice Switching Application
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Bao T. Le, Suxiang Chen, and Rakesh N. Veedu
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Chemistry ,QD1-999 - Published
- 2023
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12. Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO–PS Backbone for Splice-Switching Applications
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Bao T. Le, Suxiang Chen, and Rakesh N. Veedu
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antisense oligonucleotide ,splice-switching oligonucleotide ,phosphodiester ,phosphorothioate ,binding affinity ,exon skipping ,Microbiology ,QR1-502 - Abstract
Synthetic antisense oligonucleotides (ASOs) are emerging as an attractive platform to treat various diseases. By specifically binding to a target mRNA transcript through Watson–Crick base pairing, ASOs can alter gene expression in a desirable fashion to either rescue loss of function or downregulate pathogenic protein expression. To be clinically relevant, ASOs are generally synthesized using modified analogs to enhance resistance to enzymatic degradation and pharmacokinetic and dynamic properties. Phosphorothioate (PS) belongs to the first generation of modified analogs and has played a vital role in the majority of approved ASO drugs, mainly based on the RNase H mechanism. In contrast to RNase H-dependent ASOs that bind and cleave target mature mRNA, splice-switching oligonucleotides (SSOs) mainly bind and alter precursor mRNA splicing in the cell nucleus. To date, only one approved SSO (Nusinersen) possesses a PS backbone. Typically, the synthesis of PS oligonucleotides generates two types of stereoisomers that could potentially impact the ASO’s pharmaco-properties. This can be limited by introducing the naturally occurring phosphodiester (PO) linkage to the ASO sequence. In this study, towards fine-tuning the current strategy in designing SSOs, we reported the design, synthesis, and evaluation of several stereo-random SSOs on a mixed PO–PS backbone for their binding affinity, biological potency, and nuclease stability. Based on the results, we propose that a combination of PO and PS linkages could represent a promising approach toward limiting undesirable stereoisomers while not largely compromising the efficacy of SSOs.
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- 2024
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13. Towards a Medical Test Results Management System Based on Blockchain, Smart Contracts, and NFT: A Case Study in Vietnam
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Anh, N. T., Khanh, V. H., Phuc, N. T., Khoa, T. D., Khiem, H. G., Trong, N. D. P., Loc, V. C. P., Duy, N. T. Q., Bao, T. Q., Hieu, D. M., Nghia, H. T., Ngan, N. T. K., Huong, L. H., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Jongbae, Kim, editor, Mokhtari, Mounir, editor, Aloulou, Hamdi, editor, Abdulrazak, Bessam, editor, and Seungbok, Lee, editor
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- 2023
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14. Towards a Blockchain, Smart Contract, and NFT Based Medical Waste Classification System: A Case Study in Vietnam
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Phuc, N. T., Khoi, Q. L., Huong, L. H., Khoa, T. D., Khiem, H. G., Trong, N. D. P., Loc, V. C. P., Duy, N. T. Q., Bao, T. Q., Hieu, D. M., Anh, N. T., Nghia, H. T., Ngan, N. T. K., Khanh, V. H., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeed, Khalid, editor, Dvorský, Jiří, editor, Nishiuchi, Nobuyuki, editor, and Fukumoto, Makoto, editor
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- 2023
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15. An Automatic Recommendation System for Plant Disease Treatment
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Vo, Anh H., Nguyen, Nhu, Nguyen, Thu, Dang, Thu, Nguyen, Duong, Nguyen, Bao T., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Huang, Yo-Ping, editor, Wang, Wen-June, editor, Quoc, Hoang An, editor, Le, Hieu-Giang, editor, and Quach, Hoai-Nam, editor
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- 2023
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16. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2024
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17. A framework-based transformer and knowledge distillation for interior style classification
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Vo, Anh H. and Nguyen, Bao T.
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- 2024
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18. Nanoparticles-assisted aptamer biosensing for the detection of environmental pathogens
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Rahimizadeh, Kamal, Zahra, Qurat ul ain, Chen, Suxiang, Le, Bao T., Ullah, Ismat, and Veedu, Rakesh N.
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- 2023
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19. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- 2023
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20. Machine Learning Study of SNPs in Noncoding Regions to Predict Non-small Cell Lung Cancer Susceptibility
- Author
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Huang, Y., Bao, T., Zhang, T., Ji, G., Wang, Y., Ling, Z., and Li, W.
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- 2023
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21. An efficient framework for outfit compatibility prediction towards occasion.
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Anh Hoang Vo, Tung B. T. Le, Huy V. Pham, and Bao T. Nguyen
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- 2023
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22. Towards a Blockchain, Smart Contract, and NFT Based Medical Waste Classification System: A Case Study in Vietnam
- Author
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Phuc, N. T., primary, Khoi, Q. L., additional, Huong, L. H., additional, Khoa, T. D., additional, Khiem, H. G., additional, Trong, N. D. P., additional, Loc, V. C. P., additional, Duy, N. T. Q., additional, Bao, T. Q., additional, Hieu, D. M., additional, Anh, N. T., additional, Nghia, H. T., additional, Ngan, N. T. K., additional, and Khanh, V. H., additional
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- 2023
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23. Improving the resolving power of Isochronous Mass Spectrometry by employing an in-ring mechanical slit
- Author
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Liu, J. H., Xu, X., Zhang, P., Shuai, P., Yan, X. L., Zhang, Y. H., Wang, M., Litvinov, Yu. A., Xu, H. S., Blaum, K., Bao, T., Chen, H., Chen, X. C., Chen, R. J., Fu, C. Y., Liu, D. W., Ge, W. W., Mao, R. S., Ma, X. W., Sun, M. Z., Tu, X. L., Xing, Y. M., Yang, J. C., Yuan, Y. J., Zeng, Q., Zhou, X., Zhou, X. H., Zhan, W. L., Litvinov, S., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., and Sun, B. H.
- Subjects
Nuclear Experiment - Abstract
Isochronous Mass Spectrometry (IMS) in heavy-ion storage rings is an excellent experimental method for precision mass measurements of exotic nuclei. In the IMS, the storage ring is tuned in a special isochronous ion-optical mode. Thus, the mass-over-charge ratios of the stored ions are directly reflected by their respective revolution times in first order. However, the inevitable momentum spread of secondary ions increases the peak widths in the measured spectra and consequently limits the achieved mass precision. In order to achieve a higher mass resolving power, the ring aperture was reduced to 60 mm by applying a mechanical slit system at the dispersive straight section. The momentum acceptance was reduced as well as better isochronous conditions were achieved. The results showed a significant improvement of the mass resolving power reaching $5.2 \times 10^{5}$, though at the cost of about 40\% ion loss., Comment: 6 pages, 6 figures, proceeding of EMIS2018
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- 2019
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24. Single cell transcriptomics of human epidermis identifies basal stem cell transition states.
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Wang, Shuxiong, Drummond, Michael L, Guerrero-Juarez, Christian F, Tarapore, Eric, MacLean, Adam L, Stabell, Adam R, Wu, Stephanie C, Gutierrez, Guadalupe, That, Bao T, Benavente, Claudia A, Nie, Qing, and Atwood, Scott X
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Epidermis ,Keratinocytes ,Stem Cells ,Humans ,Gene Expression Profiling ,Cell Communication ,Signal Transduction ,Cell Differentiation ,Gene Expression Regulation ,Cell Lineage ,Homeostasis ,Models ,Biological ,Infant ,Newborn ,Male ,Foreskin ,Epidermal Cells ,Models ,Biological ,Infant ,Newborn - Abstract
How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and bottom of rete ridges and transitional positions between the basal and suprabasal epidermal layers. Cell-cell communication modeling suggests that basal cell populations serve as crucial signaling hubs to maintain epidermal communication. Combining pseudotime, RNA velocity, and cellular entropy analyses point to a hierarchical differentiation lineage supporting multi-stem cell interfollicular epidermal homeostasis models and suggest that transitional basal stem cells are stable states essential for proper stratification. Finally, alterations in differentially expressed transitional basal stem cell genes result in severe thinning of human skin equivalents, validating their essential role in epidermal homeostasis and reinforcing the critical nature of basal stem cell heterogeneity.
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- 2020
25. Experimental Investigation of the Transition Energy $\gamma_t$ in the Isochronous Mode of the HIRFL-CSRe
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Ge, W. W., Yuan, Y. J., Yang, J. C., Chen, R. J., Yan, X. L., Du, H., Li, Z. S., Yang, J., Yin, D. Y., Mao, L. J., Li, X. N., Zheng, W. H., Shen, G. D., Wu, B., Ruan, S., Wang, G., Zhao, H., Wang, M., Sun, M. Z., Xing, Y. M., Zhang, P., Fu, C. Y., Shuai, P., Xu, X., Zhang, Y. H., Bao, T., Chen, X. C., Huang, W. J., Li, H. F., Liu, J. H., Litvinov, Yu. A., Litvinov, S., Zeng, Q., and Zhou, X.
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Physics - Accelerator Physics - Abstract
The Isochronous Mass Spectrometry (IMS) based on storage rings is a powerful technique for mass measurement of short-lived exotic nuclei. The transition energy $\gamma_t$ of the storage ring is a vital parameter of the IMS technique. It is difficult to measure the $\gamma_t$ and its relation to momentum spread or circulating length, especially to monitor the variation of $\gamma_t$ during experiments. An experimental investigation on the $\gamma_t$ has been performed for the IMS experiment at the Cooler Storage Ring of the Heavy Ion Research Facility in Lanzhou (HIRFL-CSRe). With the velocity measured by two time-of-flight (TOF) detectors, the $\gamma_t$ as a function of orbital length can be determined. The influences of higher order magnetic field components on the $\gamma_t$ function were inferred for isochronous correction. This paper introduces and investigates the influence of dipole magnetic fields, quadrupole magnetic fields and sextupole magnetic fields on the $\gamma_t$ function. With the quadrupole magnets and sextupole magnets corrections, a mass resolution of 171332 (FWHM) and $\sigma(T)/T=1.34\times10^{-6}$ were reached, which shall be compared with 31319 (FWHM) and $\sigma(T)/T=7.35\times10^{-6}$ obtained without correction., Comment: 10 figures,19 pages
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- 2018
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26. Isochronous mass measurements of $T_z=-1$ $fp$-shell nuclei from projectile fragmentation of $^{58}$Ni
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Zhang, Y. H., Zhang, P., Zhou, X. H., Wang, M., Litvinov, Yu. A., Xu, H. S., Xu, X., Shuai, P., Lam, Y. H., Chen, R. J., Yan, X. L., Bao, T., Chen, X. C., Chen, H., Fu, C. Y., He, J. J., Kubono, S., Liu, D. W., Mao, R. S., Ma, X. W., Sun, M. Z., Tu, X. L., Xing, Y. M., Zeng, Q., Zhou, X., Zhan, W. L., Litvinov, S., Blaum, K., Audi, G., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., Sun, B. H., Sun, Y., and Xu, F. R.
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Nuclear Experiment - Abstract
Atomic masses of seven $T_z=-1$, $fp$-shell nuclei from $^{44}$V to $^{56}$Cu and two low-lying isomers, $^{44m}$V ($J^\pi=6^+$) and $^{52m}$Co ($J^\pi=2^+$), have been measured with relative precisions of $1-4\times 10^{-7}$ with Isochronous Mass Spectrometry (IMS) at CSRe. The masses of $^{56}$Cu, $^{52g,52m}$Co, and $^{44m}$V were measured for the first time in this experiment. The Mass Excesses ($ME^{\prime}$s) of $^{44}$V, $^{48}$Mn, $^{50}$Fe, and $^{54}$Ni are determined with an order of magnitude improved precision compared to the literature values. $^{52g,52m}$Co and $^{56}$Cu are found to be $370$~keV and $400$~keV more bound, respectively, while $^{44g,44m}$V are $\sim 300$~keV less bound than the extrapolations in the Atomic-Mass Evaluation 2012 (AME$^{\prime}$12). The masses of the four $T_z=-1/2$ nuclei $^{45}$V, $^{47}$Cr, $^{49}$Mn, and $^{51}$Fe are re-determined to be in agreement, within the experimental errors, with the recent JYFLTRAP measurements or with the previous IMS measurements in CSRe. Details of the measurements and data analysis are described, and the impact of the new $ME$ values on different aspects in nuclear structure are investigated and discussed., Comment: 16 pages, 15 figures
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- 2018
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27. A method to measure the transition energy $\gamma_{t}$ of the isochronously tuned storage ring
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Chen, R. J., Yan, X. L., Ge, W. W., Yuan, Y. J., Wang, M., Sun, M. Z., Xing, Y. M., Zhang, P., Fu, C. Y., Shuai, P., Xu, X., Zhang, Y. H., Bao, T., Chen, X. C., Hu, X. J., Huang, W. J., Li, H. F., Liu, J. H., Litvinov, Yu. A., Litvinov, S. A., Mao, L. J., Wu, B., Xu, H. S., Yang, J. C., Yin, D. Y., Zeng, Q., Zhang, X. H., Zheng, W. H., Zhou, X. H., and Zhou, X.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The Isochronous Mass Spectrometry (IMS) is a powerful technique developed in heavy-ion storage rings for measuring masses of very short-lived exotic nuclei. The IMS is based on the isochronous setting of the ring. One of the main parameters of this setting is the transition energy $\gamma_{t}$. %The transition energy $\gamma_{t}$ plays an important role in the isochronous mass spectrometry (IMS). It has been a challenge to determine the $\gamma_{t}$ and especially to monitor the variation of $\gamma_{t}$ during experiments. In this paper we introduce a method to measure the $\gamma_{t}$ online during IMS experiments by using the acquired experimental data. Furthermore, since the storage ring has (in our context) a relatively large momentum acceptance, the variation of the $\gamma_{t}$ across the ring acceptance is a source of systematic uncertainty of measured masses. With the installation of two time-of-flight (TOF) detectors, the velocity of each stored ion and its revolution time are simultaneously available for the analysis. These quantities enabled us to determine the $\gamma_{t}$ as a function of orbital length in the ring. The presented method is especially important for future IMS experiments planned at the new-generation storage ring facilities FAIR in Germany and HIAF in China., Comment: 7 pages
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- 2018
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28. An Automatic Recommendation System for Plant Disease Treatment
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Vo, Anh H., primary, Nguyen, Nhu, additional, Nguyen, Thu, additional, Dang, Thu, additional, Nguyen, Duong, additional, and Nguyen, Bao T., additional
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- 2022
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29. Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm
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Mohammed Ferdous-Ur Rahman, Yue Yang, Bao T. Le, Avik Dutta, Julia Posyniak, Patrick Faughnan, Mohammad A. Sayem, Nadine S. Aguilera, and Golam Mohi
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Science - Abstract
Chronic inflammation is frequently observed in patients with myeloproliferative neoplasms (MPN). Here the authors observe elevated levels of IL-1α and IL-1β in MPN patients and show that IL-1 contributes to clonal expansion and bone marrow fibrosis in a mouse model of MPN, proposing targeting of IL1R1 as therapeutic intervention.
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- 2022
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30. The Masses of the $T_z=-3/2$ Nuclei $^{27}$P and $^{29}$S
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Fu, C. Y., Zhang, Y. H., Zhou, X. H., Wang, M., Litvinov, Yu. A., Blaum, K., Xu, H. S., Xu, X., Shuai, P., Lam, Y. H., Chen, R. J., Yan, X. L., Bao, T., Chen, X. C., Chen, H., He, J. J., Kubono, S., Liu, D. W., Mao, R. S., Ma, X. W., Sun, M. Z., Tu, X. L., Xing, Y. M., Zhang, P., Zeng, Q., Zhou, X., Zhan, W. L., Litvinov, S., Audi, G., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., Sun, B. H., Sun, Y., and Xu, F. R.
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Nuclear Experiment - Abstract
Isochronous mass spectrometry has been applied in the storage ring CSRe to measure the masses of the $T_z=-3/2$ nuclei $^{27}$P and $^{29}$S. The new mass excess value $ME$($^{29}$S) $=-3094(13)$~keV is 66(52)~keV larger than the result of the previous $^{32}$S($^3$He,$^{6}$He)$^{29}$S reaction measurement in 1973 and a factor of 3.8 more precise. The new result for $^{29}$S, together with those of the $T=3/2$ isobaric analog states (IAS) in $^{29}$P, $^{29}$Si, and $^{29}$Al, fit well into the quadratic form of the Isobaric Multiplet Mass Equation IMME. The mass excess of $^{27}$P has been remeasured to be $ME(^{27}$P$)=-685(42)$ keV. By analyzing the linear and quadratic coefficients of the IMME in the $T_z=-3/2$ $sd$-shell nuclei, it was found that the ratio of the Coulomb radius parameters is $R\approx0.96$ and is nearly the same for all $T=3/2$ isospin multiplets. Such a nearly constant $R$-value, apparently valid for the entire light mass region with $A>9$, can be used to set stringent constraints on the isovector and isotensor components of the isospin non-conserving forces in theoretical calculations., Comment: 7 pages, 4 figures
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- 2018
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31. Mass Measurements of Neutron-Deficient Y, Zr, and Nb Isotopes and Their Impact on $rp$ and $\nu p$ Nucleosynthesis Processes
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Xing, Y. M., Li, K. A., Zhang, Y. H., Zhou, X. H., Wang, M., Litvinov, Yu. A., Blaum, K., Wanajo, S., Kubono, S., Martínez-Pinedo, G., Sieverding, A., Chen, R. J., Shuai, P., Fu, C. Y., Yan, X. L., Huang, W. J., Xu, X., Tang, X. D., Xu, H. S., Bao, T., Chen, X. C., Gao, B. S., He, J. J., Lam, Y. H., Li, H. F., Liu, J. H., Ma, X. W., Mao, R. S., Si, M., Sun, M. Z., Tu, X. L., Wang, Q., Yang, J. C., Yuan, Y. J., Zeng, Q., Zhang, P., Zhou, X., Zhan, W. L., Litvinov, S., Audi, G., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., Fröhlich, C., Rauscher, T., Thielemann, F. -K., Sun, B. H., Sun, Y., Dai, A. C., and Xu, F. R.
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Nuclear Experiment ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Using isochronous mass spectrometry at the experimental storage ring CSRe in Lanzhou, the masses of $^{82}$Zr and $^{84}$Nb were measured for the first time with an uncertainty of $\sim 10$ keV, and the masses of $^{79}$Y, $^{81}$Zr, and $^{83}$Nb were re-determined with a higher precision. %The latter differ significantly from their literature values. The latter are significantly less bound than their literature values. Our new and accurate masses remove the irregularities of the mass surface in this region of the nuclear chart. Our results do not support the predicted island of pronounced low $\alpha$ separation energies for neutron-deficient Mo and Tc isotopes, making the formation of Zr-Nb cycle in the $rp$-process unlikely. The new proton separation energy of $^{83}$Nb was determined to be 490(400)~keV smaller than that in the Atomic Mass Evaluation 2012. This partly removes the overproduction of the $p$-nucleus $^{84}$Sr relative to the neutron-deficient molybdenum isotopes in the previous $\nu p$-process simulations.
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- 2018
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32. Single cell transcriptomics of human epidermis reveals basal stem cell transition states
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Wang, Shuxiong, Drummond, Michael L, Guerrero-Juarez, Christian F, Tarapore, Eric, MacLean, Adam L, Stabell, Adam R, Wu, Stephanie C, Gutierrez, Guadalupe, That, Bao T, Benavente, Claudia A, Nie, Qing, and Atwood, Scott X
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Stem Cell Research ,Stem Cell Research - Nonembryonic - Non-Human ,Genetics ,Regenerative Medicine ,Stem Cell Research - Nonembryonic - Human ,1.1 Normal biological development and functioning ,Underpinning research ,Skin - Abstract
ABSTRACT How stem cells give rise to human interfollicular epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find at least four spatially distinct stem cell populations that decorate the top and bottom of rete ridge architecture and hold transitional positions between the basal and suprabasal epidermal layers. Cell-cell communication modeling through co-variance of cognate ligand-receptor pairs indicate that the basal cell populations distinctly serve as critical signaling hubs that maintain epidermal communication. Combining pseudotime, RNA velocity, and cellular entropy analyses point to a hierarchical differentiation lineage supporting multi-stem cell interfollicular epidermal homeostasis models and suggest the “transitional” basal stem cells are stable states essential for proper stratification. Finally, alterations in differentially expressed “transitional” basal stem cell genes result in severe thinning of human skin equivalents, validating their essential role in epidermal homeostasis and reinforcing the critical nature of basal stem cell heterogeneity.
- Published
- 2019
33. ASMCNN: An efficient brain extraction using active shape model and convolutional neural networks.
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Duy M. H. Nguyen, Duy M. Nguyen, Truong Thanh Nhat Mai, Thu Nguyen, Khanh T. Tran, Anh Triet Nguyen, Bao T. Pham, and Binh T. Nguyen 0001
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- 2022
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34. Severe Mpox Proctitis Complicated by Bowel Obstruction
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Saleh, Hasan, Ho, Bao T., Call, Justin T., Plante, Marie M., Zaver, Himesh B., Powers, Harry R., Metcalfe, Allie M., Graham, Charles G., and Lewis, Michele D.
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- 2023
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35. ASMCNN: An efficient brain extraction using active shape model and convolutional neural networks
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Nguyen, Duy H.M., Nguyen, Duy M., Mai, Truong T.N., Nguyen, Thu, Tran, Khanh T., Nguyen, Anh Triet, Pham, Bao T., and Nguyen, Binh T.
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- 2022
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36. Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models
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Dutta, Avik, Nath, Dipmoy, Yang, Yue, Le, Bao T., Rahman, Mohammad Ferdous-Ur, Faughnan, Patrick, Wang, Zhenjia, Stuver, Matthew, He, Rongquan, Tan, Wuwei, Hutchison, Robert E., Foulks, Jason M., Warner, Steven L., Zang, Chongzhi, and Mohi, Golam
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- 2022
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37. Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm
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Rahman, Mohammed Ferdous-Ur, Yang, Yue, Le, Bao T., Dutta, Avik, Posyniak, Julia, Faughnan, Patrick, Sayem, Mohammad A., Aguilera, Nadine S., and Mohi, Golam
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- 2022
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38. Attention Mechanism for Fashion Image Captioning
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Nguyen, Bao T., Prakash, Om, Vo, Anh H., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Huang, Yo-Ping, editor, Wang, Wen-June, editor, Quoc, Hoang An, editor, Giang, Le Hieu, editor, and Hung, Nguyen-Le, editor
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- 2021
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39. Precision measurement of the transition energy [formula omitted] versus magnetic rigidity for storage-ring isochronous mass spectrometry
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Zhang, M., Zhang, Y.H., Wang, M., Zhou, X., Yuan, Y.J., Yan, X.L., Xing, Y.M., Fu, C.Y., Chen, R.J., Xu, X., Shuai, P., Zeng, Q., Sun, M.Z., Li, H.F., Si, M., Wang, Q., Bao, T., Deng, H.Y., Liu, M.Z., Liao, T., Shi, J.Y., Song, Y.N., Jiao, H.Y., Zhou, X.H., Xu, H.S., Yang, J.C., Ge, W.W., Litvinov, Yu.A., Litvinov, S.A., Yamaguchi, T., and Suzuki, S.
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- 2022
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40. Design and construction of the POLAR detector
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Produit, N., Bao, T. W., Batsch, T., Bernasconi, T., Britvich, I., Cadoux, F., Cernuda, I., Chai, J. Y., Dong, Y. W., Gauvin, N., Hajdas, W., Kole, M., Kong, M. N., Kramert, R., Li, L., Liu, J. T., Liu, X., Marcinkowski, R., Orsi, S., Pohl, M., Rapin, D., Rybka, D., Rutczynska, A., Shi, H. L., Socha, P., Sun, J. C., Song, L. M., Szabelski, J., Traseira, I., Xiao, H. L., Wang, R. J., Wen, X., Wu, B. B., Zhang, L., Zhang, L. Y., Zhang, S. N., Zhang, Y. J., and Zwolinska, A.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The POLAR detector is a space based Gamma Ray Burst (GRB) polarimeter with a wide field of view, which covers almost half the sky. The instrument uses Compton scattering of gamma rays on a plastic scintillator hodoscope to measure the polarization of the incoming photons. The instrument has been successfully launched on board of the Chinese space laboratory Tiangong~2 on September 15, 2016. The construction of the instrument components is described in this article. Details are provided on problems encountered during the construction phase and their solutions. Initial performance of the instrument in orbit is as expected from ground tests and Monte Carlo simulation.
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- 2017
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41. Instrument Performance and Simulation Verification of the POLAR Detector
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Kole, M., Li, Z. H., Produit, N., Tymieniecka, T., Zhang, J., Zwolinska, A., Bao, T. W., Bernasconi, T., Cadoux, F., Feng, M. Z., Gauvin, N., Hajdas, W., Kong, S. W., Li, H. C., Li, L., Liu, X., Marcinkowski, R., Orsi, S., Pohl, M., Rybka, D., Sun, J. C., Song, L. M., Szabelski, J., Wang, R. J., Wang, Y. H., Wen, X., Wu, B. B., Wu, X., Xiao, H. L., Zhang, L., Zhang, L. Y., Zhang, S. N., Zhang, X. F., Zhang, Y. J., and Zhao, Y.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
POLAR is a new satellite-born detector aiming to measure the polarization of an unprecedented number of Gamma-Ray Bursts in the 50-500 keV energy range. The instrument, launched on-board the Tiangong-2 Chinese Space lab on the 15th of September 2016, is designed to measure the polarization of the hard X-ray flux by measuring the distribution of the azimuthal scattering angles of the incoming photons. A detailed understanding of the polarimeter and specifically of the systematic effects induced by the instrument's non-uniformity are required for this purpose. In order to study the instrument's response to polarization, POLAR underwent a beam test at the European Synchrotron Radiation Facility in France. In this paper both the beam test and the instrument performance will be described. This is followed by an overview of the Monte Carlo simulation tools developed for the instrument. Finally a comparison of the measured and simulated instrument performance will be provided and the instrument response to polarization will be presented., Comment: Preprint Accepted for Publication in Nuclear Instruments and Methods in Physics Research A
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- 2017
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42. Calibration of the Space-borne Compton Polarimeter POLAR flight model with 100% polarized X-ray beams
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Xiao, H. L., Hajdas, W., Socha, P., Marcinkowski, R., Wu, B. B., Bao, T. W., Chai, J. Y., Dong, Y. W., Kong, M. N., Li, L., Li, Z. H., Liu, J. T., Shi, H. L., Song, L. M., Sun, J. C., Wang, R. J., Wang, Y. H., Wen, X., Xiong, S. L., Zhang, J., Zhang, L. Y., Zhang, S. N., Zhang, X. F., Zhang, Y. J., Cadoux, F., Pohl, M., Wu, X., Batsch, T., Rybka, D., Rutczynska, A., Szabelski, J., Zwolinska, A., Gauvin, N., Produit, N., and Bernasconi, T.
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Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics ,Nuclear Experiment - Abstract
POLAR is space-borne detector designed for a precise measurement of gamma-ray polarization of the prompt emissions of Gamma-Ray Bursts in the energy range 50 keV - 500 keV. POLAR is a compact Compton polarimeter consisting of 40$\times$ 40 plastic scintillator bars read out by 25 multi-anode PMTs. In May 2015, we performed a series of tests of the POLAR flight model with 100\% polarized x-rays beams at the European Synchrotron Radiation Facility beam-line ID11 aming to study thresholds, crosstalk between channels and responses of POLAR flight model to polarized X-ray beams. In this paper we present the data analysis method and some analysis results. According the results, POLAR FM has good polarimetric capabilities., Comment: The paper was withdrawn by authors because the work has not yet finshed
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- 2017
43. Gain factor and parameter settings optimization of the new gamma-ray burst polarimeter POLAR
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Zhang, X. F., Hajdas, W., Xiao, H. L., Wen, X., Wu, B. B., Bao, T. W., Batsch, T., Bernasconi, T., Cadoux, F., Cernuda, I., Chai, J. Y., Dong, Y. W., Gauvin, N., He, J. J., Kole, M., Kong, M. N., Lechanoine-Leluc, C., Li, L., Li, Z. H., Liu, J. T., Liu, X., Marcinkowski, R., Orsi, S., Pohl, M., Rapin, D., Rybka, D., Shi, H. L., Song, L. M., Sun, J. C., Szabelski, J., Wang, R. J., Wang, Y. H., Wu, X., Xiong, S. L., Xu, M., Zhang, L., Zhang, L. Y., Zhang, P., Zhang, S. N., Zhang, Y. J., and Zwolinska, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
As a space-borne detector POLAR is designed to conduct hard X-ray polarization measurements of gamma-ray bursts on the statistically significant sample of events and with an unprecedented accuracy. During its development phase a number of tests, calibrations runs and verification measurements were carried out in order to validate instrument functionality and optimize operational parameters. In this article we present results on gain optimization togeter with verification data obtained in the course of broad laboratory and environmental tests. In particular we focus on exposures to the $^{137}$Cs radioactive source and determination of the gain dependence on the high voltage for all 1600 detection channels of the polarimeter. Performance of the instrument is described in detail with respect to the dynamic range, energy resolution and temperature dependence. Gain optimization algorithms and response non-uniformity studies are also broadly discussed. Results presented below constitute important parts for development of the POLAR calibration and operation database., Comment: There still some disagreement about one of the conclusions presented in the paper among all the authors
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- 2017
44. Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO–PS Backbone for Splice-Switching Applications.
- Author
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Le, Bao T., Chen, Suxiang, and Veedu, Rakesh N.
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- *
RIBONUCLEASE H , *BASE pairs , *GENE expression , *CELL nuclei , *OLIGONUCLEOTIDE synthesis - Abstract
Synthetic antisense oligonucleotides (ASOs) are emerging as an attractive platform to treat various diseases. By specifically binding to a target mRNA transcript through Watson–Crick base pairing, ASOs can alter gene expression in a desirable fashion to either rescue loss of function or downregulate pathogenic protein expression. To be clinically relevant, ASOs are generally synthesized using modified analogs to enhance resistance to enzymatic degradation and pharmacokinetic and dynamic properties. Phosphorothioate (PS) belongs to the first generation of modified analogs and has played a vital role in the majority of approved ASO drugs, mainly based on the RNase H mechanism. In contrast to RNase H-dependent ASOs that bind and cleave target mature mRNA, splice-switching oligonucleotides (SSOs) mainly bind and alter precursor mRNA splicing in the cell nucleus. To date, only one approved SSO (Nusinersen) possesses a PS backbone. Typically, the synthesis of PS oligonucleotides generates two types of stereoisomers that could potentially impact the ASO's pharmaco-properties. This can be limited by introducing the naturally occurring phosphodiester (PO) linkage to the ASO sequence. In this study, towards fine-tuning the current strategy in designing SSOs, we reported the design, synthesis, and evaluation of several stereo-random SSOs on a mixed PO–PS backbone for their binding affinity, biological potency, and nuclease stability. Based on the results, we propose that a combination of PO and PS linkages could represent a promising approach toward limiting undesirable stereoisomers while not largely compromising the efficacy of SSOs. [ABSTRACT FROM AUTHOR]
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- 2024
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45. POLAR: Final Calibration and In-Flight Performance of a Dedicated GRB Polarimeter
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Kole, M., Bao, T. W., Batsch, T., Bernasconi, T., Cadoux, F., Chai, J. Y., Dong, Y. W., Gauvin, N., Hajdas, W., He, J. J., Kong, M. N., Kong, S. W., Lechanoine-Leluc, C., Li, L., Li, Z. H., Liu, J. T., Liu, X., Marcinkowski, R., Orsi, S., Pohl, M., Produit, N., Rapin, D., Rutczynska, A., Rybka, D., Shi, H. L., Song, L. M., Sun, J. C., Szabelski, J., Wang, R. J., Wang, Y. J., Wen, X., Wu, B. B., Wu, X., Xiao, H. L., Xiong, S. L., Xu, H. H., Xu, M., Zhang, J., Zhang, L., Zhang, L. Y., Zhang, S. N., Zhang, X. F., Zhang, Y. J., and Zwolinska, A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Gamma-ray polarimetry is a new powerful tool to study the processes responsible for the emission from astrophysical sources and the environments in which this emission takes place. Few successful polarimetric measurements have however been performed thus far in the gamma-ray energy band due to the difficulties involved. POLAR is a dedicated polarimeter designed to perform high precision measurements of the polarization of the emission from gamma-ray burst in the 50-500 keV energy range. This new polarimeter is expected to detect approximately 50 gamma-ray bursts per year while performing high precision polarization measurements on approximately 10 bursts per year. The instrument was launched into lower earth orbit as part of the second Chinese space lab, the Tiangong-2, on September 15th 2016 and has been taking data successfully since being switched on one week after. The instrument uses a segmented scintillator array consisting of 1600 plastic scintillator bars, read out by 25 flat-panel multi-anode photomultipliers, to measure the Compton scattering angles of incoming photons. The small segmentation and relatively large uniform effective area allow the instrument to measure the polarization of a large number of transient events, such as gamma-ray bursts, with an unprecedented precision during its two year life-time. The final flight model underwent detailed calibration prior to launch as well as intensive space qualification tests, a summary of which will be presented in this paper. The instrument design will be discussed first followed by an overview of the on-ground tests, finally the in-orbit behavior as measured during the first weeks of the mission will be presented.
- Published
- 2016
46. Identification of the Lowest $T=2$, $J^{\pi=}0^+$ Isobaric Analog State in $^{52}$Co and Its Impact on the Understanding of $\beta$-Decay Properties of $^{52}$Ni
- Author
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Xu, X., Zhang, P., Shuai, P., Chen, R. J., Yan, X. L., Zhang, Y. H., Wang, M., Litvinov, Yu. A., Xu, H. S., Bao, T., Chen, X. C., Chen, H., Fu, C. Y., Kubono, S., Lam, Y. H., Liu, D. W., Mao, R. S., Ma, X. W., Sun, M. Z., Tu, X. L., Xing, Y. M., Yang, J. C., Yuan, Y. J., Zeng, Q., Zhou, X., Zhou, X. H., Zhan, W. L., Litvinov, S., Blaum, K., Audi, G., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., Sun, B. H., Sun, Y., Dai, A. C., and Xu, F. R.
- Subjects
Nuclear Experiment - Abstract
Masses of $^{52g,52m}$Co were measured for the first time with an accuracy of $\sim 10$ keV, an unprecedented precision reached for short-lived nuclei in the isochronous mass spectrometry. Combining our results with the previous $\beta$-$\gamma$ measurements of $^{52}$Ni, the $T=2$, $J^{\pi}=0^+$ isobaric analog state (IAS) in $^{52}$Co was newly assigned, questioning the conventional identification of IASs from the $\beta$-delayed proton emissions. Using our energy of the IAS in $^{52}$Co, the masses of the $T=2$ multiplet fit well into the Isobaric Multiplet Mass Equation. We find that the IAS in $^{52}$Co decays predominantly via $\gamma$ transitions while the proton emission is negligibly small. According to our large-scale shell model calculations, this phenomenon has been interpreted to be due to very low isospin mixing in the IAS., Comment: Accepted for publication in PRL. 5 pages, 2figures
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- 2016
- Full Text
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47. Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
- Author
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Ji-Hee Kim, Kyu-Hee Hwang, Bao T. N. Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, and Seung-Kuy Cha
- Subjects
Science - Abstract
Perturbations of Ca2+ signaling in podocytes may deteriorate kidney function and eventually lead to proteinuria. Here the authors show that insulin can affect the function of the calcium regulator Ora1 in podocytes, which is critical for maintaining kidney filter integrity.
- Published
- 2021
- Full Text
- View/download PDF
48. U2af1 is required for survival and function of hematopoietic stem/progenitor cells
- Author
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Dutta, Avik, Yang, Yue, Le, Bao T., Zhang, Yifan, Abdel-Wahab, Omar, Zang, Chongzhi, and Mohi, Golam
- Published
- 2021
- Full Text
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49. Calibration of Gamma-ray Burst Polarimeter POLAR
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Xiao, H. L., Hajdas, W., Bao, T. W., Batsch, T., Bernasconi, T., Cernuda, I., Chai, J. Y., Dong, Y. W., Gauvin, N., Kole, M., Kong, M. N., Kong, S. W., Li, L., Liu, J. T., Liu, X., Marcinkowski, R., Orsi, S., Pohl, M., Produit, N., Rapin, D., Rutczynska, A., Rybka, D., Shi, H. L., Song, L. M., Sun, J. C., Szabelski, J., Wu, B. B., Wang, R. J., Wen, X., Xu, H. H., Zhang, L., Zhang, L. Y., Zhang, S. N., Zhang, X. F., Zhang, Y. J., and Zwolinska, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
Gamma Ray Bursts (GRBs) are the strongest explosions in the universe which might be associated with creation of black holes. Magnetic field structure and burst dynamics may influence polarization of the emitted gamma-rays. Precise polarization detection can be an ultimate tool to unveil the true GRB mechanism. POLAR is a space-borne Compton scattering detector for precise measurements of the GRB polarization. It consists of a 40$\times$40 array of plastic scintillator bars read out by 25 multi-anode PMTs (MaPMTs). It is scheduled to be launched into space in 2016 onboard of the Chinese space laboratory TG2. We present a dedicated methodology for POLAR calibration and some calibration results based on the combined use of the laboratory radioactive sources and polarized X-ray beams from the European Synchrotron Radiation Facility. They include calibration of the energy response, computation of the energy conversion factor vs. high voltage as well as determination of the threshold values, crosstalk contributions and polarization modulation factors., Comment: 2015 IEEE NSS conference proceedings
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- 2015
- Full Text
- View/download PDF
50. Multiplex Aptamer Discovery through Apta-Seq and Its Application to ATP Aptamers Derived from Human-Genomic SELEX
- Author
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Abdelsayed, Michael M, Ho, Bao T, Vu, Michael MK, Polanco, Julio, Spitale, Robert C, and Lupták, Andrej
- Subjects
Human Genome ,Biotechnology ,Genetics ,Aptamers ,Nucleotide ,Base Sequence ,Binding Sites ,Cell Line ,Humans ,SELEX Aptamer Technique ,Sequence Alignment ,Chemical Sciences ,Biological Sciences ,Organic Chemistry - Abstract
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including as diagnostic and therapeutic aptamers. The majority of aptamers have been identified using in vitro selection (SELEX), a molecular evolution technique based on selecting target-binding RNAs from highly diverse pools through serial rounds of enrichment and amplification. In vitro selection typically yields multiple distinct motifs of highly variable abundance and target-binding affinities. The discovery of new aptamers is often limited by the difficulty of characterizing the selected motifs, because testing of individual sequences tends to be a tedious process. To facilitate the discovery of new aptamers within in vitro selected pools, we developed Apta-Seq, a multiplex analysis based on quantitative, ligand-dependent 2' acylation of solvent-accessible regions of the selected RNA pools, followed by reverse transcription (SHAPE) and deep sequencing. The method reveals, in a single sequencing experiment, the identity, structural features, and target dissociation constants for aptamers present in the selected pool. Application of Apta-Seq to a human genomic pool enriched for ATP-binding RNAs yielded three new aptamers, which together with previously identified human aptamers suggest that ligand-binding RNAs may be common in mammals.
- Published
- 2017
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