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23 results on '"Bao, Hechen"'

8. Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Author

McGovern Institute for Brain Research at MIT, Wander, Connor M., Li, Ya-Dong, Bao, Hechen, Asrican, Brent, Luo, Yan-Jia, Sullivan, Heather A., Chao, Tzu-Hao H., Zhang, Wei-Ting, Chéry, Samantha L., Tart, Dalton S., Chen, Ze-Ka, Shih, Yen-Yu I., Wickersham, Ian R., Cohen, Todd J., Song, Juan, McGovern Institute for Brain Research at MIT, Wander, Connor M., Li, Ya-Dong, Bao, Hechen, Asrican, Brent, Luo, Yan-Jia, Sullivan, Heather A., Chao, Tzu-Hao H., Zhang, Wei-Ting, Chéry, Samantha L., Tart, Dalton S., Chen, Ze-Ka, Shih, Yen-Yu I., Wickersham, Ian R., Cohen, Todd J., and Song, Juan

Abstract

Background Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to improve memory target neural circuits to protect their integrity. However, the vulnerable neural circuits and their dynamic remodeling during AD progression remain largely undefined. Methods Circuit-based approaches, including anterograde and retrograde tracing, slice electrophysiology, and fiber photometry, were used to investigate the dynamic structural and functional remodeling of a GABAergic circuit projected from the medial septum (MS) to the dentate gyrus (DG) in 3xTg-AD mice during AD progression. Results We identified a long-distance GABAergic circuit that couples highly connected MS and DG GABAergic neurons during spatial memory encoding. Furthermore, we found hyperactivity of DG interneurons during early AD, which persisted into late AD stages. Interestingly, MS GABAergic projections developed a series of adaptive strategies to combat DG interneuron hyperactivity. During early-stage AD, MS-DG GABAergic projections exhibit increased inhibitory synaptic strength onto DG interneurons to inhibit their activities. During late-stage AD, MS-DG GABAergic projections form higher anatomical connectivity with DG interneurons and exhibit aberrant outgrowth to increase the inhibition onto DG interneurons. Conclusion We report the structural and functional remodeling of the MS-DG GABAergic circuit during disease progression in 3xTg-AD mice. Dynamic MS-DG GABAergic circuit remodeling represents a compensatory mechanism to combat DG interneuron hyperactivity induced by reduced GABA transmission.

Published
2023

12. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Author

Liu, Kai, Kim, Juhyun, Kim, Dong Won, Zhang, Yi Stephanie, Bao, Hechen, Denaxa, Myrto, Lim, Szu-Aun, Kim, Eileen, Liu, Chang, Wickersham, Ian R., Pachinis, Vassilis, Hattar, Samer, Song, Juan, Brown, Solange P., and Blackshaw, Seth

Subjects
GABA -- Health aspects, Sleep -- Physiological aspects, Neurons -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Kai Liu [1]; Juhyun Kim [1]; Dong Won Kim [1]; Yi Stephanie Zhang [1]; Hechen Bao [2]; Myrto Denaxa [3]; Szu-Aun Lim [2]; Eileen Kim [4]; Chang Liu [1]; [...]

Published
2017
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13. Dysregulation of hippocampal adult-born immature neurons disrupts a brain-wide network for spatial memory

Author

Bao, Hechen, primary, Hu, Zhiqiang, additional, Lee, Sung-ho, additional, Kolagani, Ramya, additional, Chao, Tzu-Hao Harry, additional, Luo, Yan-Jia, additional, Ban, Woomi, additional, Sullivan, Heather Anne, additional, Gamero-Alameda, Sergio, additional, Lybrand, Zane R., additional, Yu, Yuguo, additional, Hsieh, Jenny, additional, Wickersham, Ian R, additional, Brenner, Steven E, additional, Shih, Yen-Yu Ian, additional, and Song, Juan, additional

Published
2020
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16. Assaying circuit specific regulation of adult neural precursor cells

Author

Quintanilla, Luis J, Yeh, Chia-Yu, Bao, Hechen, Catavero, Christina, and Song, Juan

Subjects
Male, Neurons, Mice, Neural Stem Cells, Neurogenesis, Animals, Clozapine, Hippocampus, Article, Electrophysiological Phenomena
Abstract

Adult neurogenesis is a dynamic process by which newly activated neural stem cells (NSCs) in the subgranular zone (SGZ) of the dentate gyrus (DG) generate new neurons, which integrate into an existing neural circuit and contribute to specific hippocampal functions. Importantly, adult neurogenesis is highly susceptible to environmental stimuli, which allows for activity-dependent regulation of various cognitive functions. A vast range of neural circuits from various brain regions orchestrates these complex cognitive functions. It is therefore important to understand how specific neural circuits regulate adult neurogenesis. Here, we describe a protocol to manipulate neural circuit activity using designer receptor exclusively activated by designer drugs (DREADDs) technology that regulates NSCs and newborn progeny in rodents. This comprehensive protocol includes stereotaxic injection of viral particles, chemogenetic stimulation of specific neural circuits, thymidine analog administration, tissue processing, immunofluorescence labeling, confocal imaging, and imaging analysis of various stages of neural precursor cells. This protocol provides detailed instructions on antigen retrieval techniques used to visualize NSCs and their progeny and describes a simple, yet effective way to modulate brain circuits using clozapine N-oxide (CNO) or CNO-containing drinking water and DREADDs-expressing viruses. The strength of this protocol lies in its adaptability to study a diverse range of neural circuits that influence adult neurogenesis derived from NSCs.

Published
2019

18. Erratum: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Author

Liu, Kai, primary, Kim, Juhyun, additional, Kim, Dong Won, additional, Stephanie Zhang, Yi, additional, Bao, Hechen, additional, Denaxa, Myrto, additional, Lim, Szu-Aun, additional, Kim, Eileen, additional, Liu, Chang, additional, Wickersham, Ian R., additional, Pachnis, Vassilis, additional, Hattar, Samer, additional, Song, Juan, additional, Brown, Solange P., additional, and Blackshaw, Seth, additional

Published
2017
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19. Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Author

Chen, Lei, primary, Serdyuk, Tatiana, additional, Yang, Beimeng, additional, Wang, Shuai, additional, Chen, Shiqing, additional, Chu, Xixia, additional, Zhang, Xu, additional, Song, Jinjing, additional, Bao, Hechen, additional, Zhou, Chengbin, additional, Wang, Xiang, additional, Dong, Shuangle, additional, Song, Lulu, additional, Chen, Fujun, additional, He, Guang, additional, He, Lin, additional, Zhou, Ying, additional, and Li, Weidong, additional

Published
2017
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20. Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.

Author

Catavero, Christina, Bao, Hechen, and Song, Juan

Subjects
*GABAERGIC neurons, *DEVELOPMENTAL neurobiology, *NEURAL stem cells, *NEURAL circuitry, *GRANULE cells
Abstract

Within the dentate gyrus of the adult hippocampus is the subgranular zone, which contains a neurogenic niche for radial-glia like cells, the most primitive neural stem cells in the adult brain. The quiescence of neural stem cells is maintained by tonic gamma-aminobutyric acid (GABA) released from local interneurons. Once these cells differentiate into neural progenitor cells, GABA continues to regulate their development into mature granule cells, the principal cell type of the dentate gyrus. Here, we review the role of GABA circuits, signaling, and receptors in regulating development of adult-born cells, as well as the molecular players that modulate GABA signaling. Furthermore, we review recent findings linking dysregulation of adult hippocampal neurogenesis to the altered GABAergic circuitry and signaling under various pathological conditions. [ABSTRACT FROM AUTHOR]

Published
2018
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22. A Simple Spatial Working Memory and Attention Test on Paired Symbols Shows Developmental Deficits in Schizophrenia Patients

Author

Song, Wei, primary, Zhang, Kai, additional, Sun, Jinhua, additional, Ma, Lina, additional, Jesse, Forrest Fabian, additional, Teng, Xiaochun, additional, Zhou, Ying, additional, Bao, Hechen, additional, Chen, Shiqing, additional, Wang, Shuai, additional, Yang, Beimeng, additional, Chu, Xixia, additional, Ding, Wenhua, additional, Du, Yasong, additional, Cheng, Zaohuo, additional, Wu, Bin, additional, Chen, Shanguang, additional, He, Guang, additional, He, Lin, additional, Chen, Xiaoping, additional, and Li, Weidong, additional

Published
2013
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23. Spatial Working Memory and Attention Test on Paired Symbols

Author

Song, Wei, primary, Zhang, Kai, additional, Sun, Jinhua, additional, Ma, Lina, additional, Jesse, Forrest Fabian, additional, Teng, Xiaochun, additional, Zhou, Ying, additional, Bao, Hechen, additional, Chen, Shiqing, additional, Wang, Shuai, additional, Yang, Beimeng, additional, Chu, Xixia, additional, Ding, Wenhua, additional, Du, Yasong, additional, Cheng, Zaohuo, additional, Wu, Bin, additional, Chen, Shanguang, additional, He, Guang, additional, He, Lin, additional, Chen, Xiaoping, additional, and Li, Weidong, additional

Published
2013
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