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Caffeic acid phenethyl ester (CAPE) is a strong antioxidant extracted from honey bee-hive propolis. The mentioned compound, a well-known NF-κB inhibitor, has been used in traditional medicine as a potent anti-inflammatory agent. CAPE has a broad spectrum of biological properties including anti-viral, anti-bacterial, anti-cancer, immunomodulatory, and wound-healing activities. This review characterizes published data about CAPE biological properties and potential therapeutic applications, that can be used in various diseases.

Introduction Tennis Elbow, known also as Lateral Epicondylitis (LE) is a very common overuse injury affecting not only tennis players. Mainly, it causes pain, weakness in grip strength and difficulties with daily activities. Most patients are successfully treated with non-surgical methods but some of them eventually require surgical intervention. Aim of study The objective of this study is to evaluate both surgical and non-surgical treatment methods for Tennis Elbow and seeks to introduce doctors and patients to the assets and downsides associated with them. State of Knowledge Tennis Elbow occurs in 1-3% of adults, most likely when frequently performing repeated movements of flexion and extension of the elbow. At the early stages inflammation is present, after that the vascular hyperplasia and active fibroblasts occur. Most common risk factors are manual labour, ipsilateral rotator cuff tear, ipsilateral Carpal Tunnel Syndrome (CTS), female sex, dominant-side involvement, and hypertriglyceridemia. Summary (Conclusion) There is a wide range of available conservative treatment methods for Lateral Epicondylitis including physical therapy, various injections, and medication. They should be considered as the first line treatment showing high success rate for mild and moderate cases. Surgical methods have high success rates as well though they are considered more invasive and performed only on chronic patients. Best approach ought to be carefully selected for each patient based on severity of symptoms and patient needs.

Introduction Elastin is a key protein in tendons and ligaments, responsible for providing elasticity, which allows these tissues to withstand mechanical stress and maintain joint stability. However, elastin integrity can decline due to factors such as aging, genetics, or injury, leading to joint instability, chronic pain, and a heightened risk of further damage. This study examines the role of elastin- focused therapies in addressing such issues, with a focus on orthopedics and sports medicine. Objectives The objective of this review is to evaluate emerging elastin-based therapeutic strategies, such as platelet-rich plasma (PRP) therapy, bioengineered scaffolds, and microRNA-based treatments, and their potential to enhance recovery in musculoskeletal injuries by improving tissue elasticity and resilience. Materials and Methods A comprehensive review of the studies available on open access sources, including PubMed, Google Scholar, and the National Library of Medicine, was conducted. The focus was on current advancements in platelet-rich plasma (PRP) therapy, bioengineered scaffolds, and microRNA-based treatments. Studies assessing the efficacy of these approaches in promoting elastin synthesis, tissue flexibility, and repair outcomes were analyzed, particularly in cases involving conditions like Achilles tendinopathy, rotator cuff injuries, and ACL reconstructions. Conclusions Elastin plays a crucial role in tendon and ligament health, and emerging elastin- focused therapies show significant potential in enhancing recovery from musculoskeletal injuries. PRP therapy, bioengineered scaffolds, and microRNA- based treatments have demonstrated promising outcomes in improving tissue flexibility, supporting cell growth, and slowing degenerative processes. Further research and clinical trials are needed to optimize these therapies for long-term patient outcomes in orthopedic and sports medicine.

Introduction: Knee Osteoarthritis (KO) is a progressive, chronic disease that damage the joint cartilage of a knee and leads to a changes in a anatomy of the joint. Both surgical and non-surgical methods are used to treat the disease. In this study, we will compare the invasive vs non-invasive methods of KO treatment. Objectives: The review and presentation of the current state of knowledge on Treating Knee Osteoarthritis, comparing surgery vs non-surgery methods. Material and Methods: Review of the studies available on open access sources at PubMed, Google Scholar and National Library of Medicine. Conclusions: Surgery approach for the Knee Osteoarthritis treatment are more durable, have better pain relief and treat casually the OA. Similar effects cannot be reached by non-surgery methods yet. However, there is a big promise in future studies about non-surgery methods, which can also raise a Quality of Life significantly and even avoid or postpone an operation in some groups of patients.

Introduction Trigger finger, also referred to as trigger finger syndrome, is a condition caused by inflammation of the flexor tendons of the fingers and digital pulleys, resulting in pain and restricted movement. This issue affects numerous individuals, particularly the elderly and those who perform repetitive hand motions. Aim The aim of this study is to explore and compare the available treatment options for trigger finger, including rest, splinting, anti-inflammatory medications, physical therapy, steroid injections, and surgical interventions. Both conservative and surgical approaches have their advantages and limitations, and their effectiveness varies depending on the individual patient’s response. State of Knowledge Medical literature describes a variety of treatment methods, ranging from pharmacological approaches and physical therapy to steroid injections and, in more complex cases, surgical interventions. Conservative treatment, often the initial approach, aims to alleviate symptoms and can be effective in the early stages of the condition. Surgery, on the other hand, is considered when conservative treatment fails or in more advanced cases. Summary The choice of treatment for trigger finger should be tailored to the individual needs of the patient and the severity of the condition. Conservative therapy is effective in the early stages but does not always provide long-lasting relief. Surgery, although more invasive, is typically effective in advanced cases and often leads to a quicker restoration of full finger function.

Introduction Disc herniation is a displacement of an intervertebral disc, most often caused by degeneration of its outer layer, the annulus fibrosus. This condition can cause various symptoms such as numbness, pain, muscle weakness or lose of sensation. While many patients can be successfully treated with non-surgical methods, some of them some require surgical intervention. Aim of study The objective of this study is to evaluate both surgical and non-surgical treatment methods for herniated disc and seeks to introduce doctors and patients to the advantages and disadvantages associated with them. State of Knowledge Disk herniation occurs when disk material prolapses beyond intervertebral disk’s space. The symptoms may arise when displaced material start to compress major structures located nearby, such as spinal nerves. The most common causes include age-related degeneration, repetitive movements, obesity, trauma or genetic predisposition. Summary (Conclusion) Disk herniation can be managed with various non-surgical and surgical methods. Conservative treatment should be considered as first line treatment showing high success rate for mild to moderate cases in long term relief and preventing recurrence of symptoms. Surgical options offer better short-term relief for sever and more advanced cases but carry greater risks of side effects and involve longer recovery time. Best approach should be carefully selected based on the severity of symptoms and patient needs.

Introduction: The term "tendinopathy" refers to pathological changes in tendons. The previously used term "tendonitis" does not fully capture the nature of the condition, as inflammatory changes, when present, are secondary to degenerative damage. Tendinopathies are quite common in the general population. Aim: The aim of this review is to characterize various types of tendinopathies, with a focus on both conservative and surgical treatment methods, in order to organize available information that may be helpful for clinicians in their practice. State of Knowledge: Chronic tendinopathies develop as a result of multiple factors. The most significant include improper exercise techniques, excessive strain, and musculoskeletal system abnormalities. Summary (Conclusions): The approach to tendinopathy treatment should vary depending on the patient's clinical condition and provoking factors. Physiotherapy plays the most important role, along with supportive methods such as analgesic pharmacotherapy and cryotherapy. Surgical intervention may be necessary in cases where conservative treatment fails.

Introduction: Developmental Dysplasia of the Hip (DDH) is an anatomical deformation resulting from abnormal formation of the structures that make up the hip joint. Due to abnormal biomechanics patients with hip dysplasia usually develop radiographic osteoarthritis. Aim of the study: Despite the introduction of screening tests in children, DDH remains an issue among adults. For this group of patients, it is essential to begin treatment as early as possible to prevent early-onset osteoarthritis of the hip joint. In adults it is often too late to implement non-invasive methods such as braces or orthoses. Therefore, in this study, we aim to describe other treatment options for adults with DDH, considering both surgical and non-surgical methods. In the following work, we present both the advantages and complications associated with these surgical methods. Additionally, we describe the non-surgical alternative method of progressive resistance training (PRT) and consider the possibilities of combining it with surgical techniques. We also discuss the potential for pharmacological treatment. Material and Methods: Review of studies available through open-access sources on PubMed, Google Scholar, and the National Library of Medicine. Conclusions: The decision to quickly implement an appropriate treatment plan is crucial for improving the patient's quality of life. The choice of treatment method should consider the patient's age and the severity of the disease. Adults with DDH are most often qualified for surgical procedures, which include periacetabular osteotomy (PAO) and total hip replacement (THR). However, for some patients, surgical procedures may be contraindicated or impossible, and in such cases, other non-invasive methods, such as resistance training or appropriate pharmacotherapy, should be considered. Keywords: hip joint, osteoarthritis, surgery, conservative therapy, hip, Surgical Correction

Rotator cuff injuries are a common cause of shoulder pain and dysfunction, resulting from acute trauma or degenerative changes. These injuries, including partial and full-thickness tears, can significantly impair daily activities and reduce quality of life. Treatment options range from conservative measures, such as physical therapy and NSAIDs, to surgical interventions like arthroscopic repair. The choice of treatment depends on factors such as tear size, patient age, and activity level. This review compares the effectiveness of conservative treatment and surgical repair for rotator cuff injuries, focusing on pain relief, functional recovery, and complication rates. Conservative treatment is typically the first-line approach for partial-thickness tears or patients with lower physical demands. Physical therapy and nonsteroidal anti-inflammatory drugs are common modalities that can improve symptoms, particularly for smaller tears. Corticosteroid injections are also used to provide short-term relief, although their long-term benefits are less clear. For larger or full-thickness tears, surgery is often necessary due to the risk of progressive degeneration and persistent symptoms. Arthroscopic repair is particularly beneficial for younger or more active patients, offering superior long-term outcomes in terms of strength and function. Studies indicate that while conservative treatment and surgery may offer similar short-term outcomes for smaller tears, surgery provides better long-term recovery for more extensive injuries. Ultimately, the decision between conservative and surgical treatment should be individualized, considering tear size, patient age, activity level, and overall health. Surgery is recommended for full-thickness tears or when conservative treatment fails to yield sufficient improvement, while conservative management remains effective for many smaller tears.

Introduction Plantar fasciitis is one of the most common reasons for visits to orthopedic clinics. This tendinopathy can cause medial heel pain, stiffness, and tenderness on the plantar surface of the foot. Both conservative and surgical methods are employed in its treatment. Aim The aim of this study is to evaluate selected conservative treatment methods, such as stretching, the use of orthotic insoles, splints, injections, extracorporeal shockwave therapy, and taping, as well as surgical treatment options. The study presents a comparison of these methods in terms of their effectiveness, advantages, and disadvantages. State of Knowledge The plantar fascia is a stiff, connective tissue structure extending along the plantar surface of the foot. Biomechanical load on the fascia, which supports the medial longitudinal arch, can lead to degenerative changes that underlie plantar fasciitis. Symptoms include pain, particularly in the mornings and late evenings, which intensifies with palpation of the heel area. Summary (Conclusions) Conservative treatments for plantar fasciitis are effective in 90% of patients. There are no studies that conclusively demonstrate the superiority of one treatment method over another. Thus, the choice of therapy should be tailored to the patient's lifestyle, activity level, and financial capability. Surgical intervention is necessary in cases of chronic plantar fasciitis which remains resistant to conservative treatments.

The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro forms on the intensity of the DMBA-induced tumor process in rats and to understand the mechanisms of this action. The effect of genistein supplementation on the content of selected eicosanoids (HETEs, HODE, and HEPE) in the serum of rats was evaluated. The levels and expression of genes encoding various pro-inflammatory cytokines (IL-1, IL-6) and MMP-9 in the blood of rats were also investigated. The biological material for the study was blood obtained from female rats of the Sprague Dawley strain (n = 32). The animals were randomly divided into four groups: animals without supplementation, and animals supplemented at a dose of 0.2 mg/kg b.w. (0.1 mg/mL) with macro, micro (587 ± 83 nm), or nano (92 ± 41 nm) genistein. To induce mammary neoplasia (adenocarcinoma), rats were given 7,12-dimethyl-1,2-benz[a]anthracene (DMBA). The content of selected eicosanoids was determined by liquid chromatography with UV detection. An immunoenzymatic method was used to determine the content of cytokines and MMP-9. The expression of the IL-6, IL-1beta, and MMP-9 genes was determined with quantitative real-time PCR (qRT-PCR) using TaqMan probes. Based on the study, it was shown that supplementation of animals with genistein in macro, micro, and nano forms increased the intensity of the tumor process in rats. It was shown that the content of 12-HEPE, HODE, and 12-HETE in the serum of genistein-supplemented rats was statistically significantly lower with respect to the content of the aforementioned markers in the serum of rats receiving only a standard diet, devoid of supplementation. It was found that animals supplemented with nano-, micro-, and macrogenistein had higher levels of metalloproteinase-9, MMP-9, compared to animals without supplementation. There was a significant increase in MMP-9 gene expression in the blood of macrogenistein-supplemented animals, relative to the other groups of rats. On the basis of the study, it was shown that supplementation of animals with nano-, micro-, and macrogenistein had an effect on the development of the tumor process. Dietary supplementation with genistein significantly decreased the level of selected eicosanoids, which may have significant impacts on cancer development and progression.

Abstract The October effect is known as a rapid and strong decrease in the signal amplitude of radio waves with very low frequency (VLF), reflected at the lowest edge of the ionosphere. This strong decrease can be observed only during the daytime. Although the October effect is long known, it is hardly investigated and its mechanism is still unknown. To get closer to a mechanism, we answer why the October effect does not occur during nighttime. Therefore, average characteristics of the October effect are obtained from different VLF transmitter‐receiver combinations. The occurrence of the October effect is then compared with characteristics of the neutral atmosphere temperature at VLF reflection heights as it seems to act as a proxy for the unknown mechanism. The temperature shows an asymmetric seasonal behavior at daytime VLF reflection heights poleward of 50°N but not during the nighttime, resulting in the October effect.

The outer boundary of the plasmasphere, the plasmapause, is characterized by a sharp electron density gradient that changes under varying space weather conditions. We developed a new model, called the Neustrelitz/ESOC PlasmaPause Model (NEPPM), for providing plasmapause location in terms of L-shell utilizing electron density measurements from the Van Allen Probes from 2012 to 2018 and the IMAGE satellite data from 2001 to 2005. Both datasets were preprocessed, and algorithms were developed for the automatic detection of plasmapause location Lpp where L denotes the McIlwain parameter. The suggested model provides a simple ellipse-based approach determined by the semi-major axis, the eccentricity, and the orientation angle of the semi-major axis. The modelled Lpp varies as a function of the Dst index and magnetic local time MLT. The NEPPM results are compared with the Global Core Plasma Model (GCPM). The plasmapause bulge in the evening hours follows the level of geomagnetic activity. The NEPPM will complete the NPSM (Neustrelitz PlasmaSphere Model), which was derived from dual-frequency GPS measurements onboard the CHAMP satellite mission.

Introduction: Home exercises are a promising alternative to outpatient care or in-hospital exercise programmes. The forms of exercises with the use of robotic devices is constantly developing, and their positive effects have been well-documented.Research objective: The aim of this study was to evaluate the effectiveness of upper limb home-based exercises with the use of the Best Arm robot following the onset of diseases causing spastic paresis in long-term observation.Materials and methods: The study comprised 40 participants at an average age of 58.73 16.80. For a period of 8 months, training of the limb with paresis using the Best Arm device was carried out to test joint mobility, hand grip strength, and to measure the circumference of the forearm and upper arm.Results: Statistical analysis shows a significant change in active and passive range of motion, as well as muscle strength after an 8-month intervention period in the group under study.Conclusions: Home-based exercises using a prototype of the Best Arm device for exercising the upper limb with paresis have had a moderate effect on improving range of motion and muscle strength. However, these exercises did not significantly improve muscle tone or the functional capabilities of the upper limb.