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1. Pharmaceutical Stingless Bees

Author

Vit, Patricia, Bankova, Vassya, Ramírez-Arriaga, Elia, Moreno, Enrique, Zamudio, Fernando, Vit, Patricia, editor, Bankova, Vassya, editor, Popova, Milena, editor, and Roubik, David W, editor

Published
2024
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9. Chemical Composition and Neuroprotective Properties of Indonesian Stingless Bee (Geniotrigona thoracica) Propolis Extract in an In-Vivo Model of Intracerebral Hemorrhage (ICH).

Author

Tandean, Steven, Japardi, Iskandar, Rusda, Muhammad, Indharty, Rr Suzy, Lelo, Aznan, Aman, Renindra Ananda, Amin, Mustafa Mahmud, Siahaan, Andre Marolop Pangihutan, Eyanoer, Putri Chairani, D'Prinzessin, Celine Augla, Lesmana, Ronny, Popova, Milena, Trusheva, Boryana, Bankova, Vassya, and Zulhendri, Felix

Abstract

Stroke is the world's second-leading cause of death. Current treatments for cerebral edema following intracerebral hemorrhage (ICH) mainly involve hyperosmolar fluids, but this approach is often inadequate. Propolis, known for its various beneficial properties, especially antioxidant and anti-inflammatory properties, could potentially act as an adjunctive therapy and help alleviate stroke-associated injuries. The chemical composition of Geniotrigona thoracica propolis extract was analyzed by GC-MS after derivatization for its total phenolic and total flavonoid content. The total phenolic content and total flavonoid content of the propolis extract were 1037.31 ± 24.10 μg GAE/mL and 374.02 ± 3.36 μg QE/mL, respectively. By GC-MS analysis, its major constituents were found to be triterpenoids (22.4% of TIC). Minor compounds, such as phenolic lipids (6.7% of TIC, GC-MS) and diterpenic acids (2.3% of TIC, GC-MS), were also found. Ninety-six Sprague Dawley rats were divided into six groups; namely, the control group, the ICH group, and four ICH groups that received the following therapies: mannitol, propolis extract (daily oral propolis administration after the ICH induction), propolis-M (propolis and mannitol), and propolis-B+A (daily oral propolis administration 7 days prior to and 72 h after the ICH induction). Neurocognitive functions of the rats were analyzed using the rotarod challenge and Morris water maze. In addition, the expression of NF-κB, SUR1-TRPM4, MMP-9, and Aquaporin-4 was analyzed using immunohistochemical methods. A TUNEL assay was used to assess the percentage of apoptotic cells. Mannitol significantly improved cognitive–motor functions in the ICH group, evidenced by improved rotarod and Morris water maze completion times, and lowered SUR-1 and Aquaporin-4 levels. It also significantly decreased cerebral edema by day 3. Similarly, propolis treatments (propolis-A and propolis-B+A) showed comparable improvements in these tests and reduced edema. Moreover, combining propolis with mannitol (propolis-M) further enhanced these effects, particularly in reducing edema and the Virchow-Robin space. These findings highlight the potential of propolis from the Indonesian stingless bee, Geniotrigona thoracica, from the Central Tapanuli region as a neuroprotective, adjunctive therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The Chemical Composition of Scaptotrigona mexicana Honey and Propolis Collected in Two Locations: Similarities and Differences

Author

Gerginova, Dessislava, primary, Popova, Milena, additional, Chimshirova, Ralitsa, additional, Trusheva, Boryana, additional, Shanahan, Maggie, additional, Guzmán, Miguel, additional, Solorzano-Gordillo, Erik, additional, López-Roblero, Estefhanía, additional, Spivak, Marla, additional, Simova, Svetlana, additional, and Bankova, Vassya, additional

Published
2023
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19. Chemical Composition of Scaptotrigona mexicana Honey and Propolis Collected in Two Locations: Similarities and Differences

Author

Gerginova, Dessislava, primary, Popova, Milena, additional, Chimshirova, Ralitsa, additional, Trusheva, Boryana, additional, Shanahan, Maggie, additional, Guzmán, MIguel, additional, Solorzano-Gordillo, Eric, additional, López-Roblero, Estefhanía, additional, Spivak, Marla, additional, Simova, Svetlana, additional, and Bankova, Vassya, additional

Published
2023
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20. Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

Author

Phuong, Diep Thi Lan, primary, Van Phuong, Nguyen, additional, Le Tuan, Nguyen, additional, Cong, Nguyen Thanh, additional, Hang, Nguyen Thu, additional, Thanh, Le Nguyen, additional, Hue, Vu Thi, additional, Vuong, Nguyen Quoc, additional, Ha, Nguyen Thi Thu, additional, Popova, Milena, additional, Trusheva, Boryana, additional, and Bankova, Vassya, additional

Published
2023
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24. Redox-modulation, suppression of 'oncogenic' superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts

Author

Mileva, Milka, Dimitrova, Lyudmila, Popova, Milena, Bankova, Vassya, Krastev, Dimo, Najdenski, Hristo, Zhelev, Zhivko, Ichio, Aoki, and Bakalova, Rumiana

Subjects
hemic and lymphatic diseases
Abstract

Burkitt’s lymphoma is a highly aggressive type of non-Hodgkin’s lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability of ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts from Geum urbanum L. roots and aerial parts on Burkitt`s lymphoma cells (BLC), to elucidate their impact on oxidative stress and cell survival. BLC Raji was treated with EtOAc and n-BuOH extracts to analyze: cell viability; induction of apoptosis; hydroperoxides and reactive nitrogen species (RNS) by 2’,7’-dichlorodihydrofluorescein assay; superoxide by dihydroethidium assay; total antioxidant capacity by TAC assay. All extracts suppressed cell growth and induce apoptosis. n-BuOH extracts possessed higher cytotoxicity and pro-apoptotic activity compared to EtOAc. The fractions decreased the hydroperoxides and RNS levels. There was no correlation between the DCF fluorescence in the treated cells and their viability (R = –0.3722; p > 0.05). Root extracts decreased the superoxide level, while the leaf extracts did not. There was a good correlation between the dihydroethidium fluorescence in the treated cells and their viability (R = 0.9843; p < 0.01). All extracts increased the TAC of BLC. G. urbanum extracts serve as redox-modulators and anti-inflammatory compounds, decreasing the intracellular level of “oncogenic” superoxide and cell proliferation.

Published
2022

29. Natural Deep Eutectic Extracts of Propolis, Sideritis scardica, and Plantago major Reveal Potential Antiageing Activity during Yeast Chronological Lifespan

Author

Vasileva, Bela, primary, Staneva, Dessislava, additional, Grozdanova, Tsvetinka, additional, Petkov, Hristo, additional, Trusheva, Boryana, additional, Alipieva, Kalina, additional, Popova, Milena, additional, Miloshev, George, additional, Bankova, Vassya, additional, and Georgieva, Milena, additional

Published
2022
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37. In Vitro Antineoplastic and Antiviral Activity and In Vivo Toxicity of Geum urbanum L. Extracts

Author

Zaharieva, Maya M., primary, Dimitrova, Lyudmila L., additional, Philipov, Stanislav, additional, Nikolova, Ivanka, additional, Vilhelmova, Neli, additional, Grozdanov, Petar, additional, Nikolova, Nadya, additional, Popova, Milena, additional, Bankova, Vassya, additional, Konstantinov, Spiro M., additional, Zheleva-Dimitrova, Dimitrina, additional, and Najdenski, Hristo M., additional

Published
2021
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46. Propolis extraction methods: a review

Author

Bankova, Vassya, Trusheva, Boryana, and Popova, Milena

Subjects
propolis, solvents
Abstract

Propolis (bee glue) is a sticky material collected by bees from plant resins, it has been proven to possess numerous beneficial pharmacological properties: antibacterial, antiviral, antioxidant, antiinflammatory, immunostimulating, hepatoprotective, cytotoxic, etc. Nowadays, propolis is a popular remedy all over the world, and is available in either pure form or combined with other natural products in over-the-counter preparations, cosmetics, and as a constituent of health foods. The interest in propolis containing commercial products is steadily growing. The extraction is a key step in making use of the bioactive constituents of propolis. The present review summarizes and discusses the available data about classical and modern methods of extraction of propolis with potential large-scale application. The published data concerning maceration, Soxhlet, ultrasound-assisted and microwave-assisted extraction, supercritical CO2 extraction, high-pressure methods, and the application of different solvents are discussed. Concerning the solvents, water – ethanol mixtures remain among the most effective, oil and natural deep eutectic solvents (NADES) have demonstrated promising potential. From the extraction processes, ultrasound-assisted extraction seems to be the optimal method, taking into account extraction time and extraction yield. Of course, more studies are necessary to find the best way to extract bioactive compounds from different types of propolis, based on chemometric optimization approaches, especially with respect to large-scale application.

Published
2021

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