Shaheen, Mohammed, Schindler, Lena, Saar‐Ashkenazy, Rotem, Bani Odeh, Kifah, Soreq, Hermona, Friedman, Alon, and Kirschbaum, Clemens
Violent conflicts are severe traumatic stressors with detrimental effects on physical and mental health, with children and adolescents being particularly at risk. For the hypothalamic–pituitary–adrenal (HPA) axis, characteristic patterns of dysregulation in trauma‐exposed individuals have been shown. This study set out to investigate self‐reported mental well‐being in Palestinian adolescents growing up during the Israeli–Palestinian conflict. Hair cortisol concentrations (HCC) as a psychoendocrine marker for long‐term HPA axis aberrations along with the potential protective factor sense of coherence (SoC; i.e., the global mindset to interpret the world and emerging stressors as comprehensible, manageable, and meaningful) were examined. Between 2014 and 2016, posttraumatic stress disorder (PTSD), depression, anxiety, HCC, and SoC were examined in 233 adolescents aged 11 to 16 from the West Bank. More than half of the participants reported trauma exposure, with 40% fulfilling the criteria of a preliminary PTSD diagnosis and a high prevalence of anxiety and depression. HCC was significantly elevated in the PTSD subgroup compared to the subgroup not exposed to any traumatic events (p = 0.046), with trauma‐exposed individuals in between. HCC was further associated with typical sequelae of traumatic stress. Notably, SoC was inversely related to self‐reported psychopathology, as well as to HCC in the trauma group. The results illustrate the situation of adolescents exposed to chronic traumatic stress and extend the literature on aberrant HPA axis functioning under such conditions. They also point out a central role of SoC, which may imply new strategies to aid individuals exposed to ongoing conflicts. We found elevated concentrations of cortisol, a hormone crucial for the human stress response, in hair samples of Palestinian adolescents with likely posttraumatic stress disorder (PTSD) compared to non‐trauma participants, with trauma‐exposed individuals in between. Notably, such elevations were only visible in individuals with low Sense of Coherence, defined as global interpretation of stressors as comprehensible, manageable and meaningful. This data increases the knowledge on psychoendrocrine sequelae of traumatic stress, highlights the role of protective factors for individual pathogenesis, and provides a potential starting point for interventions. [ABSTRACT FROM AUTHOR]