1. Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro
- Author
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Xian Peng, Yang Ge, Mingyun Li, Biao Ren, Qiang Guo, Michael D. Weir, Bina Yang, Xinxuan Zhou, Xuedong Zhou, Xiaoyu Huang, Lei Cheng, Qi Han, Jingou Liang, Bang-Cheng Yang, Xugang Lu, Dongmei Deng, Hockin H.K. Xu, Thomas W. Oates, Wen Zhou, Haohao Wang, and Preventive Dentistry
- Subjects
Peri-implantitis ,QH301-705.5 ,medicine.medical_treatment ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,Article ,Osseointegration ,Biomaterials ,SDG 3 - Good Health and Well-being ,In vivo ,medicine ,Animal model ,In patient ,Biology (General) ,Dental implant ,Materials of engineering and construction. Mechanics of materials ,Chemistry ,Implant failure ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,In vitro ,Dimethylaminododecyl methacrylate ,TA401-492 ,0210 nano-technology ,Bioactive and therapeutic ,Biotechnology ,Biomedical engineering - Abstract
Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. The method shows good osteogenic properties but weak antibacterial effect. Therefore, we developed combined strategies to combat severe peri-implantitis, which included the use of a novel compound, PD, comprising dendrimers poly(amidoamine) (PAMAM) loading dimethylaminododecyl methacrylate (DMADDM) as well as MAO treatment. Here, we explored the chemical properties of the novel compound PD, and proved that this compound was successfully synthesized, with the loading efficiency and encapsulation efficiency of 23.91% and 31.42%, respectively. We further report the two-stage double benefits capability of PD + MAO: (1) in the first stage, PD + MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo; (2) in the second stage, PD + MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo. This study first reports the two-staged, double benefits of PD + MAO, and demonstrates its potential in clinical applications for inhibiting peri-implantitis, especially in patients with severe infection risk., Graphical abstract Image 1, Highlights • PAMAM-DMADDM shows toxicity reduction and osteoconductive properties in vitro. • Micro-arc oxidation treatment shows osteoconductive but weak antibacterial effect. • PAMAM-DMADDM + Micro-arc oxidation treatment shows multifunctional properties.
- Published
- 2021
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