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4. Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies

Author

Duléry, Rémy, Goudet, Claire, Mannina, Daniele, Bianchessi, Antonio, Granata, Angela, Harbi, Samia, Maisano, Valerio, Chabannon, Christian, Malard, Florent, Brissot, Eolia, Sestili, Simona, Banet, Anne, Van de Wyngaert, Zoé, Belhocine, Ramdane, Ederhy, Stéphane, Castagna, Luca, Bramanti, Stefania, Blaise, Didier, Mohty, Mohamad, Fürst, Sabine, and Devillier, Raynier

Published
2023
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5. Thiotepa, busulfan and fludarabine conditioning-regimen is a promising approach for older adult patients with acute lymphoblastic leukemia treated with allogeneic stem cell transplantation

Author

Banet, Anne, Bazarbachi, Ali, Labopin, Myriam, Stocker, Nicolas, Duléry, Rémy, Malard, Florent, Van de Wyngaert, Zoé, Genthon, Alexis, Memoli, Mara, Legrand, Ollivier, Bonnin, Agnes, Ledraa, Tounes, Belhocine, Ramdane, Sestili, Simona, El-Cheikh, Jean, Mohty, Mohamad, and Brissot, Eolia

Published
2023
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9. Early Cardiac Toxicity Associated With Post-Transplant Cyclophosphamide in Allogeneic Stem Cell Transplantation

Author

Duléry, Rémy, Mohty, Razan, Labopin, Myriam, Sestili, Simona, Malard, Florent, Brissot, Eolia, Battipaglia, Giorgia, Médiavilla, Clémence, Banet, Anne, Van de Wyngaert, Zoé, Paviglianiti, Annalisa, Belhocine, Ramdane, Isnard, Françoise, Lapusan, Simona, Adaeva, Rosa, Vekhoff, Anne, Ledraa, Tounes, Legrand, Ollivier, Cohen, Ariel, Bonnin, Agnès, Ederhy, Stéphane, and Mohty, Mohamad

Published
2021
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10. A combination of 5-azacytidine and nivolumab is a potentially effective rescue therapy in relapsed/refractory AITL.

Author

Ricard, Laure, Cervera, Pascale, Stocker, Nicolas, Corre, Elise, Van de Wyngaert, Zoé, Banet, Anne, Marjanovic, Zora, Dulery, Rémy, Bravetti, Clotilde, Joly, Anne-Christine, Minh Tam Baylatry, and Coppo, Paul

Subjects
NIVOLUMAB, T helper cells, HEMATOPOIETIC stem cell transplantation, AZACITIDINE, T-cell lymphoma
Abstract

Introduction: Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma characterized by a T follicular helper cell phenotype expressing PD-1 (programmed cell death-1). AITL exhibits a poor response to conventional chemotherapy, with a median 5-year overall survival of 44% and a progressionfree survival of 32%. Relapse is common, resulting in a median overall survival of 6 months. Recurrent mutations are detected in genes regulating DNA methylation, including TET2, DNMT3A, and IDH2 variants, along with the prevalent RHOA G17V mutation. In this context, patients treated with the hypomethylating agent 5-azacytidine achieved overall response and complete response rates of 75% and 41%, respectively. We hypothesized that targeted therapies combining anti-PD-1 checkpoint blockers with hypomethylating agents could be efficient in AITL patients and less toxic than standard chemotherapy. Methods: Here, we report the efficacy of a regimen combining 5-azacytidine and nivolumab in nine relapsed or refractory AITL patients. Results: This regimen was well-tolerated, especially in elderly patients. The overall response rate was 78%, including four partial responses (44%) and three complete responses (33%). Allogeneic hematopoietic stem cell transplantation was performed in two patients who reached complete response. Discussion: These preliminary favorable results may serve as a basis for further investigation in prospective studies. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Human herpesvirus type 6 reactivation after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide and antithymocyte globulin: risk factors and clinical impact

Author

Paviglianiti, Annalisa, primary, Maia, Tânia, additional, Gozlan, Joël-Meyer, additional, Brissot, Eolia, additional, Malard, Florent, additional, Banet, Anne, additional, Van de Wyngaert, Zoé, additional, Ledraa, Tounes, additional, Belhocine, Ramdane, additional, Sestili, Simona, additional, Capes, Antoine, additional, Stocker, Nicolas, additional, Bonnin, Agnès, additional, Vekhoff, Anne, additional, Legrand, Ollivier, additional, Mohty, Mohamad, additional, and Duléry, Rémy, additional

Published
2024
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12. COVID-19 outcomes in patients with hematologic disease

Author

Malard, Florent, Genthon, Alexis, Brissot, Eolia, van de Wyngaert, Zoe, Marjanovic, Zora, Ikhlef, Souhila, Banet, Anne, Lapusan, Simona, Sestilli, Simona, Corre, Elise, Paviglianiti, Annalisa, Adaeva, Rosa, M.’Hammedi-Bouzina, Fella, Labopin, Myriam, Legrand, Ollivier, Dulery, Rémy, and Mohty, Mohamad

Published
2020
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13. Thiotepa, Busulfan, and Fludarabine Conditioning Regimen in T Cell-Replete HLA-Haploidentical Hematopoietic Stem Cell Transplantation

Author

Duléry, Rémy, Bastos, Juliana, Paviglianiti, Annalisa, Malard, Florent, Brissot, Eolia, Battipaglia, Giorgia, Médiavilla, Clémence, Giannotti, Federica, Banet, Anne, de Wyngaert, Zoé Van, Ledraa, Tounes, Belhocine, Ramdane, Sestili, Simona, Adaeva, Rosa, Lapusan, Simona, Isnard, Françoise, Legrand, Ollivier, Vekhoff, Anne, Rubio, Marie-Thérèse, Ruggeri, Annalisa, and Mohty, Mohamad

Published
2019
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14. Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies

Author

Malard, Florent, Gaugler, Béatrice, Gozlan, Joel, Bouquet, Lucie, Fofana, Djeneba, Siblany, Lama, Eshagh, Deborah, Adotevi, Olivier, Laheurte, Caroline, Ricard, Laure, Dulery, Rémy, Stocker, Nicolas, van de Wyngaert, Zoe, Genthon, Alexis, Banet, Anne, Memoli, Mara, Ikhlef, Souhila, Sestilli, Simona, Vekhof, Anne, Brissot, Eolia, Marjanovic, Zora, Chantran, Yannick, Cuervo, Nancy, Ballot, Eric, Morand-Joubert, Laurence, and Mohty, Mohamad

Published
2021
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16. Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies

Author

Duléry, Rémy, primary, Goudet, Claire, additional, Mannina, Daniele, additional, Bianchessi, Antonio, additional, Granata, Angela, additional, Harbi, Samia, additional, Maisano, Valerio, additional, Chabannon, Christian, additional, Malard, Florent, additional, Brissot, Eolia, additional, Sestili, Simona, additional, Banet, Anne, additional, Van de Wyngaert, Zoé, additional, Belhocine, Ramdane, additional, Ederhy, Stéphane, additional, Castagna, Luca, additional, Bramanti, Stefania, additional, Blaise, Didier, additional, Mohty, Mohamad, additional, Fürst, Sabine, additional, and Devillier, Raynier, additional

Published
2022
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17. Tixagevimab/cilgavimab for Omicron SARS-CoV-2 infection in patients with haematologic diseases

Author

Otiniano, Armelle, primary, van de Wyngaert, Zoe, additional, Brissot, Eolia, additional, Dulery, Rémy, additional, Gozlan, Joel, additional, Daguenel, Anne, additional, Abi Aad, Yasmine, additional, Ricard, Laure, additional, Stocker, Nicolas, additional, Banet, Anne, additional, Bonnin, Agnes, additional, Alsuliman, Tamim, additional, Marjanovic, Zora, additional, Schnuriger, Aurélie, additional, Coppo, Paul, additional, Legrand, Ollivier, additional, Lacombe, Karine, additional, Mohty, Mohamad, additional, and Malard, Florent, additional

Published
2022
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18. Reduced Post-Transplant Cyclophosphamide Dose Associated with Antithymocyte Globulin in Peripheral Blood Stem Cell Haploidentical Transplantation

Author

Dulery, Remy, primary, Malard, Florent, additional, Brissot, Eolia, additional, Banet, Anne, additional, Sestili, Simona, additional, Belhocine, Ramdane, additional, Calabrò, Martina, additional, Van De Wyngaert, Zoé, additional, Bonnin, Agnès, additional, Ledraa, Tounes, additional, Legrand, Ollivier, additional, Labopin, Myriam, additional, Capderou, Elodie, additional, Cohen, Ariel, additional, Ederhy, Stéphane, additional, and Mohty, Mohamad, additional

Published
2022
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19. Thiotepa, busulfan and fludarabine conditioning-regimen is a promising approach for older adult patients with acute lymphoblastic leukemia treated with allogeneic stem cell transplantation

Author

Banet, Anne, primary, Bazarbachi, Ali, additional, Labopin, Myriam, additional, Stocker, Nicolas, additional, Duléry, Rémy, additional, Malard, Florent, additional, Van de Wyngaert, Zoé, additional, Genthon, Alexis, additional, Memoli, Mara, additional, Legrand, Ollivier, additional, Bonnin, Agnes, additional, Ledraa, Tounes, additional, Belhocine, Ramdane, additional, Sestili, Simona, additional, El-Cheikh, Jean, additional, Mohty, Mohamad, additional, and Brissot, Eolia, additional

Published
2022
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21. Isocitrate dehydrogenase inhibitors as a bridge to allogeneic stem cell transplant in relapsed or refractory acute myeloid leukaemia

Author

Genthon, Alexis, primary, Dragoi, Diana, additional, Memoli, Mara, additional, Hirsch, Pierre, additional, Favale, Fabrizia, additional, Suner, Ludovic, additional, Chaquin, Michael, additional, Boncoeur, Pierre, additional, Marjanovic, Zora, additional, Bonnin, Agnès, additional, Sestili, Simona, additional, Dulery, Remy, additional, Malard, Florent, additional, Brissot, Eolia, additional, Banet, Anne, additional, van de Wyngaert, Zoe, additional, Vekhoff, Anne, additional, Delhommeau, Francois, additional, Mohty, Mohamad, additional, and Legrand, Ollivier, additional

Published
2022
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22. Photobiomodulation: a promising innovative approach for preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation

Author

Stocker, Nicolas, primary, Baltes, Virginie, additional, Bellaiche, Solal, additional, Brouillard, Flora, additional, Belmoufid, Nadia, additional, Rousseau, Céline, additional, Bonnin, Agnès, additional, de Wyngaert, Zoé Van, additional, Ricard, Laure, additional, Banet, Anne, additional, Malard, Florent, additional, Dulery, Remy, additional, Mohty, Mohamad, additional, and Brissot, Eolia, additional

Published
2022
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23. Prognostic impact of early minimal residual disease combined with complete molecular evaluation in acute myeloid leukemia with mutated NPM1: a single center study

Author

Memoli, Mara, primary, Genthon, Alexis, additional, Favale, Fabrizia, additional, Lapusan, Simona, additional, Johnson, Natacha, additional, Adaeva, Rosa, additional, Deswarte, Caroline, additional, Battipaglia, Giorgia, additional, Malard, Florent, additional, Duléry, Rémy, additional, Brissot, Eolia, additional, Banet, Anne, additional, Van de Wyngaert, Zoé, additional, Mohty, Mohamad, additional, Delhommeau, François, additional, Legrand, Ollivier, additional, and Hirsch, Pierre, additional

Published
2022
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25. Sequential Conditioning Regimen with Thiotepa in Allogeneic Hematopoietic Cell Transplantation for the Treatment of Refractory Myeloid Malignancies

Author

Duléry, Rémy, primary, Belmoufid, Nadia, additional, Malard, Florent, additional, Brissot, Eolia, additional, Banet, Anne, additional, Sestili, Simona, additional, Van De Wyngaert, Zoé, additional, Stocker, Nicolas, additional, Radici, Vera, additional, Wieczorek, Michele, additional, Belhocine, Ramdane, additional, Lapusan, Simona, additional, Memoli, Mara, additional, Genthon, Alexis, additional, Vekhoff, Anne, additional, Ledraa, Tounes, additional, Bonnin, Agnès, additional, Legrand, Ollivier, additional, Fenaux, Pierre, additional, Labopin, Myriam, additional, and Mohty, Mohamad, additional

Published
2021
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26. Stable pulmonary function after haploidentical stem cell transplantation with post-transplant cyclophosphamide: a single center experience

Author

Paviglianiti, Annalisa, primary, Sestili, Simona, additional, Bianchessi, Antonio, additional, Memoli, Mara, additional, Dulery, Remy, additional, Banet, Anne, additional, Van De Wyngaert, Zoe, additional, Belhocine, Ramdane, additional, Ledraa, Tounes, additional, Malard, Florent, additional, Mohty, Mohamad, additional, and Brissot, Eolia, additional

Published
2021
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28. Air Transfer of Patients with Newly Diagnosed Acute Myeloid Leukemia: The Experience of French Polynesia

Author

Genthon, Alexis, Memoli, Mara, Genet, Philippe, Heuberger, Laurence, Hirschauer, Claire, Berberian, Anthony, Pierre Louis, Dufens, Van De Wyngaert, Zoé, Banet, Anne, Bonnin, Agnès, Brissot, Eolia, Hirsch, Pierre, Favale, Fabrizia, Suner, Ludovic, Chaquin, Michael, Abermil, Nasséra, Delhommeau, Francois, Vekoff, Anne, Marjanovic, Zora, Mohty, Mohamad, and Legrand, Ollivier

Published
2023
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29. Gemtuzumab Ozogamicin Combined With Intensive Chemotherapy in Patients With Acute Myeloid Leukemia Relapsing After Allogenic Stem Cell Transplantation

Author

Genthon, Alexis, primary, Brissot, Eolia, additional, Malard, Florent, additional, van de Wyngaert, Zoe, additional, Bonnin, Agnès, additional, Banet, Anne, additional, Marjanovic, Zora, additional, Ikhlef, Souhila, additional, Lapusan, Simona, additional, Sestili, Simona, additional, Corre, Elise, additional, Paviglianiti, Annalisa, additional, Adaeva, Rosa, additional, ’Hammedi-Bouzina, Fella M., additional, Labopin, Myriam, additional, Dulery, Rémy, additional, Mohty, Mohamad, additional, and Legrand, Ollivier, additional

Published
2020
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30. Stable Pulmonary Function after Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide: A Single Center Experience

Author

Paviglianiti, Annalisa, primary, Sestili, Simona, additional, Bianchessi, Antonio, additional, Brissot, Eolia, additional, Memoli, Mara, additional, Duléry, Remy, additional, Banet, Anne, additional, Van De Wyngaert, Zoe, additional, Belhocine, Ramdane, additional, Ledraa, Tounes, additional, Malard, Florent, additional, and Mohty, Mohamad, additional

Published
2020
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31. Thiotepa-busulfan-fludarabine as a conditioning regimen for patients with myelofibrosis undergoing allogeneic hematopoietic transplantation: a single center experience

Author

Memoli, Mara, primary, Paviglianiti, Annalisa, additional, Malard, Florent, additional, Battipaglia, Giorgia, additional, Brissot, Eolia, additional, Médiavilla, Clémence, additional, Bianchessi, Antonio, additional, Banet, Anne, additional, Van de Wyngaert, Zoé, additional, Ledraa, Tounes, additional, Belhocine, Ramdane, additional, Sestili, Simona, additional, Lapusan, Simona, additional, Hirsch, Pierre, additional, Favale, Fabrizia, additional, Boussaroque, Agathe, additional, Bonnin, Agnès, additional, Vekhoff, Anne, additional, Legrand, Ollivier, additional, Mohty, Mohamad, additional, and Duléry, Rémy, additional

Published
2020
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32. Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: A single-center experience

Author

Sestili, Simona, primary, Eder, Sandra, additional, Belhocine, Ramdane, additional, Dulery, Remy, additional, Battipaglia, Giorgia, additional, Brissot, Eolia, additional, Mediavilla, Clemence, additional, Banet, Anne, additional, van de Wyngaert, Zoe, additional, Paviglianiti, Annalisa, additional, Ledraa, Tounes, additional, Bonin, Agnes, additional, Mohty, Mohamad, additional, and Malard, Florent, additional

Published
2020
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33. High‐dose post‐transplant cyclophosphamide impairs γδ T‐cell reconstitution after haploidentical haematopoietic stem cell transplantation using low‐dose antithymocyte globulin and peripheral blood stem cell graft

Author

Stocker, Nicolas, primary, Gaugler, Béatrice, additional, Labopin, Myriam, additional, Farge, Agathe, additional, Ye, Yishan, additional, Ricard, Laure, additional, Brissot, Eolia, additional, Duléry, Remy, additional, Sestili, Simona, additional, Battipaglia, Giorgia, additional, Médiavilla, Clémence, additional, Paviglianiti, Annalisa, additional, Banet, Anne, additional, Van De Wyngaert, Zoe, additional, Ledraa, Tounes, additional, Mohty, Mohamad, additional, and Malard, Florent, additional

Published
2020
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34. Stable pulmonary function after haploidentical stem cell transplantation with post-transplant cyclophosphamide: a single center experience.

Author

Paviglianiti, Annalisa, Sestili, Simona, Bianchessi, Antonio, Memoli, Mara, Dulery, Remy, Banet, Anne, Van De Wyngaert, Zoe, Belhocine, Ramdane, Ledraa, Tounes, Malard, Florent, Mohty, Mohamad, and Brissot, Eolia

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, PULMONARY function tests, BRONCHIOLITIS, LUNG volume measurements, CYCLOPHOSPHAMIDE, INTERSTITIAL lung diseases
Abstract

Prior studies have reported pulmonary function tests (PFT) before and after related and unrelated allogeneic hematopoietic stem cell transplantation (HSCT). However, limited data exist on the evaluation of lung function after haploidentical stem cell transplantation (HAPLO) with post-transplant cyclophosphamide (PTCY). We retrospectively reported the evaluation of PFTs at screening before HAPLO in 80 patients at 100 days and 1 year of follow-up. The proportion of surviving patients with available PFTs at 100 days and 1 year were 86% and 68%, respectively. During the follow-up period, four patients met the criteria for bronchiolitis obliterans syndrome and two for interstitial lung disease. Overall survival was 73% (95% CI 62–82%) at 2 years. We observed a significant reduction in diffusing capacity of the lungs for carbon monoxide (DLCO) corrected for the most recent hemoglobin concentration (DLCOc) at 100 days after HAPLO. However, an overall substantial stable pulmonary function was observed at 1 year. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Severe cytopenia after chimeric antigen receptor‐T cell driven by large granular lymphocytes and responsive to steroids.

Author

Capes, Antoine, Morin, Alexandra, Banet, Anne, Suner, Ludovic, Ricard, Laure, Corre, Elise, Brissot, Eolia, Stocker, Nicolas, Marjanovic, Zora, Sarkozy, Clémentine, Mohty, Mohamad, and Malard, Florent

Abstract

Summary Immune effector cell‐associated hematotoxicity (ICAHT) is a common toxicity associated with an important morbidity after chimeric antigen receptor (CAR)‐T‐cell therapy. Multiple factors seem to be involved in the development of severe ICAHT, making its management difficult. Here, we report three cases of severe ICAHT after axicabtagene‐ciloleucel (axi‐cel) for diffuse large B‐cell lymphoma showing an expansion of large granular lymphocyte in the bone marrow with a CD3/CD57‐positive non‐CAR‐T immunophenotype. We show that it is possible to treat them with low‐dose steroids, obtaining a striking resolution of cytopenias with no deleterious impact on the underlying malignancy. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Thiotepa-busulfan-fludarabine as a conditioning regimen for patients with myelofibrosis undergoing allogeneic hematopoietic transplantation: a single center experience.

Author

Memoli, Mara, Paviglianiti, Annalisa, Malard, Florent, Battipaglia, Giorgia, Brissot, Eolia, Médiavilla, Clémence, Bianchessi, Antonio, Banet, Anne, Van de Wyngaert, Zoé, Ledraa, Tounes, Belhocine, Ramdane, Sestili, Simona, Lapusan, Simona, Hirsch, Pierre, Favale, Fabrizia, Boussaroque, Agathe, Bonnin, Agnès, Vekhoff, Anne, Legrand, Ollivier, and Mohty, Mohamad

Subjects
TOTAL body irradiation, MYELOFIBROSIS, GRAFT versus host disease, BUSULFAN, STEM cells, BLOOD cells
Abstract

We assessed the outcomes associated with thiotepa, busulfan and fludarabine (TBF) conditioning regimen in a cohort of 29 consecutive patients allografted for myelofibrosis (MF). The median age was 56 (range 42–70) years. According to the refined Dynamic International Prognostic Scoring System (DIPSS-plus), 15 (52%) patients were classified as high risk. Graft source was peripheral blood stem cells in 27 patients. Donor type was HLA-matched related (n = 5), matched unrelated (n = 16), mismatched unrelated (n = 1), and haploidentical (n = 7). All but 2 patients engrafted. The cumulative incidence (CI) of grade II–IV acute graft-versus-host disease (GVHD) was 21% (95% CI, 10–42) at day 100. The CI of chronic GVHD was 39% (95% CI, 23–65) at 3 years. The median follow-up period was 39 (range 14–60) months. Overall survival was 69% (95% CI, 50–83) at 3 years. No relapse was observed. TBF is a valid conditioning strategy in patients with MF. [ABSTRACT FROM AUTHOR]

Published
2021
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