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MicroRNAs are a class of regulatory, non-coding small ribonucleic acid (RNA) molecules found in eukaryotes. Dysregulated expression of microRNAs can lead to downregulation or upregulation of their target gene. In general, microRNAs bind with the Argonaute protein and its interacting partners to form a silencing complex. This silencing complex binds with fully or partial complementary sequences in the 3’-UTR of their cognate target mRNAs and leads to degradation of the transcripts or translational inhibition, respectively. However, recent developments point towards the ability of these microRNAs to bind to the promoters, enhancers or coding sequences, leading to upregulation of their target genes. This review briefly summarizes the various non-canonical binding sites of microRNAs and their regulatory roles in various diseased conditions.

Teams are essential for most modern work. But who or what is a team? With today’s rapidly diverse team contexts and the diversity of research frameworks for studying them, there is no longer a definitive answer to this question. Thus, Cooke et al. introduced “teamness,” a construct through which future research can describe teamwork as a function of the many dimensions of variability between and within teams. In this multidisciplinary panel moderated by the two lead authors, we discuss the current state and future directions of team cognitive science in light of teamness as a guiding construct, along with its implications for human factors practice.