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Your search keyword '"Bandar Al Hamyari"' showing total 3 results
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3 results on '"Bandar Al Hamyari"'

1. Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies

Author

Eskandar Qaed, Bandar Al-Hamyari, Ahmed Al-Maamari, Abdullah Qaid, Haneen Alademy, Marwan Almoiliqy, Jean Claude Munyemana, Murad Al-Nusaif, Jameel Alafifi, Eman Alyafeai, Mohammed Safi, Zhaohong Geng, Zeyao Tang, and Xiaodong Ma

Subjects
apoptosis, autophagy, cell cycle arrest, fisetin, Genetics, QH426-470, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background Cancer remains a critical global health challenge and a leading cause of mortality. Flavonoids found in fruits and vegetables have gained attention for their potential anti-cancer properties. Fisetin, abundantly present in strawberries, apples, onions, and other plant sources, has emerged as a promising candidate for cancer prevention. Epidemiological studies linking a diet rich in these foods to lower cancer risk have sparked extensive research on fisetin’s efficacy.

Published
2023
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2. Comparative pharmacokinetics of rhubarb anthraquinones loaded nanoemulsion by different plasma drug concentration calculation methods

Author

Shuaibo Yang, Jian-Yin Li, Zhigang Yang, Guifang Zhang, Jincheng Li, Yanbin Shi, Chunxi Qian, Huijuan Lyu, Bandar Al Hamyari, and Xuefeng Li

Subjects
Pharmacology, chemistry.chemical_compound, Chromatography, Plasma drug concentration, Pharmacokinetics, Chemistry, Anthraquinones, Pharmaceutical Science, Calculation methods
Published
2021
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3. Tamsulosin alters the pharmacokinetics of metformin via inhibition of renal multidrug and toxin extrusion protein 1 and organic cation transporter 2 in rats

Author

Abdulaziz Ahmed A. Saad, Fan Zhang, Moath Refat, Eyad Abdulwhab H. Mohammed, Mingkang Zhang, Yuyue Chen, Bandar Al Hamyari, Jameel Alafifi, and Xin’an Wu

Subjects
Male, Tamsulosin, Organic Cation Transport Proteins, Clinical Biochemistry, Organic Cation Transporter 2, Pharmaceutical Science, Kidney, Metformin, Rats, Analytical Chemistry, HEK293 Cells, Tandem Mass Spectrometry, Drug Discovery, Animals, Humans, Spectroscopy, Chromatography, Liquid
Abstract

Among the endocrine and metabolic disorders, type-2 diabetes mellitus (T2DM) and benign prostatic hyperplasia (BPH) are common progressive diseases related to aging. Metformin and tamsulosin as the first-choice drug for patients with T2DM and BPH, respectively, are often co-administered to male patients with T2DM and BPH. However, whether concomitantly administering metformin and tamsulosin leads to drug-drug interactions (DDIs) remains unclear. This study aimed to evaluate the effect of tamsulosin on the pharmacokinetics of metformin and explore the relevant underlying mechanism. The plasma, urine, and tissue concentrations of metformin were analyzed using HPLC, and metformin cell uptake was analyzed using LC-MS/MS. In addition, western blotting was used to investigate the expression of Oct1, Oct2, and Mate1. As demonstrated by comparison with metformin alone, tamsulosin significantly increased the area under concentration-time curves (AUC

Published
2022
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