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Your search keyword '"Banchereau, Jacques F."' showing total 7 results
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7 results on '"Banchereau, Jacques F."'

1. Type I IFN drives unconventional IL-1β secretion in lupus monocytes

Author

Caielli, Simone, Balasubramanian, Preetha, Rodriguez-Alcazar, Juan, Balaji, Uthra, Robinson, Lauren, Wan, Zurong, Baisch, Jeanine, Smitherman, Cynthia, Walters, Lynnette, Sparagana, Paola, Nehar-Belaid, Djamel, Marches, Radu, Nassi, Lorien, Stewart, Katie, Fuller, Julie, Banchereau, Jacques F., Gu, Jinghua, Wright, Tracey, and Pascual, Virginia

Published
2024
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2. Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Author

Nehar-Belaid, Djamel, Hong, Seunghee, Marches, Radu, Chen, Guo, Bolisetty, Mohan, Baisch, Jeanine, Walters, Lynnette, Punaro, Marilynn, Rossi, Robert J., Chung, Cheng-Han, Huynh, Richie P., Singh, Prashant, Flynn, William F., Tabanor-Gayle, Joy-Ann, Kuchipudi, Navya, Mejias, Asuncion, Collet, Magalie A., Lucido, Anna Lisa, Palucka, Karolina, Robson, Paul, Lakshminarayanan, Santhanam, Ramilo, Octavio, Wright, Tracey, Pascual, Virginia, and Banchereau, Jacques F.

Published
2020
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3. An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

Author

Caielli, Simone, primary, Balasubramanian, Preetha, additional, Rodriguez-Alcazar, Juan, additional, Balaji, Uthra, additional, Wan, Zurong, additional, Baisch, Jeanine, additional, Smitherman, Cynthia, additional, Walters, Lynnette, additional, Sparagana, Paola, additional, Nehar-Belaid, Djamel, additional, Marches, Radu, additional, Nassi, Lorien, additional, Stewart, Katie, additional, Fuller, Julie, additional, Banchereau, Jacques F., additional, Gu, Jinghua, additional, Wright, Tracey, additional, and Pascual, Virginia, additional

Published
2023
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4. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

Author

Caielli, Simone, primary, Cardenas, Jacob, additional, de Jesus, Adriana Almeida, additional, Baisch, Jeanine, additional, Walters, Lynnette, additional, Blanck, Jean Philippe, additional, Balasubramanian, Preetha, additional, Stagnar, Cristy, additional, Ohouo, Marina, additional, Hong, Seunghee, additional, Nassi, Lorien, additional, Stewart, Katie, additional, Fuller, Julie, additional, Gu, Jinghua, additional, Banchereau, Jacques F., additional, Wright, Tracey, additional, Goldbach-Mansky, Raphaela, additional, and Pascual, Virginia, additional

Published
2021
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5. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Author

Singhania, Akul, primary, Graham, Christine M., additional, Gabryšová, Leona, additional, Moreira-Teixeira, Lúcia, additional, Stavropoulos, Evangelos, additional, Pitt, Jonathan M., additional, Chakravarty, Probir, additional, Warnatsch, Annika, additional, Branchett, William J., additional, Conejero, Laura, additional, Lin, Jing-Wen, additional, Davidson, Sophia, additional, Wilson, Mark S., additional, Bancroft, Gregory, additional, Langhorne, Jean, additional, Frickel, Eva, additional, Sesay, Abdul K., additional, Priestnall, Simon L., additional, Herbert, Eleanor, additional, Ioannou, Marianna, additional, Wang, Qian, additional, Humphreys, Ian R., additional, Dodd, Jonathan, additional, Openshaw, Peter J. M., additional, Mayer-Barber, Katrin D., additional, Jankovic, Dragana, additional, Sher, Alan, additional, Lloyd, Clare M., additional, Baldwin, Nicole, additional, Chaussabel, Damien, additional, Papayannopoulos, Venizelos, additional, Wack, Andreas, additional, Banchereau, Jacques F., additional, Pascual, Virginia M., additional, and O’Garra, Anne, additional

Published
2019
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6. The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease

Author

Conejero, Laura, primary, Potempa, Krzysztof, additional, Graham, Christine M., additional, Spink, Natasha, additional, Blankley, Simon, additional, Salguero, Francisco J., additional, Pankla-Sranujit, Rungnapa, additional, Khaenam, Prasong, additional, Banchereau, Jacques F., additional, Pascual, Virginia, additional, Chaussabel, Damien, additional, Lertmemongkolchai, Ganjana, additional, O’Garra, Anne, additional, and Bancroft, Gregory J., additional

Published
2015
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7. An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes.

Author

Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P, Nehar-Belaid D, Marches R, Nassi L, Stewart K, Fuller J, Banchereau JF, Gu J, Wright T, and Pascual V

Abstract

Systemic Lupus Erythematosus (SLE) is characterized by autoreactive B cell activation, upregulation of Type I Interferon (IFN) and widespread inflammation. Mitochondrial nucleic acids (NAs) are increasingly recognized as triggers of IFN 1 . Thus, defective removal of mitochondria from mature red blood cells (Mito + RBCs), a feature of SLE, contributes to IFN production by myeloid cells 2 . Here we identify blood monocytes (Mo) that have internalized RBCs and co-express IFN-stimulated genes (ISGs) and interleukin-1β (IL-1β) in SLE patients with active disease. We show that ISG expression requires the interaction between Mito + RBC-derived mitochondrial DNA (mtDNA) and cGAS, while IL-1β production entails Mito + RBC-derived mitochondrial RNA (mtRNA) triggering of RIG-I-like receptors (RLRs). This leads to the cytosolic release of Mo-derived mtDNA that activates the NLRP3 inflammasome. Importantly, IL-1β release depends on the IFN-inducible myxovirus resistant protein 1 (MxA), which enables the translocation of this cytokine into a trans-Golgi network (TGN)-mediated unconventional secretory pathway. Our study highlights a novel and synergistic pathway involving IFN and the NLRP3 inflammasome in SLE.

Published
2023
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