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1. Exploration of the Shared Gene Signatures and Molecular Mechanisms Between Ischemic Stroke and Atherosclerosis

Author

Ban R, Huo C, Wang J, Zhang G, and Zhao X

Subjects
ischemic stroke, atherosclerosis, risk factors, co-expression, biomarker, Medicine (General), R5-920
Abstract

Ru Ban,* Chengju Huo,* Jingru Wang, Guifeng Zhang, Xin Zhao Department of Neurology, Liaocheng People’s Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guifeng Zhang; Xin Zhao, Department of Neurology, Liaocheng People’s Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, No. 67 West Dongchang Road, Liaocheng, Shandong, 252000, People’s Republic of China, Email GFZhangNo.1@gmail.com; zhaoxinsdlc@163.comPurpose: Atherosclerosis (AS) is a chronic inflammatory vascular disease and the predominant cause of ischemic stroke (IS). AS is a potential pathogenetic factor in IS. However, the processes by which they interact remain unknown. The purpose of this paper was to investigate the shared gene signatures and putative molecular processes in AS and IS.Methods: Gene Expression Omnibus (GEO) data for AS and IS microarrays were retrieved. The co-expression modules associated with AS and IS were identified using the Weighted Gene Co-Expression Network Analysis (WGCNA). We constructed an interaction network of shared differentially expressed genes in AS and IS and conducted an enrichment analysis using ClueGO software. We validated the results in a separate cohort through differential gene analysis. Additionally, we retrieved AS and IS-related miRNAs from the Human microRNA Disease Database (HMDD) and predicted their target genes using miRWalk. We then built a network of miRNAs-mRNAs-KEGG pathways using the shared genes.Results: Through WGCNA, we identified five modules and six modules as significant in AS and IS, respectively. A ClueGO enrichment analysis of common genes showed that highly active CCR1 chemokine receptor binding is critical to AS and IS pathogenesis. The differential analysis expression results in another cohort closely matched these findings. The miRNA-mRNA network suggested that hsa-miR-330-5p, hsa-miR-143-3p, hsa-miR-16-5p, hsa-miR-152-3p might regulate the shared gene KRAS, which could be a key player in AS and IS.Conclusion: We integrated ischemic stroke and carotid atherosclerosis public database data and found that ATF3, CCL3, CCL4, JUNB, KRAS, and ZC3H12A may affect both, making them novel biomarkers or therapeutic target genes. Clinical samples and expression trends supported our analyses of pivotal genes.Keywords: ischemic stroke, atherosclerosis, risk factors, co-expression, biomarker

Published
2024

5. Absorption Spectrum and Raman Spectroscopy of Coumarin507 Dye Laser in Different Solvents

Author

Israa Al-Sharuee and Ban R. Ali

Abstract

Coumarin dye laser compounds are often used as components in coloring agents and sprays., as well as in the odorization of foods. Therefore, the important of these compounds in many felids leading to growth of several ways aiming to advance the control of pharmaceutical and superficial producing. Solvents play an important role in changing the character of coumarin. The investigated spectral properties, as well as the effect of changing the solvent on this property, have been published. results referred that the molar electronic transition energy increased with decreasing the maximum absorption wavelength, and the highest intensity of the absorption spectrum was in the case of acetone solvent. In addition, many bands appear in Raman shift attributed to the ''C=O'' band, ''O=C–O, C–C'', and ''C–O'' deformation. The characteristic vibrations involving the ''O-H'' group is the stretching and bending modes of the ''O-H'' and ''C-O'' parts.

Published
2023

7. Sodium silicate-based aerogel in ambient pressure drying: Structural and properties.

Author

Al-Husseny, Wasan H., Al-Sharuee, Israa F., and Ali, Ban R.

Subjects
SOLUBLE glass, AEROGELS, CONTACT angle, ACID catalysts, SODIUM, POLLUTANTS
Abstract

Experiments using silica aerogel powders have yielded positive results. produced from a glass of water and Tetraethylorthosilicate TEOS and ambient pressure desiccating within short time are presented in this work. a glass of water the acid catalyst was HCl, which was hydrolyzed in water. To put it another way to cut down on the amount of modification and preparation During this time, a new mechanical technical procedure was developed. Crushing and filtering were added, as well as a solvent. The process of exchange/surface modification can be completed quickly. in this manner in addition, we used a water glass. instead of the base catalyst NH3H2O It does, to some extent. Contaminants from entering the aerogels were avoided shown to have a significant impact on the chemical and physical characteristics of land-based aerogels. Due to this, when the water glass relative dilution is 4, aerogels develop as a base catalyst. Possesses an advanced mesoporous structure (mean pore size of 20 nm)and a high degree of hydrophobicity (contact angle of 152°). [ABSTRACT FROM AUTHOR]

Published
2023
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12. Clinical implementation of RNA sequencing for Mendelian disease diagnostics

Author

Yépez, V.A., Gusic, M., Kopajtich, R., Mertes, C., Smith, N.H., Alston, C.L., Ban, R., Beblo, S., Berutti, R., Blessing, H., Ciara, E., Distelmaier, F., Freisinger, P., Häberle, J., Hayflick, S.J., Hempel, M., Itkis, Y.S., Kishita, Y., Klopstock, T., Krylova, T.D., Lamperti, C., Lenz, D., Makowski, C., Mosegaard, S., Müller, M.F., Muñoz-Pujol, G., Nadel, A., Ohtake, A., Okazaki, Y., Procopio, E., Schwarzmayr, T., Smet, J., Staufner, C., Stenton, S.L., Strom, T.M., Terrile, C., Tort, F., Coster, R. van, Vanlander, A., Wagner, M., Xu, M., Fang, F., Ghezzi, D., Mayr, J.A., Piekutowska-Abramczuk, D., Ribes, A., Rötig, A., Taylor, R.W., Wortmann, S.B., Murayama, K., Meitinger, T., Gagneur, J., Prokisch, H., Yépez, V.A., Gusic, M., Kopajtich, R., Mertes, C., Smith, N.H., Alston, C.L., Ban, R., Beblo, S., Berutti, R., Blessing, H., Ciara, E., Distelmaier, F., Freisinger, P., Häberle, J., Hayflick, S.J., Hempel, M., Itkis, Y.S., Kishita, Y., Klopstock, T., Krylova, T.D., Lamperti, C., Lenz, D., Makowski, C., Mosegaard, S., Müller, M.F., Muñoz-Pujol, G., Nadel, A., Ohtake, A., Okazaki, Y., Procopio, E., Schwarzmayr, T., Smet, J., Staufner, C., Stenton, S.L., Strom, T.M., Terrile, C., Tort, F., Coster, R. van, Vanlander, A., Wagner, M., Xu, M., Fang, F., Ghezzi, D., Mayr, J.A., Piekutowska-Abramczuk, D., Ribes, A., Rötig, A., Taylor, R.W., Wortmann, S.B., Murayama, K., Meitinger, T., Gagneur, J., and Prokisch, H.

Abstract

Contains fulltext : 283137.pdf (Publisher’s version ) (Open Access), BACKGROUND: Lack of functional evidence hampers variant interpretation, leaving a large proportion of individuals with a suspected Mendelian disorder without genetic diagnosis after whole genome or whole exome sequencing (WES). Research studies advocate to further sequence transcriptomes to directly and systematically probe gene expression defects. However, collection of additional biopsies and establishment of lab workflows, analytical pipelines, and defined concepts in clinical interpretation of aberrant gene expression are still needed for adopting RNA sequencing (RNA-seq) in routine diagnostics. METHODS: We implemented an automated RNA-seq protocol and a computational workflow with which we analyzed skin fibroblasts of 303 individuals with a suspected mitochondrial disease that previously underwent WES. We also assessed through simulations how aberrant expression and mono-allelic expression tests depend on RNA-seq coverage. RESULTS: We detected on average 12,500 genes per sample including around 60% of all disease genes-a coverage substantially higher than with whole blood, supporting the use of skin biopsies. We prioritized genes demonstrating aberrant expression, aberrant splicing, or mono-allelic expression. The pipeline required less than 1 week from sample preparation to result reporting and provided a median of eight disease-associated genes per patient for inspection. A genetic diagnosis was established for 16% of the 205 WES-inconclusive cases. Detection of aberrant expression was a major contributor to diagnosis including instances of 50% reduction, which, together with mono-allelic expression, allowed for the diagnosis of dominant disorders caused by haploinsufficiency. Moreover, calling aberrant splicing and variants from RNA-seq data enabled detecting and validating splice-disrupting variants, of which the majority fell outside WES-covered regions. CONCLUSION: Together, these results show that streamlined experimental and computational processes can

Published
2022

13. Diagnosing pediatric mitochondrial disease: lessons from 2,000 exomes

Author

Husain Ra, Thomas Meitinger, Wilichowski E, Robert Kopajtich, Smirnov D, Ewa Pronicka, Christine Makowski, Elżbieta Ciara, Michael Wagner, Felix Distelmaier, René Santer, Olsen R, Wolstein T, Theresa Brunet, Muller-Felber W, Buchner B, Wolfgang Sperl, Maja Hempel, Stefan Kölker, Dominic Lenz, Sarah L. Stenton, Saskia B. Wortmann, Leiz S, Kei Murayama, Munoz-Pujol G, Konstantopoulou, Xu M, Tobias B. Haack, Tim M. Strom, Riccardo Berutti, Tsygankova P, Lim Az, Daniele Ghezzi, Robert McFarland, Deen D, Kotzaeridou U, Daniela Karall, Ardissone A, Charlotte L. Alston, Markus Schuelke, Thomas Klopstock, Peter Freisinger, Robert W. Taylor, Ban R, Verloo P, van Coster R, Shimura M, Agnès Rötig, Dariusz Rokicki, Yepez, Mandel H, Akira Ohtake, Angela Pyle, Yasushi Okazaki, Mirjana Gusic, Antonia Ribes, Costanza Lamperti, Fang F, Holger Prokisch, von Kleist-Retzow J, Ivo Barić, Julien Gagneur, Bader Alhaddad, Dorota Piekutowska-Abramczuk, Johannes A. Mayr, Michael Zech, Frederic Tort, and Schiff M

Subjects
0303 health sciences, business.industry, Mitochondrial disease, Precision medicine, medicine.disease, Bioinformatics, Phenotype, 3. Good health, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, medicine, Functional studies, business, Gene, Mitochondrial protein, 030217 neurology & neurosurgery, Exome sequencing, 030304 developmental biology
Abstract

BackgroundThe spectrum of mitochondrial disease is genetically and phenotypically diverse, resulting from pathogenic variants in over 400 genes, with aerobic energy metabolism defects as a common denominator. Such heterogeneity poses a significant challenge in making an accurate diagnosis, critical for precision medicine.MethodsIn an international collaboration initiated by the European Network for Mitochondrial Diseases (GENOMIT) we recruited 2,023 pediatric patients at 11 specialist referral centers between October 2010 and January 2021, accumulating exome sequencing and HPO-encoded phenotype data. An exome-wide search for variants in known and potential novel disease genes, complemented by functional studies, followed ACMG guidelines.Results1,109 cases (55%) received a molecular diagnosis, of which one fifth have potential disease-modifying treatments (236/1,109, 21%). Functional studies enabled diagnostic uplift from 36% to 55% and discovery of 62 novel disease genes. Pathogenic variants were identified within genes encoding mitochondrial proteins or RNAs in 801 cases (72%), while, given extensive phenotype overlap, the remainder involved proteins targeted to other cellular compartments. To delineate genotype-phenotype associations, our data was complemented with registry and literature data to develop “GENOMITexplorer”, an open access resource detailing patient- (n=3,940), gene- (n=427), and variant-level (n=1,492) associations (prokischlab.github.io/GENOMITexplorer/).ConclusionsReaching a molecular diagnosis was essential for implementation of precision medicine and clinical trial eligibility, underlining the need for genome-wide screening given inability to accurately define mitochondrial diseases clinically. Key to diagnostic success were functional studies, encouraging early acquisition of patient- derived tissues and routine integration of high-throughput functional data to improve patient care by uplifting diagnostic rate.

Published
2021

17. Estimating Safely Managed Sanitation in Urban Areas; Lessons Learned From a Global Implementation of Excreta-Flow Diagrams

Author

Peal, A, Evans, B, Sangaralingam, A, Ban, R, Blackett, I, Hawkins, P, Schoebitz, L, Scott, R, Sleigh, A, Strande, L, and Veses, O

Abstract

The urban population will rise to 6.7 billion by 2050. The United Nations has committed to provide everyone with safely managed sanitation, but there is limited understanding of the scale of the challenge. This paper describes a methodology for rapid assessment of sanitation in cities including a graphical representation (a shit-flow diagram or SFD) and reports on findings from implementation in 39 cities. The SFD provides high level information for planning purposes covering the entire sanitation system in a city. More than half of the human excreta produced in these cities is not safely managed. The most significant portions of the unsafely managed excreta are: (i) contents of pits and tanks which are not emptied and are overflowing, leaking, or discharging to the surrounding environment (14%); (ii) contents of pits and tanks which are emptied but not delivered to treatment (18%); (iii) fecal sludge and supernatant delivered to treatment but not treated (3%); (iv) wastewater in sewers not delivered to treatment (14%); and (v) wastewater delivered to treatment but not treated (6%). Many cities currently relying on onsite sanitation for safe storage, particularly in Africa, will need new strategies as populations grow. Containment systems that discharge to open drains are common in some Asian cities; these pose a public health risk. Dumping of excreta is widespread and there is a lack of realistic performance data on which estimates of the extent and effectiveness of treatment can be made. The SFD production process can be challenging due to a lack of data and low technical capacity in cities. There is often uncertainty over terminology and over the status of infrastructure. Formalizing definitions for the SFD preparation process was found to be useful in overcoming capacity constraints in cities. The SFD produces a credible snapshot of the sanitation situation in a city. The paper provides evidence of the urgent need for improved management and monitoring of urban sanitation in cities around the world and highlights the role of the SFD as a planning tool.

Published
2020

20. Self-help groups, savings and social capital: Evidence from a field experiment in Cambodia

Author

Ban, R., Gilligan, M.J., Rieger, M. (Matthias), Ban, R., Gilligan, M.J., and Rieger, M. (Matthias)

Abstract

Do self-help groups (SHGs), village-based associations designed to encourage savings, household production and social cohesion among the poor, meet their goals? We examine economic outcomes and the pro-social behavior of 540 households in a randomized control trial (RCT) of a SHG program (randomized at the commune level) in rural Siem Reap, Cambodia using survey data and a rich set of economic and social capital indicators. We measured social capital—defined as social norms and the social networks that support them—with household and network surveys and lab activities that gauge altruism, trust, trustworthiness and the willingness to contribute to public goods. We find that the program successfully increased participation in SHGs and strengthened SHG-related networks. As intended the program significantly increased the number of households with non-zero savings as well as savings levels and it led to a noticeable shift in household production towards livestock. We cannot document increases in household incomes, assets or expenditure. There were also no sizeable wider effects on social capital and networks other than those related to SHGs directly, although we cannot statistically rule out small positive effects in the case of some social capital indicators. In addition to these empirical findings the study provides an example of innovative program evaluation techniques that employed a field experiment, lab-in-the-field behavioral measures, network measures as well as traditional survey measures.

Published
2020
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22. Decreasing azole sensitivity of Z. tritici in Europe contributes to reduced and varying field efficacy

Author

Jørgensen, L. N., primary, Matzen, N., additional, Heick, T. M., additional, Havis, N., additional, Holdgate, S., additional, Clark, B., additional, Blake, J., additional, Glazek, M., additional, Korbas, M., additional, Danielewicz, J., additional, Maumene, C., additional, Rodemann, B., additional, Weigand, S., additional, Kildea, S., additional, Bataille, C., additional, Brauna-Morževska, E., additional, Gulbis, K., additional, Ban, R., additional, Berg, G., additional, Semaskiene, R., additional, and Stammler, G., additional

Published
2020
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23. Improving riboflavin production by modifying related metabolic pathways in Bacillus subtilis.

Author

Xu, J., Wang, C., and Ban, R.

Subjects
VITAMIN B2, BACILLUS subtilis, PYRIMIDINE nucleotides, NUCLEOTIDE synthesis, GENETIC overexpression, FEED additives
Abstract

Riboflavin is a feed additive, food additive and clinical drug, with a significant annual demand of nearly 8000 t. Fermentation using recombinant Bacillus subtilis is currently one of the most important industrial production method for riboflavin. First, a suitable medium was selected and the expression of the ureABC operon was modified. The ykgB gene was overexpressed in B. subtilis RX10, the production of the derivative strain RX20 was increased to 4·61 g l−1 riboflavin, and the yield was increased to 52 mg riboflavin g‐1 glucose. The relative transcription level of pyr operon in RX20 was reduced to 71%, the production of the derivative strain RX21 was increased to 5·82 g l−1 riboflavin, and the yield was 76 mg riboflavin g−1 glucose. The start codon of the pyrE gene in RX21 was modified to 'TTG', the production of the derivative strain RX22 was increased to 7·01 g l−1 riboflavin, and the yield was 89 mg riboflavin g−1 glucose. These results indicated that overexpression of the ykgB gene and reduction of the metabolic flux of de novo synthesis of pyrimidine nucleotides were beneficial to the synthesis of riboflavin. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Development of a high resolution beta camera for a direct measurement of positron distribution on brain surface

Author

Yamamoto, S., Seki, C., Kashikura, K., Fujita, H., Matsuda, T., Ban, R., and Kanno, I.

Subjects
Cameras -- Research, Positrons -- Measurement, Brain mapping -- Equipment and supplies, Business, Electronics, Electronics and electrical industries
Abstract

We have developed and tested a high resolution beta camera for a direct measurement of positron distribution on the brain surface of animals. The beta camera consists of a thin Ca[F.sub.2](Eu) scintillator, a tapered fiber optic plate (tapered fiber) and a position sensitive photomultiplier tube (PSPMT). The tapered fiber is the key component of the camera. We have developed two different sizes of beta cameras. One is 20mm diameter field of view camera for imaging brain surface of cats. The other is 10mm diameter camera for that of rats. Spatial resolutions of the beta camera for cats and rats were 0.8mm FWHM and 0.5mm FWHM, respectively. We demonstrated that developed beta cameras may overcome the limitation of the spatial resolution of positron emission tomography (PET).

Published
1997

25. Combining big data for college students’ network ideological and political innovation education

Author

Ban Ruijun

Subjects
big data, college students, education field, monte carlo algorithm, mca-sampling model, 65y04, Mathematics, QA1-939
Abstract

Do a good job in the way of college students’ network political innovation based on big data thinking, so that it can play a stronger advantage and energy in college education. Carrying out innovative exploration of college students’ curriculum education based on big data thinking can continuously deepen the theoretical research significance of Internet political education. It can also put forward suggestions for better practice of network ideological and political education in colleges and universities, which has the dual significance of theoretical construction and practical guidance. Therefore, the MCA-sampling model is designed in this paper. According to the calculation of the sampling model, the opportunity for online ideological and political data literacy is 11%, and the challenge is 89%. This is because any flaws at any level will bring a severe test to the calculation of the effectiveness of online political teaching methods for students, which greatly increases the difficulty of online political educators. Through the horizontal comparison, it can be seen that the acceptance theory focusing on “receiver-centered” is the most innovative. Its innovativeness is 83%. The probability of timely method innovation is as high as 89%. The most unstable aspect of innovation probability is the root cause. Its probability of innovation is at least 24%.

Published
2024
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27. Search for $h_censuremath ightarrowensuremathpi^+ensuremathpi^ensuremath-J/ensuremathpsi$ via $ensuremathpsi(3686)ensuremath ightarrowensuremathpi^0ensuremathpi^+ensuremathpi^ensuremath-J/ensuremathpsi$

Author

Ablikim, and Achasov, M., and Ahmed, M. N., and Ai, S., and Albrecht, X. C., and Ambrose, M., and Amoroso, D. J., and An, A., and An, F. F., and Bai, Q., and Bakina, J. Z., and Ferroli, O., Baldini and Ban, R., and Bennett, Y., and Bennett, D. W., and Berger, J. V., and Bertani, N., and Bettoni, M., and Bian, D., and Bianchi, J. M., and Boger, F., and Boyko, E., and Briere, I., and Cai, R. A., and Cai, H., and Cakir, X., and Calcaterra, O., and Cao, A., and Cetin, G. F., and Chai, S. A., and Chang, J., and Chelkov, J. F., and Chen, G., and Chen, H. S., and Chen, J. C., and Chen, M. L., and Chen, P. L., and Chen, S. J., and Chen, X. R., and Chu, Y. B., and Cibinetto, X. K., and Dai, G., and Dai, H. L., and Dbeyssi, J. P., and Dedovich, A., and Deng, D., and Denig, Z. Y., and Denysenko, A., and Destefanis, I., and De Mori, M., and Ding, F., and Dong, Y., and Dong, C., and Dong, J., and Dong, L. Y., and Dou, M. Y., and Du, Z. L., and Duan, S. X., and Fang, P. F., and Fang, J., and Fang, S. S., and Farinelli, Y., and Fava, R., and Fegan, L., and Feldbauer, S., and Felici, F., and Feng, G., and Fioravanti, C. Q., and Fritsch, E., and Fu, M., and Gao, C. D., and Gao, Q., and Gao, X. L., and Gao, Y., and Garzia, Z., and Goetzen, I., and Gong, K., and Gong, L., and Gradl, W. X., and Greco, W., and Gu, M., and Gu, M. H., and Guo, Y. T., and Guo, A. Q., and Guo, R. P., and Haddadi, Y. P., and Han, Z., and Hao, S., and Harris, X. Q., and He, F. A., and He, K. L., and Heinsius, X. Q., and Held, F. H., and Heng, T., and Holtmann, Y. K., and Hou, T., and Hu, Z. L., and Hu, H. M., and Hu, T., and Huang, Y., and Huang, G. S., and Huang, J. S., and Huang, X. T., and Huang, X. Z., and Hussain, Z. L., and Andersson, T., Ikegami and Ji, W., and Ji, Q., and Ji, Q. P., and Ji, X. B., and Jiang, X. L., and Jiang, L. W., and Jiang, X. S., and Jiao, X. Y., and Jiao, J. B., and Jie, Z., and Jin, Q. L., and Jin, D. P., and Johansson, S., and Julin, T., and Kalantar-Nayestanaki, A., and Kang, N., and Kang, X. L., and Kavatsyuk, X. S., and Ke, M., and Kiese, B. C., and Kliemt, P., and Kloss, R., and Kolcu, B., and Kopf, O. B., and Kornicer, B., and Kupsc, M., and Pacetti, S.

Published
2018

28. Improved measurements of $ensuremathchi_cJensuremath ightarrowmathrmensuremathSigma^+overlinemathrmensuremathSigma^ensuremath-$ and $mathrmensuremathSigma^0overlinemathrmensuremathSigma^0$ decays

Author

Ablikim, and Achasov, M., and Ahmed, M. N., and Albrecht, S., and Alekseev, M., and Amoroso, M., and An, A., and An, F. F., and Bai, Q., and Bai, J. Z., and Bakina, Y., and Baldini Ferroli, O., and Ban, R., and Bennett, Y., and Bennett, D. W., and Berger, J. V., and Bertani, N., and Bettoni, M., and Bian, D., and Bianchi, J. M., and Boger, F., and Boyko, E., and Briere, I., and Cai, R. A., and Cai, H., and Cakir, X., and Calcaterra, O., and Cao, A., and Cetin, G. F., and Chai, S. A., and Chang, J., and Chelkov, J. F., and Chen, G., and Chen, H. S., and Chen, J. C., and Chen, M. L., and Chen, S. J., and Chen, X. R., and Chu, Y. B., and Cibinetto, X. K., and Dai, G., and Dai, H. L., and Dbeyssi, J. P., and Dedovich, A., and Deng, D., and Denig, Z. Y., and Denysenko, A., and Destefanis, I., and De Mori, M., and Ding, F., and Dong, Y., and Dong, C., and Dong, J., and Dong, L. Y., and Dorjkhaidav, M. Y., and Dou, O., and Du, Z. L., and Duan, S. X., and Fang, P. F., and Fang, J., and Fang, S. S., and Fang, X., and Farinelli, Y., and Fava, R., and Fegan, L., and Feldbauer, S., and Felici, F., and Feng, G., and Fioravanti, C. Q., and Fritsch, E., and Fu, M., and Gao, C. D., and Gao, Q., and Gao, X. L., and Gao, Y., and Gao, Y. G., and Garillon, Z., and Garzia, B., and Goetzen, I., and Gong, K., and Gong, L., and Gradl, W. X., and Greco, W., and Gu, M., and Gu, M. H., and Gu, S., and Guo, Y. T., and Guo, A. Q., and Guo, L. B., and Guo, R. P., and Haddadi, Y. P., and Han, Z., and Hao, S., and Harris, X. Q., and He, F. A., and He, K. L., and Heinsius, X. Q., and Held, F. H., and Heng, T., and Holtmann, Y. K., and Hou, T., and Hu, Z. L., and Hu, C., and Hu, H. M., and Hu, J. F., and Hu, T., and Huang, Y., and Huang, G. S., and Huang, J. S., and Huang, S. H., and Huang, X. T., and Huang, X. Z., and Hussain, Z. L., and Ikegami Andersson, T., and Ji, W., and Ji, Q., and Ji, Q. P., and Ji, X. B., and Jiang, X. L., and Jiang, X. S., and Jiao, X. Y., and Jiao, J. B., and Jin, Z., and Jin, D. P., and Jin, S., and Johansson, Y., and Julin, T., and Kalantar-Nayestanaki, A., and Kang, N., and Kang, X. L., and Kavatsyuk, X. S., and Ke, M., and Khan, B. C., and Khoukaz, T., and Kiese, A., and Kliemt, P., and Koch, R., and Kolcu, L., and Kopf, O. B., and Kornicer, B., and Kuemmel, M., and Kuhlmann, M., M. and Kupsc A., and Pacetti, S.

Published
2018

29. Azoles Have Different Strengths and Perform Diversely Across Europe

Author

Jørgensen, Lise Nistrup, Matzen, Niels, Semaskiene, R., Korbas, M., Danielewicz, J., Glazek, M., Maumene, C., Rodemann, B., Weigand, S., Hess, M., Blake, J., Clark, B., Kildea, S., Bataille, C., Ban, R., Deising, H.B., Fraaije, B., Mehl, A., Oerke, E.C., Sierotzki, H., and Stammler, G.

Published
2017

30. Axial muscle weakness and the rimmed vacuoles in muscle histology in inflammatory myopathy with anti-ku antibody: a case report.

Author

Qiao, L, Ban, R, and Shi, Q

Subjects
*MUSCLE weakness, *MYOSITIS, *HISTOLOGY, *MUSCLE diseases, *INCLUSION body myositis, *IMMUNOGLOBULINS
Abstract

A 41-year-old male Chinese patient had an incidental finding of elevated serum creatine kinase (4000 U/L, normal range 2-200 U/L) during a routine physical examination 3 years ago, which fluctuated between 300 and 400 U/L in a series of re-examinations. The proximal muscle strength of the extremities was 4/4 and bilateral distal muscle strength was 5/5, according to the Medical Research Council scale of muscle strength. 3 Yoshida T, Yoshida M, Mitsuyo K, Jonosono M, Higuchi I. Dropped head syndrome and the presence of rimmed vacuoles in a muscle biopsy in scleroderma-polymyositis overlap syndrome associated with anti-ku antibody. [Extracted from the article]

Published
2022
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33. Decreasing azole sensitivity of Z. triticiin Europe contributes to reduced and varying field efficacy

Author

Jørgensen, L. N., Matzen, N., Heick, T. M., Havis, N., Holdgate, S., Clark, B., Blake, J., Glazek, M., Korbas, M., Danielewicz, J., Maumene, C., Rodemann, B., Weigand, S., Kildea, S., Bataille, C., Brauna-Morževska, E., Gulbis, K., Ban, R., Berg, G., Semaskiene, R., and Stammler, G.

Abstract

Septoria tritici blotch (STB; Zymoseptoria tritici) is the most important leaf disease of wheat in Northern and Western Europe. The problem of fungicide resistance in Z. triticipopulations is challenging future control options. In order to investigate differences in azole performances against STB, 55 field trials were carried out during four seasons (2015–2018). These trials were undertaken in ten different countries across Europe covering a diversity of climatic zones and agricultural practices. During all four seasons, four single azoles (epoxiconazole, prothioconazole, tebuconazole and metconazole) were tested. Increasing variability in the performances of these azoles against STB was observed across Europe. The efficacy of the tested azoles varied considerably across the continent and between countries. The shifts in disease control from these commonly used azoles were confirmed by increasing EC50values for epoxiconazole, prothioconazole-desthio and metconazole. The sensitivity towards tebuconazole remained relatively low across the four years. The frequencies of CYP51mutations varied substantially across Europe, with a clear pattern of significantly decreasing frequencies of D134G, V136A and S524T in the local Z. triticipopulations from west to east. In contrast, no major differences were seen for CYP51mutations V136C, A379 and I381V. The four azoles showed different levels of cross-resistance, which again depended on specific CYP51mutations. Across the four seasons, the single azoles increased the yields between 9 and 11% on average.

Published
2021
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36. Fabrication and characterization of ZnO/Si Heterojunction by Laser Ablation for Solar Cell Application.

Author

Ali, Ban R.

Subjects
LASER ablation, SOLAR cells, HETEROJUNCTIONS, SOLAR cell efficiency, SEMICONDUCTOR materials, OPTICAL microscopes, ND-YAG lasers
Abstract

Copyright of Al-Mustansiriyah Journal of Science is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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37. Shifting sensitivity of septoria tritici blotch compromises field performance and yield of main fungicides in Europe

Author

Lise Nistrup Jørgensen, Niels Matzen, Thies Marten Heick, Aoife O’Driscoll, Bill Clark, Katherine Waite, Jonathan Blake, Mariola Glazek, Claude Maumene, Gilles Couleaud, Bernd Rodemann, Stephan Weigand, Charlotte Bataille, Bán R, Pierre Hellin, Steven Kildea, and Gerd Stammler

Subjects
14α-demethylase, SDHI fungicides, cross-resistance, fenpicoxamid, yield response, Zymoseptoria tritici, Plant culture, SB1-1110
Abstract

Septoria tritici blotch (STB; Zymoseptoria tritici) is a severe leaf disease on wheat in Northern Europe. Fungicide resistance in the populations of Z. tritici is increasingly challenging future control options. Twenty-five field trials were carried out in nine countries across Europe from 2019 to 2021 to investigate the efficacy of specific DMI and SDHI fungicides against STB. During the test period, two single DMIs (prothioconazole and mefentrifluconazole) and four different SDHIs (fluxapyroxad, bixafen, benzovindiflupyr and fluopyram) along with different co-formulations of DMIs and SDHIs applied at flag leaf emergence were tested. Across all countries, significant differences in azole performances against STB were seen; prothioconazole was outperformed in all countries by mefentrifluconazole. The effects also varied substantially between the SDHIs, with fluxapyroxad providing the best efficacy overall, while the performance of fluopyram was inferior to other SDHIs. In Ireland and the UK, the efficacy of SDHIs was significantly lower compared with results from continental Europe. This reduction in performances from both DMIs and SDHIs was reflected in yield responses and also linked to decreased sensitivity of Z. tritici isolates measured as EC50 values. A clear and significant gradient in EC50 values was seen across Europe. The lower sensitivity to SDHIs in Ireland and the UK was coincident with the prevalence of SDH-C-alterations T79N, N86S, and sporadically of H152R. The isolates’ sensitivity to SDHIs showed a clear cross-resistance between fluxapyroxad, bixafen, benzovindiflupyr and fluopyram, although the links with the latter were less apparent. Co-formulations of DMIs + SDHIs performed well in all trials conducted in 2021. Only minor differences were seen between fluxapyroxad + mefentrifluconazole and bixafen + fluopyram + prothioconazole; the combination of benzovindiflupyr + prothioconazole gave an inferior performance at some sites. Fenpicoxamid performed in line with the most effective co-formulations. This investigation shows a clear link between reduced field efficacy by solo SDHIs as a result of increasing problems with sensitivity shifting and the selection of several SDH-C mutations. The presented data stress the need to practice anti-resistance strategies to delay further erosion of fungicide efficacy.

Published
2022
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38. A longitudinal study of strength and gait after arthroscopic partial meniscectomy

Author

Tim V. Wrigley, Rana S Hinman, Michelle Hall, Kim L Bennell, David Lloyd, Ban R. Metcalf, Alasdair R. Dempsey, Flavia M. Cicuttini, and Peter Mills

Subjects
Adult, Male, medicine.medical_specialty, Longitudinal study, Sports medicine, Knee Joint, Physical Therapy, Sports Therapy and Rehabilitation, Osteoarthritis, Isometric exercise, Walking, Menisci, Tibial, Quadriceps Muscle, Arthroscopy, Isometric Contraction, medicine, Humans, Orthopedics and Sports Medicine, Longitudinal Studies, Muscle Strength, Gait, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Biomechanical Phenomena, Adduction moment, Case-Control Studies, Physical therapy, Female, business, human activities
Abstract

Purpose: Individuals after arthroscopic partial meniscectomy (APM) are at increased risk of developing knee osteoarthritis (OA). Knee muscle weakness and a higher external knee adduction moment (KAM) are potential risk factors for knee OA. This exploratory longitudinal study assessed these risk factors at baseline in an APM group (3 months after surgery) and control group, and again 2 yrs later (follow-up). Methods: Eighty-two participants with medial APM and 38 healthy controls were assessed at baseline, with 66 (79%) and 23 (61%), respectively, retested at follow-up. Outcome measures included isokinetic knee muscle strength and medial knee joint load inferred through indices of the KAM during normal and fast-pace walking. Results: Knee muscle strength was reduced by 14%–16% in the APM leg compared with controls at baseline (P ≤ 0.006). However, strength increased in the APM leg over the 2 yrs such that there were no differences compared with controls at follow-up. KAM impulse was at least 20% higher for the APM group (both legs) when compared with controls at baseline and remained similarly higher 2 yrs later (P ≤ 0.022). At baseline peak, KAM was 18% higher in the APM leg as compared with controls only during fast-pace walking (P = 0.013). The peak KAM increased over the 2 yrs in the APM leg by 8%–9% (P ≤ 0.032), although there were no differences in change in KAM between the APM leg and controls. Conclusion: This study found that although knee muscle strength improved, dynamic medial joint load increased over the 2 yrs after APM surgery. These findings may aid in developing therapeutic interventions aimed to prevent or delay the onset of knee OA after APM.

Published
2013

43. Organisatie van grote gemeenten bij stedelijke gebiedsontwikkeling - Sturen in een netwerkomgeving

Author

Van den Ban, R. (author) and Van den Ban, R. (author)

Abstract

De organisatie van een stereotype gemeente staat lijnrecht tegenover een effectieve organisatie bij gebiedsontwikkeling. Gebiedsontwikkeling wordt gekenmerkt door dynamiek en wederzijdse afhankelijkheden. Een effectieve organisatie is als reactie daarop flexibel en extern gericht, in tegenstelling tot de gemeentelijke organisatie die op stabiliteit en intern gericht is. Omdat beide reacties binnen de organisatie noodzakelijk zijn, moet de gemeente een balans vinden waarin het beide kanten op kan., Urban Area Development, Real Estate & Housing, Architecture and The Built Environment

Published
2014

49. A syntax of hoverfly flight prototypes.

Author

Geurten, Ban R. H., Kern, Roland, Braun, Elke, and Egelhaaf, Martin

Subjects
*SYRPHIDAE, *SACCADIC eye movements, *ERISTALIS, *RETINAL (Visual pigment), *ANIMAL mechanics, *CLUSTER analysis (Statistics)
Abstract

Hoverflies such as Eristalis tenax Linnaeus are known for their distinctive flight style. They can hover on the same spot for several seconds and then burst into movement in apparently any possible direction. In order to determine a quantitative and structured description of complex flight manoeuvres, we searched for a set of repeatedly occurring prototypical movements (PMs) and a set of rules for their ordering. PM5 were identified by applying clustering algorithms to the translational and rotational velocities of the body of Eristalis during free-flight sequences. This approach led to nine stable and reliable PMs, and thus provided a tremendous reduction in the complexity of behavioural description. This set of PMs together with the probabilities of transition between them constitute a syntactical description of flight behaviour. The PMs themselves can be roughly segregated into fast rotational turns (saccades) and a variety of distinct translational movements (intersaccadic intervals). We interpret this segregation as reflecting an active sensing strategy which facilitates the extraction of spatial information from retinal image displacements. Detailed analysis of saccades shows that they are performed around all rotational axes individually and in all possible combinations. We found the probability of occurrence of a given saccade type to depend on parameters such as the angle between the long body axis and the direction of flight. [ABSTRACT FROM AUTHOR]

Published
2010
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