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Additional file 3: Additional Table 1. Association between the incidence rate of childhood acute lymphoblastic leukaemia and three potential ecological confounders characterising the municipality of residence at birth: size of urban unit, residential UV radiation exposure, and a socioeconomic deprivation index (RNCE, 1990–2015).

Additional file 4: Additional Table 2. Distribution of the at-risk population a over 1990-2015 by category of crop density and potential confounding factor stratum (size of urban unit, residential UV radiation exposure, and a French deprivation index), children born in 1990-2015, mainland France.

Additional file 5: Additional Table 3. Association between AL incidence rate and crop densitya in municipalities of residence at birth with restriction to municipalities situated outside of the Paris urban unit, and municipalities in urban units with a population of less than 100,000, mainland France, RNCE, 1990–2015.

Additional file 6: Additional Table 4. Association between ALL and BCP-ALL incidence rates and crop densitiesa in the municipalities of residence at birth, stratified by age group (mainland France, RNCE, 1990–2015).

Additional file 7: Additional Table 5. Bibliography.

Additional file 1: Additional Figure 1. Annual standardized incidence ratio (SIR) of childhood AL, RNCE, 1990-2015, mainland France.

Additional file 1.

Viral hepatitis is a major public health problem worldwide and in Burkina Faso. Traditional healers are widely involved in its therapeutic management. The aim of our study was to investigate the knowledge attitudes and practices of traditional healers on viral hepatitis. This is a descriptive cross-acted study of February the 1st to April the 30th, 2015 with 100 traditional practitioners affiliated to the two associations of traditional practitioners in Bobo Dioulasso. The knowledge on viral hepatitis appeared generally unsufficient in 95%. We recorded a good level of knowledge on the definition in 57% of viral etiology in 8.8%, on the kinds of viral hepatitis in 3.5%. The main routes of contamination pathways namely sexual and blood were known to 44.4% and 11.1% respectively. The mother-child transmission was known only 5.5%. Regarding the clinical, jaundice and fever were known only to 14,03% and 3.5% respectively. Vaccination was only known to only 26.4%. Literacy has been associated with a good overall knowledge of viral hepatitis (p=0.01) as opposed to ancienty in practice (0.16). The plants are central to the therapeutic arsenal for 91.5% of TP. Most cited were Chrysantheliumamericana, Combretummicranthum, Cochlespermumtinctorium, Anogeissusleiocarpus, Terminaliamacropter. The leaves were the most used (62.5%). The form of the most common presentation was decoction (82.6%). The route of administration the most recommended was oral (91.3). Medical Analyses were the main reason for reference to modern medicine (62.5%). This study demonstrated a knowledge of TP deficiency on viral hepatitis. The knowledge was associated with literacy. The plants dominate in the armamentarium of the TP, some found in our study should be the subject of pharmacological studies.

International audience; Background Several studies have addressed the potential seasonality of childhood acute leukaemia (AL) without conclusive results. Using data from the National Registry of Childhood Cancers over 1990-2014 in mainland France, we investigated the seasonal variations in childhood AL taken together, and lymphoblastic (ALL) and myeloid (AML) leukaemia separately. Methods Assuming constant variations over 1990-2014, we used a Poisson regression model to evaluate variations in standardized incidence ratios (SIRs) by month of birth or diagnosis. A scan method for temporal cluster detection was used to identify windows of several consecutive months with high or low SIR. The yearly reproducibility of the observed monthly variations was then evaluated. Results We included 11,528 AL, of which 9,493 ALL and 1,843 AML. No seasonal variation was detected for ALL. With a clear seasonal pattern, differences in AML incidence rates were evidenced between January-April and May-December birth periods (SIR=0.85 95% CI 0.77-0.94 and SIR=1.07 95% CI 1.01-1.14, respectively). AML incidence variations by month of diagnosis were less clear-cut. Conclusion Based on a large number of cases from a high-quality registry, we did not evidence any seasonality in ALL incidence rates but evidenced seasonal variations in AML incidence rates by month of birth.