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20. Effekte eines mit Brain-Derived Neurotrophic Factor funktionalisierten pastenartigen Knochenzements auf die metaphysäre Heilung in einem neuen murinen osteoporotischen Frakturmodell

Author

Kauschke, V, additional, Schneider, M, additional, Jauch, A, additional, Schumacher, M, additional, Kampschulte, M, additional, Rohnke, M, additional, Henß, A, additional, Bamberg, C, additional, Trinkaus, K, additional, Gelinsky, M, additional, Heiß, C, additional, and Lips, KS, additional

Published
2019
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30. First-trimester intervention in twin reversed arterial perfusion sequence.

Author

Tavares de Sousa, M., Glosemeyer, P., Diemert, A., Bamberg, C., and Hecher, K.

Subjects
FETOSCOPY, FIRST trimester of pregnancy, CHILDBIRTH, TWINS, PERFUSION, NEODYMIUM lasers, ULTRASONIC imaging, FETOFETAL transfusion, LASER therapy, GESTATIONAL age, RETROSPECTIVE studies, PREGNANCY outcomes, SURVIVAL analysis (Biometry), PRENATAL care, MULTIPLE pregnancy, LONGITUDINAL method, FETAL ultrasonic imaging, SURGERY
Abstract

Objective: To report the outcome of monochorionic twins with twin reversed arterial perfusion (TRAP) sequence following interstitial laser therapy in the first trimester.Methods: This was a retrospective cohort study of all consecutive cases of TRAP that underwent interstitial laser therapy at ≤ 14 + 3 weeks' gestation between January 2014 and April 2016. Interstitial laser treatment was performed under ultrasound guidance using a 400-nm Nd:YAG laser fiber. Hospital records were reviewed to ascertain perinatal survival and morbidity.Results: Twelve monochorionic twin pregnancies underwent interstitial laser treatment of the umbilical artery of the acardiac fetus, at a median gestational age of 13 + 5 (interquartile range (IQR), 13 + 4 to 14 + 0) weeks. In all cases, one treatment was sufficient to achieve complete interruption of the perfusion of the acardiac twin. There were no procedure-related complications during or within 48 h after the procedure. In one (8.3%) case, intrauterine death of the pump twin occurred 2 weeks after the intervention. All other cases (91.7%) resulted in a live birth at a median gestational age of 39 + 6 (IQR, 37 + 1 to 41 + 2) weeks and with a median birth weight of 3370 (IQR, 2980-3480) g. No neonatal mortality or serious morbidity occurred.Conclusions: Our results support the use of interstitial laser therapy in the first trimester of pregnancy complicated by TRAP sequence, showing a live birth rate of 92%. The results of a randomized controlled trial, evaluating early vs late intervention in pregnancy with TRAP sequence, are awaited. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2020
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31. In utero development of symmetric thalamic and brainstem necrosis in a preterm hydropic stillborn

Author

Szekessy Dp, Gisela Stoltenburg-Didinger, Angela M. Kaindl, Blechschmidt C, and Bamberg C

Subjects
Adult, Male, Pathology, medicine.medical_specialty, HELLP Syndrome, Necrosis, Hydrops Fetalis, Pathology and Forensic Medicine, Thalamus, Pregnancy, Intensive care, otorhinolaryngologic diseases, Medicine, Humans, Lung hypoplasia, reproductive and urinary physiology, Fetus, business.industry, Infant, Newborn, General Medicine, Stillbirth, Neurology, In utero, Anesthesia, Gestation, Premature Birth, Female, Neurology (clinical), Brainstem, medicine.symptom, business, Thalamic lesions, Brain Stem
Abstract

Focal and symmetric necrotic lesions of the brainstem are thought to result from fetal hypotension or cardiac arrest in the perinatal period and thus occur in the course of postnatal intensive care rather than in utero. Here, we report for the first time on brainstem necrosis in a preterm stillborn demonstrating that brainstem necrosis occurs already in utero. The preterm stillborn of 28 weeks gestation of a mother that suffered from HELLP-syndrome was severely affected by a fetal hydrops with bilateral pleural effusions and lung hypoplasia. Bilateral tegmental brainstem necrosis and thalamic lesions were detected.

Published
2010

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