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4. EP13.01-002 Radiomic Signature on CT Images: A Noninvasive Biomarker for Pretreatment Discrimination of EGFR Mutations in NSCLC Patients

Author

Kahya, Y., primary, Orhan, K., additional, Buyukceran, E.U., additional, Gumustepe, E., additional, Ozakinci, H., additional, Koksoy, E.B., additional, Ibrahimov, F., additional, Baloglu, S., additional, Coruh, A. Gursoy, additional, Akyurek, S., additional, Sak, S. Dizbay, additional, and Cangir, A. Kayi, additional

Published
2022
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11. Motivation scales.

Author

Gursoy, D., primary, Uysal, M., additional, Sirakaya-Turk, E., additional, Ekinci, Y., additional, and Baloglu, S., additional

Published
2014
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13. Introduction.

Author

Gursoy, D., primary, Uysal, M., additional, Sirakaya-Turk, E., additional, Ekinci, Y., additional, and Baloglu, S., additional

Published
2014
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14. Human resources scales.

Author

Gursoy, D., primary, Uysal, M., additional, Sirakaya-Turk, E., additional, Ekinci, Y., additional, and Baloglu, S., additional

Published
2014
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16. Tourist behavior scales.

Author

Gursoy, D., primary, Uysal, M., additional, Sirakaya-Turk, E., additional, Ekinci, Y., additional, and Baloglu, S., additional

Published
2014
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17. Image scales.

Author

Gursoy, D., primary, Uysal, M., additional, Sirakaya-Turk, E., additional, Ekinci, Y., additional, and Baloglu, S., additional

Published
2014
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19. Coronavirus Disease 2019: Associated Multiple Organ Damage: Associated Multiple Organ Damage

Author

Collange, O. (Olivier), Tacquard, C. (Charles), Delabranche, X. (Xavier), Leonard-Lorant, I. (Ian), Ohana, M. (Mickaël), Onea, M. (Mihaela), Anheim, M. (Mathieu), Solis, M. (Morgane), Sauer, A. (Arnaud), Baloglu, S. (Seyyid), Pessaux, P. (Patrick), Ohlmann, P. (Patrick), Kaeuffer, C. (Charlotte), Oulehri, W. (Walid), Kremer, S. (Stephane), and Mertes, P. (Paul-michel)

Subjects
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Abstract

A 56-year-old man presented a particularly severe and multisystemic case of coronavirus disease 2019 (COVID-19). In addition to the common lung and quite common pulmonary embolism and kidney injuries, he presented ocular and intestinal injuries that, to our knowledge, have not been described in COVID-19 patients. Although it is difficult to make pathophysiological hypotheses about a single case, the multiplicity of injured organs argues for a systemic response to pulmonary infection. A better understanding of physiopathology should feed the discussion about therapeutic options in this type of multifocal damage related to severe acute respiratory syndrome coronavirus 2.

Published
2020

20. Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study

Author

Kremer, S. (Stéphane), Boulay, C. (Clotilde), de Sèze, J. (Jérome), Ferré, J. (Jean-Christophe), Maamar, A. (Adel), Carsin-Nicol, B. (Béatrice), Collange, O. (Olivier), Bonneville, F. (Fabrice), Adam, G. (Gilles), Martin-Blondel, G. (Guillaume), Rafiq, M. (Marie), Geeraerts, T. (Thomas), Delamarre, L. (Louis), Grand, S. (Sylvie), Krainik, A. (Alexandre), Kremer, S. (Stephane), Alleg, M. (Manel), Anheim, M. (Mathieu), Anxionnat, R. (René), Ardellier, F. (François-Daniel), Baloglu, S. (Seyyid), Bapst, B. (Blanche), Benzakoun, J. (Joseph), Berge, J. (Jérome), Bolognini, F. (Federico), Bornet, G. (Grégoire), Boulouis, G. (Grégoire), Boutet, C. (Claire), Brisset, J. (Jean Christophe), Caillard-ohlmann, S. (Sophie), Carré, S. (Sophie), Comby, P. (Pierre-Olivier), Constans, J. (Jean Marc), David, J. (Jean-Stéphane), de Beaurepaire, I. (Isaure), De Seze, J. (Jerome), Desal, H. (Hubert), Edjlali-Goujon, M. (Myriam), Fabre, X. (Xavier), Fafi-Kremer, S. (Samira), Feuerstein, P. (Philippe), Henry Feugeas, M. (Marie-Cécile), Forestier, G. (Géraud), Gaudemer, A. (Augustin), Hansmann, Y. (Yves), Heintz, A. (Adrien), Boisrame, J. (Julie), Hemmert, C. (Céline), Hmeydia, G. (Ghazi), Jager, L. (Lavinia), Kazémi, A. (Apolline), Kerleroux, B. (Basile), Khalil, A. (Antoine), Lacalm, A. (Audrey), Lecler, A. (Augustin), Lecocq, C. (Claire), Lefebvre, N. (Nicolas), Lersy, F. (François), Matthieu, M. (Muriel), Megdiche, I. (Imen), Mertes, P. (Paul-michel), Messié, J. (Julien), Metanbou, S. (Serge), Meyer, N. (Nicolas), Meziani, F. (Ferhat), Mutschler, V. (Veronique), Nesser, P. (Patrick), Oesterlé, H. (Hélène), Ohana, M. (Mickaël), Oppenheim, C. (Catherine), Pyatigorskaya, N. (Nadya), Ricolfi, F. (Frédéric), Saleme, S. (Suzana), Schenck, M. (Maleka), Schmitt, E. (Emmanuelle), Schneider, F. (Francis), Sebag, N. (Nathan), Talla Mba, Y. (Yannick), Thouant, P. (Pierre), Willaume, T. (Thibault), Zhu, F. (François), Zorn, P. (Pierre-Emmanuel), Cotton, F. (François), Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Radiologie [CHU de Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], CHU Toulouse [Toulouse], CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre hospitalier de Haguenau, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nancy (CHU Nancy), CHU Henri Mondor, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CHU Bordeaux [Bordeaux], Hôpitaux Civils de Colmar, Hôpital Privé d'Antony, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Observatoire Français de la Sclérose En Plaques [Lyon] (OFSEP), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Amiens-Picardie, Hospices Civils de Lyon (HCL), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier de Roanne (CH Roanne), CH de Roanne, Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Limoges, CHU Strasbourg, Nouvel Hôpital Civil de Strasbourg, Université de Strasbourg (UNISTRA), Hôpital Marie-Madeleine [Forbach], CHU Lille, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Les Hôptaux universitaires de Strasbourg (HUS), Nanomédecine Régénérative (NanoRegMed), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Henri Mondor [Créteil], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ferré, Jean-Christophe, and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, Male, medicine.medical_specialty, Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC], Adolescent, Pneumonia, Viral, Gastroenterology, 030218 nuclear medicine & medical imaging, Temporal lobe, White matter, Cohort Studies, 03 medical and health sciences, symbols.namesake, Betacoronavirus, Young Adult, 0302 clinical medicine, Cerebrospinal fluid, Internal medicine, Intensive care, medicine, Humans, Radiology, Nuclear Medicine and imaging, 10. No inequality, Child, Pandemics, Fisher's exact test, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, SARS-CoV-2, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Brain, COVID-19, Retrospective cohort study, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, 3. Good health, Venous thrombosis, medicine.anatomical_structure, Neuroradiology, 030220 oncology & carcinogenesis, symbols, Female, business, Coronavirus Infections
Abstract

International audience; BackgroundBrain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).PurposeTo describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection.Materials and MethodsThis was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (a) positive nasopharyngeal or lower respiratory tract reverse transcriptase polymerase chain reaction assays, (b) severe COVID-19 infection defined as a requirement for hospitalization and oxygen therapy, (c) neurologic manifestations, and (d) abnormal brain MRI findings. Exclusion criteria were patients with missing or noncontributory data regarding brain MRI or brain MRI showing ischemic infarcts, cerebral venous thrombosis, or chronic lesions unrelated to the current event. Categorical data were compared using the Fisher exact test. Quantitative data were compared using the Student t test or Wilcoxon test. P < .05 represented a significant difference.ResultsThirty men (81%) and seven women (19%) met the inclusion criteria, with a mean age of 61 years ± 12 (standard deviation) (age range, 8–78 years). The most common neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wakefulness when sedation was stopped (15 of 37, 41%), confusion (12 of 37, 32%), and agitation (seven of 37, 19%). The most frequent MRI findings were signal abnormalities located in the medial temporal lobe in 16 of 37 patients (43%; 95% confidence interval [CI]: 27%, 59%), nonconfluent multifocal white matter hyperintense lesions seen with fluid-attenuated inversion recovery and diffusion-weighted sequences with variable enhancement, with associated hemorrhagic lesions in 11 of 37 patients (30%; 95% CI: 15%, 45%), and extensive and isolated white matter microhemorrhages in nine of 37 patients (24%; 95% CI: 10%, 38%). A majority of patients (20 of 37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation and a higher admission rate in intensive care units (20 of 20 patients [100%] vs 12 of 17 patients without hemorrhage [71%], P = .01) and development of the acute respiratory distress syndrome (20 of 20 patients [100%] vs 11 of 17 patients [65%], P = .005). Only one patient had SARS-CoV-2 RNA in the cerebrospinal fluid.ConclusionPatients with severe coronavirus disease 2019 and without ischemic infarcts had a wide range of neurologic manifestations that were associated with abnormal brain MRI scans. Eight distinctive neuroradiologic patterns were described.

Published
2020

21. Guillain-Barré syndrome related to SARS-CoV-2 infection

Author

Bigaut, K. (Kévin), Mallaret, M. (Martial), Baloglu, S. (Seyyid), Nemoz, B. (Benjamin), Morand, P. (Patrice), Baicry, F. (Florent), Godon, A. (Alexandre), Voulleminot, P. (Paul), Kremer, L. (Laurent), Chanson, J. (Jean-Baptiste), and De Sèze, J. (Jérôme)

Subjects
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Published
2020

26. Advanced multiparametric magnetic resonance imaging of multinodular and vacuolating neuronal tumor

Author

Lecler, A., primary, Broquet, V., additional, Bailleux, J., additional, Carsin, B., additional, Adle‐Biassette, H., additional, Baloglu, S., additional, Forestier, G., additional, Bonneville, F., additional, Calvier, E., additional, Chauvet, D., additional, Comby, P. O., additional, Cottier, J. P., additional, Cotton, F., additional, Deschamps, R., additional, Diard‐Detoeuf, C., additional, Ducray, F., additional, Drissi, C., additional, Elmaleh, M., additional, Farras, J., additional, Aguilar Garcia, J., additional, Gerardin, E., additional, Grand, S., additional, Jianu, D. C., additional, Kremer, S., additional, Loiseau, H., additional, Magne, N., additional, Mejdoubi, M., additional, Moulignier, A., additional, Ollivier, M., additional, Nagi, S., additional, Rodallec, M., additional, Shor, N., additional, Tourdias, T., additional, Vandendries, C., additional, Anxionnat, R., additional, Duron, L., additional, and Savatovsky, J., additional

Published
2020
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27. Resting-state functional MRI demonstrates brain network reorganization in neuromyelitis optica spectrum disorder (NMOSD)

Author

Bigaut, K. (Kévin), Achard, S. (Sophie), Hemmert, C. (Céline), Baloglu, S. (Seyyid), Kremer, L. (Laurent), Collongues, N. (Nicolas), De Seze, J. (Jerome), Kremer, S. (Stephane), De Vico Fallani, F. (Fabrizio) (editor), GIPSA - Communication Information and Complex Systems (GIPSA-CICS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques (BMNST), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Les Hôpitaux Universitaires de Strasbourg (HUS), GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Groupe hospitalier de la région de Mulhouse et Sud-Alsace, École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Central Nervous System, Global Health, Topology, Nervous System, 030218 nuclear medicine & medical imaging, Diagnostic Radiology, Correlation, 0302 clinical medicine, Functional Magnetic Resonance Imaging, Medicine and Health Sciences, Spectrum disorder, Public and Occupational Health, ComputingMilieux_MISCELLANEOUS, Brain Mapping, Multidisciplinary, medicine.diagnostic_test, Radiology and Imaging, Neuromyelitis Optica, Brain, Neurodegenerative Diseases, Middle Aged, Magnetic Resonance Imaging, Neurology, Physical Sciences, Medicine, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Anatomy, Research Article, Adult, Computer and Information Sciences, Multiple Sclerosis, Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC], Patients, Neural Networks, Imaging Techniques, Science, Rest, Immunology, Neuroimaging, Research and Analysis Methods, Autoimmune Diseases, 03 medical and health sciences, Diagnostic Medicine, Echo Planar Imaging, Neuroplasticity, medicine, Humans, Aged, Expanded Disability Status Scale, Neuromyelitis optica, Resting state fMRI, business.industry, Multiple sclerosis, Biology and Life Sciences, medicine.disease, Demyelinating Disorders, Health Care, Case-Control Studies, Clinical Immunology, Clinical Medicine, Functional magnetic resonance imaging, business, Neuroscience, 030217 neurology & neurosurgery, Mathematics
Abstract

Background The relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear. Objective Compare brain functional connectivity of patients with NMOSD to healthy subjects in resting-state functional MRI (rs-fMRI). Methods We compared the rs-fMRI connectivity in 12 NMOSD patients with 20 healthy subjects matched for age and sex. Graph theory analysis was used to quantify the role of each node using a set of metrics: degree, global efficiency, clustering and modularity. To summarize the abnormal connectivity profile of brain regions in patients compared to healthy subjects, we defined a hub disruption index κ. Results Concerning the global organization of networks in NMOSD, a small-world topology was preserved without significant modification concerning all average metrics. However, visual networks and the sensorimotor network showed decreased connectivity with high interindividual variability. The hub disruption index κ was correlated to the Expanded Disability Status Scale (EDSS). Conclusion These results demonstrate a correlation between disability according to the EDSS and neuronal reorganization using the rs-fMRI graph methodology. The conservation of a normal global topological structure despite local modifications in functional connectivity seems to show brain plasticity in response to the disability.

Published
2019

31. P2-327: CEREBRAL MICROBLEEDS IN EARLY STAGES OF DEMENTIA WITH LEWY BODIES ARE NOT ASSOCIATED WITH CLINICAL SYMPTOMS OR ALZHEIMER'S DISEASE CSF BIOMARKERS

Author

Mendes, Aline, primary, Noblet, Vincent, additional, Mondino, Mary, additional, Loureiro de Sousa, Paulo, additional, Manji, S., additional, Archenault, Anne, additional, Casanovas, M., additional, Philippi, N., additional, Baloglu, S., additional, Cretin, B., additional, Demuynck, C., additional, Martin-Hunyadi, C., additional, and Blanc, Frederic, additional

Published
2019
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32. Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19.

Author

Perrin, P., Collongues, N., Baloglu, S., Bedo, D., Bassand, X., Lavaux, T., Gautier‐Vargas, G., Keller, N., Kremer, S., Fafi‐Kremer, S., Moulin, B., Benotmane, I., and Caillard, S.

Subjects
COVID-19, CYTOKINE release syndrome, INTRAVENOUS immunoglobulins, CHIMERIC antigen receptors, BRAIN diseases
Abstract

Background and purpose: Neurological manifestations in coronavirus disease (COVID)‐2019 may adversely affect clinical outcomes. Severe COVID‐19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role of the cytokine release syndrome (CRS), is currently hampering effective therapeutic interventions. The aims of this study were to describe the neurological manifestations of patients with COVID‐19 and to gain pathophysiological insights with respect to CRS. Methods: In this longitudinal study, we performed extensive clinical, laboratory and imaging phenotyping in five patients admitted to our renal unit. Results: Neurological presentation included confusion, tremor, cerebellar ataxia, behavioral alterations, aphasia, pyramidal syndrome, coma, cranial nerve palsy, dysautonomia, and central hypothyroidism. Notably, neurological disturbances were accompanied by laboratory evidence of CRS. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was undetectable in the cerebrospinal fluid (CSF). Hyperalbuminorrachia and increased levels of the astroglial protein S100B were suggestive of blood−brain barrier (BBB) dysfunction. Brain magnetic resonance imaging findings comprised evidence of acute leukoencephalitis (n = 3, one of whom had a hemorrhagic form), cytotoxic edema mimicking ischaemic stroke (n = 1), or normal results (n = 2). Treatment with corticosteroids and/or intravenous immunoglobulins was attempted, resulting in rapid recovery from neurological disturbances in two cases. SARS‐CoV2 was undetectable in 88 of the 90 patients with COVID‐19 who underwent Reverse Transcription‐PCR testing of CSF. Conclusions: Patients with COVID‐19 can develop neurological manifestations that share clinical, laboratory and imaging similarities with those of chimeric antigen receptor T‐cell‐related encephalopathy. The pathophysiological underpinnings appear to involve CRS, endothelial activation, BBB dysfunction, and immune‐mediated mechanisms. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Handbook of Scales in Tourism and Hospitality Research

Author

Gursoy, D, Uysal, M., Sirakaya-Turk, E., Ekinci, Y., Baloglu, S., Gursoy, D, Uysal, M., Sirakaya-Turk, E., Ekinci, Y., and Baloglu, S.

Abstract

By introducing the importance of measurement and scales and providing groupings of existing scales The Handbook of Scales in Tourism and Hospitality Research serves as the state of the art reference book in the field of tourism, hospitality ...

Published
2015

38. Urginea maritima (L.) is a new host of Allexivirus group on onion and garlic plants in Turkey

Author

Fidan H., Çaglar B.K., Baloglu S., Yilmaz M.A., and Çukurova Üniversitesi

Subjects
PCR, fungi, bacteria, food and beverages, Urginea maritima, LYSV, Allexivirus, Virus
Abstract

The means of bulb production, use of the infected plants in production, the presence of vectors and presence of virus in wild host plants are important factors influencing the spread of virus diseases in a given area. During a survey that was made in 2008 and 2009, heavily virus infected onion and garlic plants were observed near Urginea maritima (L) (Baker) plants in Adana and Mersin provinces. The virus diseases symptoms that were noticed on the wild plants were similar to that of onion and garlic plants. Samples of suspected infected garlic, onion and U. maritima plants were collected from fields and were tested by ELISA against Leek yellow stripe virus (LYSV) which is a major onion and garlic viruses disease. The highest absorbance value was obtained from the infected U. maritima samples. The samples were also tested by RT-PCR against the same and other viruses. Allexivirus coat protein genes of group specific AL-N30 (+) and AL-C10 (-) RT-PCR using primers U. maritima and garlic as a result work, 456 bp DNA bands were seen on the agarose gel. DNA fragments were directly sequenced and compared with the isolates. Japanese isolate is 93% similar to that of selected isolates. The 96 collected samples of U. maritima were found to be infected with LYSV and Allexivirus. 28 samples out of 96 U. maritima samples were found to be mix-infected with LYSV and Allexivirus. The study suggested that U. maritima serves as a source of inocula as well as overwintering host of and Potyvirus diseases spread. Finally, the result of studies revealed that U.maritima is a new recorded host of Allexivirus on the leek onion and garlic plants in Turkey.

Published
2013

40. Control of zucchini yellow mosaic virus (ZYMV) in cucurbits by ZYMV-WK strain

Author

Yilmaz, M., Abak, K., Lecoq, Hervé, Baloglu, S., Sari, Nebahat, Kesici, S., Ozaslan, M., Guldur, M., ProdInra, Migration, Unité de Pathologie Végétale (PV), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], PASTEQUE, INSECTE, COURGETTE, [SDV]Life Sciences [q-bio], VECTEUR, ZYMV, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

44. Domateste sari yaprak kivirciklik virusune (DSYKV) dayaniklilik

Author

Abak, K., Yilmaz, M.A., Laterrot, H., Baloglu, S., ProdInra, Migration, Station d'amélioration des plantes maraîchères, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], TYLCV
Published
1991

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