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2 results on '"Ballestero, Eduard Perez"'

1. The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers

Author

Genetica Klinische Genetica, Cancer, Genetica Sectie Genoomdiagnostiek, Bancroft, Elizabeth K., Page, Elizabeth C., Brook, Mark N., Pope, Jennifer, Thomas, Sarah, Myhill, Kathryn, Helfand, Brian T., Talaty, Pooja, Ong, Kai Ren, Douglas, Emma, Cook, Jackie, Rosario, Derek J., Salinas, Monica, Buys, Saundra S., Anson, Jo, Davidson, Rosemarie, Longmuir, Mark, Side, Lucy, Eccles, Diana M., Tischkowitz, Marc, Taylor, Amy, Cruellas, Mara, Ballestero, Eduard Perez, Cleaver, Ruth, Varughese, Mohini, Barwell, Julian, LeButt, Mandy, Greenhalgh, Lynn, Hart, Rachel, Azzabi, Ashraf, Jobson, Irene, Cogley, Lynn, Evans, D. Gareth, Rothwell, Jeanette, Taylor, Natalie, Hogben, Matthew, Saya, Sibel, Ausems, Margreet G.E.M., Van der Luijt, Rob B., Lock, M. T.W.T., IMPACT Study Steering Committee; IMPACT Collaborators, Genetica Klinische Genetica, Cancer, Genetica Sectie Genoomdiagnostiek, Bancroft, Elizabeth K., Page, Elizabeth C., Brook, Mark N., Pope, Jennifer, Thomas, Sarah, Myhill, Kathryn, Helfand, Brian T., Talaty, Pooja, Ong, Kai Ren, Douglas, Emma, Cook, Jackie, Rosario, Derek J., Salinas, Monica, Buys, Saundra S., Anson, Jo, Davidson, Rosemarie, Longmuir, Mark, Side, Lucy, Eccles, Diana M., Tischkowitz, Marc, Taylor, Amy, Cruellas, Mara, Ballestero, Eduard Perez, Cleaver, Ruth, Varughese, Mohini, Barwell, Julian, LeButt, Mandy, Greenhalgh, Lynn, Hart, Rachel, Azzabi, Ashraf, Jobson, Irene, Cogley, Lynn, Evans, D. Gareth, Rothwell, Jeanette, Taylor, Natalie, Hogben, Matthew, Saya, Sibel, Ausems, Margreet G.E.M., Van der Luijt, Rob B., Lock, M. T.W.T., and IMPACT Study Steering Committee; IMPACT Collaborators

Published
2024

2. The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.

Author

Bancroft EK, Page EC, Brook MN, Pope J, Thomas S, Myhill K, Helfand BT, Talaty P, Ong KR, Douglas E, Cook J, Rosario DJ, Salinas M, Buys SS, Anson J, Davidson R, Longmuir M, Side L, Eccles DM, Tischkowitz M, Taylor A, Cruellas M, Ballestero EP, Cleaver R, Varughese M, Barwell J, LeButt M, Greenhalgh L, Hart R, Azzabi A, Jobson I, Cogley L, Evans DG, Rothwell J, Taylor N, Hogben M, Saya S, Eeles RA, and Aaronson NK

Subjects
Humans, Male, Middle Aged, Aged, Quality of Life, Genes, BRCA1, Surveys and Questionnaires, Genes, BRCA2, Heterozygote, Anxiety etiology, Longitudinal Studies, Prostatic Neoplasms psychology, Prostatic Neoplasms genetics, Prostatic Neoplasms diagnosis, Genetic Predisposition to Disease psychology, Early Detection of Cancer psychology
Abstract

Objectives: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls' (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2)., Subjects and Methods: Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36-item Short-Form Health Survey, Memorial Anxiety Scale for PrCa, Cancer Worry Scale, risk perception and knowledge., Results: A total of 760 participants completed questionnaires: 207 participants with GPV in BRCA1, 265 with GPV in BRCA2 and 288 controls (non-carriers from families with a known GPV). We found no evidence of clinically concerning levels of general or cancer-specific distress or poor health-related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about PrCa compared with the carriers; however, all mean scores were low and within reported general population norms, where available. BRCA2 carriers with previously high prostate-specific antigen (PSA) levels experience a small but significant increase in PrCa anxiety (P = 0.01) and PSA-specific anxiety (P < 0.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time., Conclusion: This is the first study to report the longitudinal psychosocial impact of a targeted PrCa screening programme for BRCA1 and BRCA2 carriers. The results reassure that an annual PSA-based screening programme does not have an adverse impact on psychosocial health or health-related quality of life in these higher-risk individuals. These results are important as more PrCa screening is targeted to higher-risk groups., (© 2024 The Author(s). BJU International published by John Wiley & Sons Ltd on behalf of BJU International.)

Published
2024
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