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14 results on '"Ballester-Cuenca, Carlos"'

1. Inter-individual Age-independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

Author

García-Mendívil, Laura, primary, Pérez-Zabalza, María, additional, Vallejo-Gil, José María, additional, Fañanás-Mastral, Javier, additional, Vázquez-Sancho, Manuel, additional, Bellido-Morales, Javier André, additional, Vaca-Núñez, Alexánder Sebastián, additional, Ballester-Cuenca, Carlos, additional, Diez, Emiliano, additional, Ordovás, Laura, additional, Pueyo, Esther, additional, and Oliver-Gelabert, Antoni, additional

Published
2023
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2. Minimally invasive system to reliably characterize ventricular electrophysiology from living donors

Author

Oliván-Viguera, Aida, Pérez-Zabalza, María, García-Mendívil, Laura, Mountris, Konstantinos A., Orós-Rodrigo, Sofía, Ramos-Marquès, Estel, Vallejo-Gil, José María, Fresneda-Roldán, Pedro Carlos, Fañanás-Mastral, Javier, Vázquez-Sancho, Manuel, Matamala-Adell, Marta, Sorribas-Berjón, Fernando, Bellido-Morales, Javier André, Mancebón-Sierra, Francisco Javier, Vaca-Núñez, Alexánder Sebastián, Ballester-Cuenca, Carlos, Marigil, Miguel Ángel, Pastor, Cristina, Ordovás, Laura, Köhler, Ralf, Diez, Emiliano, and Pueyo, Esther

Published
2020
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4. Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Author

García-Mendívil, Laura, primary, Pérez-Zabalza, María, additional, Mountris, Konstantinos, additional, Duwé, Sam, additional, Smisdom, Nick, additional, Pérez, Marta, additional, Luján, Lluís, additional, Wolfs, Esther, additional, Driesen, Ronald B., additional, Vallejo-Gil, José María, additional, Fresneda-Roldán, Pedro Carlos, additional, Fañanás-Mastral, Javier, additional, Vázquez-Sancho, Manuel, additional, Matamala-Adell, Marta, additional, Sorribas-Berjón, Juan Fernando, additional, Bellido-Morales, Javier André, additional, Mancebón-Sierra, Francisco Javier, additional, Vaca-Núñez, Alexánder Sebastián, additional, Ballester-Cuenca, Carlos, additional, Oliván-Viguera, Aida, additional, Diez, Emiliano, additional, Ordovás, Laura, additional, and Pueyo, Esther, additional

Published
2022
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5. Age-associated changes in fibrosis amount and spatial organization and its effects on human ventricular electrophysiology

Author

Perez-Zabalza, Maria, primary, Garcta-Mendtvil, Laura, additional, Mountris, Kostantinos A, additional, Smisdom, Nick, additional, Vallejo-Gil, Jose M, additional, Fresneda-Roldan, Pedro C, additional, Fananas-Mastral, Javier, additional, Matamala-Adell, Marta, additional, Sorribas-Berjon, Fernando, additional, Vazquez-Sancho, Manuel, additional, Bellido-Morales, Javier Andre, additional, Mancebon-Sierra, Francisco Javier, additional, Vaca-Nunez, Alexander Sebastian, additional, Ballester-Cuenca, Carlos, additional, Olivan-Viguera, Aida, additional, Ordovas, Laura, additional, and Pueyo, Esther, additional

Published
2021
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6. Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

Author

Ramos‐Marquès, Estel, primary, García‐Mendívil, Laura, additional, Pérez‐Zabalza, María, additional, Santander‐Badules, Hazel, additional, Srinivasan, Sabarathinam, additional, Oliveros, Juan Carlos, additional, Torres‐Pérez, Rafael, additional, Cebollada, Alberto, additional, Vallejo‐Gil, José María, additional, Fresneda‐Roldán, Pedro Carlos, additional, Fañanás‐Mastral, Javier, additional, Vázquez‐Sancho, Manuel, additional, Matamala‐Adell, Marta, additional, Sorribas‐Berjón, Juan Fernando, additional, Bellido‑Morales, Javier André, additional, Mancebón‑Sierra, Francisco Javier, additional, Vaca‑Núñez, Alexánder Sebastián, additional, Ballester‐Cuenca, Carlos, additional, Jiménez‐Navarro, Manuel, additional, Villaescusa, José Manuel, additional, Garrido‐Huéscar, Elisa, additional, Segovia‐Roldán, Margarita, additional, Oliván‐Viguera, Aida, additional, Gómez‐González, Carlos, additional, Muñiz, Gorka, additional, Diez, Emiliano, additional, Ordovás, Laura, additional, and Pueyo, Esther, additional

Published
2021
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7. Improved Methods for Processing Optical Mapping Signals From Human Left Ventricular Tissues at Baseline and Following Adrenergic Stimulation

Author

Pérez-Zabalza, María, primary, Raúl Diez, Emiliano, additional, Rhyins, Julia, additional, Mountris, Konstantinos, additional, María Vallejo-Gil, Jose, additional, Carlos Fresneda-Roldán, Pedro, additional, Fañanás-Mastral, Javier, additional, Matamala-Adell, Marta, additional, Sorribas-Berjón, Fernando, additional, Vázquez-Sancho, Manuel, additional, Ballester-Cuenca, Carlos, additional, Segovia-Roldán, Margarita, additional, Oliván-Viguera, Aida, additional, and Pueyo, Esther, additional

Published
2020
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8. Automatic Quantification of Cardiomyocyte Dimensions and Connexin 43 Lateralization in Fluorescence Images

Author

Oliver-Gelabert, Antoni, primary, García-Mendívil, Laura, additional, Vallejo-Gil, José María, additional, Fresneda-Roldán, Pedro Carlos, additional, Andelová, Katarína, additional, Fañanás-Mastral, Javier, additional, Vázquez-Sancho, Manuel, additional, Matamala-Adell, Marta, additional, Sorribas-Berjón, Fernando, additional, Ballester-Cuenca, Carlos, additional, Tribulova, Narcisa, additional, Ordovás, Laura, additional, Raúl Diez, Emiliano, additional, and Pueyo, Esther, additional

Published
2020
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12. Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Author

Laura García-Mendívil, María Pérez-Zabalza, Konstantinos Mountris, Sam Duwé, Nick Smisdom, Marta Pérez, Lluís Luján, Esther Wolfs, Ronald B. Driesen, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Juan Fernando Sorribas-Berjón, Javier André Bellido-Morales, Francisco Javier Mancebón-Sierra, Alexánder Sebastián Vaca-Núñez, Carlos Ballester-Cuenca, Aida Oliván-Viguera, Emiliano Diez, Laura Ordovás, Esther Pueyo, Garcia-Mendivil, Laura, Perez-Zabalza, Maria, Mountris, Konstantinos, DUWE, Sam, SMISDOM, Nick, Perez, Marta, Lujan, Lluis, WOLFS, Esther, DRIESEN, Ronald, Maria Vallejo-Gil, Jose, Carlos Fresneda-Roldan, Pedro, Fananas-Mastral, Javier, Vazquez-Sancho, Manuel, Matamala-Adell, Marta, Fernando Sorribas-Berjon, Juan, Andre Bellido-Morales, Javier, Javier Mancebon-Sierra, Francisco, Sebastian Vaca-Nunez, Alexander, Ballester-Cuenca, Carlos, Olivan-Viguera, Aida, Diez, Emiliano, Ordovas, Laura, and Pueyo, Esther

Subjects
ARRHYTHMIAS, Science & Technology, Multidisciplinary, MYOCARDIAL FIBROSIS, IMAGES, Science, HEARTS, Computational bioinformatics, QUANTIFICATION, Pathophysiology, Multidisciplinary Sciences, CONDUCTION, LIPOFUSCIN, Science & Technology - Other Topics, Disease, CARDIAC FIBROSIS, MATRIX, SYSTEM
Abstract

Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. This work was supported by Ministerio de Ciencia e Innovacio´ n (Spain) (PID2019-105674RB-I00), by Gobierno de Arago´ n (LMP94_21) and (LMP128_21), by the European Research Council through grant ERC-StG 638284 and by European Social Fund and by Gobierno de Arago´ n (Reference Group BSICoS T39-20R) cofunded by FEDER 2014–2020 ‘‘Building Europe from Aragon‘‘. L.G-M was supported by a predoctoral fellowship from the Departamento de Ciencia, Universidad y Sociedad del Conocimiento from the Gobierno de Arago´ n 2016–2020 cofounded by Programa Operativo del Fondo Social Europeo Arago´ n (C150/2016), EMBO Short-Term fellowship (7710), and Ibercaja-CAI Estancias de Investigacio´ n IT18/18. Authors would like to acknowledge the Experimental Surgery Service of Aragon Health Sciences Institute (CIBA, Zaragoza, Spain), Mercazaragoza slaughterhouse (Zaragoza, Spain), and The Pink Pig slaughterhouse (Zuera, Spain) for their collaboration in the collection of young, adult, and boar tissue specimens, respectively.

Published
2022

13. Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk.

Author

García-Mendívil L, Pérez-Zabalza M, Oliver-Gelabert A, Vallejo-Gil JM, Fañanás-Mastral J, Vázquez-Sancho M, Bellido-Morales JA, Vaca-Núñez AS, Ballester-Cuenca C, Diez E, Ordovás L, and Pueyo E

Abstract

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis., Competing Interests: Competing interests: The authors declare that they have no competing interests., (Copyright © 2023 Laura García-Mendívil et al.)

Published
2023
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