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8. HP-1-1 Anti Inflammatory Effects of Androgenic Signaling in Human Vagina: A Potential Therapeutical Application for the Genitourinary Syndrome of Menopause

Author

Cipriani, S., primary, Maseroli, E., additional, Cellai, I., additional, Filippi, S., additional, Comeglio, P., additional, Frison, M., additional, Amoriello, R., additional, Ballerini, C., additional, Sarchielli, E., additional, Guarnieri, G., additional, Morelli, A., additional, Maggi, M., additional, and Vignozzi, L., additional

Published
2020
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9. Cerebrospinal fluid analysis and the determination of oligoclonal bands

Author

Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, M, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F, Franciotta, D, Gastaldi M., Zardini E., Leante R., Ruggieri M., Costa G., Cocco E., De Luca G., Cataldo I., Biagioli T., Ballerini C., Castellazzi M., Fainardi E., Pettini P., Zaffaroni M., Giunti D., Capello E., Bernardi G., Ciusani E., Giannotta C., Nobile-Orazio E., Bazzigaluppi E., Passerini G., Bedin R., Sola P., Brivio R., Cavaletti G., Sala A., Bertolotto A., Desina G., Leone M. A., Mariotto S., Ferrari S., Paternoster A., Giavarina D., Lolli F., Franciotta D., Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, M, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F, Franciotta, D, Gastaldi M., Zardini E., Leante R., Ruggieri M., Costa G., Cocco E., De Luca G., Cataldo I., Biagioli T., Ballerini C., Castellazzi M., Fainardi E., Pettini P., Zaffaroni M., Giunti D., Capello E., Bernardi G., Ciusani E., Giannotta C., Nobile-Orazio E., Bazzigaluppi E., Passerini G., Bedin R., Sola P., Brivio R., Cavaletti G., Sala A., Bertolotto A., Desina G., Leone M. A., Mariotto S., Ferrari S., Paternoster A., Giavarina D., Lolli F., and Franciotta D.

Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroin flammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Published
2017

14. Myelin-specific T cells carry and release magnetite PGLA–PEG COOH nanoparticles in the mouse central nervous system

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, D'Elios, M. M., Aldinucci, A., Amoriello, R., Benagiano, M., Bonechi, E., Maggi, Pietro, Flori, A., Ravagli, C., Saer, D., Cappiello, L., Conti, L., Valtancoli, B., Bencini, A., Menichetti, L., Baldi, G., Ballerini, C., UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, D'Elios, M. M., Aldinucci, A., Amoriello, R., Benagiano, M., Bonechi, E., Maggi, Pietro, Flori, A., Ravagli, C., Saer, D., Cappiello, L., Conti, L., Valtancoli, B., Bencini, A., Menichetti, L., Baldi, G., and Ballerini, C.

Abstract

Progress in nanotechnology has determined new strategies concerning drug delivery into the central nervous system for the treatment of degenerative and inflammatory diseases. To date, brain targeting through systemic drug administration, even in a nano-composition, is often unsuccessful. Therefore, we investigated the possibility of loading T lymphocytes with PGLA–PEG COOH magnetite nanoparticles (30 nm), which can be built up to easily bind drugs and monoclonal antibodies, and to exploit the ability of activated T cells to cross the blood–brain barrier and infiltrate the brain parenchyma. Iron oxide nanoparticles have been widely used in biomedical applications due to their theranostic properties and are therefore a well-established nanomaterial. The magnetite core is easily hybridized with polymeric compounds that may enhance the possibility of the nanoparticles entering cells with low phagocytic properties. Taking advantage of these material characteristics, after in vitro assessment of the viability and functionality of nano-loaded MOG35–55 specific T cells, we transferred cells containing the nano-cargo into naïve mice affected by experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. By means of histological and immunohistological methods, we were able to identify the nano-loaded T cells in the central nervous system. Our data demonstrated that T cells containing nanomaterials hold the possibility of carrying and releasing nanoparticles in the brain.

Published
2018

17. Myelin-specific T cells carry and release magnetite PGLA–PEG COOH nanoparticles in the mouse central nervous system

Author

D'Elios, M. M., primary, Aldinucci, A., additional, Amoriello, R., additional, Benagiano, M., additional, Bonechi, E., additional, Maggi, P., additional, Flori, A., additional, Ravagli, C., additional, Saer, D., additional, Cappiello, L., additional, Conti, L., additional, Valtancoli, B., additional, Bencini, A., additional, Menichetti, L., additional, Baldi, G., additional, and Ballerini, C., additional

Published
2018
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28. An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population

Author

D Alfonso, S., Lorenza Nisticò, Bocchio, D., Bomprezzi, R., Marrosu, M. G., Murru, M. R., Lai, M., Massacesi, L., Ballerini, C., Repice, A., Salvetti, M., Montesperelli, C., Ristori, G., Trojano, M., Liguori, M., Gambi, D., Quattrone, A., Tosi, R., and Momigliano-Richiardi, P.

Subjects
Family Health, Multiple Sclerosis, Genetic Linkage, Histocompatibility Testing, association study, candidate regions, italian families, microsatellites, multiple sclerosis, HLA-DR Antigens, Italy, Humans, Chromosomes, Human, Pair 19, Alleles, Follow-Up Studies, HLA-DRB1 Chains, Microsatellite Repeats
Abstract

Subsequent to a genomic linkage study on Sardinian and Continental Italian families, we considered the possibility that some of the tested microsatellite markers showed association to MS. Markers selected on the basis of the data obtained in the original set of 70 multiplex families were tested for MS association in an additional set of 154 simplex families. A limited set of markers were further tested on an additional set of 100 simplex families. The results indicate the presence of a putative MS gene in 19q13.13.

Published
2000

32. Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis

Author

Mazzanti, B, Biagioli, T, Aldinucci, A, Cavaletti, G, Cavalletti, E, Oggioni, N, Frigo, M, Rota, S, Tagliabue, E, Ballerini, C, Massacesi, L, Riccio, P, Lolli, F, Lolli, F., CAVALETTI, GUIDO ANGELO, OGGIONI, NORBERTO, ROTA, STEFANIA, TAGLIABUE, ELENA, Mazzanti, B, Biagioli, T, Aldinucci, A, Cavaletti, G, Cavalletti, E, Oggioni, N, Frigo, M, Rota, S, Tagliabue, E, Ballerini, C, Massacesi, L, Riccio, P, Lolli, F, Lolli, F., CAVALETTI, GUIDO ANGELO, OGGIONI, NORBERTO, ROTA, STEFANIA, and TAGLIABUE, ELENA

Abstract

Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.

Published
2005

34. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy

Author

D'Alfonso, S, primary, Bolognesi, E, additional, Guerini, F R, additional, Barizzone, N, additional, Bocca, S, additional, Ferrante, D, additional, Castelli, L, additional, Bergamaschi, L, additional, Agliardi, C, additional, Ferrante, P, additional, Naldi, P, additional, Leone, M, additional, Caputo, D, additional, Ballerini, C, additional, Salvetti, M, additional, Galimberti, D, additional, Massacesi, L, additional, Trojano, M, additional, and Momigliano-Richiardi, P, additional

Published
2007
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43. Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.

Author

Ballerini, C, Aldinucci, A, Luccarini, I, Galante, A, Manuelli, C, Blandina, P, Katebe, M, Chazot, P L, Masini, E, and Passani, M B

Subjects
*ANTIHISTAMINES, *HISTAMINE receptors, *ENCEPHALOMYELITIS, *AUTOIMMUNE diseases, *DISEASE exacerbation, *INFLAMMATION treatment, *ASTHMA treatment
Abstract

Background and Purpose The histamine H4 receptor has a primary role in inflammatory functions, making it an attractive target for the treatment of asthma and refractory inflammation. These observations suggested a facilitating action on autoimmune diseases. Here we have assessed the role of H4 receptors in experimental autoimmune encephalomyelitis ( EAE) a model of multiple sclerosis ( MS). Experimental Approach We induced EAE with myelin oligodendrocyte glycoprotein ( MOG35-55) in C57BL/6 female mice as a model of MS. The histamine H4 receptor antagonist 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1 H-indole ( JNJ7777120) was injected i.p. daily starting at day 10 post-immunization ( D10 p.i.). Disease severity was monitored by clinical and histopathological evaluation of inflammatory cells infiltrating into the spinal cord, anti- MOG35-55 antibody production, assay of T-cell proliferation by [ 3H]-thymidine incorporation, mononucleate cell phenotype by flow cytometry, cytokine production by elisa assay and transcription factor quantification of mRNA expression. Key Results Treatment with JNJ7777120 exacerbated EAE, increased inflammation and demyelination in the spinal cord of EAE mice and increased IFN-γ expression in lymph nodes, whereas it suppressed IL-4 and IL-10, and augmented expression of the transcription factors Tbet, FOXP3 and IL-17 mRNA in lymphocytes. JNJ7777120 did not affect proliferation of anti- MOG35-55 T-cells, anti- MOG35-55 antibody production or mononucleate cell phenotype. Conclusions and Implications H4 receptor blockade was detrimental in EAE. Given the interest in the development of H4 receptor antagonists as anti-inflammatory compounds, it is important to understand the role of H4 receptors in immune diseases to anticipate clinical benefits and also predict possible detrimental effects. Linked Articles This article is part of a themed issue on Histamine Pharmacology Update. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2013.170.issue-1 [ABSTRACT FROM AUTHOR]

Published
2013
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47. Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis.

Author

Soldan, Samantha S., Fogdell-Hahn, Anna, Brennan, Meghan B., Mittleman, Barbara B., Ballerini, Clara, Massacesi, Luca, Seya, Tsukasa, McFarland, Henry F., Jacobson, Steven, Soldan, S S, Fogdell-Hahn, A, Brennan, M B, Mittleman, B B, Ballerini, C, Massacesi, L, Seya, T, McFarland, H F, and Jacobson, S

Published
2001
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48. Cerebrospinal Fluid T-Regulatory Cells Recognize Borrelia BurgdorferiNapa in Chronic Lyme Borreliosis

Author

Amedei, A., Codolo, G., Ozolins, D., Ballerini, C., Biagioli, T., Jaunalksne, I., Zilevica, A., D'Elios, S., De Bernard, M., and D'Elios, M.M.

Abstract

The NapA protein of B. burgdorferiis essential for the persistence of spirochetes in ticks. One of the most intriguing aspects of NapA is its potential to interfere with the host immune system. Here, we investigated the role of the acquired immune responses induced by NapA in the cerebrospinal fluids (CSF) of patients with chronic Lyme borreliosis. We evaluated the cytokine profile induced in microglia cells and CSF T cells following NapA stimulation. We report here that NapA induced a regulatory T (Treg) response in the CSF of patients with chronic Lyme borreliosis and it is able to expand this suppressive response by promoting the production of TGF-ß and IL-10 by microglia cells. Collectively, these data strongly support a central role of NapA in promoting both Treg response and immune suppression in the CSF of patients with chronic Lyme borreliosis and suggest that NapA and the Treg pathway may represent novel therapeutic targets for the prevention and treatment of the disease.

Published
2013
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