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1. Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia

Author

Upadhyay, Neeraj, Spottke, Annika, Schneider, Anja, Hoffmann, Daniel C., Frommann, Ingo, Ballarini, Tommaso, Fliessbach, Klaus, Bender, Benjamin, Heekeren, Hauke R., Haynes, John Dylan, Ewers, Michael, Düzel, Emrah, Glanz, Wenzel, Dobisch, Laura, Buerger, Katharina, Janowitz, Daniel, Levin, Johannes, Danek, Adrian, Teipel, Stefan, Kilimann, Ingo, Synofzik, Matthis, Wilke, Carlo, Peters, Oliver, Preis, Lukas, Priller, Josef, Spruth, Eike Jakob, Jessen, Frank, and Boecker, Henning

Published
2024
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2. Structural parameters are superior to eigenvector centrality in detecting progressive supranuclear palsy with machine learning & multimodal MRI

Author

Danek, Adrian, Diehl-Schmid, Janine, Jahn, Holger, Kassubek, Jan, Kornhuber, Johannes, Landwehrmeyer, Bernhard, Lauer, Martin, Prudlo, Johannes, Schneider, Anja, Ludolph, Albert C., Fliesbach, Klaus, Anderl-Straub, Sarah, Brüggen, Katharina, Fischer, Marie, Förstl, Hans, Hammer, Anke, Homola, György, Just, Walter, Levin, Johannes, Marroquin, Nicolai, Marschhauser, Anke, Pino, Danielé, Nagl, Magdalena, Oberstein, Timo, Hüper, Lea, Polyakova, Maryna, Pellkofer, Hannah, Richter-Schmidinger, Tanja, Rossmeier, Carola, Kulko, Marianna, Semler, Elisa, Spottke, Annika, Steinacker, Petra, Thöne-Otto, Angelika, Uttner, Ingo, Zech, Heike, Albrecht, Franziska, Mueller, Karsten, Ballarini, Tommaso, Fassbender, Klaus, Wiltfang, Jens, Otto, Markus, Jech, Robert, and Schroeter, Mattias L.

Published
2024
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3. The Human Affectome

Author

Schiller, Daniela, Yu, Alessandra N.C., Alia-Klein, Nelly, Becker, Susanne, Cromwell, Howard C., Dolcos, Florin, Eslinger, Paul J., Frewen, Paul, Kemp, Andrew H., Pace-Schott, Edward F., Raber, Jacob, Silton, Rebecca L., Stefanova, Elka, Williams, Justin H.G., Abe, Nobuhito, Aghajani, Moji, Albrecht, Franziska, Alexander, Rebecca, Anders, Silke, Aragón, Oriana R., Arias, Juan A., Arzy, Shahar, Aue, Tatjana, Baez, Sandra, Balconi, Michela, Ballarini, Tommaso, Bannister, Scott, Banta, Marlissa C., Barrett, Karen Caplovitz, Belzung, Catherine, Bensafi, Moustafa, Booij, Linda, Bookwala, Jamila, Boulanger-Bertolus, Julie, Boutros, Sydney Weber, Bräscher, Anne-Kathrin, Bruno, Antonio, Busatto, Geraldo, Bylsma, Lauren M., Caldwell-Harris, Catherine, Chan, Raymond C.K., Cherbuin, Nicolas, Chiarella, Julian, Cipresso, Pietro, Critchley, Hugo, Croote, Denise E., Demaree, Heath A., Denson, Thomas F., Depue, Brendan, Derntl, Birgit, Dickson, Joanne M., Dolcos, Sanda, Drach-Zahavy, Anat, Dubljević, Olga, Eerola, Tuomas, Ellingsen, Dan-Mikael, Fairfield, Beth, Ferdenzi, Camille, Friedman, Bruce H., Fu, Cynthia H.Y., Gatt, Justine M., de Gelder, Beatrice, Gendolla, Guido H.E., Gilam, Gadi, Goldblatt, Hadass, Gooding, Anne Elizabeth Kotynski, Gosseries, Olivia, Hamm, Alfons O., Hanson, Jamie L., Hendler, Talma, Herbert, Cornelia, Hofmann, Stefan G., Ibanez, Agustin, Joffily, Mateus, Jovanovic, Tanja, Kahrilas, Ian J., Kangas, Maria, Katsumi, Yuta, Kensinger, Elizabeth, Kirby, Lauren A.J., Koncz, Rebecca, Koster, Ernst H.W., Kozlowska, Kasia, Krach, Sören, Kret, Mariska E., Krippl, Martin, Kusi-Mensah, Kwabena, Ladouceur, Cecile D., Laureys, Steven, Lawrence, Alistair, Li, Chiang-shan R., Liddell, Belinda J., Lidhar, Navdeep K., Lowry, Christopher A., Magee, Kelsey, Marin, Marie-France, Mariotti, Veronica, Martin, Loren J., Marusak, Hilary A., Mayer, Annalina V., Merner, Amanda R., Minnier, Jessica, Moll, Jorge, Morrison, Robert G., Moore, Matthew, Mouly, Anne-Marie, Mueller, Sven C., Mühlberger, Andreas, Murphy, Nora A., Muscatello, Maria Rosaria Anna, Musser, Erica D., Newton, Tamara L., Noll-Hussong, Michael, Norrholm, Seth Davin, Northoff, Georg, Nusslock, Robin, Okon-Singer, Hadas, Olino, Thomas M., Ortner, Catherine, Owolabi, Mayowa, Padulo, Caterina, Palermo, Romina, Palumbo, Rocco, Palumbo, Sara, Papadelis, Christos, Pegna, Alan J., Pellegrini, Silvia, Peltonen, Kirsi, Penninx, Brenda W.J.H., Pietrini, Pietro, Pinna, Graziano, Lobo, Rosario Pintos, Polnaszek, Kelly L., Polyakova, Maryna, Rabinak, Christine, Helene Richter, S., Richter, Thalia, Riva, Giuseppe, Rizzo, Amelia, Robinson, Jennifer L., Rosa, Pedro, Sachdev, Perminder S., Sato, Wataru, Schroeter, Matthias L., Schweizer, Susanne, Shiban, Youssef, Siddharthan, Advaith, Siedlecka, Ewa, Smith, Robert C., Soreq, Hermona, Spangler, Derek P., Stern, Emily R., Styliadis, Charis, Sullivan, Gavin B., Swain, James E., Urben, Sébastien, Van den Stock, Jan, vander Kooij, Michael A., van Overveld, Mark, Van Rheenen, Tamsyn E., VanElzakker, Michael B., Ventura-Bort, Carlos, Verona, Edelyn, Volk, Tyler, Wang, Yi, Weingast, Leah T., Weymar, Mathias, Williams, Claire, Willis, Megan L., Yamashita, Paula, Zahn, Roland, Zupan, Barbra, and Lowe, Leroy

Published
2024
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4. Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: Evaluation in Alzheimer's disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Background: Although convolutional neural networks (CNN) achieve high diagnostic accuracy for detecting Alzheimer's disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N=663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including N=1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps. Results: Across three independent datasets, group separation showed high accuracy for AD dementia vs. controls (AUC$\geq$0.92) and moderate accuracy for MCI vs. controls (AUC$\approx$0.75). Relevance maps indicated that hippocampal atrophy was considered as the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson's r$\approx$-0.86, p<0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels., Comment: 24 pages, 9 figures/tables, supplementary material, source code available on GitHub

Published
2020
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6. Linking early-life bilingualism and cognitive advantage in older adulthood

Author

Ballarini, Tommaso, Kuhn, Elizabeth, Röske, Sandra, Altenstein, Slawek, Bartels, Claudia, Buchholz, Friederike, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Gabelin, Tatjana, Glanz, Wenzel, Görß, Doreen, Haynes, John Dylan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Kobeleva, Xenia, Laske, Christoph, Lohse, Andrea, Maier, Franziska, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Düzel, Emrah, Jessen, Frank, and Wagner, Michael

Published
2023
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7. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Published
2023
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8. Multiclass prediction of different dementia syndromes based on multi-centric volumetric MRI imaging

Author

Lampe, Leonie, Huppertz, Hans-Jürgen, Anderl-Straub, Sarah, Albrecht, Franziska, Ballarini, Tommaso, Bisenius, Sandrine, Mueller, Karsten, Niehaus, Sebastian, Fassbender, Klaus, Fliessbach, Klaus, Jahn, Holger, Kornhuber, Johannes, Lauer, Martin, Prudlo, Johannes, Schneider, Anja, Synofzik, Matthis, Kassubek, Jan, Danek, Adrian, Villringer, Arno, Diehl-Schmid, Janine, Otto, Markus, and Schroeter, Matthias L.

Published
2023
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9. Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease

Author

Ballarini, Tommaso, Iaccarino, Leonardo, Magnani, Giuseppe, Ayakta, Nagehan, Miller, Bruce L, Jagust, William J, Gorno‐Tempini, Maria Luisa, Rabinovici, Gil D, and Perani, Daniela

Subjects
Biological Psychology, Psychology, Mental Health, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Basic Behavioral and Social Science, Dementia, Neurodegenerative, Alzheimer's Disease, Brain Disorders, Acquired Cognitive Impairment, Neurosciences, Mental Illness, Aging, Behavioral and Social Science, 2.1 Biological and endogenous factors, Mental health, Neurological, Affect, Age of Onset, Alzheimer Disease, Apathy, Brain, Brain Mapping, Female, Fluorodeoxyglucose F18, Glucose, Humans, Male, Middle Aged, Mood Disorders, Motor Activity, Neural Pathways, Neuropsychological Tests, Positron-Emission Tomography, Psychiatric Status Rating Scales, Psychotic Disorders, Radiopharmaceuticals, Retrospective Studies, early onset Alzheimer's Disease, neuropsychiatric subsyndromes, positron-emission tomography, metabolic connectivity, functional networks, frontal lobe, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Neuropsychiatric symptoms (NPSs) often occur in early-age-of-onset Alzheimer's disease (EOAD) and cluster into sub-syndromes (SSy). The aim of this study was to investigate the association between 18 F-FDG-PET regional and connectivity-based brain metabolic dysfunctions and neuropsychiatric SSy. NPSs were assessed in 27 EOAD using the Neuropsychiatric Inventory and further clustered into four SSy (apathetic, hyperactivity, affective, and psychotic SSy). Eighty-five percent of EOAD showed at least one NPS. Voxel-wise correlations between SSy scores and brain glucose metabolism (assessed with 18 F-FDG positron emission tomography) were studied. Interregional correlation analysis was used to explore metabolic connectivity in the salience (aSN) and default mode networks (DMN) in a larger sample of EOAD (N = 51) and Healthy Controls (N = 57). The apathetic, hyperactivity, and affective SSy were highly prevalent (>60%) as compared to the psychotic SSy (33%). The hyperactivity SSy scores were associated with increase of glucose metabolism in frontal and limbic structures, implicated in behavioral control. A comparable positive correlation with part of the same network was found for the affective SSy scores. On the other hand, the apathetic SSy scores were negatively correlated with metabolism in the bilateral orbitofrontal and dorsolateral frontal cortex known to be involved in motivation and decision-making processes. Consistent with these SSy regional correlations with brain metabolic dysfunction, the connectivity analysis showed increases in the aSN and decreases in the DMN. Behavioral abnormalities in EOAD are associated with specific dysfunctional changes in brain metabolic activity, in particular in the aSN that seems to play a crucial role in NPSs in EOAD. Hum Brain Mapp 37:4234-4247, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

10. Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum

Author

Herdick, Meret, Dyrba, Martin, Fritz, Hans-Christian J., Altenstein, Slawek, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Can Cetindag, Arda, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Dawn Freiesleben, Silka, Frommann, Ingo, Glanz, Wenzel, Dylan Haynes, John, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Priller, Josef, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Jakob Spruth, Eike, Tscheuschler, Maike, Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, Teipel, Stefan, and Grothe, Michel J.

Published
2020
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12. Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging

Author

Anderl-Straub, Sarah, Brüggen, Katharina, Fischer, Marie, Förstl, Hans, Hammer, Anke, Homola, György, Just, Walter, Levin, Johannes, Marroquin, Nicolai, Marschhauser, Anke, Nagl, Magdalena, Oberstein, Timo, Polyakova, Maryna, Pellkofer, Hannah, Richter-Schmidinger, Tanja, Rossmeier, Carola, Schuemberg, Katharina, Semler, Elisa, Spottke, Annika, Steinacker, Petra, Thöne-Otto, Angelika, Uttner, Ingo, Zech, Heike, Albrecht, Franziska, Mueller, Karsten, Ballarini, Tommaso, Lampe, Leonie, Diehl-Schmid, Janine, Fassbender, Klaus, Fliessbach, Klaus, Jahn, Holger, Jech, Robert, Kassubek, Jan, Kornhuber, Johannes, Landwehrmeyer, Bernhard, Lauer, Martin, Ludolph, Albert C., Lyros, Epameinondas, Prudlo, Johannes, Schneider, Anja, Synofzik, Matthis, Wiltfang, Jens, Danek, Adrian, Otto, Markus, and Schroeter, Matthias L.

Published
2019
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15. The Human Affectome

Author

Schiller, Daniela, primary, Yu, Alessandra N.C., additional, Alia-Klein, Nelly, additional, Becker, Susanne, additional, Cromwell, Howard C., additional, Dolcos, Florin, additional, Eslinger, Paul J., additional, Frewen, Paul, additional, Kemp, Andrew H., additional, Pace-Schott, Edward F., additional, Raber, Jacob, additional, Silton, Rebecca L., additional, Stefanova, Elka, additional, Williams, Justin H.G., additional, Abe, Nobuhito, additional, Aghajani, Moji, additional, Albrecht, Franziska, additional, Alexander, Rebecca, additional, Anders, Silke, additional, Aragón, Oriana R., additional, Arias, Juan A., additional, Arzy, Shahar, additional, Aue, Tatjana, additional, Baez, Sandra, additional, Balconi, Michela, additional, Ballarini, Tommaso, additional, Bannister, Scott, additional, Banta, Marlissa C., additional, Barrett, Karen Caplovitz, additional, Belzung, Catherine, additional, Bensafi, Moustafa, additional, Booij, Linda, additional, Bookwala, Jamila, additional, Boulanger-Bertolus, Julie, additional, Boutros, Sydney Weber, additional, Bräscher, Anne-Kathrin, additional, Bruno, Antonio, additional, Busatto, Geraldo, additional, Bylsma, Lauren M., additional, Caldwell-Harris, Catherine, additional, Chan, Raymond C.K., additional, Cherbuin, Nicolas, additional, Chiarella, Julian, additional, Cipresso, Pietro, additional, Critchley, Hugo, additional, Croote, Denise E., additional, Demaree, Heath A., additional, Denson, Thomas F., additional, Depue, Brendan, additional, Derntl, Birgit, additional, Dickson, Joanne M., additional, Dolcos, Sanda, additional, Drach-Zahavy, Anat, additional, Dubljević, Olga, additional, Eerola, Tuomas, additional, Ellingsen, Dan-Mikael, additional, Fairfield, Beth, additional, Ferdenzi, Camille, additional, Friedman, Bruce H., additional, Fu, Cynthia H.Y., additional, Gatt, Justine M., additional, deGelder, Beatrice, additional, Gendolla, Guido H.E., additional, Gilam, Gadi, additional, Goldblatt, Hadass, additional, Gooding, Anne Elizabeth Kotynski, additional, Gosseries, Olivia, additional, Hamm, Alfons O., additional, Hanson, Jamie L., additional, Hendler, Talma, additional, Herbert, Cornelia, additional, Hofmann, Stefan G., additional, Ibanez, Agustin, additional, Joffily, Mateus, additional, Jovanovic, Tanja, additional, Kahrilas, Ian J., additional, Kangas, Maria, additional, Katsumi, Yuta, additional, Kensinger, Elizabeth, additional, Kirby, Lauren A.J., additional, Koncz, Rebecca, additional, Koster, Ernst H.W., additional, Kozlowska, Kasia, additional, Krach, Sören, additional, Kret, Mariska E., additional, Krippl, Martin, additional, Kusi-Mensah, Kwabena, additional, Ladouceur, Cecile D., additional, Laureys, Steven, additional, Lawrence, Alistair, additional, Li, Chiang-shan R., additional, Liddell, Belinda J., additional, Lidhar, Navdeep K., additional, Lowry, Christopher A., additional, Magee, Kelsey, additional, Marin, Marie-France, additional, Mariotti, Veronica, additional, Martin, Loren J., additional, Marusak, Hilary A., additional, Mayer, Annalina V., additional, Merner, Amanda R., additional, Minnier, Jessica, additional, Moll, Jorge, additional, Morrison, Robert G., additional, Moore, Matthew, additional, Mouly, Anne-Marie, additional, Mueller, Sven C., additional, Mühlberger, Andreas, additional, Murphy, Nora A., additional, Muscatello, Maria Rosaria Anna, additional, Musser, Erica D., additional, Newton, Tamara L., additional, Noll-Hussong, Michael, additional, Norrholm, Seth Davin, additional, Northoff, Georg, additional, Nusslock, Robin, additional, Okon-Singer, Hadas, additional, Olino, Thomas M., additional, Ortner, Catherine, additional, Owolabi, Mayowa, additional, Padulo, Caterina, additional, Palermo, Romina, additional, Palumbo, Rocco, additional, Palumbo, Sara, additional, Papadelis, Christos, additional, Pegna, Alan J., additional, Pellegrini, Silvia, additional, Peltonen, Kirsi, additional, Penninx, Brenda W.J.H., additional, Pietrini, Pietro, additional, Pinna, Graziano, additional, Lobo, Rosario Pintos, additional, Polnaszek, Kelly L., additional, Polyakova, Maryna, additional, Rabinak, Christine, additional, HeleneRichter, S., additional, Richter, Thalia, additional, Riva, Giuseppe, additional, Rizzo, Amelia, additional, Robinson, Jennifer L., additional, Rosa, Pedro, additional, Sachdev, Perminder S., additional, Sato, Wataru, additional, Schroeter, Matthias L., additional, Schweizer, Susanne, additional, Shiban, Youssef, additional, Siddharthan, Advaith, additional, Siedlecka, Ewa, additional, Smith, Robert C., additional, Soreq, Hermona, additional, Spangler, Derek P., additional, Stern, Emily R., additional, Styliadis, Charis, additional, Sullivan, Gavin B., additional, Swain, James E., additional, Urben, Sébastien, additional, Van den Stock, Jan, additional, vander Kooij, Michael A., additional, van Overveld, Mark, additional, Van Rheenen, Tamsyn E., additional, VanElzakker, Michael B., additional, Ventura-Bort, Carlos, additional, Verona, Edelyn, additional, Volk, Tyler, additional, Wang, Yi, additional, Weingast, Leah T., additional, Weymar, Mathias, additional, Williams, Claire, additional, Willis, Megan L., additional, Yamashita, Paula, additional, Zahn, Roland, additional, Zupan, Barbra, additional, Lowe, Leroy, additional, Gabriela, Gan, additional, Charlotte F, Huggins, additional, and Leonie, Loeffler, additional

Published
2023
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18. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Author

Boris-Stephan Rauchmann, Patrizia Gross, Ersin Ersoezlue, Michael Wagner, Ballarini Tommaso, Carolin Kurz, Maia Tatò, Julia Utecht, Boris Papazov, Selim Guersel, Marie Totzke, Lena Trappmann, Lena Burow, Gabriele Koller, Sophia Stöcklein, Daniel Keeser, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Doreen Goeerss, Daria Gref, John Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Okka Kimmich, Luca Kleineidam, Christoph Laske, Andrea Lohse, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Lukas Preis, Josef Priller, Sandra Roeske, Nina Roy, Carolin Sanzenbacher, Klaus Scheffler, Anja Schneider, Björn Hendrik Schott, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Debora Melo van Lent, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Düzel, Frank Jessen, and Robert Perneczky

Subjects
Nutrition and Dietetics, Medicine (miscellaneous), Biochemistry, Food Science
Abstract

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use. OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD. METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions. RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p

Published
2023
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20. FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort

Author

Parnetti, Lucilla, Eusebi, Paolo, Frisoni, Giovanni, Nobili, Flavio, Picco, Agnese, Scarpini, Elio, Caminiti, Silvia Paola, Ballarini, Tommaso, Sala, Arianna, Cerami, Chiara, Presotto, Luca, Santangelo, Roberto, Fallanca, Federico, Vanoli, Emilia Giovanna, Gianolli, Luigi, Iannaccone, Sandro, Magnani, Giuseppe, and Perani, Daniela

Published
2018
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22. Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia

Author

Upadhyay, Neeraj, primary, Spottke, Annika, additional, Schneider, Anja, additional, Hoffmann, Daniel C., additional, Frommann, Ingo, additional, Ballarini, Tommaso, additional, Fliessbach, Klaus, additional, Bender, Benjamin, additional, Heekeren, Hauke R., additional, Haynes, John Dylan, additional, Ewers, Michael, additional, Düzel, Emrah, additional, Glanz, Wenzel, additional, Dobisch, Laura, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Levin, Johannes, additional, Danek, Adrian, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Synofzik, Matthis, additional, Wilke, Carlo, additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Spruth, Eike Jakob, additional, Jessen, Frank, additional, and Boecker, Henning, additional

Published
2023
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24. Engagement, Retention, and Acceptability in a Digital Health Program for Atopic Dermatitis: Prospective Interventional Study

Author

Gudmundsdóttir, Sigrídur Lára, primary, Ballarini, Tommaso, additional, Ámundadóttir, María L, additional, Mészáros, Judit, additional, Eysteinsdottir, Jenna Huld, additional, Thorleifsdottir, Ragna H, additional, Hrafnkelsdóttir, Sigrídur K, additional, Helgadottir, Halla, additional, Oddsson, Saemundur, additional, and Silverberg, Jonathan I, additional

Published
2023
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26. A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum

Author

Ersoezlue, Ersin, Perneczky, Robert, Keeser, Daniel, Papazov, Boris, Totzke, Marie, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Tato, Maia, Glanz, Wenzel, Haynes, John Dylan, Heneka, Michael T, Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Laske, Christoph, Maier, Franziska, Munk, Matthias H, Peters, Oliver, Utecht, Julia, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H, Spottke, Annika, Spruth, Eike J, Teipel, Stefan, Kurz, Carolin, Unterfeld, Chantal, Wagner, Michael, Wang, Xiao, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, Rauchmann, Boris-Stephan, group, DELCODE study, Häckert, Jan, Guersel, Selim, Burow, Lena, Koller, Gabriele, and Stoecklein, Sophia

Subjects
cognition, General Neuroscience, resting-state functional connectivity, General Medicine, cognitive reserve, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, pathology [Alzheimer Disease], intrinsic network connectivity, Neural Pathways, Humans, functional MRI, ddc:610, Geriatrics and Gerontology, Nerve Net, diagnostic imaging [Brain], Alzheimer’s disease
Abstract

Background: Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored. Objective: To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer’s disease (ADN). Methods: Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models. Results: CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+. Conclusion: Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.

Published
2023
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28. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Author

Rauchmann, Boris-Stephan, Gross, Patrizia, Ersoezlue, Ersin, Wagner, Michael, Ballarini, Tommaso, Kurz, Carolin, Tatò, Maia, Utecht, Julia, Papazov, Boris, Guersel, Selim, Totzke, Marie, Trappmann, Lena, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Altenstein, Slawek, Bartels, Claudia, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Goeerss, Doreen, Gref, Daria, Haynes, John Dylan, Janowitz, Daniel, Kilimann, Ingo, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Roeske, Sandra, Roy, Nina, Sanzenbacher, Carolin, Scheffler, Klaus, Schneider, Anja, Schott, Björn Hendrik, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, van Lent, Debora Melo, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Düzel, Emrah, Jessen, Frank, and Perneczky, Robert

Abstract

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use.OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD.METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions.RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (? = 0.25, p< 0.001) and the MIND score (? = 0.37, p= < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (ß = 0.1, p= 0.008) and bilateral hippocampal volumes (left: ß = 0.15, p< 0.001); (right: ß = 0.18, p< 0.001)).CONCLUSIONS: The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints.

Published
2023
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30. The Human Affectome

Author

Schiller, Daniela, primary, Yu, Alessandra Nicoletta Cruz, additional, Alia-Klein, Nelly, additional, Becker, Susanne, additional, Cromwell, Howard Casey, additional, Dolcos, Florin, additional, Eslinger, Paul J., additional, Frewen, Paul, additional, Kemp, Andrew Haddon, additional, Pace-Schott, Edward, additional, Raber, Jacob, additional, Silton, Rebecca Levin, additional, Stefanova, Elka, additional, Williams, Justin H. G., additional, Abe, Nobuhito, additional, Aghajani, Moji, additional, Albrecht, Franziska, additional, Alexander, Rebecca, additional, Anders, Silke, additional, Aragón, Oriana R., additional, Arias, Juan A, additional, Arzy, Shahar, additional, Aue, Tatjana, additional, Baez, Sandra, additional, Balconi, Michela, additional, Ballarini, Tommaso, additional, Bannister, Scott, additional, Amole, Marlissa C., additional, Barrett, Karen Caplovitz, additional, Belzung, Catherine, additional, Bensafi, Moustafa, additional, Booij, Linda, additional, Bookwala, Jamila, additional, Boulanger-Bertolus, Julie, additional, Boutros, Sydney Weber, additional, Bräscher, Anne-Kathrin, additional, Bruno, Antonio, additional, Busatto, Geraldo, additional, Bylsma, Lauren, additional, Caldwell-Harris, Catherine, additional, Chan, Raymond C. K., additional, Cherbuin, Nicolas, additional, Chiarella, Julian, additional, Cipresso, Pietro, additional, Critchley, HUgo, additional, Croote, Denise, additional, Demaree, Heath A., additional, Denson, Thomas F, additional, Depue, Brendan, additional, Dernt, Birgit, additional, Dickson, Joanne M., additional, Dolcos, Sanda, additional, Drach-Zahavy, Anat, additional, Dubljević, Olga, additional, Eerola, Tuomas, additional, Ellingsen, Dan-Mikael, additional, Fairfield, Beth, additional, Ferdenzi, Camille, additional, Scarpa-Friedman, Bruce H, additional, Fu, Cynthia H.Y., additional, Gatt, Justine, additional, de Gelder, Beatrice, additional, Gendolla, Guido H. E., additional, Gilam, Gadi, additional, Goldblatt, Hadass, additional, Kotynski, Anne, additional, Gosseries, Olivia, additional, Hamm, Alfons O., additional, Hanson, Jamie Lars, additional, Hendler, Talma, additional, Herbert, Cornelia, additional, Hofmann, Stefan G., additional, Ibanez, Agustin, additional, Joffily, Mateus, additional, Jovanovic, Tanja, additional, Kahrilas, Ian J., additional, Kangas, Maria, additional, Katsumi, Yuta, additional, Kensinger, Elizabeth, additional, Kirby, Lauren A. J., additional, Koncz, Rebecca, additional, Koster, Ernst H. W., additional, Kozlowska, Kasia, additional, Krach, Sören, additional, Kret, Mariska, additional, Krippl, Martin, additional, Kusi-Mensah, Kwabena, additional, Ladouceur, Cecile D., additional, Laureys, Steven, additional, Lawrence, Alistair, additional, Li, Chiang-Shan R., additional, Liddell, Belinda, additional, Lidhar, Navdeep K., additional, Lowry, Christopher A., additional, Magee, Kelsey, additional, Marin, Marie-France, additional, Mariotti, Veronica, additional, Martin, Loren, additional, Marusak, Hilary A., additional, Mayer, Annalina V., additional, Merner, Amanda R., additional, Minnier, Jessica, additional, Moll, Jorge, additional, Morrison, Robert, additional, Moore, Matthew, additional, Mouly, Anne-Marie, additional, Mueller, Sven C, additional, Mühlberger, Andreas, additional, Murphy, Nora A., additional, Muscatello, Maria Rosaria Anna, additional, Musser, Erica D., additional, Newton, Tamara L., additional, Noll-Hussong, Michael, additional, Norrholm, Seth Davin, additional, Northoff, Georg, additional, Nusslock, Robin, additional, Okon-Singer, Hadas, additional, Olino, Thomas M, additional, Ortner, Catherine Nicole Marie, additional, Owolabi, Mayowa, additional, Padulo, Caterina, additional, Palermo, Romina, additional, Palumbo, Rocco, additional, Palumbo, Sara, additional, Papadelis, Christos, additional, Pegna, Alan J., additional, Pellegrini, Silvia, additional, Peltonen, Kirsi, additional, Penninx, Brenda, additional, Pietrini, Pietro, additional, Pinna, Graziano, additional, Pintos Lobo, Rosario, additional, Polnaszek, Kelly L, additional, Polyakova, Maryna, additional, Rabinak, Christine, additional, Richter, S. Helene, additional, Richter, Thalia, additional, Riva, Giuseppe, additional, Rizzo, Amelia, additional, Robinson, Jennifer L., additional, Rosa, Pedro, additional, Sachdev, Perminder S, additional, Satomi, Wataru, additional, Schroeter, Matthias L., additional, Schweizer, Susanne, additional, Shiban, Youssef, additional, Siddharthan, Advaith, additional, Siedlecka, Ewa, additional, Smith, Robert C., additional, Soreq, Hermona, additional, Spangler, Derek P., additional, Stern, Emily R., additional, Styliadis, Charis, additional, Sullivan, Gavin Brent, additional, Swain, James E., additional, Urben, Sébastien, additional, Van den Stock, Jan, additional, van der Kooij, Michael A., additional, van Overveld, Mark, additional, Van Rheenen, Tamsyn, additional, VanElzakker, Michael B., additional, Ventura-Bort, Carlos, additional, Verona, Edelyn, additional, Volk, Tyler, additional, Wang, Yi, additional, Weingast, Leah T., additional, Weymar, Mathias, additional, Williams, Claire, additional, Willis, Megan, additional, Yamashita, Paula, additional, Zahn, Roland, additional, Zupan, Barbra, additional, and Lowe, Leroy, additional

Published
2022
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31. Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum

Author

Teipel, Stefan J., Dyrba, Martin, Ballarini, Tommaso, Brosseron, Frederic, Bruno, Davide, Buerger, Katharina, Cosma, Nicoleta-Carmen, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ewers, Michael, Fliessbach, Klaus, Haynes, John D., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Pomara, Nunzio, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Bjoern H., Spottke, Annika, Spruth, Eike J., Wagner, Michael, Wiltfang, Jens, Jessen, Frank, Heneka, Michael T., Teipel, Stefan J., Dyrba, Martin, Ballarini, Tommaso, Brosseron, Frederic, Bruno, Davide, Buerger, Katharina, Cosma, Nicoleta-Carmen, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ewers, Michael, Fliessbach, Klaus, Haynes, John D., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Pomara, Nunzio, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Bjoern H., Spottke, Annika, Spruth, Eike J., Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Heneka, Michael T.

Abstract

Background: Inflammation has been described as a key pathogenic event in Alzheimer's disease (AD), downstream of amyloid and tau pathology. Preclinical and clinical data suggest that the cholinergic basal forebrain may moderate inflammatory response to different pathologies. Objective: To study the association of cholinergic basal forebrain volume and functional connectivity with measures of neuroinflammation in people from the AD spectrum. Methods: We studied 261 cases from the DELCODEcohort, including people with subjective cognitive decline, mild cognitive impairment, AD dementia, first degree relatives, and healthy controls. Using Bayesian ANCOVA, we tested associations of MRI indices of cholinergic basal forebrain volume and functional connectivity with cerebrospinal fluid (CSF) levels of sTREM2 as a marker of microglia activation, and serum levels of complement C3. Using Bayesian elastic net regression, we determined associations between basal forebrain measures and a large inflammation marker panel from CSF and serum. Results: We found anecdotal to moderate evidence in favor of the absence of an effect of basal forebrain volume and functional connectivity on CSF sTREM2 and serum C3 levels both in A beta(42)/ptau-positive and negative cases. Bayesian elastic net regression identified several CSF and serum markers of inflammation that were associated with basal forebrain volume and functional connectivity. The effect sizes were moderate to small. Conclusion: Our data-driven analyses generate the hypothesis that cholinergic basal forebrain may be involved in the neuroinflammation response to A beta(42) and phospho-tau pathology in people from the AD spectrum. This hypothesis needs to be tested in independent samples.

Published
2022

32. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stoecklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, Perneczky, Robert, Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stoecklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Abstract

Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-beta (A beta) negative healthy controls and 152 A beta positive individ-uals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by ed-ucation and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively in-tact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.(c) 2022 Elsevier Inc. All rights reserved.

Published
2022

33. Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer’s Disease Spectrum

Author

Teipel, Stefan J., primary, Dyrba, Martin, additional, Ballarini, Tommaso, additional, Brosseron, Frederic, additional, Bruno, Davide, additional, Buerger, Katharina, additional, Cosma, Nicoleta-Carmen, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Düzel, Emrah, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Haynes, John D., additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Laske, Christoph, additional, Maier, Franziska, additional, Metzger, Coraline D., additional, Munk, Matthias H., additional, Peters, Oliver, additional, Pomara, Nunzio, additional, Preis, Lukas, additional, Priller, Josef, additional, Ramírez, Alfredo, additional, Roy, Nina, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Schott, Björn H., additional, Spottke, Annika, additional, Spruth, Eike J., additional, Wagner, Michael, additional, Wiltfang, Jens, additional, Jessen, Frank, additional, and Heneka, Michael T., additional

Published
2022
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34. Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited

Author

Koutsouleris, Nikolaos, Pantelis, Christos, Kambeitz, Joseph, Toivonen, Anna, Turtonen, Otto, Botterweck, Sonja, Kluthausen, Norman, Antoch, Gerald, Caspers, Julian, Wittsack, Hans-Jörg, Blasi, Giuseppe, Pergola, Giulio, Caforio, Grazia, Salokangas, Raimo K R, Fazio, Leonardo, Quarto, Tiziana, Gelao, Barbara, Romano, Raffaella, Andriola, Ileana, Falsetti, Andrea, Barone, Marina, Passiatore, Roberta, Sangiuliano, Marina, Surmann, Marian, Hietala, Jarmo, Bienek, Olga, Dannlowski, Udo, Solana, Ana Beatriz, Abraham, Manuela, Schirmer, Timo, Ferro, Adele, Re, Marta, Sberna, Maurizio, D'Agostino, Armando, Del Fabro, Lorenzo, Bertolino, Alessandro, Perna, Giampaolo, Nobile, Maria, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Delvecchio, Giuseppe, Maggioni, Eleonora, Squarcina, Letizia, Gritti, Davide, Brambilla, Paolo, Rossetti, Maria Gloria, Ferrari, Raffaele, Hernandez, Dena Michelle Godwin, Nalls, Michael, Rohrer, Jonathan, Ramasamy, Adaikalavan, Kwok, John, Dobson-Stone, Carol, Brooks, William, Schofield, Peter, Upthegrove, Rachel, Halliday, Glenda, Hodges, John, Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Wood, Stephen J, Cruchaga, Carlos, Cairns, Nigel, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Albani, Diego, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Lencer, Rebekka, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Landqvist Waldö, Maria, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek, Mann, David, Borgwardt, Stefan, Grafman, Jordan, Morris, Christopher, Attems, Johannes, McKeith, Ian, Thomas, Alan, Pietrini, Pietro, Huey, Edward, Wassermann, Eric, Baborie, Atik, Jaros, Evelyn, Maj, Carlo, Tierney, Michael, Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Velakoulis, Dennis, Nöthen, Markus M., Pinessi, Lorenzo, Rogaeva, Ekaterina, George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James, Schlachetzki, Johannes, Uphill, James, Collinge, John, Degenhardt, Franziska, Mead, Simon, Van Deerlin, Vivianna, Marschhauser, Anke, Regenbrecht, Frank, Thoene-Otto, Angelika, Gordulla, Jannis, Ballarini, Tommaso, Engel, Annerose, Pino, Daniele, Leuthold, Dominique, Polyakova, Maryna, Naumann, Heike, Grossman, Murray, Trojanowski, John Q, van der Zee, Julie, Van Broeckhofen, Christine, Cappa, Stefano F, Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Mueller, Karsten, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E, Hjermind, Lena E, Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Villringer, Arno, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N, Fox, Nick C, Warren, Jason D, Spillantini, Maria Grazia, Morris, Huw R, Rizzu, Patrizia, Heutink, Peter, Danek, Adrian, Snowden, Julie S, Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C, Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Fassbender, Klaus, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W, Graff-Radford, Neill R, Petersen, Ronald C, Knopman, David S, Josephs, Keith A, Fliessbach, Klaus, Boeve, Bradley F, Parisi, Joseph E, Seeley, William W, Miller, Bruce L, Karydas, Anna M, Rosen, Howard, van Swieten, John C, Dopper, Elise Gp, Seelaar, Harro, Pijnenburg, Yolande Al, Jahn, Holger, Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A, Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Kornhuber, Johannes, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebouvier, Thibaud, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B, McGuire, Philip, Landwehrmeyer, Bernhard, Hardy, John, Momeni, Parastoo, Barthel, Henryk, Elisa, Semler, Jolina, Lombardi, Christine, von Arnim, Felix, Oberahauser, Kai, Schumacher, Jan, Lehmbeck, Juan-Manuel, Maler, Anderl-Straub, Sarah, Tanja, Richter-Schmidinger, Anke, Hammer-Kaspereit, Timo, Oberstein, Felix, Müller-Sarnowski, Carola, Roßmeier, Albert, Ludolph, Jan, Kassubek, Anja, Schneider, Johannes, Levin, Prudlo, Johannes, Synofzik, Matthis, Wiltfang, Jens, Riedl, Lina, Diehl-Schmid, Janine, Otto, Markus, Meisenzahl, Eva, Falkai, Peter, Dwyer, Dominic B, Schroeter, Matthias L, Consortium, the PRONIA, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Yanis, Urquijo-Castro, Maria-Fernanda, Öztürk, Ömer, Penzel, Nora, Rangnick, Adrian, von Saldern, Sebastian, Spangemacher, Moritz, Tupac, Ana, Weiske, Johanna, Wosgien, Antonia, Krämer, Camilla, Blume, Karsten, Paul, Riya, Hedderich, Dennis, Julkowski, Dominika, Kaiser, Nathalie, Lichtenstein, Thorsten, Milz, Ruth, Nikolaides, Alexandra, Pilgram, Tanja, Seves, Mauro, Wassen, Martina, Andreou, Christina, Dong, Sen, Egloff, Laura, Harrisberger, Fabienne, Heitz, Ulrike, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Popovic, David, Day, Chris, Lowri Griffiths, Sian, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Lalousis, Paris, Denissoff, Alexander, Ellilä, Anu, Oeztuerk, Oemer, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, International FTD-Genetics Consortium (IFGC), German Frontotemporal Lobar Degeneration (FTLD) Consortium, PRONIA Consortium, and International FTD-Genetics Consortium Consortium

Subjects
Adult, Male, Medizin, genetics [Alzheimer Disease], genetics [Psychotic Disorders], Neuropsychological Tests, diagnostic imaging [Frontotemporal Dementia], diagnostic imaging [Psychotic Disorders], Machine Learning, methods [Magnetic Resonance Imaging], Brain, Female, Humans, Magnetic Resonance Imaging, Alzheimer Disease, Frontotemporal Dementia, Psychotic Disorders, Schizophrenia, pathology [Brain], genetics [Schizophrenia], ddc:610, diagnostic imaging [Brain], genetics [Frontotemporal Dementia], Settore MED/25 - Psichiatria, Psychiatry and Mental health, diagnostic imaging [Schizophrenia], diagnostic imaging [Alzheimer Disease]
Abstract

Weitere Nicht-UDE Autoren sind nicht genannt. Importance: The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far. Objective: To use machine learning to compare the expression of structural magnetic resonance imaging (MRI) patterns of behavioral-variant frontotemporal dementia (bvFTD), Alzheimer disease (AD), and schizophrenia; estimate predictability in patients with bvFTD and schizophrenia based on sociodemographic, clinical, and biological data; and examine prognostic value, genetic underpinnings, and progression in patients with clinical high-risk (CHR) states for psychosis or recent-onset depression (ROD). Design, Setting, and Participants: This study included 1870 individuals from 5 cohorts, including (1) patients with bvFTD (n = 108), established AD (n = 44), mild cognitive impairment or early-stage AD (n = 96), schizophrenia (n = 157), or major depression (n = 102) to derive and compare diagnostic patterns and (2) patients with CHR (n = 160) or ROD (n = 161) to test patterns' prognostic relevance and progression. Healthy individuals (n = 1042) were used for age-related and cohort-related data calibration. Data were collected from January 1996 to July 2019 and analyzed between April 2020 and April 2022. Main Outcomes and Measures: Case assignments based on diagnostic patterns; sociodemographic, clinical, and biological data; 2-year functional outcomes and genetic separability of patients with CHR and ROD with high vs low pattern expression; and pattern progression from baseline to follow-up MRI scans in patients with nonrecovery vs preserved recovery. Results: Of 1870 included patients, 902 (48.2%) were female, and the mean (SD) age was 38.0 (19.3) years. The bvFTD pattern comprising prefrontal, insular, and limbic volume reductions was more expressed in patients with schizophrenia (65 of 157 [41.2%]) and major depression (22 of 102 [21.6%]) than the temporo-limbic AD patterns (28 of 157 [17.8%] and 3 of 102 [2.9%], respectively). bvFTD expression was predicted by high body mass index, psychomotor slowing, affective disinhibition, and paranoid ideation (R2= 0.11). The schizophrenia pattern was expressed in 92 of 108 patients (85.5%) with bvFTD and was linked to the C9orf72 variant, oligoclonal banding in the cerebrospinal fluid, cognitive impairment, and younger age (R2= 0.29). bvFTD and schizophrenia pattern expressions forecasted 2-year psychosocial impairments in patients with CHR and were predicted by polygenic risk scores for frontotemporal dementia, AD, and schizophrenia. Findings were not associated with AD or accelerated brain aging. Finally, 1-year bvFTD/schizophrenia pattern progression distinguished patients with nonrecovery from those with preserved recovery. Conclusions and Relevance: Neurobiological links may exist between bvFTD and psychosis focusing on prefrontal and salience system alterations. Further transdiagnostic investigations are needed to identify shared pathophysiological processes underlying the neuroanatomical interface between the 2 disease spectra.

Published
2022
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35. The Human Affectome

Author

Schiller, Daniela, Yu, Alessandra, Alia-Klein, Nelly, Becker, Susanne, Cromwell, Howard, Dolcos, Florin, Eslinger, Paul, Frewen, Paul, Kemp, Andrew, Pace-Schott, Edward, Raber, Jacob, Silton, Rebecca, Stefanova, Elka, Williams, Justin, Abe, Nobuhito, Aghajani, Moji, Albrecht, Franziska, Alexander, Rebecca, Anders, Silke, Aragón, Oriana, Arias, Juan, Arzy, Shahar, Aue, Tatjana, Baez, Sandra, Balconi, Michela, Ballarini, Tommaso, Bannister, Scott, Banta, Marlissa, Caplovitz Barrett, Karen, Belzung, Catherine, Bensafi, Moustafa, Booij, Linda, Bookwala, Jamila, Boulanger-Bertolus, Julie, Boutros, Sydney, Bräscher, Anne-Kathrin, Bruno, Antonio, Busatto, Geraldo, Bylsma, Lauren, Caldwell-Harris, Catherine, Chan, Raymond, Cherbuin, Nicolas, Chiarella, Julian, Cipresso, Pietro, Critchley, Hugo, Croote, Denise, Demaree, Heath, Denson, Thomas, Depue, Brendan, Derntl, Birgit, Dickson, Joanne, Dolcos, Sanda, Drach-Zahavy, Anat, Dubljević, Olga, Eerola, Tuomas, Ellingsen, Dan-Mikael, Fairfield, Beth, Ferdenzi, Camille, Friedman, Bruce, Fu, Cynthia, Gatt, Justine, de Gelder, Beatrice, Gendolla, Guido, Gilam, Gadi, Goldblatt, Hadass, Elizabeth, Anne, Gooding, Kotynski, Gosseries, Olivia, Hamm, Alfons, Hanson, Jamie, Hendler, Talma, Herbert, Cornelia, Hofmann, Stefan, Ibanez, Agustin, Joffily, Mateus, Jovanovic, Tanja, Kahrilas, Ian, Kangas, Maria, Katsumi, Yuta, Kensinger, Elizabeth, Kirby, Lauren, Koncz, Rebecca, Koster, Ernst, Kozlowska, Kasia, Krach, Sören, Kret, Mariska, Krippl, Martin, Kusi-Mensah, Kwabena, Ladouceur, Cecile, Laureys, Steven, Lawrence, Alistair, Li, Chiang-Shan, Liddell, Belinda, Lidhar, Navdeep, Lowry, Christopher, Magee, Kelsey, Marin, Marie-France, Mariotti, Veronica, Martin, Loren, Marusak, Hilary, Mayer, Annalina, Merner, Amanda, Minnier, Jessica, Moll, Jorge, Morrison, Robert, Moore, Matthew, Mouly, Anne-Marie, Mueller, Sven, Mühlberger, Andreas, Murphy, Nora, Rosaria, Maria, Muscatello, Anna, Musser, Erica, Newton, Tamara, Noll-Hussong, Michael, Norrholm, Seth, Northoff, Georg, Nusslock, Robin, Okon-Singer, Hadas, Olino, Thomas, Ortner, Catherine, Owolabi, Mayowa, Padulo, Caterina, Palermo, Romina, Palumbo, Rocco, Palumbo, Sara, Papadelis, Christos, Pegna, Alan, Pellegrini, Silvia, Peltonen, Kirsi, Penninx, Brenda, Pietrini, Pietro, Pinna, Graziano, Pintos Lobo, Rosario, Polnaszek, Kelly, Polyakova, Maryna, Rabinak, Christine, Richter, S, Richter, Thalia, Riva, Giuseppe, Rizzo, Amelia, Robinson, Jennifer, Rosa, Pedro, Sachdev, Perminder, Sato, Wataru, Schroeter, Matthias, Schweizer, Susanne, Shiban, Youssef, Siddharthan, Advaith, Siedlecka, Ewa, Smith, Robert, Soreq, Hermona, Spangler, Derek, Stern, Emily, Styliadis, Charis, Sullivan, Gavin, Swain, James, Urben, Sébastien, van den Stock, Jan, van der Kooij, Michael, van Overveld, Mark, van Rheenen, Tamsyn, Vanelzakker, Michael, Ventura-Bort, Carlos, Verona, Edelyn, Volk, Tyler, Wang, Yi, Weingast, Leah, Weymar, Mathias, Williams, Claire, Willis, Megan, Yamashita, Paula, Zahn, Roland, Zupan, Barbra, Lowe, Leroy, and MOULY, Anne-Marie

Subjects
[SCCO] Cognitive science
Published
2022

37. The neuroscience of social feelings: mechanisms of adaptive social functioning

Author

Eslinger, Paul J., primary, Anders, Silke, additional, Ballarini, Tommaso, additional, Boutros, Sydney, additional, Krach, Sören, additional, Mayer, Annalina V., additional, Moll, Jorge, additional, Newton, Tamara L., additional, Schroeter, Matthias L., additional, de Oliveira-Souza, Ricardo, additional, Raber, Jacob, additional, Sullivan, Gavin B., additional, Swain, James E., additional, Lowe, Leroy, additional, and Zahn, Roland, additional

Published
2021
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38. Additional file 5 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Additional file 5: Supplementary Figure 3. Comparison of mean relevance maps between samples.

Published
2021
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39. Additional file 2 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Additional file 2: Supplementary Table 2. Group separation performance for hippocampus volume and the convolutional neural network models for raw input data.

Published
2021
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40. Additional file 6 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Subjects
nervous system
Abstract

Additional file 6: Supplementary Figure 4. Correlation matrix of hippocampus volume (residualized) and several brain regions’ relevance scores for DELCODE participants and the model trained on the whole ADNI-GO/2 dataset.

Published
2021
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41. Additional file 3 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Additional file 3: Supplementary Figure 1. UML diagram of the interactive visualization application.

Published
2021
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42. Additional file 1 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Additional file 1: Supplementary Table 1. Group separation performance for hippocampus volume and the convolutional neural network models for residualized data (extended).

Published
2021
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43. Additional file 4 of Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Additional file 4: Supplementary Figure 2. Sequence diagram of function calls when selecting a new person.

Published
2021
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44. SERIAL-ORDER recall in working memory across the cognitive spectrum of Parkinson’s disease and neuroimaging correlates

Author

Bezdicek, Ondrej, Ballarini, Tommaso, Albrecht, Franziska, Libon, David J., Lamar, Melissa, Růžička, Filip, Roth, Jan, Hurlstone, Mark J., Mueller, Karsten, Schroeter, Matthias L., Jech, Robert, Bezdicek, Ondrej, Ballarini, Tommaso, Albrecht, Franziska, Libon, David J., Lamar, Melissa, Růžička, Filip, Roth, Jan, Hurlstone, Mark J., Mueller, Karsten, Schroeter, Matthias L., and Jech, Robert

Abstract

We sought to determine if Parkinson's disease (PD) with mild cognitive impairment (MCI) is associated with a greater SERIAL-ORDER (mental manipulation) than ANY-ORDER (auditory span, storage) deficit in working memory (WM). We investigated WM combining neuropsychological measures with the study of brain functional connectivity. A cohort of 160 patients with idiopathic PD, classified as PD-MCI (n = 87) or PD with normal cognition (PD-NC; n = 73), and 70 matched healthy controls were studied. Verbal WM was assessed with the Backward Digit Span Task (BDT; Lamar et al., 2007, Neuropsychologia, 45, 245), measuring SERIAL-ORDER and ANY-ORDER recall. Resting-state MRI data were collected for 15 PD-MCI, 15 PD-NC and 30 controls. Hypothesis-driven seed-based functional connectivity of the dorsolateral prefrontal cortex (DLPFC) was compared between the three groups and correlated with BDT performance. We found the main effect of the test (impairment in SERIAL ORDER > ANY ORDER) and group ((NC = PD-NC) > PD-MCI) in BDT performance that was even more pronounced in SERIAL ORDER when controlling for ANY ORDER variability but not vice versa. Furthermore, PD-MCI compared to other groups were characterized by the functional disconnection between the bilateral DLPFC and the cerebellum. In functional correlations, DLPFC connectivity was positively related to both SERIAL- and ANY-ORDER performance. In conclusion, PD-MCI patients evidenced greater SERIAL-ORDER (manipulation and cognitive control) than ANY-ORDER (storage) working memory impairment than PD-NC and controls with a disrupted DLPFC resting-state connectivity that was also related to the verbal WM performance.

Published
2021

45. Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantre, Daniel, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Bjoern H., Spottke, Annika, Spruth, Eike J., Weber, Marc-Andre, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, Teipel, Stefan J., Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantre, Daniel, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Bjoern H., Spottke, Annika, Spruth, Eike J., Weber, Marc-Andre, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Abstract

Background Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer's disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined by prior knowledge. Methods We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC >= 0.91) and moderate accuracy for amnestic MCI versus controls (AUC approximate to 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson's r approximate to -0.86, p < 0.001). Conclusion The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relev

Published
2021

46. Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Author

Ballarini, Tommaso, van Lent, Debora Melo, Brunner, Julia, Schroeder, Alina, Wolfsgruber, Steffen, Altenstein, Slawek, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Hauser, Dietmar, Haynes, John Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline Danielle, Munk, Matthias, Perneczky, Robert, Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, Wagner, Michael, Ballarini, Tommaso, van Lent, Debora Melo, Brunner, Julia, Schroeder, Alina, Wolfsgruber, Steffen, Altenstein, Slawek, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Hauser, Dietmar, Haynes, John Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline Danielle, Munk, Matthias, Perneczky, Robert, Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, and Wagner, Michael

Abstract

Objective To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment and Dementia Study. Method The sample (n = 512, mean age 69.5 +/- 5.9 years) included 169 cognitively normal participants and individuals at higher AD risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 with mild cognitive impairment). We defined MeDi adherence according to the food frequency questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI, and cognitive performance was assessed with an extensive neuropsychological battery. AD-related biomarkers (beta-amyloid(42/40) [A beta(42/40)] ratio, phosphorylated tau 181 [pTau181]) in CSF were assessed in n = 226 individuals. We analyzed the associations between MeDi and outcomes with linear regression models controlling for several covariates. In addition, we applied hypothesis-driven mediation and moderation analysis. Results Higher MeDi adherence related to larger mediotemporal gray matter volume (p < 0.05 family-wise error corrected), better memory (beta +/- SE = 0.03 +/- 0.02; p = 0.038), and less amyloid (A beta(42/40) ratio, beta +/- SE = 0.003 +/- 0.001; p = 0.008) and pTau181 (beta +/- SE = -1.96 +/- 0.68; p = 0.004) pathology. Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations among A beta(42/40) ratio, pTau181, and mediotemporal atrophy. Results were consistent correcting for APOE-epsilon 4 status. Conclusion Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. They suggest that these associations might be explained by a decrease of amyloidosis and tau pathology. Longitudinal and dietary intervention studies should further examine this conjecture and it

Published
2021

47. The effects of Mediterranean diet on memory and Alzheimer's disease biomarkers

Author

Ballarini, Tommaso, primary, Schröder, Alina, additional, van Lent, Debora Melo, additional, Wolfsgruber, Steffen, additional, Priller, Josef, additional, Teipel, Stefan J, additional, Buerger, Katharina, additional, Laske, Christoph, additional, Peters, Oliver, additional, Wiltfang, Jens, additional, Düzel, Emrah, additional, Spottke, Annika, additional, Perneczky, Robert, additional, Fließbach, Klaus, additional, Schneider, Anja, additional, Heneka, Michael T, additional, Jessen, Frank, additional, and Wagner, Michael, additional

Published
2020
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49. SERIAL‐ORDER recall in working memory across the cognitive spectrum of Parkinson’s disease and neuroimaging correlates

Author

Bezdicek, Ondrej, primary, Ballarini, Tommaso, additional, Albrecht, Franziska, additional, Libon, David J., additional, Lamar, Melissa, additional, Růžička, Filip, additional, Roth, Jan, additional, Hurlstone, Mark J., additional, Mueller, Karsten, additional, Schroeter, Matthias L., additional, and Jech, Robert, additional

Published
2020
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