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281 results on '"Ball, David L."'

5. Impact of Medical Operability and Total Metastatic Ablation on Outcomes After SABR for Oligometastases

Author

Siva, Shankar, primary, Jones, Gavin, additional, Bressel, Mathias, additional, Shaw, Mark, additional, Chander, Sarat, additional, Chu, Julie, additional, Plumridge, Nikki, additional, Byrne, Keelan, additional, Kothari, Gargi, additional, Hardcastle, Nicholas, additional, Gaudreault, Mathieu, additional, Kron, Tomas, additional, Wheeler, Greg, additional, MacManus, Michael, additional, Hanna, Gerard G., additional, Ball, David L, additional, and David, Steven, additional

Published
2022
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6. The complex relationship between lung tumor volume and survival in patients with non-small cell lung cancer treated by definitive radiotherapy: A prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05)

Author

Ball, David L., Fisher, Richard J., Burmeister, Bryan H., Poulsen, Michael G., Graham, Peter H., Penniment, Michael G., Vinod, Shalini K., Krawitz, Hedley E., Joseph, David J., Wheeler, Greg C., and McClure, Bev E.

Published
2013
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32. Positron emission tomography in pulmonary masses where tissue diagnosis is unhelpful or not possible

Author

Pitman, Alex G., Hicks, Rodney J., Kalff, Victor, Binns, David S., Ware, Robert E., McKenzie, Allan F., Ball, David L., and MacManus, Michael P.

Subjects
PET imaging -- Evaluation, Respiratory disease nursing -- Methods, Tomography -- Health aspects, Health
Abstract

An investigation is conducted into the usefulness of positron emission topography (PET) in the diagnosis of lung masses, where tissue diagnosis is not available or useful. It is seen that PET could be used to avoid pen biopsy and contributed to improvements in the management of patients.

Published
2001

33. F-18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with nonsmall cell lung carcinoma: powerful correlation with survival and high impact on treatment

Author

Manus, Michael P. Mac, Hicks, Rodney J., Ball, David L., Kalff, Victor, Matthews, Jane P., Salminen, Eeva, Khaw, Pearly, Wirth, Andrew, Rischin, Danny, and McKenzie, Alan

Subjects
Lung cancer, Non-small cell -- Radiotherapy, Tumor staging -- Methods, PET imaging -- Evaluation, Health
Published
2001

36. Symptom duration and delay in referral for palliative radiotherapy in cancer patients: a pilot study

Author

Wirth, Andrew, Smith, Jennifer G., Ball, David L., Mameghan, Hedy, Corry, June, Bernshaw, David L.M., and Drummond, Roslyn M.

Subjects
Cancer -- Palliative treatment, Radiotherapy -- Health aspects, Cancer pain -- Care and treatment, Health
Abstract

Referral for palliative radiotherapy for symptoms of cancer may be greatly delayed in Australia, subjecting patients to unnecessary pain. Researchers evaluated 158 cancer patients referred for radiation therapy to treat pain, spinal cord compression, and other complications. Radiotherapy referral was delayed an average of four weeks after symptoms began, and 24% of patients were delayed an average of 12 weeks. Eighteen percent of cases of delay resulted from initial use of other, often ineffective, treatment.

Published
1998

39. What 18F-FDG PET Response-Assessment Method Best Predicts Survival After Curative-Intent Chemoradiation in Non–Small Cell Lung Cancer: EORTC, PERCIST, Peter Mac Criteria, or Deauville Criteria?

Author

Turgeon, Guy-Anne, primary, Iravani, Amir, additional, Akhurst, Tim, additional, Beaulieu, Alexis, additional, Callahan, Jason W., additional, Bressel, Mathias, additional, Cole, Aidan J., additional, Everitt, Sarah J., additional, Siva, Shankar, additional, Hicks, Rodney J., additional, Ball, David L., additional, and Mac Manus, Michael P., additional

Published
2018
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41. Radiation therapy

Author

Ball, david L. and Burmeister, Bryan H.

Subjects
Lung cancer, Non-small cell -- Care and treatment, Radiotherapy -- Evaluation, Combined modality therapy -- Methods, Health
Abstract

The palliative and therapeutic roles of radiation therapy for non-small-cell lung cancer are presented. Combination therapies may include chemotherapy and radiotherapy for cancers that cannot be surgically treated.

Published
1997

43. Respiratory-gated (4D) FDG-PET detects tumour and normal lung response after stereotactic radiotherapy for pulmonary metastases

Author

Siva, Shankar, Callahan, Jason W., Kron, Tomas, Chesson, Brent, Barnett, Stephen A., Macmanus, Michael P., Hicks, Rodney J., and Ball, David L.

Abstract

Background. Response assessment after stereotactic ablative body radiotherapy (SABR) in lung can be confounded by radiation-induced inflammation, fibrosis and subsequent alteration of tumour motion. The purpose of this prospective pilot study was to evaluate the utility of four-dimensional (4D) FDG-PET/CT for post-SABR tumour and normal lung response assessment in pulmonary oligometastases.Material and methods. Patients enrolled from February 2010 to December 2011 in this prospective ethics approved study had 1–2 pulmonary metastases on staging FDG-PET. Serial contemporaneous 3D and 4D FDG-PET/CT scans were performed at baseline, 14 days and 70 days after a single fraction of 26 Gy SABR. Tumour response was evaluated in 3D and 4D using SUVmax, RECIST and PERCIST criteria. Normal lung radiotoxicity was evaluated using SUVmean within 0–2 Gy, 2–5 Gy, 5–10 Gy, 10–20 Gy and 20 + Gy isodose volumes.Results. In total, 17 patients were enrolled of which seven were ineligible due to interval progression from staging PET to baseline 4D-PET. The mean time between scans was 62 days. At a median follow-up of 16 months, 10 patients with 13 metastases received SABR, with no patient having local progression. The vector of tumour motion was larger in patients with discordant 3D and 4D PET PERCIST response (p < 0.01), with a mean (± SEM) motion of 10.5 mm (± 0.96 mm) versus 6.14 mm (± 0.81 mm) in those patients with concordant 3D and 4D response. Surrounding normal lung FDG uptake at 70 days was strongly correlated to delivered radiation dose (r2 = 0.99, p < 0.01), with significant elevations across all dose levels (p ≤ 0.05), except the < 2 Gy volume (p = 0.30).Conclusions. We demonstrate high rates of interval progression between staging PET scans in patients with oligometastases. We found that tumour response on conventional 3D PET is not concordant with 4D PET for tumours with large motion. Normal lung metabolic uptake is strongly dose dependent after SABR, a novel finding that should be further validated.

Published
2015
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44. Long-term survival following chemoradiation for inoperable non-small cell lung cancer

Author

Plumridge, Nikki M., Millward, Michael J., Rischin, Danny, MacManus, Michael P., Wirth, Andrew, Michael, Michael, Yuen, Kelly, and Ball, David L.

Subjects
Lung cancer, Non-small cell -- Care and treatment, Lung cancer, Non-small cell -- Prognosis, Chemotherapy -- Usage, Radiotherapy -- Usage, Cancer -- Chemotherapy, Cancer -- Usage, Health
Abstract

A study was conducted to evaluate the rate of long-term survival after treatment with chemotherapy combined with radiotherapy for inoperable non-small cell lung cancer. Results indicated that survival rate could be improved for patients with inoperable non-small cell lung cancer when treated by radical chemoradiation alone.

Published
2008

46. Ventilation/perfusion positron emission tomography-based assessment of radiation injury to lung

Author

Siva, Shankar, Hardcastle, Nicholas G, Kron, Tomas, Bressel, Mathias, Callahan, Jason, Macmanus, Michael P, Shaw, Mark, Plumridge, Nikki, Hicks, Rodney J, Steinfort, Daniel, Ball, David L, Hofman, Michael S, Siva, Shankar, Hardcastle, Nicholas G, Kron, Tomas, Bressel, Mathias, Callahan, Jason, Macmanus, Michael P, Shaw, Mark, Plumridge, Nikki, Hicks, Rodney J, Steinfort, Daniel, Ball, David L, and Hofman, Michael S

Abstract

2015. Purpose: To investigate 68Ga-ventilation/perfusion (V/Q) positron emission tomography (PET)/computed tomography (CT) as a novel imaging modality for assessment of perfusion, ventilation, and lung density changes in the context of radiation therapy(RT). Methods and Materials: In a prospective clinical trial, 20 patients underwent 4-dimensional (4D)-V/Q PET/CT before, midway through, and 3 months after definitive lung RT. Eligible patients were prescribed 60Gy in 30 fractions with or without concurrent chemotherapy. Functional images were registered to the RT planning 4D-CT, and isodose volumes were averaged into 10-Gy bins. Within each dose bin, relative loss in standardized uptake value (SUV) was recorded for ventilation and perfusion, and loss in air-filled fraction was recorded to assess RT-induced lung fibrosis. A dose-effect relationship was described using both linear and 2-parameter logistic fit models, and goodness of fit was assessed with Akaike Information Criterion (AIC). Results: A total of 179 imaging datasets were available for analysis (1 scan was unrecoverable). An almost perfectly linear negative dose-response relationship was observed for perfusion and air-filled fraction (r 2=0.99, P<.01), with ventilation strongly negatively linear (r 2=0.95, P<.01). Logistic models did not provide a better fit as evaluated by AIC. Perfusion, ventilation, and the air-filled fraction decreased 0.75±0.03%, 0.71±0.06%, and 0.49±0.02%/Gy, respectively. Within high-dose regions, higher baseline perfusion SUV was associated with greater rate of loss. At 50Gy and 60Gy, the rate of loss was 1.35% (P=.07) and 1.73% (P=.05) per SUV, respectively. Of 8/20 patients with peritumoral reperfusion/reventilation during treatment, 7/8 did not sustain this effect after treatment. Conclusions: Radiation-induced regional lung functional deficits occur in a dose-dependent manner and can be estimated by simple linear models with 4D-V/Q PET/CT imaging. These findings may inform fut

Published
2015

47. Accuracy and utility of deformable image registration in 68Ga 4D PET/CT assessment of pulmonary perfusion changes during and after lung radiation therapy

Author

Hardcastle, Nicholas G, Hofman, Michael S, Hicks, Rodney J, Callahan, Jason, Kron, Tomas, Macmanus, Michael P, Ball, David L, Jackson, Price, Siva, Shankar, Hardcastle, Nicholas G, Hofman, Michael S, Hicks, Rodney J, Callahan, Jason, Kron, Tomas, Macmanus, Michael P, Ball, David L, Jackson, Price, and Siva, Shankar

Abstract

Purpose: Measuring changes in lung perfusion resulting from radiation therapy dose requires registration of the functional imaging to the radiation therapy treatment planning scan. This study investigates registration accuracy and utility for positron emission tomography (PET)/computed tomography (CT) perfusion imaging in radiation therapy for non-small cell lung cancer.

Published
2015

49. Ventilation/Perfusion Positron Emission Tomography—Based Assessment of Radiation Injury to Lung

Author

Siva, Shankar, primary, Hardcastle, Nicholas, additional, Kron, Tomas, additional, Bressel, Mathias, additional, Callahan, Jason, additional, MacManus, Michael P., additional, Shaw, Mark, additional, Plumridge, Nikki, additional, Hicks, Rodney J., additional, Steinfort, Daniel, additional, Ball, David L., additional, and Hofman, Michael S., additional

Published
2015
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