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23 results on '"Baliff, Jeffrey P."'

7. Can Transarterial Chemoembolization of Hepatocellular Carcinoma Result in Transformation to Combined Hepatocellular-Cholangiocarcinoma with Stem Cell Features? A Case Study

Author

Joneja, Upasana, Hann, Hie-Won, Brown, Daniel B., Littman, Susan J., and Baliff, Jeffrey P.

Subjects
stem cell, transarterial chemoembolization, hepatocellular carcinoma, digestive system diseases
Abstract

Transarterial chemoembolization (TACE) is currently one of the favored treatment modalities for non-curative hepatocellular carcinoma (HCC) and can be used to shrink tumor size in order to make a patient eligible for transplantation. Furthermore, with the advent of effective antiviral drugs for hepatitis B virus (HBV), concomitant antiviral therapy with local tumor ablation including TACE for HBV-associated HCC has been successful for long term survival. Over the last decade, however, concern has been raised about a phenomenon whereby a subset of TACE-treated HCCs becomes more aggressive after TACE treatment. One current hypothesis is that TACE eliminates only the hepatocellular cells and that hepatic progenitor cells that have the potential for developing to cholangiocarcinoma are then selected for and induced to proliferate post-TACE with possible dual differentiation along hepatocellular and biliary lines. We present a case of a patient with HCC who underwent TACE and subsequently experienced tumor regrowth as biopsy-proven combined hepatocellular-cholangiocarcinoma. Furthermore, we provide immunohistochemical evidence of hepatic progenitor cells in the post-TACE tumor biopsy, possibly accounting for its aggressive course. &nbsp

Published
2017

8. A case of periampullary adenocarcinoma in neurofibromatosis type 1

Author

Kistler, C. Andrew, Johnson, Jennifer M., Winter, Jordan M., Baliff, Jeffrey P., Siddiqui, Ali A., and Sama, Ashwin R.

Subjects
Case Report
Abstract

Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder with a known predisposition to gastrointestinal neoplasms such as stromal tumors and carcinoids. Adenocarcinomas (ACs) of the gastrointestinal tract are relatively rare in patients with NF-1, especially those found in the periampullary region. We present a case report of periampullary adenocarcinoma in a 56-year-old woman with NF-1 who presented with abdominal pain and obstructive jaundice.

Published
2014

13. Chronic Liver Disease: Noninvasive Subharmonic Aided Pressure Estimation of Hepatic Venous Pressure Gradient

Author

Eisenbrey, John R., primary, Dave, Jaydev K., additional, Halldorsdottir, Valgerdur G., additional, Merton, Daniel A., additional, Miller, Cynthia, additional, Gonzalez, José M., additional, Machado, Priscilla, additional, Park, Suhyun, additional, Dianis, Scott, additional, Chalek, Carl L., additional, Kim, Christopher E., additional, Baliff, Jeffrey P., additional, Thomenius, Kai E., additional, Brown, Daniel B., additional, Navarro, Victor, additional, and Forsberg, Flemming, additional

Published
2013
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16. Mouse models of IgG- and IgM-mediated hemolysis

Author

Schirmer, David A., primary, Song, Shuh-Chyung, additional, Baliff, Jeffrey P., additional, Harbers, Stephanie O., additional, Clynes, Raphael A., additional, Krop-Watorek, Anna, additional, Halverson, Gregory R., additional, Czerwinski, Marcin, additional, and Spitalnik, Steven L., additional

Published
2006
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18. In Situ Hybridization for Coccidioides immitis5.8S Ribosomal RNA Sequences in Formalin-fixed, Paraffin-embedded Pulmonary Specimens Using a Locked Nucleic Acid Probe

Author

Montone, Kathleen T., Litzky, Leslie A., Feldman, Michael D., Peterman, Heather, Mathis, Benjamin, Baliff, Jeffrey, Kaiser, Larry R., Kucharczuk, John, and Nachamkin, Irving

Abstract

Coccidioides immitisCoccidioides posadasiiare common causes of pulmonary infection in certain geographic areas, and are highly infectious when working with culture isolates in the laboratory. Rapid techniques to accurately identify this pathogen in tissues may be of benefit for diagnosis and in limiting the exposure of laboratory personnel to this agent. Locked nucleic acids (LNA) are modified nucleotides in which a ribonucleoside is linked between the 2′-oxygen and the 4′-carbon atoms with a methylene unit. LNA oligonucleotides exhibit increased thermal stability and make excellent probes for in situ hybridization (ISH). In this study, ISH utilizing a biotin-labeled LNA probe targeting Coccidioides sp. ribosomal RNA sequences in 6 formalin-fixed, paraffin-embedded pulmonary tissue specimens from 6 patients with culture positive or histologic findings suggestive of Coccidioides sp.infection is described. The cultures of the pulmonary specimens confirmed C. immitisin 3 of 6 patients. The ISH procedure with the LNA probe was positive in all 6 cases, although the number of organisms that were highlighted varied from rare to numerous. ISH with a biotin-labeled DNA probe of the same sequence was positive in 4 of the 6 cases and the signal intensity and number of organisms was much less than that observed with the LNA probe. Negative control tissues containing a variety of different fungal pathogens including Aspergillus sp., Fusarium sp., Blastomyces dermatitidis, Candida sp, Histoplasma capsulatum, and Zygomyces did not hybridize with the LNA and DNA probes. ISH with an LNA oligonucleotide probe targeting Coccidioides sp.ribosomal RNA is useful for rapid ISH. ISH could be rapidly performed when fungal pathogens are observed in tissue but cultures are negative or have not been performed.

Published
2010
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19. New developments in prenatal screening for Down syndrome.

Author

Baliff, Jeffrey P and Mooney, Robert A

Abstract

Since the introduction of the triple screen, the emergence of additional analytes found to be associated with trisomy 21 pregnancies has challenged the clinical pathology and obstetric communities to determine which combination provides the best performance characteristics as a screening test. The cost, practicality, and psychosocial and ethical dimensions of different screening regimens further complicate the issue. This review attempts to give an overview of the various markers, current methods of screening, and most promising recent developments in antenatal screening for Down syndrome, with an emphasis on performance in prospective studies that have emerged during the last few years, rather than on estimates from statistical modeling.

Published
2003

22. A case of periampullary adenocarcinoma in neurofibromatosis type 1.

Author

Kistler CA, Johnson JM, Winter JM, Baliff JP, Siddiqui AA, and Sama AR

Abstract

Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder with a known predisposition to gastrointestinal neoplasms such as stromal tumors and carcinoids. Adenocarcinomas (ACs) of the gastrointestinal tract are relatively rare in patients with NF-1, especially those found in the periampullary region. We present a case report of periampullary adenocarcinoma in a 56-year-old woman with NF-1 who presented with abdominal pain and obstructive jaundice.

Published
2014
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23. Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.

Author

Koo CW, Baliff JP, Torigian DA, Litzky LA, Gefter WB, and Akers SR

Subjects
Carcinoid Tumor diagnostic imaging, Cell Proliferation, Contrast Media, Diagnosis, Differential, Humans, Lung Neoplasms diagnostic imaging, Neuroendocrine Tumors diagnostic imaging, Neurosecretory Systems pathology, Precancerous Conditions diagnostic imaging, Precancerous Conditions pathology, Risk Factors, Tomography, X-Ray Computed, Carcinoid Tumor pathology, Lung Neoplasms pathology, Neuroendocrine Cells pathology, Neuroendocrine Tumors pathology
Abstract

Objective: The objectives of this article are to review the radiologic, pathologic, and clinical features of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids and to discuss the possible role of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and tumorlet in the development of carcinoids., Conclusion: Given the potential significant morbidity of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and its neoplastic counterparts, it is important to understand and recognize these disease entities. A conceptual continuum of these neuroendocrine entities is suggested.

Published
2010
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