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153 results on '"Balducci, Enrico"'

13. NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis

Author

Masignani, Vega, Balducci, Enrico, Di Marcello, Federica, Savino, Silvana, Serruto, Davide, Veggi, Daniele, Bambini, Stefania, Scarselli, Maria, Aricò, Beatrice, Comanducci, Maurizio, Adu-Bobie, Jeannette, Giuliani, Marzia M., Rappuoli, Rino, and Pizza, Mariagrazia

Published
2003

20. Structural and Functional Consequences Induced by Post-Translational Modifications in α-Defensins

Author

Balducci, Enrico, Bonucci, Alessio, Picchianti, Monica, Pogni, Rebecca, and Talluri, Eleonora

Subjects
Article Subject
Abstract

HNP-1 is an antimicrobial peptide that undergoes proteolytic cleavage to become a mature peptide. This process represents the mechanism commonly used by the cells to obtain a fully active antimicrobial peptide. In addition, it has been recently described that HNP-1 is recognized as substrate by the arginine-specific ADP-ribosyltransferase-1. Arginine-specific mono-ADP-ribosylation is an enzyme-catalyzed post-translational modification in which NAD+ serves as donor of the ADP-ribose moiety, which is transferred to the guanidino group of arginines in target proteins. While the arginine carries one positive charge, the ADP-ribose is negatively charged at the phosphate moieties at physiological pH. Therefore, the attachment of one or more ADP-ribose units results in a marked change of cationicity. ADP-ribosylation of HNP-1 drastically reduces its cytotoxic and antibacterial activities. While the chemotactic activity of HNP-1 remains unaltered, its ability to induce interleukin-8 production is enhanced. The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.

Published
2011
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43. Structural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidis

Author

Sub NMR Spectroscopy, NMR Spectroscopy, Koehler, Christian, Carlier, L.P.A., Veggi, Daniele, Balducci, Enrico, Di Marcello, Federica, Ferrer-Navarro, Mario, Pizza, Mariagrazia, Daura, Xavier, Soriani, Marco, Boelens, Rolf, Bonvin, Alexandre M. J. J., Sub NMR Spectroscopy, NMR Spectroscopy, Koehler, Christian, Carlier, L.P.A., Veggi, Daniele, Balducci, Enrico, Di Marcello, Federica, Ferrer-Navarro, Mario, Pizza, Mariagrazia, Daura, Xavier, Soriani, Marco, Boelens, Rolf, and Bonvin, Alexandre M. J. J.

Published
2011

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