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Background: Invasive aspergillosis is an extremely rare condition in healthy and immunocompetent individuals, and very few cases have been reported in previously healthy, pregnant, or postpartum women. Method: We describe a case of invasive aspergillosis in a puerperal patient and present literature review results. Case: We present a case of fulminant invasive pulmonary aspergillosis with cerebral, cardiac, and gastric involvement in a young woman, occurring a few days after an elective cesarean section. The patient succumbed after intensive care unit admission, and the diagnosis was made postmortem through autopsy. Conclusion: A total of 20 cases of invasive aspergillosis have been previously reported in pregnant or postpartum women, with high mortality. The risk of opportunistic fungal infections during pregnancy and postpartum should not be underestimated. [ABSTRACT FROM AUTHOR]

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, and it is characterized by an excessive hepatic fat accumulation in more than 5% of hepatocytes documented by histology in the absence of alcohol consumption. It is a multifactorial pathology, where genetic component plays a fundamental role: the loss-offunction polymorphisms of genes coding for glutathione S-transferases would predispose to the pathology onset, also in the absence of other risk factors. The aim of the study was to evaluate the relation between the "NULL" GST-T1 and GST-M1 polymorphisms and the onset of NAFLD. Methods: A group of 117 "apparently healthy" Caucasian volunteers, selected from a larger population through the analysis of previously administered short questionnaires, underwent both magnetic resonance imaging-proton density fat fraction (MRI-PDFF) and buccal swabs: the aim was to identify the possible presence of hepatic steatosis and of the aforementioned "NULL" polymorphisms of interest. Results: A statistically significant association between the GST-T1 and GST-M1 "NULL" genotypes and the probability of developing NAFLD has been identified. In particular, the GST-T1 "NULL" genotype has been associated with a greater probability of developing steatosis in early age, while the GST-M1 "NULL" genotype seems to increase the risk of developing a higher grade of steatosis. No statistically significant correlations between the "NULL" genotype and sex have been detected. Discussion: Among the numerous risk factors capable of predisposing to NAFLD onset and progression, the genetic factors seem to play an important role. In particular, GST-T1 and GST-M1 "NULL" polymorphisms would appear to acquire even greater importance, as their loss of function results in an increase of oxidative stress. At high concentrations, ROS can determine oxidative modifications of cellular macromolecules, such as lipids, determining their accumulation into hepatocytes. The study also highlighted the importance of MRI-PDFF for hepatic steatosis diagnosis: this method allows the acquisition of data comparable to those of conventional biopsy; however, it permits the entire liver parenchyma to be visualized. Conclusion: A statistically significant correlation between the presence of GSTT1 and GST-M1 "NULL" genotypes and the presence of hepatic steatosis has been found. [ABSTRACT FROM AUTHOR]

The paper reports the results of training experiences in the field of education in forensic and biomedical sciences carried out during two editions of summer schools. Two simulated serious crimes, involving dummies used as victims, were prepared for practitioners in outdoor places. The scenes simulate a suspect murder case of homicide with staging and a corpse concealment with dismembered human remains found into a clandestine grave, respectively. During the simulations, laser scanning technology was applied to reproduce the outdoor crime scenes in order to verify the capacity of the innovative technique as advantageous tool during educational and forensic training. Judicial inspections conducted during the simulation provided preliminary physical evidence, in the fields of forensic medicine, forensic geology, and engineering, highlighting the importance of the multidisciplinary approach. These experiences, through the use of the laser scanner that allowed for the recreation of virtual environments in which practitioners were able to confront crime scenes, demonstrated how such an approach can be useful in education and training activities. [ABSTRACT FROM AUTHOR]

Italy is the European country with the second highest number of novel Coronavirus disease 19 (COVID-19) deaths. Several factors interfered with the spread of this phenomenon, both clinical, political, and bioethical. In this scenario, where the need for care goes far beyond the capacity of a health system able to cope with it, what should be the criteria for an equitable distribution of the available resources? The mass quarantine required physical distancing in order to limit the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and contextually created additional problems for the organization Italian National Health Service. The delicate ethical questions posed by the current emergency are beginning to unveil some proposals for solutions in literature, which, although still insufficient for understandable reasons, is increasing. [ABSTRACT FROM AUTHOR]

Trauma involving the neck region are to always be considered as clinical/surgical emergencies because of the presence of vascular, nervous and lymphatic vessels, along with the pharyngoesophageal and laryngo-tracheal structures. For this reason, therapeutic and diagnostic timing arouses great interest. The authors report the case of a conscious and hemodynamically stable man, presented to the emergency room for a neck penetrating trauma, caused by a knife passing through his neck (zone II) from right to left. A correct instrumental examination (CT angiography and selective right carotid axis angiography) and the multidisciplinary surgical approach proved to be fundamental for the safe extraction of the knife. [ABSTRACT FROM AUTHOR]

The importance of microbial colonization of human organs in a living body has long been assessed. What still remains unclear are the microbial changes occurring after death, thus leading to the advent of a relatively novel field of research called "Postmortem microbiology". It is applied to several forensic fields such as post-mortem interval assessment and cause of death determination. In this contest, a major limit is thus represented by the correct interpretation of the microbial data and by the actual lack of standard procedures. Here we propose a standard operative protocol in order to avoid false positives given by contamination (the main problem), post-mortem translocation and agonal spread. The protocol was implemented in 36 judiciary autopsies and allowed in the assessment of an infection in 10 cases. The study showed the usefulness of the protocol which also supports the contribution of forensic microbiology, together with clinical, histopathological, biochemical and autopsy data, to the determination of infectious cause of death. [ABSTRACT FROM AUTHOR]

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The use of non-destructive methods guaranteeing high standards of accuracy, speed, simplicity of use, and low costs may be crucial during judicial inspection aimed to reconstruct the spatial arrangement of crime scenes. Three-dimensional (3D) laser scanning and structured blue light scanning are two modern and advanced technologies widely used in many sectors of the sciences, included forensic sciences. Limiting itself to forensic applications, these technologies may be successfully used for acquiring point clouds in 3D space and reconstruct 3D virtual models of large-, medium-, and small-scale forensic scenarios. These two technologies were applied for reconstructing 3D virtual models from real crime scenes and geological evidence, respectively. Different investigative places and items were investigated and discussed. The research evidenced the advantages of using these modern techniques in order to assist investigators in: i) providing 3D virtual models for reconstructing even complex crime scenes occurred outdoor; ii) reconstructing of the dynamics of events, and iii) individuating possible interactions between the actors of the scene and the surrounding places. [ABSTRACT FROM AUTHOR]