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1. Acute ischemic STROKE – from laboratory to the Patient’s BED (STROKELABED): A translational approach to reperfusion injury. Study Protocol

Author

Sodero Alessandro, Conti Emilia, Piccardi Benedetta, Sarti Cristina, Palumbo Vanessa, Kennedy James, Gori Anna Maria, Giusti Betti, Fainardi Enrico, Nencini Patrizia, Allegra Mascaro Anna Letizia, Pavone Francesco Saverio, and Baldereschi Marzia

Subjects
stroke, cerebral edema, hemorrhagic transformation, reperfusion injury, biomarkers, translational stroke research, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Cerebral edema (CE) and hemorrhagic transformation (HT) are frequent and unpredictable events in patients with acute ischemic stroke (AIS), even when an effective vessel recanalization has been achieved. These complications, related to blood-brain barrier (BBB) disruption, remain difficult to prevent or treat and may offset the beneficial effect of recanalization, and lead to poor outcomes. The aim of this translational study is to evaluate the association of circulating and imaging biomarkers with subsequent CE and HT in stroke patients with the dual purpose of investigating possible predictors as well as molecular dynamics underpinning those events and functional outcomes. Concurrently, the preclinical study will develop a new mouse model of middle cerebral artery (MCA) occlusion and recanalization to explore BBB alterations and their potentially harmful effects on tissue. The clinical section of the study is based on a single-center observational design enrolling consecutive patients with AIS in the anterior circulation territory, treated with recanalization therapies from October 1, 2015 to May 31, 2020. The study will employ an innovative evaluation of routine CT scans: in fact, we will assess and quantify the presence of CE and HT after stroke in CT scans at 24 h, through the quantification of anatomical distortion (AD), a measure of CE and HT. We will investigate the relationship of AD and several blood biomarkers of inflammation and extracellular matrix, with functional outcomes at 3 months. In parallel, we will employ a newly developed mouse model of stroke and recanalization, to investigate the emergence of BBB changes 24 h after the stroke onset. The close interaction between clinical and preclinical research can enhance our understanding of findings from each branch of research, enabling a deeper interpretation of the underlying mechanisms of reperfusion injury following recanalization treatment for AIS.

Published
2024
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3. Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings From 2010 to 2019

Author

Prendes, Carlota F., Rantner, Barbara, Hamwi, Tarek, Stana, Jan, Feigin, Valery L., Stavroulakis, Konstantinos, Tsilimparis, Nikolaos, Fernandez Prendes, Carlota, Rantner, Barbara, Hamwi, Tarek, Stana, Jan, Feigin, Prof Valery L, Stavroulakis, Konstantinos, Tsilimparis, Nikolaos, Aboyans, Prof Victor, Olusola Akinyemi, Rufus, Al-Shahi Salman, Prof Rustam, Artamonov, Anton A, Aujayeb, Avinash, Baldereschi, Marzia, Basu, Sanjay, Béjot, Prof Yannick, Belo, Luis, Bennett, Derrick A, Srikanth Bhagavathula, Akshaya, Bikbov, Boris, Brenner, Prof Hermann, Luciano Caetano dos Santos, Florentino, Carrero, Prof Juan J, Carvalho, Prof Felix, Catapano, Prof Alberico L, Charalampous, Periklis, Christensen, Prof Hanne, Chung, Sheng-Chia, Angelo Cortesi, Paolo, Marisa Costa, Vera, Cyganska, Malgorzata, D’Amico, Emanuele, Davletov, Kairat, Georgieva Dokova, Klara, Douiri, Abdel, Francis Fagbamigbe, Adeniyi, Fischer, Florian, Ghith, Nermin, Giampaoli, Simona, Singh Gill, Prof Paramjit, Gnedovskaya, Elena V, Havmoeller, Rasmus J, Hostiuc, Sorin, Iavicoli, Prof Ivo, Ilic, Prof Milena D, Isola, Prof Gaetano, Jerzy Jozwiak, Jacek, Jürisson, Mikk, Kayode, Gbenga A, Khan, Moien AB, Khatab, Prof Khaled, Kisa, Prof Adnan, Kivimäki, Prof Mika, Koyanagi, Ai, Kulimbet, Mukhtar, Kusuma, Dian, La Vecchia, Prof Carlo, Lacey, Ben, Lallukka, Prof Tea, Lorkowski, Prof Stefan, Majeed, Prof Azeem, Giovanni Mantovani, Prof Lorenzo, Mazzaglia, Giampiero, Mentis, Alexios-Fotios A, Meretoja, Atte, Miao Jonasson, Junmei, Mirica, Andreea, Mirrakhimov, Prof Erkin M, Mohammed, Shafiu, Molokhia, Mariam, Monasta, Lorenzo, Mons, Prof Ute, Morze, Jakub, Irina Negoi, Ruxandra, Norrving, Prof Bo, Oancea, Prof Bogdan, O’Caoimh, Rónán, Orru, Hans, Padron-Monedero, Alicia, Pedersini, Paolo, Perico, Norberto, Polibin, Roman V, Polinder, Suzanne, Raggi, Alberto, Rawaf, Prof Salman, Remuzzi, Prof Giuseppe, Romoli, Michele, Sacco, Prof Simona, Reza Saeb, Prof Mohammad, Vasco Santos, João, Santric-Milicevic, Prof Milena M, Aleksandrovna Skryabina, Anna, Smith, Lee, Starodubova, Antonina V, Stevanović, Aleksandar, Stranges, Prof Saverio, Teuschl, Yvonne, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Unim, Brigid, Juhani Vasankari, Prof Tommi, Volovici, Victor, Wafa, Hatem A, Wang, Yanzhong, Westerman, Ronny, Wolfe, Prof Charles D A, Yesiltepe, Metin, Zanghì, Aurora, and Sergeevich Zastrozhin, Prof Mikhail

Published
2024
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6. Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings from 2010 to 2019

Author

Prendes, C, Rantner, B, Hamwi, T, Stana, J, Feigin, V, Stavroulakis, K, Tsilimparis, N, Fernandez Prendes, C, Aboyans, P, Olusola Akinyemi, R, Al-Shahi Salman, R, Artamonov, A, Aujayeb, A, Baldereschi, M, Basu, S, Bejot, Y, Belo, L, Bennett, D, Srikanth Bhagavathula, A, Bikbov, B, Brenner, H, Dos Santos, F, Carrero, J, Carvalho, F, Catapano, A, Charalampous, P, Christensen, H, Chung, S, Angelo Cortesi, P, Marisa Costa, V, Cyganska, M, D'Amico, E, Davletov, K, Georgieva Dokova, K, Douiri, A, Francis Fagbamigbe, A, Fischer, F, Ghith, N, Giampaoli, S, Singh Gill, P, Gnedovskaya, E, Havmoeller, R, Hostiuc, S, Iavicoli, I, Ilic, M, Isola, G, Jerzy Jozwiak, J, Jurisson, M, Kayode, G, Khan, M, Khatab, K, Kisa, A, Kivimaki, M, Koyanagi, A, Kulimbet, M, Kusuma, D, La Vecchia, C, Lacey, B, Lallukka, T, Lorkowski, S, Majeed, P, Giovanni Mantovani, L, Mazzaglia, G, Mentis, A, Meretoja, A, Miao Jonasson, J, Mirica, A, Mirrakhimov, E, Mohammed, S, Molokhia, M, Monasta, L, Mons, U, Morze, J, Irina Negoi, R, Norrving, B, Oancea, B, O'Caoimh, R, Orru, H, Padron-Monedero, A, Pedersini, P, Perico, N, Polibin, R, Polinder, S, Raggi, A, Rawaf, S, Remuzzi, G, Romoli, M, Sacco, P, Reza Saeb, P, Vasco Santos, J, Santric-Milicevic, M, Aleksandrovna Skryabina, A, Smith, L, Starodubova, A, Stevanovic, A, Stranges, P, Teuschl, Y, Topor-Madry, R, Touvier, M, Tovani-Palone, M, Unim, B, Juhani Vasankari, T, Volovici, V, Wafa, H, Wang, Y, Westerman, R, Wolfe, P, Yesiltepe, M, Zanghi, A, Sergeevich Zastrozhin, M, Prendes C. F., Rantner B., Hamwi T., Stana J., Feigin V. L., Stavroulakis K., Tsilimparis N., Fernandez Prendes C., Aboyans P. V., Olusola Akinyemi R., Al-Shahi Salman R., Artamonov A. A., Aujayeb A., Baldereschi M., Basu S., Bejot Y., Belo L., Bennett D. A., Srikanth Bhagavathula A., Bikbov B., Brenner H., Dos Santos F., Carrero J. J., Carvalho F., Catapano A. L., Charalampous P., Christensen H., Chung S. -C., Angelo Cortesi P., Marisa Costa V., Cyganska M., D'Amico E., Davletov K., Georgieva Dokova K., Douiri A., Francis Fagbamigbe A., Fischer F., Ghith N., Giampaoli S., Singh Gill P., Gnedovskaya E. V., Havmoeller R. J., Hostiuc S., Iavicoli I., Ilic M. D., Isola G., Jerzy Jozwiak J., Jurisson M., Kayode G. A., Khan M. A. B., Khatab K., Kisa A., Kivimaki M., Koyanagi A., Kulimbet M., Kusuma D., La Vecchia C., Lacey B., Lallukka T., Lorkowski S., Majeed P. A., Giovanni Mantovani L., Mazzaglia G., Mentis A. -F. A., Meretoja A., Miao Jonasson J., Mirica A., Mirrakhimov E. M., Mohammed S., Molokhia M., Monasta L., Mons U., Morze J., Irina Negoi R., Norrving B., Oancea B., O'Caoimh R., Orru H., Padron-Monedero A., Pedersini P., Perico N., Polibin R. V., Polinder S., Raggi A., Rawaf S., Remuzzi G., Romoli M., Sacco P. S., Reza Saeb P. M., Vasco Santos J., Santric-Milicevic M. M., Aleksandrovna Skryabina A., Smith L., Starodubova A. V., Stevanovic A., Stranges P. S., Teuschl Y., Topor-Madry R., Touvier M., Tovani-Palone M. R., Unim B., Juhani Vasankari T., Volovici V., Wafa H. A., Wang Y., Westerman R., Wolfe P. C. D. A., Yesiltepe M., Zanghi A., Sergeevich Zastrozhin M., Prendes, C, Rantner, B, Hamwi, T, Stana, J, Feigin, V, Stavroulakis, K, Tsilimparis, N, Fernandez Prendes, C, Aboyans, P, Olusola Akinyemi, R, Al-Shahi Salman, R, Artamonov, A, Aujayeb, A, Baldereschi, M, Basu, S, Bejot, Y, Belo, L, Bennett, D, Srikanth Bhagavathula, A, Bikbov, B, Brenner, H, Dos Santos, F, Carrero, J, Carvalho, F, Catapano, A, Charalampous, P, Christensen, H, Chung, S, Angelo Cortesi, P, Marisa Costa, V, Cyganska, M, D'Amico, E, Davletov, K, Georgieva Dokova, K, Douiri, A, Francis Fagbamigbe, A, Fischer, F, Ghith, N, Giampaoli, S, Singh Gill, P, Gnedovskaya, E, Havmoeller, R, Hostiuc, S, Iavicoli, I, Ilic, M, Isola, G, Jerzy Jozwiak, J, Jurisson, M, Kayode, G, Khan, M, Khatab, K, Kisa, A, Kivimaki, M, Koyanagi, A, Kulimbet, M, Kusuma, D, La Vecchia, C, Lacey, B, Lallukka, T, Lorkowski, S, Majeed, P, Giovanni Mantovani, L, Mazzaglia, G, Mentis, A, Meretoja, A, Miao Jonasson, J, Mirica, A, Mirrakhimov, E, Mohammed, S, Molokhia, M, Monasta, L, Mons, U, Morze, J, Irina Negoi, R, Norrving, B, Oancea, B, O'Caoimh, R, Orru, H, Padron-Monedero, A, Pedersini, P, Perico, N, Polibin, R, Polinder, S, Raggi, A, Rawaf, S, Remuzzi, G, Romoli, M, Sacco, P, Reza Saeb, P, Vasco Santos, J, Santric-Milicevic, M, Aleksandrovna Skryabina, A, Smith, L, Starodubova, A, Stevanovic, A, Stranges, P, Teuschl, Y, Topor-Madry, R, Touvier, M, Tovani-Palone, M, Unim, B, Juhani Vasankari, T, Volovici, V, Wafa, H, Wang, Y, Westerman, R, Wolfe, P, Yesiltepe, M, Zanghi, A, Sergeevich Zastrozhin, M, Prendes C. F., Rantner B., Hamwi T., Stana J., Feigin V. L., Stavroulakis K., Tsilimparis N., Fernandez Prendes C., Aboyans P. V., Olusola Akinyemi R., Al-Shahi Salman R., Artamonov A. A., Aujayeb A., Baldereschi M., Basu S., Bejot Y., Belo L., Bennett D. A., Srikanth Bhagavathula A., Bikbov B., Brenner H., Dos Santos F., Carrero J. J., Carvalho F., Catapano A. L., Charalampous P., Christensen H., Chung S. -C., Angelo Cortesi P., Marisa Costa V., Cyganska M., D'Amico E., Davletov K., Georgieva Dokova K., Douiri A., Francis Fagbamigbe A., Fischer F., Ghith N., Giampaoli S., Singh Gill P., Gnedovskaya E. V., Havmoeller R. J., Hostiuc S., Iavicoli I., Ilic M. D., Isola G., Jerzy Jozwiak J., Jurisson M., Kayode G. A., Khan M. A. B., Khatab K., Kisa A., Kivimaki M., Koyanagi A., Kulimbet M., Kusuma D., La Vecchia C., Lacey B., Lallukka T., Lorkowski S., Majeed P. A., Giovanni Mantovani L., Mazzaglia G., Mentis A. -F. A., Meretoja A., Miao Jonasson J., Mirica A., Mirrakhimov E. M., Mohammed S., Molokhia M., Monasta L., Mons U., Morze J., Irina Negoi R., Norrving B., Oancea B., O'Caoimh R., Orru H., Padron-Monedero A., Pedersini P., Perico N., Polibin R. V., Polinder S., Raggi A., Rawaf S., Remuzzi G., Romoli M., Sacco P. S., Reza Saeb P. M., Vasco Santos J., Santric-Milicevic M. M., Aleksandrovna Skryabina A., Smith L., Starodubova A. V., Stevanovic A., Stranges P. S., Teuschl Y., Topor-Madry R., Touvier M., Tovani-Palone M. R., Unim B., Juhani Vasankari T., Volovici V., Wafa H. A., Wang Y., Westerman R., Wolfe P. C. D. A., Yesiltepe M., Zanghi A., and Sergeevich Zastrozhin M.

Abstract

BACKGROUND: While most European Regions perform well in global comparisons, large discrepancies within stroke epidemiological parameters exist across Europe. The objective of this analysis was to evaluate the stroke burden across European regions and countries in 2019 and its difference to 2010. METHODS: The GBD 2019 analytical tools were used to evaluate regional and country-specific estimates of incidence, prevalence, deaths, and disability-adjusted life years of stroke for the European Region as defined by the World Health Organization, with its 53 member countries (EU-53) and for European Union as defined in 2019, with its 28 member countries (EU-28), between 2010 and 2019. Results were analyzed at a regional, subregional, and country level. RESULTS: In EU-53, the absolute number of incident and prevalent strokes increased by 2% (uncertainty interval [UI], 0%-4%), from 1 767 280 to 1 802 559 new cases, and by 4% (UI, 3%-5%) between 2010 and 2019, respectively. In EU-28, the absolute number of prevalent strokes and stroke-related deaths increased by 4% (UI, 2%-5%) and by 6% (UI, 1%-10%), respectively. All-stroke age-standardized mortality rates, however, decreased by 18% (UI, -22% to -14%), from 82 to 67 per 100 000 people in the EU-53, and by 15% (UI, -18% to -11%), from 49.3 to 42.0 per 100 000 people in EU-28. Despite most countries presenting reductions in age-adjusted incidence, prevalence, mortality, and disability-adjusted life year rates, these rates remained 1.4×, 1.2×, 1.6×, and 1.7× higher in EU-53 in comparison to the EU-28. CONCLUSIONS: EU-53 showed a 2% increase in incident strokes, while they remained stable in EU-28. Age-standardized rates were consistently lower for all-stroke burden parameters in EU-28 in comparison to EU-53, and huge discrepancies in incidence, prevalence, mortality, and disability-adjusted life-year rates were observed between individual countries.

Published
2024

8. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

Author

Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Maggi, S., Minicucci, N., Noale, M., Grigoletto, F., Perissinotto, E., Carbonin, P., Solfrizzi, Vincenzo, Scafato, Emanuele, Lozupone, Madia, Seripa, Davide, Giannini, Michele, Sardone, Rodolfo, Bonfiglio, Caterina, Abbrescia, Daniela I., Galluzzo, Lucia, Gandin, Claudia, Baldereschi, Marzia, Di Carlo, Antonio, Inzitari, Domenico, Daniele, Antonio, Sabbà, Carlo, Logroscino, Giancarlo, and Panza, Francesco

Published
2017
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12. Comparison of the Clinical and Metabolic Characteristics of Patients With Acute Coronary Syndromes Between the Pre- and Post-lockdown Periods

Author

Capobianco, Tommaso, primary, Iannotti, Walther, additional, Agostini, Riccardo, additional, Persiani, Luca, additional, Chiostri, Marco, additional, Baldereschi, Giorgio Iacopo, additional, Di Mario, Carlo, additional, Meucci, Francesco, additional, Valenti, Renato, additional, and Cecchi, Emanuele, additional

Published
2023
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13. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

Author

Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., Di Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., Black, Sandra E., Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., O'Brien, John, Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.

Published
2018
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14. Schottky barrier heights at polar metal/semiconductor interfaces

Author

Berthod, C., Binggeli, N., and Baldereschi, A.

Subjects
Condensed Matter - Materials Science
Abstract

Using a first-principle pseudopotential approach, we have investigated the Schottky barrier heights of abrupt Al/Ge, Al/GaAs, Al/AlAs, and Al/ZnSe (100) junctions, and their dependence on the semiconductor chemical composition and surface termination. A model based on linear-response theory is developed, which provides a simple, yet accurate description of the barrier-height variations with the chemical composition of the semiconductor. The larger barrier values found for the anion- than for the cation-terminated surfaces are explained in terms of the screened charge of the polar semiconductor surface and its image charge at the metal surface. Atomic scale computations show how the classical image charge concept, valid for charges placed at large distances from the metal, extends to distances shorter than the decay length of the metal-induced-gap states., Comment: REVTeX 4, 11 pages, 6 EPS figures

Published
2003
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15. Electronic Properties of Mn-Compounds Under Strain

Author

Debernardi, A., Peressi, M., and Baldereschi, A.

Subjects
Condensed Matter - Materials Science
Abstract

We study the physical properties of MnAs under strain by using accurate first-principles pseudopotential calculations. Our results provide new insight on the physics of strained multilayer that are grown epitaxially on different lattice mismatched substrates and which are presently of interest for spintronic applications. We compute the strain dependence of the structural parameters, electronic bands, density of states and magnetization. In the region of strain/stress that is easily directly accessible to measurements, the effects on these physical quantities are linear. We also address the case of uniaxial stress inducing sizeable and strongly non linear effects on electronic and magnetic properties., Comment: 8 pages, 6 figures

Published
2002

16. Maximally-localized Wannier Functions in Antiferromagnetic MnO within the FLAPW Formalism

Author

Posternak, Michel, Baldereschi, Alfonso, Massidda, Sandro, and Marzari, Nicola

Subjects
Condensed Matter - Materials Science
Abstract

We have calculated the maximally-localized Wannier functions of MnO in its antiferromagnetic (AFM) rhombohedral unit cell, which contains two formula units. Electron Bloch functions are obtained with the linearized augmented plane-wave method within both the LSD and the LSD+U schemes. The thirteen uppermost occupied spin-up bands correspond in a pure ionic scheme to the five Mn 3d orbitals at the Mn_1 (spin-up) site, and the four O 2s/2p orbitals at each of the O_1 and O_2 sites. Maximal localization identifies uniquely four Wannier functions for each O, which are trigonally-distorted sp^3-like orbitals. They display a weak covalent bonding between O 2s/2p states and minority-spin d states of Mn_2, which is absent in a fully ionic picture. This bonding is the fingerprint of the interaction responsible for the AFM ordering, and its strength depends on the one-electron scheme being used. The five Mn Wannier functions are centered on the Mn_1 site, and are atomic orbitals modified by the crystal field. They are not uniquely defined by the criterion of maximal localization and we choose them as the linear combinations which diagonalize the r^2 operator, so that they display the D_3d symmetry of the Mn_1 site., Comment: 11 pages, 6 PostScript figures. Uses Revtex4. Hi-res figures available from the authors

Published
2002
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18. Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian Longitudinal Study on Aging

Author

Vincenzo Solfrizzi, Emanuele Scafato, Carlo Custodero, Francesca Loparco, Alessandro Ciavarella, Francesco Panza, Davide Seripa, Bruno Pietro Imbimbo, Madia Lozupone, Nicola Napoli, Giuseppina Piazzolla, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Alberto Pilotto, Carlo Sabbà, and for the Italian Longitudinal Study on Aging Working Group

Subjects
dementia, frailty, NAFLD fibrosis score, older adults, population‐based study, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Introduction Liver fibrosis increases progressively with aging and has been associated with poorer cognitive performance in middle‐aged and older adults. We investigated the relationships between a non‐invasive score for advanced liver fibrosis (non‐alcoholic fatty liver disease [NAFLD] fibrosis score [NFS]) and dementia risk. We also assessed physical frailty, a common geriatric condition which is associated to dementia. We tested the joint effects of physical frailty and fibrosis on dementia incidence. Methods A total of 1061 older adults (65 to 84 years), from the Italian Longitudinal Study on Aging, were prospectively evaluated for the risk of dementia in a period between 1992 and 2001. Liver fibrosis was defined according to the NFS. Physical frailty was assessed according to the Fried's criteria. Cox proportional hazards models were used to estimate the short‐ and long‐term risk of overall dementia, associated to the NFS, testing the effect modifier of physical frailty status. Results Older adults with only high NFS (F3‐F4) did not exhibit a significant increased risk of overall dementia. Over 8 years of follow‐up, frail older adults with high NFS had an increased risk of overall dementia (hazard ratio [HR]: 4.23; 95% confidence interval [CI]: 1.22 to 14.70, P = .023). Finally, physically frail older adults with low albumin serum levels (albumin

Published
2020
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19. Wannier-functions characterization of floating bonds in a-Si

Author

Fornari, M., Marzari, N., Peressi, M., and Baldereschi, A.

Subjects
Condensed Matter - Materials Science
Abstract

We investigate the electronic structure of over-coordinated defects in amorphous silicon via density-functional total-energy calculations, with the aim of understanding the relationship between topological and electronic properties on a microscopic scale. Maximally-localized Wannier functions are computed in order to characterize the bonding and the electronic properties of these defects. The five-fold coordination defects give rise to delocalized states extending over several nearest neighbors, and therefore to very polarizable bonds and anomalously high Born effective charges for the defective atoms., Comment: Proceedings of the "Workshop of Computational Material Science, Cagliari 1999"

Published
1999

20. Floating bonds and gap states in a-Si and a-Si:H from first principles calculations

Author

Fornari, M., Peressi, M., de Gironcoli, S., and Baldereschi, A.

Subjects
Condensed Matter - Materials Science
Abstract

We study in detail by means of ab-initio pseudopotential calculations the electronic structure of five-fold coordinated (T_5) defects in a-Si and a-Si:H, also during their formation and their evolution upon hydrogenation. The atom-projected densities of states (DOS) and an accurate analysis of the valence charge distribution clearly indicate the fundamental contribution of T_5 defects in originating gap states through their nearest neighbors. The interaction with hydrogen can reduce the DOS in the gap annihilating T_5 defects., Comment: To appear in Europhysics Lett

Published
1999
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21. Coordination defects in a-Si and a-Si:H : a characterization from first principles calculations

Author

Peressi, M., Fornari, M., de Gironcoli, S., De Santis, L., and Baldereschi, A.

Subjects
Condensed Matter - Materials Science
Abstract

We study by means of first-principles pseudopotential method the coordination defects in a-Si and a-Si:H, also in their formation and their evolution upon hydrogen interaction. An accurate analysis of the valence charge distribution and of the ``electron localization function'' (ELF) allows to resolve possible ambiguities in the bonding configuration, and in particular to identify clearly three-fold (T_3) and five-fold (T_5) coordinated defects. We found that electronic states in the gap can be associated to both kind of defects, and that in both cases the interaction with hydrogen can reduce the density of states in the gap., Comment: To appear in Philos. Mag

Published
1999
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22. Translational Stroke Research Review: Using the Mouse to Model Human Futile Recanalization and Reperfusion Injury in Ischemic Brain Tissue

Author

Emilia Conti, Benedetta Piccardi, Alessandro Sodero, Laura Tudisco, Ivano Lombardo, Enrico Fainardi, Patrizia Nencini, Cristina Sarti, Anna Letizia Allegra Mascaro, and Marzia Baldereschi

Subjects
brain, ischemic stroke, reperfusion, futile recanalization, mechanical thrombectomy, translational stroke research, Cytology, QH573-671
Abstract

The approach to reperfusion therapies in stroke patients is rapidly evolving, but there is still no explanation why a substantial proportion of patients have a poor clinical prognosis despite successful flow restoration. This issue of futile recanalization is explained here by three clinical cases, which, despite complete recanalization, have very different outcomes. Preclinical research is particularly suited to characterize the highly dynamic changes in acute ischemic stroke and identify potential treatment targets useful for clinical translation. This review surveys the efforts taken so far to achieve mouse models capable of investigating the neurovascular underpinnings of futile recanalization. We highlight the translational potential of targeting tissue reperfusion in fully recanalized mouse models and of investigating the underlying pathophysiological mechanisms from subcellular to tissue scale. We suggest that stroke preclinical research should increasingly drive forward a continuous and circular dialogue with clinical research. When the preclinical and the clinical stroke research are consistent, translational success will follow.

Published
2021
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23. Effect of an educational intervention to increase stroke awareness among Italian high school students: A prospective study in Tuscany

Author

Di Carlo, Antonio, primary, Baldereschi, Marzia, additional, Bovis, Francesca, additional, Piccardi, Benedetta, additional, Linoli, Giovanni, additional, Orlandi, Giovanni, additional, Volpi, Gino, additional, Chiti, Alberto, additional, Tassi, Rossana, additional, Brescia, Alfonso, additional, and Inzitari, Domenico, additional

Published
2023
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24. Polarized Wannier functions: ab-initio study of the dielectric properties of silicon and gallium arsenide

Author

Fernández, Pablo, Corso, Andrea Dal, and Baldereschi, Alfonso

Subjects
Condensed Matter - Materials Science
Abstract

We present a first-principles calculation of the electronic properties of crystalline silicon and gallium arsenide in a uniform electric field. Polarized Wannier-like functions which are confined in a finite region are obtained by minimizing a total-energy functional which depends explicitly on the macroscopic polarization of the solid. The polarization charge density and the electronic dielectric constant are computed via finite differences. The results coincide with those of the linear response approach in the limit of vanishing electric field and infinite localization region., Comment: 4 pages, two-column style + 3 figures (GIF)

Published
1998

26. The Vascular Impairment of Cognition Classification Consensus Study

Author

Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., DI Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., O'Brien, John, Black, Sandra, Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.

Published
2017
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27. Non-Nominal Value of the Dynamical Effective Charge in Alkaline-Earth Oxides

Author

Posternak, M., Baldereschi, A., Krakauer, H., and Resta, R.

Subjects
Condensed Matter - Materials Science
Abstract

We calculate ab-initio the electronic states and the Born dynamical charge Z* of the alkaline-earth oxides in the local-density approximation. We investigate the trend of increasing Z* values through the series, using band-by-band decompositions and computational experiments performed on fake materials with artificially-modified covalence. The deviations of Z* from the nominal value 2 are due to the increasing interaction between O 2p orbitals and unoccupied cation d states. We also explain the variations, along the series, of the individual contributions to Z* arising from the occupied band manifolds., Comment: 12 pages Latex, plus 2 Postscript figures

Published
1997
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28. First-Principles Wannier Functions of Silicon and Gallium Arsenide

Author

Fernández, Pablo, Corso, Andrea Dal, Mauri, Francesco, and Baldereschi, Alfonso

Subjects
Condensed Matter - Materials Science
Abstract

We present a self-consistent, real-space calculation of the Wannier functions of Si and GaAs within density functional theory. We minimize the total energy functional with respect to orbitals which behave as Wannier functions under crystal translations and, at the minimum, are orthogonal. The Wannier functions are used to calculate the total energy, lattice constant, bulk modulus, and the frequency of the zone-center TO phonon of the two semiconductors with the accuracy required nowadays in ab-initio calculations. Furthermore, the centers of the Wannier functions are used to compute the macroscopic polarization of Si and GaAs in zero electric field. The effective charges of GaAs, obtained by finite differentiation of the polarization, agree with the results of linear response theory., Comment: 12 pages, 2 PostScript figures, RevTeX, to appear in Physical Review B

Published
1996
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29. Electronic Structure and Bonding in Epitaxially Stabilized Cubic Iron Silicides

Author

Mader, K. A., von Kanel, H., and Baldereschi, A.

Subjects
Condensed Matter
Abstract

We present an ab initio full-potential linearized augmented plane-wave (FLAPW) study of the structural and electronic properties of the two bulk unstable compounds FeSi (CsCl structure) and FeSi$_2$ (CaF$_2$ structure) which have recently been grown by molecular beam epitaxy on Si(111). We obtain equilibrium bulk lattice constants of 2.72 \AA\ and 5.32 \AA\ for FeSi and FeSi$_2$, respectively. The density of states (DOS) of FeSi agrees well with experiment, and shows metallic behavior. In agreement with a previous calculation the DOS of FeSi$_2$ shows a large density of $d$-states at the Fermi level, explaining the instability of the bulk phase. The electron charge distributions reveal a small charge transfer from Si to Fe atomic spheres in both compounds. While in FeSi the Fe-Si bond is indeed partially ionic, we show that in FeSi$_2$ the electron distribution corresponds to a covalent charge accumulation in the Fe-Si bond region. The reversed order of $d$-bands in FeSi with respect to FeSi$_2$ is understood in terms of crystal field splitting and Fe-Fe nearest neighbor $dd$-interactions in the CsCl structure, and a strong Si $p$/Fe $d$ bonding in the fluorite structure, respectively., Comment: 15 pages, REVTeX 3.0

Published
1993

34. A systematic review of the quality of studies on dementia prevalence in Italy

Author

Gianluca Bruti, Elisabetta Cavallucci, Michele Mancini, Alessandro Bitossi, Marzia Baldereschi, and Sandro Sorbi

Subjects
Alzheimer’s disease, Dementia, Epidemiology, Italy, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Dementia, including Alzheimer’s disease (AD), is one of the most burdensome medical conditions. In order to better understand the epidemiology of dementia in Italy, we conducted a systematic search of studies published between 1980 and April 2014 investigating the prevalence of dementia and AD in Italy and then evaluated the quality of the selected studies. Methods A systematic search was performed using PubMed/Medline and Embase to identify Italian population-based studies on the prevalence of dementia among people aged ≥60 years. The quality of the studies was scored according to Alzheimer’s Disease International (ADI) criteria. Results Sixteen articles on the prevalence of dementia and AD in Italy were eligible and 75 % of them were published before the year 2000. Only one study was a national survey, whereas most of the studies were locally based (Northern Italy and Tuscany). Overall, the 16 studies were attributed a mean ADI quality score of 7.6 (median 7.75). Conclusions Available studies on the prevalence of dementia and AD in Italy are generally old, of weak quality, and do not include all regions of Italy. The important limitations of the few eligible studies included in our analysis, mostly related to their heterogeneous design, make our systematic review difficult to interpret from an epidemiologic point of view. Full implementation of a Dementia National Plan is highly needed to better understand the epidemiology of the disease and monitor dementia patients.

Published
2016
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35. Administrative data underestimate acute ischemic stroke events and thrombolysis treatments: Data from a multicenter validation survey in Italy.

Author

Marzia Baldereschi, Daniela Balzi, Valeria Di Fabrizio, Lucia De Vito, Renzo Ricci, Paola D'Onofrio, Antonio Di Carlo, Maria Teresa Mechi, Francesco Bellomo, and Domenico Inzitari

Subjects
Medicine, Science
Abstract

Informing health systems and monitoring hospital performances using administrative data sets, mainly hospital discharge data coded according to International-Classification-Diseases-9edition-Clinical-Modifiers (ICD9-CM), is now commonplace in several countries, but the reliability of diagnostic coding of acute ischemic stroke in the routine practice is uncertain. This study aimed at estimating accuracy of ICD9-CM codes for the identification of acute ischemic stroke and the use of thrombolysis treatment comparing hospital discharge data with medical record review in all the six hospitals of the Florence Area, Italy, through 2015.We reviewed the medical records of all the 3915 potential acute stroke events during 2015 across the six hospitals of the Florence Area, Italy. We then estimated sensitivity and Positive Predictive Value of ICD9-CM code-groups 433*1, 434*1 and thrombolysis code 99.10 against medical record review with clinical adjudication. For each false-positive case we obtained the actual diagnosis. For each false-negative case we obtained the primary and secondary ICD9-CM diagnoses.The medical record review identified 1273 acute ischemic stroke events. The hospital discharge records identified 898 among those (true-positive cases),but missed 375 events (false-negative cases), and identified 104 events that were not eventually confirmed as acute ischemic events (false-positive cases). Code-group specific Positive Predictive Value was 85.7% (95%CI,74.6-93.3) for 433*1 and 89.9% (95%CI, 87.8-91.7) for 434*1 codes. Thrombolysis treatment, as identified by ICD9-CM code 99.10, was only documented in 6.0% of acute ischemic stroke events, but was 13.6% in medical record review.Hospital discharge data were found to be fairly specific but insensitive in the reporting of acute ischemic stroke and thrombolysis, providing misleading indications about both quantity and quality of acute ischemic stroke hospital care. Efforts to improve coding accuracy should precede the use of hospital discharge data to measure hospital performances in acute ischemic stroke care.

Published
2018
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37. Effect of an educational intervention to increase stroke awareness among Italian high school students: A prospective study in Tuscany

Author

Antonio Di Carlo, Marzia Baldereschi, Francesca Bovis, Benedetta Piccardi, Giovanni Linoli, Giovanni Orlandi, Gino Volpi, Alberto Chiti, Rossana Tassi, Alfonso Brescia, and Domenico Inzitari

Subjects
Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Stroke in young people shares traditional modifiable risk factors with older groups, and greatly affects quality of life. However, evidence on the effectiveness of educational interventions in young populations, aiming at spreading stroke knowledge and enhancing prevention, is still scarce. We evaluated baseline knowledge of stroke and possible improvements after an educational intervention among Italian high school students, also considering differences related to sex and type of school. Subjects and methods: Using a mixed educational strategy, a prospective evaluation of stroke knowledge was performed in five humanities and sciences (lyceums) and five vocational high schools of Tuscany (students of the 12th and 13th grade). A baseline assessment with a structured questionnaire (21 questions) was followed by a standardized oral presentation, using audiovisual materials. After 3 months, the same questionnaire was re-administered to evaluate the long-term impact of the educational intervention. Results: Overall, 573 students (50.8% males; age range, 17–19 years) were enrolled; 288 (50.3%) were from lyceums and 285 (49.7%) from vocational schools. Follow-up participation was 97.2%. Baseline performances were comparable between groups for most variables examined. At 3 months, all groups showed a significant improvement from baseline regarding reaction to a stroke event, identification of stroke risk factors, such as smoking (from 62.9% to 83.7%; p Conclusions: Our educational intervention improved stroke awareness in high school students. The effects persisted after 3 months. Improved knowledge in young populations may reduce stroke burden in adult life, increase timely access to therapies, and spread knowledge across families.

Published
2023

38. Denervazione renale nell’ipertensione arteriosa resistente. Esperienza 2012-2019 in Toscana

Author

Carlo Di Mario, Massimo Fineschi, Jacopo Lomi, Roberto Lorenzoni, Alessio Mattesini, Alessandro Iadanza, Roberto Pedrinelli, Stefano Taddei, Marco Ciardetti, Marco De Carlo, Guido Parodi, Alessio Montereggi, and Giorgio Baldereschi

Subjects
Marketing, Strategy and Management, Media Technology, General Materials Science
Abstract

Introduzione. L’ipertensione arteriosa resistente è correlata ad un alto rischio di eventi cardiovascolari maggiori (MACE), e non tutti i pazienti sono in grado di tollerare le terapie, o di ottenere una risposta adeguata a causa di una risposta incompleta ai farmaci o di una ridotta aderenza alla terapia. La denervazione renale transcatetere è un trattamento non farmacologico che potrebbe migliorare il controllo dell’ipertensione resistente. Ad oggi la sua applicazione clinica è limitata dai risultati contrastanti degli studi eseguiti per verificarne l’efficacia. Scopo. Questo studio si pone l’obiettivo di analizzare l’efficacia a lungo termine della denervazione renale transcatetere nel trattamento dell’ipertensione arteriosa (IA) resistente. Si sono ricercati inoltre criteri preoperatori predittivi di efficacia della procedura, confrontando vari sottogruppi di pazienti, e considerando le diverse tecniche esecutive (cateteri unipolari, cateteri multipolari o a palloncino). Metodi e risultati. In questo studio multicentrico sono stati coinvolti 38 pazienti con un’età media di 61,2 anni trattati con denervazione renale transcatetere tra luglio 2012 e dicembre 2018 in cinque centri toscani: Azienda Ospedaliero- Universitaria Careggi (Firenze), Azienda Ospedaliero-Universitaria Pisana, Azienda Ospedaliero-Universitaria Senese, Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica – CNR Regione Toscana (Pisa) ed Ospedale di Lucca. Sono stati registrati i dettagli tecnici delle procedure di denervazione e le immagini acquisite tramite procedure diagnostiche in preparazione agli interventi e durante il loro svolgimento. L’efficacia della procedura è stata valutata con un follow-up clinico medio di 5,1 anni e con un follow-up strumentale con 24h ABPM di un anno. Inoltre, durante il follow-up, prolungato fino a settembre 2019, sono state eseguite misurazioni della funzionalità renale e sono state registrate le modifiche della terapia farmacologica fino a 7 anni dall’intervento mediante consultazione delle cartelle cliniche ed interviste ai pazienti. In seguito alla denervazione renale, sono state rilevate diminuzioni statisticamente significative dei valori di PA sistolica (– 10,7 ± 6,0 mmHg) e diastolica (5,3 ± 3,9 mmHg) al 24h ABPM. Inoltre, è stata osservata una diminuzione significativa della terapia farmacologica antiipertensiva (-1,2 farmaci). Non si sono verificate complicanze correlate alla procedura, ad eccezione di due lievi ematomi nel sito di accesso femorale. Non sono state rilevate differenze significative di efficacia analizzando i pazienti in base alla tipologia di catetere utilizzato per l’intervento, all’età, al sesso ed alla presenza di diabete mellito. Conclusioni. I risultati di questo studio confermano l’efficacia e la sicurezza a lungo termine della denervazione renale transcatetere nel trattamento dell’IA resistente. Non sono state individuati parametri clinici o procedurali per identificare pazienti più o meno responsivi alla terapia.

Published
2021

42. Frailty Prevalence, Incidence, and Association with Incident Disability in the Italian Longitudinal Study on Aging.

Author

Galluzzo, Lucia, Noale, Marianna, Maggi, Stefania, Feraldi, Alessandro, Baldereschi, Marzia, Di Carlo, Antonio, and Onder, Graziano

Subjects
FRAIL elderly, POPULATION aging, FRAILTY, PROPORTIONAL hazards models, ACTIVITIES of daily living, LONGITUDINAL method, OLDER people
Abstract

Introduction: Data on frailty frequency are heterogeneous and mostly based on cross-sectional studies. Little is known about frailty development and progression over time. Our aim was to conduct a systematic analysis of frailty prevalence and incidence in a large cohort of older adults and to evaluate the association with incident disability, in order to tackle the current paucity and fragmentation of longitudinal data on frailty. Methods: As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort (n = 5,632, 65–84), frailty status was operationalized according to Fried criteria (n = 2,457). Weighted prevalence and incidence rates were calculated at each ILSA wave (T0 1992–1993, T1 1995–1996, T2 2000–2001). The association with incident disability in Activities of Daily Living (ADL) or Instrumental Activities of Daily Living (IADL) was investigated through Cox proportional hazard models, controlling for possible confounders. Results: Prevalence of frailty and pre-frailty at baseline (mean age 71.6 years; women 58.9%) were 4.0% (95% confidence interval [CI]: 3.4–4.6) and 44.6% (95% CI: 43.1–46.1), respectively. Incidence rates per 1,000 person-years for the T0–T1 interval were 7.3 (95% CI: 5.2–9.3) for frailty and 83.7 (95% CI: 73.6–93.8) for pre-frailty. Prevalence and incidence of frailty, and to a lesser degree of pre-frailty, were overall higher for women and increased with age, yet no increasing trend with advancing age was detected for pre-frailty incidence. Frailty incidence rates were significantly higher among pre-frail than non-frail individuals at follow-up entry. After full adjustment, being frail markedly increased the risk of incident disability in ADL (hazard ratio [HR] 3.58, 95% CI: 1.97–6.52) and IADL (HR 2.56, 95% CI: 1.58–4.16) over a 4-year period. Discussion/Conclusion: According to our findings, frailty is common among older people and is a strong and independent predictor of disability. Further research on factors and characteristics related to frailty progression, and especially remission, over time is crucial to calibrate effective public health preventive measures. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Stroke knowledge in Italy

Author

Baldereschi, Marzia, Di Carlo, Antonio, Vaccaro, Concetta, Polizzi, Biancamaria, Inzitari, Domenico, and The Promotion Implementation of Stroke Care in Italy Project Working Group

Published
2015
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46. Prevalence of Atrial Fibrillation Subtypes in Italy and Projections to 2060 for Italy and Europe

Author

Augusto Zaninelli, Marzia Baldereschi, Maria Grazia DʼAlfonso, Giovanni Pracucci, Alessandro Cattarinussi, Benedetta Piccardi, Leonardo Bellino, Bianca Maria Polizzi, Fabio Mori, Chiara Gradia, Domenico Consoli, Domenico Inzitari, Antonio Di Carlo, and Bruno Sgherzi

Subjects
Male, medicine.medical_specialty, Population, 030204 cardiovascular system & hematology, Risk Assessment, Older population, Electrocardiography, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Atrial Fibrillation, Epidemiology, Prevalence, medicine, Humans, Mass Screening, media_common.cataloged_instance, 030212 general & internal medicine, Sex Distribution, European union, education, Stroke, Opportunistic screening, Aged, media_common, Aged, 80 and over, education.field_of_study, business.industry, Atrial fibrillation, medicine.disease, Confidence interval, Europe, Cross-Sectional Studies, Italy, Female, Geriatrics and Gerontology, business, Demography
Abstract

BACKGROUND/OBJECTIVES Atrial fibrillation (AF) subtypes may carry different cardiovascular risk profiles, but information on their frequency from population-based studies is lacking. We estimated prevalence of AF subtypes in a representative sample of the Italian older population, projecting figures for Italy and the European Union. DESIGN Cross-sectional study. SETTING Three primary care practices in northern, central, and southern Italy. PARTICIPANTS All individuals aged 65 years or older, for a total sample of 6,016 subjects. Excluding 235 noneligible, participation was 78.3%, which left 4,528 participants. MEASUREMENTS A double systematic and opportunistic screening procedure identified possible AF cases, followed by clinical and electrocardiogram confirmation. Patients were categorized with paroxysmal, persistent, or permanent AF. Prevalence was calculated by sex and 5-year age groups. Prevalence figures were applied to population projections for all 28 European Union states to estimate AF subtypes expected in future decades. RESULTS In the 4,528 participants (mean age = 74.5 ± 6.8 years; 47.2% men), 331 AF cases were identified: 140 (42.3%) paroxysmal, 77 (23.3%) persistent, and 114 (34.4%) permanent. Prevalence was 3.1% (95% confidence interval (CI) = 2.6%-3.6%) for paroxysmal, 1.7% (95% CI = 1.4%-2.1%) for persistent, and 2.5% (95% CI = 2.1%-3.0%) for permanent AF. Italian older persons having AF in 2016 were estimated at approximately 449,000 for paroxysmal, approximately 240,000 for persistent, and approximately 391,000 for permanent AF, projected to increase in 2060 to approximately 785,000, approximately 358,000, and approximately 748,000, respectively. European Union older persons having AF in 2016 were estimated at approximately 3,185,000 for paroxysmal, approximately 1,722,000 for persistent, and approximately 2,710,000 for permanent AF, projected to increase in 2060 to approximately 5,989,000, approximately 2,833,000, and approximately 5,579,000, respectively. CONCLUSION We provided first projections of AF subtypes for Italy and Europe. The worse cardiovascular risk profile of persistent and permanent forms indicates an increased burden in future decades.

Published
2020

47. Frailty Prevalence, Incidence, and Association with Incident Disability in the Italian Longitudinal Study on Aging

Author

Antonio Di Carlo, Lucia Galluzzo, Marzia Baldereschi, Alessandro Feraldi, Stefania Maggi, Graziano Onder, and Marianna Noale

Subjects
Aging, Cohort study, Disability, Epidemiology, Frailty, Geriatrics and Gerontology
Abstract

Introduction: Data on frailty frequency are heterogeneous and mostly based on cross-sectional studies. Little is known about frailty development and progression over time. Our aim was to conduct a systematic analysis of frailty prevalence and incidence in a large cohort of older adults and to evaluate the association with incident disability, in order to tackle the current paucity and fragmentation of longitudinal data on frailty. Methods: As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort (n = 5,632, 65–84), frailty status was operationalized according to Fried criteria (n = 2,457). Weighted prevalence and incidence rates were calculated at each ILSA wave (T0 1992–1993, T1 1995–1996, T2 2000–2001). The association with incident disability in Activities of Daily Living (ADL) or Instrumental Activities of Daily Living (IADL) was investigated through Cox proportional hazard models, controlling for possible confounders. Results: Prevalence of frailty and pre-frailty at baseline (mean age 71.6 years; women 58.9%) were 4.0% (95% confidence interval [CI]: 3.4–4.6) and 44.6% (95% CI: 43.1–46.1), respectively. Incidence rates per 1,000 person-years for the T0–T1 interval were 7.3 (95% CI: 5.2–9.3) for frailty and 83.7 (95% CI: 73.6–93.8) for pre-frailty. Prevalence and incidence of frailty, and to a lesser degree of pre-frailty, were overall higher for women and increased with age, yet no increasing trend with advancing age was detected for pre-frailty incidence. Frailty incidence rates were significantly higher among pre-frail than non-frail individuals at follow-up entry. After full adjustment, being frail markedly increased the risk of incident disability in ADL (hazard ratio [HR] 3.58, 95% CI: 1.97–6.52) and IADL (HR 2.56, 95% CI: 1.58–4.16) over a 4-year period. Discussion/Conclusion: According to our findings, frailty is common among older people and is a strong and independent predictor of disability. Further research on factors and characteristics related to frailty progression, and especially remission, over time is crucial to calibrate effective public health preventive measures.

Published
2022

48. Influence of atrial fibrillation subtypes on anticoagulant therapy in a high-risk older population: the FAI project

Author

Antonio, Di Carlo, Fabio, Mori, Domenico, Consoli, Leonardo, Bellino, Augusto, Zaninelli, Marzia, Baldereschi, Maria Grazia, D'Alfonso, Chiara, Gradia, Alessandro, Cattarinussi, Bruno, Sgherzi, Giovanni, Pracucci, Benedetta, Piccardi, Bianca Maria, Polizzi, and Domenico, Inzitari

Subjects
Aged, 80 and over, Male, Stroke, Cross-Sectional Studies, Risk Factors, Atrial Fibrillation, Administration, Oral, Anticoagulants, Humans, Female, Aged, Factor Xa Inhibitors
Abstract

Benefits of oral anticoagulants (OAC) in atrial fibrillation (AF) patients with moderate-to-high risk of stroke are independent of AF pattern. We evaluated whether AF clinical subtype influenced OAC use in a representative sample of the Italian older population.A cross-sectional examination of all subjects aged 65 + years from three general practices in northern, central, and southern Italy started in 2016. A double-screening procedure was followed by clinical and ECG confirmation. Patients were categorized as having paroxysmal, persistent, or permanent AF. OAC use was evaluated in confirmed AF patients.The sample included 6016 subjects. Excluding 235 non-eligible, participation was 78.3%, which left 4528 participants (mean age 74.5 ± 6.8 years, 47.2% men). Overall, 319 AF cases were identified: 43.0% had paroxysmal, 21.3% persistent, and 35.7% permanent AF. Frequency of OAC therapy was 91.2% in permanent, 85.3% in persistent, and only 43.0% in paroxysmal AF (P 0.001). In multivariate analysis, controlled for baseline variables and risk scales, persistent and permanent AF were associated with a significant increase in the likelihood of receiving OAC compared with paroxysmal AF (P 0.001). This was confirmed for permanent AF also in multivariate analyses considering separately vitamin K antagonists or direct-acting oral anticoagulants (OR, 4.37, 95% CI, 2.43-7.85; and 1.92, 95% CI, 1.07-3.42, respectively) and for persistent AF and direct-acting oral anticoagulants (OR, 4.33, 95% CI, 2.30-8.15).In a population-based survey, AF pattern was an independent predictor of OAC treatment. Paroxysmal AF is still perceived as carrying a lower risk of vascular events.

Published
2021

49. Epidemiology of Alzheimer’s Disease and Other Types of Dementias

Author

Marzia Baldereschi for the Consiglio Nazionale delle Ricerche, Progetto Finalizzato Invecchiamento (Italian National Research Council Targeted Project on Aging), Amaducci, Luigi, Di Carlo, Antonio, Paoletti, R., editor, Crosignani, P. G., editor, Kenemans, P., editor, Samsioe, G., editor, Soma, M. R., editor, and Jackson, A. S., editor

Published
1997
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