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516 results on '"Baldacci, Filippo"'

1. Alzheimer's disease pathophysiology in the Retina

Author

Gaire, Bhakta Prasad, Koronyo, Yosef, Fuchs, Dieu-Trang, Shi, Haoshen, Rentsendorj, Altan, Danziger, Ron, Vit, Jean-Philippe, Mirzaei, Nazanin, Doustar, Jonah, Sheyn, Julia, Hampel, Harald, Vergallo, Andrea, Davis, Miyah R., Jallow, Ousman, Baldacci, Filippo, Verdooner, Steven R., Barron, Ernesto, Mirzaei, Mehdi, Gupta, Vivek K., Graham, Stuart L., Tayebi, Mourad, Carare, Roxana O., Sadun, Alfredo A., Miller, Carol A., Dumitrascu, Oana M., Lahiri, Shouri, Gao, Liang, Black, Keith L., and Koronyo-Hamaoui, Maya

Published
2024
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3. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Author

Sexton, Claire E, Anstey, Kaarin J, Baldacci, Filippo, Barnum, CJ, Barron, Anna M, Blennow, Kaj, Brodaty, Henry, Burnham, Samantha, Elahi, Fanny M, Götz, Jürgen, Jeon, Yun‐Hee, Koronyo‐Hamaoui, Maya, Landau, Susan M, Lautenschlager, Nicola T, Laws, Simon M, Lipnicki, Darren M, Lu, Hanzhang, Masters, Colin L, Moyle, Wendy, Nakamura, Akinori, Pasinetti, Giulio Maria, Rao, Naren, Rowe, Christopher, Sachdev, Perminder S, Schofield, Peter R, Sigurdsson, Einar M, Smith, Kate, Srikanth, Velandai, Szoeke, Cassandra, Tansey, Malú G, Whitmer, Rachel, Wilcock, Donna, Wong, Tien Y, Bain, Lisa J, and Carrillo, Maria C

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Dementia, Neurodegenerative, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Aging, Brain Disorders, Behavioral and Social Science, Neurological, Alzheimer Disease, Australia, Biomarkers, Biomedical Research, Cognitive Dysfunction, Disease Progression, Humans, Life Style, Positron-Emission Tomography, Prodromal Symptoms, Alzheimer&apos, s, dementia, behavioral symptoms, biomarkers, prevention, Alzheimer's, Geriatrics, Clinical sciences, Biological psychology
Abstract

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.

Published
2022

4. Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study.

Author

Baldacci, Filippo, Lista, Simone, Manca, Maria Laura, Chiesa, Patrizia A, Cavedo, Enrica, Lemercier, Pablo, Zetterberg, Henrik, Blennow, Kaj, Habert, Marie-Odile, Potier, Marie Claude, Dubois, Bruno, Vergallo, Andrea, Hampel, Harald, INSIGHT-preAD study group, and Alzheimer Precision Medicine Initiative (APMI)

Subjects
INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative, Alzheimer’s disease, Biomarkers, Mild cognitive impairment, Neurofilament light chain, Subjective memory complainers, Tau, Medical and Health Sciences
Abstract

BackgroundPlasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer's disease (AD). The impact of biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect of sex, age, APOE ε4 allele, comorbidities, brain amyloid-β (Aβ) burden, and cognitive scores on plasma NFL and t-Tau concentrations in cognitively healthy individuals with SMC, a condition associated with AD development.MethodsThree hundred sixteen and 79 individuals, respectively, have baseline and three-time point assessments (at baseline, 1-year, and 3-year follow-up) of the two biomarkers. Plasma biomarkers were measured with an ultrasensitive assay in a mono-center cohort (INSIGHT-preAD study).ResultsWe show an effect of age on plasma NFL, with women having a higher increase of plasma t-Tau concentrations compared to men, over time. The APOE ε4 allele does not affect the biomarker concentrations while plasma vitamin B12 deficiency is associated with higher plasma t-Tau concentrations. Both biomarkers are correlated and increase over time. Baseline NFL is related to the rate of Aβ deposition at 2-year follow-up in the left-posterior cingulate and the inferior parietal gyri. Baseline plasma NFL and the rate of change of plasma t-Tau are inversely associated with cognitive score.ConclusionWe find that plasma NFL and t-Tau longitudinal trajectories are affected by age and female sex, respectively, in SMC individuals. Exploring the influence of biological variables on AD biomarkers is crucial for their clinical validation in blood.

Published
2020

7. Precision pharmacology for Alzheimer’s disease

Author

Hampel, Harald, Vergallo, Andrea, Aguilar, Lisi Flores, Benda, Norbert, Broich, Karl, Cuello, A Claudio, Cummings, Jeffrey, Dubois, Bruno, Federoff, Howard J, Fiandaca, Massimo, Genthon, Remy, Haberkamp, Marion, Karran, Eric, Mapstone, Mark, Perry, George, Schneider, Lon S, Welikovitch, Lindsay A, Woodcock, Janet, Baldacci, Filippo, Lista, Simone, and Initiative, for the Alzheimer Precision Medicine

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Neurosciences, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Acquired Cognitive Impairment, Neurodegenerative, Brain Disorders, Aging, 2.1 Biological and endogenous factors, Aetiology, Neurological, Good Health and Well Being, Alzheimer Disease, Amyloid beta-Peptides, Animals, Biomarkers, Drug Discovery, Humans, Precision Medicine, tau Proteins, Alzheimer's disease, Precision pharmacology, Precision medicine, Pathway-based therapy, Pathophysiology, Clinical trials, Alzheimer Precision Medicine Initiative, Alzheimer’s disease, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion across multiple systems levels - from molecules to organ systems - and through adaptation, to compensation, and decompensation to systems failure. Adaptation and compensation maintain homeostasis: a dynamic equilibrium resulting from the dynamic non-linear interaction between genome, epigenome, and environment. An individual vulnerability to stressors exists on the basis of individual triggers, drivers, and thresholds accounting for the initiation and failure of adaptive and compensatory responses. Consequently, the distinct pattern of AD pathophysiology in space and time must be investigated on the basis of the individual biological makeup. This requires the implementation of systems biology and neurophysiology to facilitate Precision Medicine (PM) and Precision Pharmacology (PP). The regulation of several processes at multiple levels of complexity from gene expression to cellular cycle to tissue repair and system-wide network activation has different time delays (temporal scale) according to the affected systems (spatial scale). The initial failure might originate and occur at every level potentially affecting the whole dynamic interrelated systems within an organism. Unraveling the spatial and temporal dynamics of non-linear pathophysiological mechanisms across the continuum of hierarchical self-organized systems levels and from systems homeostasis to systems failure is key to understand AD. Measuring and, possibly, controlling space- and time-scaled adaptive and compensatory responses occurring during AD will represent a crucial step to achieve the capacity to substantially modify the disease course and progression at the best suitable timepoints, thus counteracting disrupting critical pathophysiological inputs. This approach will provide the conceptual basis for effective disease-modifying pathway-based targeted therapies. PP is based on an exploratory and integrative strategy to complex diseases such as brain proteinopathies including AD, aimed at identifying simultaneous aberrant molecular pathways and predicting their temporal impact on the systems levels. The depiction of pathway-based molecular signatures of complex diseases contributes to the accurate and mechanistic stratification of distinct subcohorts of individuals at the earliest compensatory stage when treatment intervention may reverse, stop, or delay the disease. In addition, individualized drug selection may optimize treatment safety by decreasing risk and amplitude of side effects and adverse reactions. From a methodological point of view, comprehensive "omics"-based biomarkers will guide the exploration of spatio-temporal systems-wide morpho-functional shifts along the continuum of AD pathophysiology, from adaptation to irreversible failure. The Alzheimer Precision Medicine Initiative (APMI) and the APMI cohort program (APMI-CP) have commenced to facilitate a paradigm shift towards effective drug discovery and development in AD.

Published
2018

8. Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

Author

Teipel, Stefan J, Cavedo, Enrica, Hampel, Harald, Grothe, Michel J, Initiative, Alzheimer's Disease Neuroimaging, Initiative, Alzheimer Precision Medicine, Aguilar, Lisi Flores, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L, Bokde, Arun LW, Bonuccelli, Ubaldo, Broich, Karl, Bun, René S, Cacciola, Francesco, Castrillo, Juan, Ceravolo, Roberto, chiesa, Patrizia A, Colliot, Olivier, Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L, Depypere, Herman, Dubois, Bruno, Duggento, Andrea, Durrleman, Stanley, Escott-price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A, Garaci, Francesco, Genthon, Remy, George, Nathalie, Giorgi, Filippo S, Graziani, Manuela, Haberkamp, Marion, Habert, Marie-Odile, Herholz, Karl, Karran, Eric, Seung, H KIM, Koronyo, Yosef, Koronyo-Hamaoui, Maya, Lamari, Foudil, Langevin, Todd, Lehéricy, Stéphane, Lista, Simone, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, O'Bryant, Sid E, Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S, Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R, Vergallo, Andrea, Villain, Nicolas, Welikovitch, Lindsay A, Woodcock, Janet, and Younesi, Erfan

Subjects
Biological Psychology, Psychology, Neurosciences, Brain Disorders, Dementia, Neurodegenerative, Clinical Research, Acquired Cognitive Impairment, Behavioral and Social Science, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Neurological, Alzheimer's Disease Neuroimaging Initiative, Alzheimer Precision Medicine Initiative, MRI, basal forebrain, cholinergic treatment, executive function, hippocampus, memory, prediction, Clinical Sciences, Clinical sciences, Biological psychology
Abstract

Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments for the prediction of cognitive decline. The primary objective was to determine the predictive value of hippocampus and basal forebrain volumes for global and domain specific cognitive decline in AD dementia during cholinergic treatment. Methods: We used MRI and cognitive data from 124 patients with the clinical diagnosis of AD dementia, derived from the ADNI-1 cohort, who were on standard of care cholinesterase inhibitor treatment during a follow-up period between 0.4 and 3.1 years. We used linear mixed effects models with cognitive function as outcome to assess the main effects as well as two-way interactions between baseline volumes and time controlling for age, sex, and total intracranial volume. This model accounts for individual variation in follow-up times. Results: Basal forebrain volume, but not hippocampus volume, was a significant predictor of rates of global cognitive decline. Larger volumes were associated with smaller rates of cognitive decline. Left hippocampus volume had a modest association with rates of episodic memory decline. Baseline performance in global cognition and memory was significantly associated with hippocampus and basal forebrain volumes; in addition, basal forebrain volume was associated with baseline performance in executive function. Conclusions: Our findings indicate that in AD dementia patients, basal forebrain volume may be a useful marker to predict subsequent cognitive decline during cholinergic treatment.

Published
2018

10. Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Author

Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaut, Vergallo, Andrea, Younsi, Nadjia, Afshar, Mohammad, Aguilar, Lisi Flores, Akman-Anderson, Leyla, Arenas, Joaquín, Ávila, Jesús, Babiloni, Claudio, Baldacci, Filippo, Batrla, Richard, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Caraci, Filippo, Caruso, Giuseppe, Castrillo†, Juan, Ceravolo, Roberto, Chiesa, Patrizia A., Corbo, Massimo, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Emanuele, Enzo, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, Geerts, Hugo, Giacobini, Ezio, Giorgi, Filippo S., Goetzl, Edward J., Graziani, Manuela, Haberkamp, Marion, Hänisch, Britta, Herholz, Karl, Hernandez, Felix, Imbimbo, Bruno P., Kapogiannis, Dimitrios, Karran, Eric, Kiddle, Steven J., Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lemercier, Pablo, Llavero, Francisco, Lorenceau, Jean, Lucía, Alejandro, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticò, Robert, O’bryant, Sid E., Palermo, Giovanni, Perry, George, Ritchie, Craig, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Valenzuela, Pedro L., Vellas, Bruno, Verdooner, Steven R., Villain, Nicolas, Giudici, Kelly Virecoulon, Watling, Mark, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, Zugaza, José L., Zetterberg, Henrik, and Blennow, Kaj

Published
2020
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13. Biomarker-guided clustering of Alzheimer's disease clinical syndromes

Author

Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, Thiebaut de Schotten, Michel, Vergallo, Andrea, Younsi, Nadjia, Toschi, Nicola, Baldacci, Filippo, Zetterberg, Henrik, Blennow, Kaj, Kilimann, Ingo, Teipel, Stefan J., Melo dos Santos, Antonio, Floris, Roberto, and Garaci, Francesco

Published
2019
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14. Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

Author

Bakardjian, H., Benali, H., Bertin, H., Bonheur, J., Boukadida, L., Boukerrou, N., Cavedo, E., Chiesa, P., Colliot, O., Dubois, B., Dubois, M., Epelbaum, S., Gagliardi, G., Genthon, R., Habert, M.O., Hampel, H., Houot, M., Kas, A., Lamari, F., Levy, M., Lista, S., Metzinger, C., Mochel, F., Nyasse, F., Poisson, C., Potier, M.C., Revillon, M., Santos, A., Andrade, K.S., Sole, M., Surtee, M., Thiebaud de Schotten, M., Vergallo, A., Younsi, N., Afshar, Mohammad, Flores Aguilar, Lisi, Akman-Anderson, Leyla, Arenas, Joaquín, Avila, Jesus, Babiloni, Claudio, Baldacci, Filippo, Batrla, Richard, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Caraci, Filippo, Castrillo, Juan, Cavedo, Enrica, Ceravolo, Roberto, Chiesa, Patrizia A., Corvol, Jean-Christophe, Claudio Cuello, Augusto, Cummings, Jeffrey L., Depypere, Herman, Dubois, Bruno, Duggento, Andrea, Emanuele, Enzo, Escott-Price, Valentina, Federoff, Howard, Teresa Ferretti, Maria, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, Geerts, Hugo, Giorgi, Filippo S., Goetzl, Edward J., Graziani, Manuela, Haberkamp, Marion, Marie-Odile, Habert, Hampel, Harald, Herholz, Karl, Hernandez, Felix, Kapogiannis, Dimitrios, Karran, Eric, Kiddle, Steven J., Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lucía, Alejandro, Lista, Simone, Lorenceau, Jean, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticò, Robert, O'Bryant, Sid E., Palermo, Giovanni, Perry, George, Ritchie, Craig, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Vergallo, Andrea, Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, Houot, Marion, Lemercier, Pablo, Vanmechelen, Eugeen, De Vos, Ann, Habert, Marie-Odile, and Potier, Marie-Claude

Published
2019
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15. Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

Author

Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Vergallo, Andrea, Younsi, Nadjia, Afshar, Mohammad, Aguilar, Lisi Flores, Akman-Anderson, Leyla, Arenas, Joaquín, Avila, Jesus, Babiloni, Claudio, Baldacci, Filippo, Batrla, Richard, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Caraci, Filippo, Castrillo, Juan, Ceravolo, Roberto, Chiesa, Patrizia A., Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Emanuele, Enzo, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, Geerts, Hugo, Giorgi, Filippo S., Goetzl, Edward J., Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Hernandez, Felix, Kapogiannis, Dimitrios, Karran, Eric, Kiddle, Steven J., Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lucía, Alejandro, Lorenceau, Jean, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticó, Robert, O’Bryant, Sid E., Palermo, Giovanni, Perry, George, Ritchie, Craig, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, and Thiebaut de Schotten, Michel

Published
2019
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16. Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

Author

Bakardjian, H., Benali, H., Bertin, H., Bonheur, J., Boukadida, L., Boukerrou, N., Cavedo, E., Chiesa, P., Colliot, O., Dubois, B., Dubois, M., Epelbaum, S., Gagliardi, G., Genthon, R., Habert, M.O., Hampel, H., Houot, M., Kas, A., Lamari, F., Levy, M., Lista, S., Metzinger, C., Mochel, F., Nyasse, F., Poisson, C., Potier, M.C., Revillon, M., Santos, A., Andrade, K.S., Sole, M., Surtee, M., de Schotten M, Thiebaud, Vergallo, A., Younsi, N., Aguilar, Lisi Flores, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Castrillo, Juan, Cavedo, Enrica, Ceravolo, Roberto, Chiesa, Patrizia A., Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Dubois, Bruno, Duggento, Andrea, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, Geerts, Hugo, Giorgi, Filippo S., Graziani, Manuela, Haberkamp, Marion, Habert, Marie-Odile, Hampel, Harald, Herholz, Karl, Karran, Eric, Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Lamari, Foudil, Langevin, Todd, Lehéricy, Stéphane, Lista, Simone, Lorenceau, Jean, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticò, Robert, O'Bryant, Sid E., Perry, George, Ritchie, Craig, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Vergallo, Andrea, Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, Mégret, Lucile, Zetterberg, Henrik, Blennow, Kaj, Vanmechelen, Eugeen, De Vos, Ann, and Potier, Marie-Claude

Published
2019
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19. Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Author

Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A., Boukadida, L., Cacciamani, F., Causse, V., Cavedo, E., Cherif Touil, S., Chiesa, P.A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, B., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M.O., Hampel, H., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S., Letondor, C., Levy, M., Lista, S., Lowrey, M., Ly, J., Makiese, O., Masetti, I., Mendes, A., Metzinger, C., Michon, A., Mochel, F., Nait Arab, R., Nyasse, F., Perrin, C., Poirier, F., Poisson, C., Potier, M.C., Ratovohery, S., Revillon, M., Rojkova, K., Santos-Andrade, K., Schindler, R., Servera, M.C., Seux, L., Simon, V., Skovronsky, D., Thiebaut, M., Uspenskaya, O., Vlaincu, M., Aguilar, L.F., Babiloni, C., Benda, N., Black, K.L., Bokde, A.L.W., Bonuccelli, U., Broich, K., Bun, R.S., Cacciola, F., Castrillo, J., Ceravolo, R., Coman, C.M., Corvol, J.C., Cuello, A.C., Cummings, J.L., Depypere, H., Duggento, A., Durrleman, S., Escott-Price, V., Federoff, H., Ferretti, M.T., Fiandaca, M., Frank, R.A., Garaci, F., George, N., Giorgi, F.S., Graziani, M., Haberkamp, M., Herholz, K., Karran, E., Kim, S.H., Koronyo, Y., Koronyo-Hamaoui, M., Lamari, F., Langevin, T., Lehéricy, S., Lorenceau, J., Mapstone, M., Neri, C., Nisticò, R., Nyasse-Messene, F., O'Bryant, S.E., Perry, G., Ritchie, C., Rossi, S., Santarnecchi, E., Schneider, L.S., Sporns, O., Toschi, N., Verdooner, S.R., Vergallo, A., Villain, N., Welikovitch, L., Woodcock, J., Younesi, E., Vergallo, Andrea, Bun, René-Sosata, Toschi, Nicola, Baldacci, Filippo, Zetterberg, Henrik, Blennow, Kaj, Cavedo, Enrica, Lamari, Foudil, Habert, Marie-Odile, Dubois, Bruno, Floris, Roberto, Garaci, Francesco, Lista, Simone, and Hampel, Harald

Published
2018
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20. Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

Author

Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Vergallo, Andrea, Younsi, Nadjia, Aguilar, Lisi Flores, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Bun, René S., Cacciola, Francesco, Castrillo, Juan, Ceravolo, Roberto, Chiesa, Patrizia A., Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Durrleman, Stanley, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, George, Nathalie, Giorgi, Filippo S., Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Karran, Eric, Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, O'bryant, Sid E., Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, Grothe, Michel J., and Teipel, Stefan J.

Published
2018
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21. Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1–42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40

Author

Hampel, Harald, Toschi, Nicola, Baldacci, Filippo, Zetterberg, Henrik, Blennow, Kaj, Kilimann, Ingo, Teipel, Stefan J., Cavedo, Enrica, Melo dos Santos, Antonio, Epelbaum, Stéphane, Lamari, Foudil, Genthon, Remy, Dubois, Bruno, Floris, Roberto, Garaci, Francesco, and Lista, Simone

Published
2018
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22. Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Author

Audrain, Christelle, Auffret, Alexandra, Baldacci, Filippo, Benakki, Ismahane, Bertin, Hugo, Boukadida, Laurie, Cavedo, Enrica, Chiesa, Patrizia, Dauphinot, Luce, Dos Santos, Antonio, Dubois, Marion, Durrleman, Stanley, Fontaine, Gaëlle, Genin, Alexis, Glasman, Pauline, Jungalee, Navichka, Kas, Aurélie, Kilani, Maya, La Corte, Valentina, Lehericy, Stephane, Letondor, Claire, Levy, Marcel, Lowrey, Mark, Ly, Juliette, Makiese, Ornella, Metzinger, Christiane, Michon, Agnès, Mochel, Fanny, Poisson, Catherine, Ratovohery, Stephie, Revillon, Marie, Rojkova, Katrine, Roy, Perrine, Santos-Andrade, Katia, Schindler, Rachel, Seux, Laure, Simon, Valérie, Sole, Marine, Tandetnik, Caroline, Teichmann, Marc, Thiebaut de Shotten, Michel, Younsi, Nadjia, Dubois, Bruno, Epelbaum, Stephane, Nyasse, Francis, Bakardjian, Hovagim, Gagliardi, Geoffroy, Uspenskaya, Olga, Houot, Marion, Lista, Simone, Cacciamani, Federica, Potier, Marie-Claude, Bertrand, Anne, Lamari, Foudil, Benali, Habib, Mangin, Jean-François, Colliot, Olivier, Genthon, Remy, Habert, Marie-Odile, and Hampel, Harald

Published
2018
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23. Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer’s Disease

Author

Baldacci, Filippo, Daniele, Simona, Piccarducci, Rebecca, Giampietri, Linda, Pietrobono, Deborah, Giorgi, Filippo Sean, Nicoletti, Valentina, Frosini, Daniela, Libertini, Paolo, Lo Gerfo, Annalisa, Petrozzi, Lucia, Donadio, Elena, Betti, Laura, Trincavelli, Maria Letizia, Siciliano, Gabriele, Ceravolo, Roberto, Tognoni, Gloria, Bonuccelli, Ubaldo, and Martini, Claudia

Published
2019
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24. Mild Behavioral Impairment in Psychogeriatric Patients: Clinical Features and Psychopathology Severity

Author

Elefante, Camilla, primary, Brancati, Giulio Emilio, additional, Ismail, Zahinoor, additional, Ricciardulli, Sara, additional, Beatino, Maria Francesca, additional, Lepri, Vittoria, additional, Famà, Antonella, additional, Ferrari, Elisabetta, additional, Giampietri, Linda, additional, Baldacci, Filippo, additional, Ceravolo, Roberto, additional, Maremmani, Icro, additional, Lattanzi, Lorenzo, additional, and Perugi, Giulio, additional

Published
2023
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26. α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects

Author

Daniele, Simona, Pietrobono, Deborah, Fusi, Jonathan, Iofrida, Caterina, Chico, Lucia, Petrozzi, Lucia, Gerfo, Annalisa Lo, Baldacci, Filippo, Galetta, Fabio, Siciliano, Gabriele, Bonuccelli, Ubaldo, Santoro, Gino, Trincavelli, Maria Letizia, Franzoni, Ferdinando, and Martini, Claudia

Published
2018
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27. Different Patterns of Locus Coeruleus MRI Alteration in Alzheimer’s and Dementia with Lewy Bodies

Author

Galgani, Alessandro, primary, Palermo, Giovanni, additional, Lombardo, Francesco, additional, Martini, Nicola, additional, Bastiani, Luca, additional, Vergallo, Andrea, additional, Tommasini, Luca, additional, Bellini, Gabriele, additional, Baldacci, Filippo, additional, Frosini, Daniela, additional, Tognoni, Gloria, additional, Gesi, Marco, additional, Cademartiri, Filippo, additional, Fornai, Francesco, additional, Pavese, Nicola, additional, Ceravolo, Roberto, additional, and Giorgi, Filippo Sean, additional

Published
2023
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30. Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia

Author

Galgani, Alessandro, primary, Lombardo, Francesco, additional, Martini, Nicola, additional, Vergallo, Andrea, additional, Bastiani, Luca, additional, Hampel, Harald, additional, Hlavata, Hana, additional, Baldacci, Filippo, additional, Tognoni, Gloria, additional, De Marchi, Daniele, additional, Ghicopulos, Irene, additional, De Cori, Sara, additional, Biagioni, Francesca, additional, Busceti, Carla Letizia, additional, Ceravolo, Roberto, additional, Bonuccelli, Ubaldo, additional, Chiappino, Dante, additional, Siciliano, Gabriele, additional, Fornai, Francesco, additional, Pavese, Nicola, additional, and Giorgi, Filippo Sean, additional

Published
2022
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32. Alzheimer's Disease and Neurosyphilis: Meaningful Commonalities and Differences of Clinical Phenotype and Pathophysiological Biomarkers.

Author

Milano, Chiara, Hoxhaj, Domeniko, Del Chicca, Marta, Pascazio, Alessia, Paoli, Davide, Tommasini, Luca, Vergallo, Andrea, Pizzanelli, Chiara, Tognoni, Gloria, Nuti, Angelo, Ceravolo, Roberto, Siciliano, Gabriele, Hampel, Harald, and Baldacci, Filippo

Subjects
NEUROSYPHILIS, ALZHEIMER'S disease, NEUROLOGICAL disorders, SPATIAL ability, CEREBRAL atrophy, MEMORY disorders
Abstract

Background: Neurosyphilis-associated cognitive and behavioral impairment— historically coined as "general paralysis of the insane"— share clinical and neuroradiological features with the neurodegenerative disease spectrum, in particular Alzheimer's disease (AD). Anatomopathological similarities have been extensively documented, i.e., neuronal loss, fibrillary alterations, and local amyloid-β deposition. Consequently, accurate classification and timely differential diagnosis may be challenging. Objective: To describe clinical, bio-humoral, brain MRI, FDG-PET, and amyloid-PET features in cases of neurosyphilis with an AD-like phenotypical presentation, as well as clinical outcome in terms of response to antibiotic therapy. Methods: We selected the studies comparing patients with AD and with neurosyphilis associated cognitive impairment, to investigate candidate biomarkers classifying the two neurological diseases. Results: The neuropsychological phenotype of general paralysis, characterized by episodic memory impairment and executive disfunction, substantially mimics clinical AD features. Neuroimaging often shows diffuse or medial temporal cortical atrophy, thus contributing to a high rate of misdiagnosis. Cerebrospinal fluid (CSF)-based analysis may provide supportive diagnostic value, since increased proteins or cells are often found in neurosyphilis, while published data on pathophysiological AD candidate biomarkers are controversial. Finally, psychometric testing using cross-domain cognitive tests, may highlight a wider range of compromised functions in neurosyphilis, involving language, attention, executive function, and spatial ability, which are atypical for AD. Conclusion: Neurosyphilis should be considered a potential etiological differential diagnosis of cognitive impairment whenever imaging, neuropsychological or CSF features are atypical for AD, in order to promptly start antibiotic therapy and delay or halt cognitive decline and disease progression. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Correction: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Author

Sakr, Fatemah A, Grothe, Michel J, Teipel, Stefan, Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S, Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R, Dubois, Bruno, Vergallo, Andrea, Villain, Nicolas, Welikovitch, Lindsay A, Woodcock, Janet, Younesi, Erfan, Hampel, Harald, group, INSIGHT-preAD study, Initiative, Alzheimer Precision Medicine, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Cavedo, Enrica, Boukerrou, Nadia, Chiesa, Patrizia, Colliot, Olivier, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Jelistratova, Irina, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Younsi, Nadjia, Aguilar, Lisi Flores, Dyrba, Martin, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L, Bokde, Arun L W, Bonuccelli, Ubaldo, Broich, Karl, Bun, René S, Cacciola, Francesco, Castrillo, Juan, Gonzalez-Escamilla, Gabriel, Ceravolo, Roberto, Chiesa, Patrizia A, Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L, Depypere, Herman, Duggento, Andrea, Durrleman, Stanley, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A, Garaci, Francesco, George, Nathalie, Locatelli, Maxime, Giorgi, Filippo S, Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Karran, Eric, Kim, Seung H, Koronyo, Yosef, Koronyo-Hamaoui, Maya, Lehericy, Stephane, Langevin, Todd, Lehéricy, Stéphane, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, and O'bryant, Sid E

Subjects
Neurology, Cognitive Neuroscience, ddc:610, Neurology (clinical)
Published
2022
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36. Biological determinants of blood‐based cytokines in the Alzheimer's disease clinical continuum

Author

Galgani, Alessandro, primary, Vergallo, Andrea, additional, Campese, Nicole, additional, Lombardo, Francesco, additional, Pavese, Nicola, additional, Petrozzi, Lucia, additional, LoGerfo, Annalisa, additional, Franzini, Maria, additional, Cecchetti, Denise, additional, Puglisi‐Allegra, Stefano, additional, Busceti, Carla L., additional, Siciliano, Gabriele, additional, Tognoni, Gloria, additional, Baldacci, Filippo, additional, Lista, Simone, additional, Hampel, Harald, additional, Fornai, Francesco, additional, and Giorgi, Filippo S., additional

Published
2022
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37. Alzheimer's disease research progress in Australia: The Alzheimer's association international conference satellite symposium in Sydney

Author

Sexton, Claire E., Anstey, Kaarin J., Baldacci, Filippo, Barnum, C. J., Barron, Anna M., Blennow, Kaj, Brodaty, Henry, Burnham, Samantha, Elahi, Fanny M., Götz, Jürgen, Jeon, Yun-Hee, Koronyo-Hamaoui, Maya, Landau, Susan M., Lautenschlager, Nicola T., Laws, Simon M., Lipnicki, Darren M., Lu, Hanzhang, Masters, Colin L., Moyle, Wendy, Nakamura, Akinori, Pasinetti, Giulio Maria, Rao, Naren, Rowe, Christopher, Sachdev, Perminder S., Schofield, Peter R., Sigurdsson, Einar M., Sexton, Claire E., Anstey, Kaarin J., Baldacci, Filippo, Barnum, C. J., Barron, Anna M., Blennow, Kaj, Brodaty, Henry, Burnham, Samantha, Elahi, Fanny M., Götz, Jürgen, Jeon, Yun-Hee, Koronyo-Hamaoui, Maya, Landau, Susan M., Lautenschlager, Nicola T., Laws, Simon M., Lipnicki, Darren M., Lu, Hanzhang, Masters, Colin L., Moyle, Wendy, Nakamura, Akinori, Pasinetti, Giulio Maria, Rao, Naren, Rowe, Christopher, Sachdev, Perminder S., Schofield, Peter R., and Sigurdsson, Einar M.

Abstract

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.

Published
2022

42. α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease

Author

Beatino, Maria Francesca, primary, De Luca, Ciro, additional, Campese, Nicole, additional, Belli, Elisabetta, additional, Piccarducci, Rebecca, additional, Giampietri, Linda, additional, Martini, Claudia, additional, Perugi, Giulio, additional, Siciliano, Gabriele, additional, Ceravolo, Roberto, additional, Vergallo, Andrea, additional, Hampel, Harald, additional, and Baldacci, Filippo, additional

Published
2022
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43. Lactobacillus rhamnosus BMX 54 + Lactose, A Symbiotic Long-Lasting Vaginal Approach to Improve Women’s Health

Author

Baldacci, Filippo, Baldacci, Mara, and Bertini, Marco

Subjects
Lactobacillus rhamnosus BMX 54, pathobiosis pathway, bacterial vaginosis, Article Commentary
Abstract

The proposal to restore vaginal microbiota using biotherapeutic agents ended with controversial results. Vaginal microbiota modifications from eubiosis to dysbiosis (desquamative inflammatory vaginitis, “aerobic vaginitis”) and pathobiosis have recently been demonstrated to have a pivotal role in women’s clinical health. Bacterial vaginosis (BV) and its related women’s pathology seem to be “the most common vaginal infections” in women; the Center for Disease Control (CDC) recommended treatment for this pathology: metronidazole, clyndamicin or other well known treatment such as dequalinium chloride, unfortunately, has been demonstrated to fail in control of this infection and especially in its recurrence rates. A long-lasting vaginal approach with a symbiotic drug (Lactobacillus rhamnosus BMX 54 + lactose) (NORMOGIN™) has demonstrated on a large sample of women enrolled in clinical trials (more than 3000 patients) not only to be able to significantly reduce the BV recurrences, after the CDC standard of care administration, but also to control the vaginal pathobiosis pathway, restoring the physiological eubiosis from dysbiosis. These results are really very encouraging and clearly demonstrate that a symbiotic long-lasting vaginal application of a selected Lactobacillus population plus a prebiotic could be helpful if added to the recommended standard of care.

Published
2020

46. Fluid Biomarkers in Alzheimer’s Disease and Other Neurodegenerative Disorders: Toward Integrative Diagnostic Frameworks and Tailored Treatments

Author

Giampietri, Linda, primary, Belli, Elisabetta, additional, Beatino, Maria Francesca, additional, Giannoni, Sara, additional, Palermo, Giovanni, additional, Campese, Nicole, additional, Tognoni, Gloria, additional, Siciliano, Gabriele, additional, Ceravolo, Roberto, additional, De Luca, Ciro, additional, and Baldacci, Filippo, additional

Published
2022
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48. Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia.

Author

Galgani, Alessandro, Lombardo, Francesco, Martini, Nicola, Vergallo, Andrea, Bastiani, Luca, Hampel, Harald, Hlavata, Hana, Baldacci, Filippo, Tognoni, Gloria, De Marchi, Daniele, Ghicopulos, Irene, De Cori, Sara, Biagioni, Francesca, Busceti, Carla Letizia, Ceravolo, Roberto, Bonuccelli, Ubaldo, Chiappino, Dante, Siciliano, Gabriele, Fornai, Francesco, and Pavese, Nicola

Subjects
AMNESTIC mild cognitive impairment, MAGNETIC resonance imaging, LOCUS coeruleus, MILD cognitive impairment, ALZHEIMER'S disease
Abstract

Background and purpose: Human neuropathological studies indicate that the pontine nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's disease. This line of evidence alongside experimental data suggests that the LC functional/structural decay may represent a critical factor for Alzheimer's disease pathophysiological and clinical progression. In the present prospective study, we used Magnetic Resonance Imaging (MRI) with LC‐sensitive sequence (LC‐MRI) to investigate in vivo the LC involvement in Alzheimer's disease progression, and whether specific LC‐MRI features at baseline are associated with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. Methods: LC‐MRI parameters were measured at baseline by a template‐based method on 3.0‐T magnetic resonance images in 34 patients with Alzheimer's disease dementia, 73 patients with amnestic Mild Cognitive Impairment, and 53 cognitively intact individuals. A thorough neurological and neuropsychological assessment was performed at baseline and 2.5‐year follow‐up. Results: In subjects with Mild Cognitive Impairment who converted to dementia (n = 32), the LC intensity and number of LC‐related voxels were significantly lower than in cognitively intact individuals, resembling those observed in demented patients. Such a reduction was not detected in Mild Cognitive Impairment individuals, who remained stable at follow‐up. In Mild Cognitive Impairment subjects converting to dementia, LC‐MRI parameter reduction was maximal in the rostral part of the left nucleus. Structural equation modeling analysis showed that LC‐MRI parameters positively correlate with cognitive performance. Conclusions: Our findings highlight a potential role of LC‐MRI for predicting clinical progression in Mild Cognitive Impairment and support the key role of LC degeneration in the Alzheimer clinical continuum. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Comparison of plasmatic interleukins patterns among cognitively unimpaired subjects, patients affected by mild cognitive impairment and subjects with Alzheimer's disease dementia

Author

Galgani, Alessandro, Campese, Nicole, Logerfo, Annalisa, Petrozzi, Lucia, Baldacci, Filippo, Tognoni, Gloria, Ceravolo, Roberto, Lombardo, Francesco, Pavese, Nicola, Fornai, Francesco, Paolicchi, Aldo, Vergallo, Andrea, Hampel, Harald, Siciliano, Gabriele, and Giorgi, Filippo

Published
2021
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