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Female pelvic floor instability provokes urinary incontinence, genito-urinary and rectal prolapsus, and sexual dysfunction. Both vaginal and abdominal methods to treat pelvic organ prolapsus (POP) have been developing. Abdominal interventions became less invasive and less morbid with the use of laparoscopy. In this report, two cases of POP treated with a combined application of vaginal mesh by transobturator approach and laparoscopic sacrocolpopexy in the same operational session were presented. Case 1, a 77 year old woman, was diagnosed with stage III cystocele and stage III collum uteri rest prolapsus. The patient had a history of abdominal subtotal hysterectomy and left ooferectomy for a large uterine myoma 30 years ago. Case 2, a 67-year-old woman, was diagnosed with stage III cystocele and vaginal vault prolapse. The patient had a history of total abdominal hysterectomy plus bilateral salpingooophorectomy operation 16 years ago.