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222 results on '"Balasubramanian, Sivakumar"'

1. Towards noise robust trigger-word detection with contrastive learning pre-task for fast on-boarding of new trigger-words

Author

Balasubramanian, Sivakumar, Jajodia, Aditya, and Srinivasan, Gowtham

Subjects
Computer Science - Sound, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract

Trigger-word detection plays an important role as the entry point of user's communication with voice assistants. But supporting a particular word as a trigger-word involves huge amount of data collection, augmentation and labelling for that word. This makes supporting new trigger-words a tedious and time consuming process. To combat this, we explore the use of contrastive learning as a pre-training task that helps the detection model to generalize to different words and noise conditions. We explore supervised contrastive techniques and also propose a novel self-supervised training technique using chunked words from long sentence audios. We show that both supervised and the new self-supervised contrastive pre-training techniques have comparable results to a traditional classification pre-training on new trigger words with less data availability., Comment: submitted to ICMLA

Published
2021

6. Design of Single Degree-of-Freedom Mechanisms for Hand Neurorehabilitation

Author

Nehrujee, Aravind, Guguloth, Sandeep, Reethajanetsurekha, Selvaraj, Samuelkamaleshkumar, Srinivasan, Sujatha, Balasubramanian, Sivakumar, Chaari, Fakher, Series Editor, Haddar, Mohamed, Series Editor, Kwon, Young W., Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Sen, Dibakar, editor, Mohan, Santhakumar, editor, and Ananthasuresh, Gondi Kondaiah, editor

Published
2021
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13. Red Cell Indexes Made Easy Using an Interactive Animation: Do Students and Their Scores Concur?

Author

Kachroo, Upasana, Vinod, Elizabeth, Balasubramanian, Sivakumar, W., Jesi, and Prince, Neetu

Abstract

A good understanding of red cell indexes can aid medical students in a considerable manner, serving as a basis to unravel both concepts in red cell physiology and abnormalities associated with the same. In this study, we tried to assess whether an interactive animation was helpful in improving student comprehension and understanding of red cell indexes compared with conventional classroom teaching. Eighty-eight first-year MBBS students participated, of which 44 were assigned to "group A" and 44 were assigned to "group B" after randomization. After further creation of smaller groups, students were provided with 45 min to revise red cell indexes, after which they were required to complete a multimodal questionnaire. "Group A" subgroups used written material for revision, whereas "group B" subgroups had access to an interactive animation. After completion of the questionnaire, "group A" students also used the animation after which feedback was collected from all students. Efficacy of the animation to improve learning and retention was demonstrated, as "group B" students scored significantly higher than "group A" students on the questionnaire (P = 0.0003). A clear majority of the students agreed/strongly agreed that the animation was easy to operate, conveyed important concepts efficiently, and improved their knowledge of related clinical aspects as well. From the results and feedback, we found that the animation was a simple, well-received model, which, by significantly improving student performance, corroborated our hypothesis that inclusion of interactive animation into student curriculum can advance their academic attainment, compared with didactic teaching alone.

Published
2018
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22. GERD symptoms often improve after magnetic sphincter augmentation (MSA) device removal – an observational study

Author

Nicholas Buniak, Borys Buniak, Atul Maini, Balasubramanian Sivakumar, John Sun, Stacey Jantsch, Danielle L. Obrien, and Tara Frey

Abstract

Hypothesis: Magnetic Sphincter Augmentation device causes fibrosis at the distal esophagus which prevents reflux even after device removal Background: Gastroesophageal reflux disease (GERD) affects over 20 million people in the United States. If left untreated, chronic reflux of gastric contents into the distal esophagus may result in benign or malignant esophageal strictures, causing varying degrees of dysphagia. We currently offer interventions which artificially create a narrowing at the distal esophagus to prevent complications of GERD. Magnetic Sphincter Augmentation device (MSA), or LINX, creates such a narrowing of the distal esophagus at the level of the LES. Individuals intolerant of this device need surgical removal which leaves scarring at the site of implantation. Methods: There were 118 MSA devices placed at our institution between 2017 and 2021. During this time, 8 out of 118 (6.7%) patients needed to have their LINX removed due to side effects attributed to the implant. Causes for removal included esophageal perforation, dysphagia or hypersensitivity related chest pressure presumably caused by the device. Patients, who have had the LINX device removed, were followed for recurrence of reflux using Barium Swallow imaging, endoscopic findings and GERD-HRQL scores. Results: The longer the MSA implants remained before removal, the more extensive the scar tissue encountered at site of excision. Five of eight patients (62%) experienced improvement in their GERD-HRQL scores after removal of the MSA device when compared to results before LINX implantation. The residual band of scar tissue observed after device removal appeared to control reflux by restricting the relaxation of the esophageal outlet. Conclusions: These results indicate that fibrosis at the site of MSA device removal improves heartburn symptoms in a majority of patients. We do not recommend fundoplication at time of LINX removal as symptoms of GERD may be adequately controlled by scar tissue at the LES.

Published
2023

24. Comparing algorithms for assessing upper limb use with inertial measurement units

Author

Subash, Tanya, primary, David, Ann, additional, ReetaJanetSurekha, StephenSukumaran, additional, Gayathri, Sankaralingam, additional, Samuelkamaleshkumar, Selvaraj, additional, Magimairaj, Henry Prakash, additional, Malesevic, Nebojsa, additional, Antfolk, Christian, additional, SKM, Varadhan, additional, Melendez-Calderon, Alejandro, additional, and Balasubramanian, Sivakumar, additional

Published
2022
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28. Palladium-Based Metal Organic Frameworks as Heterogeneous Catalysts for C-C Couplings

Author

Arputham Shophia Lawrence, Nuria Martin, Balasubramanian Sivakumar, Francisco G. Cirujano, and Amarajothi Dhakshinamoorthy

Subjects
Inorganic Chemistry, Suzuki-Miyaura, Heterogeneous catalysis, Organic Chemistry, Metal organic frameworks, Physical and Theoretical Chemistry, C−C cross coupling, Catalysis, Palladium
Abstract

Among the various cross coupling reactions, C−C cross coupling reaction has attracted many researchers to investigate in the last four decades. The continuous, constant, and consistent progress in this field fetched a Noble prize in 2010, showing the importance of this reaction in diversified fields. Among the various transition metals studied for this reaction, Pd is one of the metals that has exhibited the highest activity due to its unique features and reactivity. Although Pd-based homogeneous catalyst was the preferred choice for many researchers, the field slowly diverted towards the development of Pd-based heterogeneous catalysts for C−C coupling reactions. This is obviously due to the high cost of Pd precursor, its self-deactivation. In this context, metal organic frameworks (MOFs) are one of the solid catalysts frequently employed as host matrix for the deposition of Pd(II) salts and Pd nanoparticles. This is due to the widespread possibilities available for the functionalization of MOFs and their stability during the synthetic procedure. This review provides the design and development of Pd-based MOFs as heterogeneous catalysts for the C−C cross coupling reactions. After a brief introduction on MOFs and the importance of C−C coupling reactions, the main part of the review summarizes the catalytic data with respect to Pd(II) and Pd nanoparticles as active sites. The last section provides our views in this field for the further development in the near future.

Published
2022

33. INFLUENCE OF CeO2 NANOPARTICLES ON METHYL TERTIARY BUTYL ETHER GASOLINE BLEND IN SPARK IGNITION ENGINE.

Author

DURAISWAMY BALASUBRAMANIAN, Sivakumar, MUTHUKUMARASAMY, Arulmozhi, TAMILKOLUNDU, Senthilkumar, CHANDRAN, Mohanraj, AROCKIARAJ, Godwin Antony, and MOHAN, Sridharan

Subjects
*SPARK ignition engines, *BUTYL methyl ether, *GASOLINE, *OXYGENATED gasoline, *GASOLINE blending, *ANTIKNOCK gasoline, *ENERGY consumption
Abstract

The search for suitable alternative for fossil fuel has been a challenge to the research community for the past two decades. So many alternatives have been identified and tested. However, a complete replacement cannot be provided without any penalties of cost, excess emission, poor operation, etc. The alcohols gave a new opportunity and a solution for that problem but had some setbacks of increased density and lower octane number. The present work focuses on striking a balance between advantages and disadvantages by using oxygenated additive with gasoline fuel. The additive CeO2 along with methyl tertiary butyl ether (MTBE) offers many advantages. The seven samples, namely M10, M15, M20, M25, M20 + 50 mg/l, M20+100 mg/l, M20+150 mg/l have been prepared and tested on spark ignition engine. Here, 10, 15, 20, and 25 denote the MTBE volume in blends and 50 mg/l, 100 mg/l, and 150 mg/l indicate the CeO2 in blends. The results have shown that only MTBE has caused an increase of 4% in brake thermal efficiency with M15 and then brake thermal efficiency has improved by 3% with M15 + 100 mg/l compared with pure gasoline. Fuel consumption has also been reduced upto 9% with M20 and 11% with M15+150 mg/l compared with pure gasoline. The maximum HC and CO reductions have also been observed from M20 and M20 + 150 mg/l. It was up to 19% and 22%, 23%, and 25% of HC and CO with M20, M20 + 150 mg/l. However, there has been an increase in CO2 emission level because of excessive unburned HC reduction. The MTBE with CeO2 has proved to be suited to all running conditions. The blends having more amounts of additive produce good combustion characteristics yet it should be restricted within 20 vol.% of MTBE and 150 mg/l of CeO2. [ABSTRACT FROM AUTHOR]

Published
2022
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34. List of contributors

Author

Ad Adams, Ebenezer, Adebowale, Akintunde, Agrawal, Abha, Aguilar, Javier Sánchez, Akgul, Yusuf Sinan, Akinniyi, Oluwasegun T., Asongafac, Ayenowowan, Sunday O., Ayodele, Kayode P., Badhal, Suman, Balasubramanian, Sivakumar, Baldwin, Jakita, Balivada, Santosh, Barger, Cori, Barkana, Duygun Erol, Behzadipour, Saeed, Bello, Abiodun H., Boldrini, Paolo, Bonaiuti, Donatella, Bui, Kevin Doan-Khang, Bustamante Valles, Karla D., Cao, Ning, Carrasquilla Batista, Arys, Chen, Zhen, Cifuentes, Carlos A., Comadurán Márquez, Daniel, Coto-Solano, Beatriz, Crocher, Vincent, Dillingham, Timothy, Djordjevic, Olivera C., Fawale, Michael B., Feingold-Polak, Ronit, Fong, Justin, García-Aracil, Nicolás, Garzón, Andrea, Goldberg, Carly, Hajjioui, Abderrazak, Hamilton, Taya, Hanapiah, Fazah Akhtar, Hirata, Yasuhisa, Hong (Zen), Koh Teck, Hua, Zikai, Idowu, Ahmed O., Iturralde-Duenas, Gabriel, Ivorra, Andrea Blanco, Jamisola, Rodrigo S., Jr, Johnson, Michelle J., Jubril, Abimbola M., Jung, Bong-Keun, Kachroo, Kavita, Kambou, Sinforian, Kebaetse, Maikutlo, Keyvanian, Shafagh, Khor, Kang Xiang, Khor, Yvonne Y.W., Kim, JiHyun, Kimmatudawage, Sumudu Perera, Klaic, Marlena, Kommula, Venkata P., Komolafe, Morenikeji A., Konstantinovic, Ljubica M., Krebs, Hermano I., Lamou, Eric Gueumekane Bila, Levy-Tzedek, Shelly, Loeza Magaña, Pavel, Mazzoleni, Stefano, Mbakile-Mahlanza, Lingani, McIntyre, Amanda, Mehr, Javad K., Mendonca, Rochelle J., Mitrovic, Sindi Z., Miyai, Ichiro, Mogorosi, Ntsatsi, Mohamad Hashim, Natiara, Moon, Inhyuk, Múnera, Marcela, Nafai, Said, Naqvi, Imama A., Ndlovu, Kagiso, Nehrujee, Aravind, Nilsen, Dawn M., Noda, Tomoyuki, Nthitu, Justus Mackenzie, Nyarko, Frank Kwabena Afriyie, Ocampo, Cassandra, Ogunba, Kolawole S., Ogunbona, Philip O., Ogundele, Abiola O., Oktay, Ayse Betul, Olaogun, Matthew O.B., Ortiz-Prado, Esteban, Orts, José María Catalán, Owen Tsai, Chung-Ying, Park, Jin-Hyuck, Pino, Angie, Posteraro, Federico, Quao, Benedict Okoe, Rahimi, Narges, Rakesh Srivastava, Saha, Shovan, Saikaley, Marcus, Sánchez, Jose López, Sanusi, Ahmad A., Savic, Andrej M., Song, Won-Kyung, Srinivasan, Sujatha, Su, Eileen L.M., Su, Hao, Tannor, Abena Yeboaa, Tarakci, Devrim, Tarakci, Ela, Tavakoli, Mahdi, Temgoua, Michael, Tonye, Philomène Synthia, Trejos, Ana Luisa, Tsima, Billy, Tsinda, Valery Labou, Uzun, Ismail, V., Guruprasad, Vidakovic, Aleksandra S., Wamsley, Carol A., Weiss, Patrice L., Winterbottom, Lauren, Wolfe, Dalton L., Yang, Dixon, Yeong, Che Fai, Zammouri, Amin, and Zollo, Loredana

Published
2024
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36. Citric acid coated CoFe2O4 nanoparticles transformed through rapid mechanochemical ligand exchange for efficient magnetic hyperthermia applications

Author

D. Sakthikumar, Sandeep Munjal, Balasubramanian Sivakumar, and Neeraj Khare

Subjects
010302 applied physics, Materials science, Biocompatibility, Ligand, Nanoparticle, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Magnetic hyperthermia, Chemical engineering, chemistry, 0103 physical sciences, Zeta potential, Hydrothermal synthesis, Magnetic nanoparticles, 0210 nano-technology, Citric acid
Abstract

We report the hydrothermal synthesis of uniform size (∼6 nm) oleic acid capped CoFe 2 O 4 (OA-CoFe 2 O 4 ) nanoparticles. These OA-CoFe 2 O 4 nanoparticles were initially hydrophobic and not dispersible in water which were transformed into hydrophilic nanoparticles by modifying their surface with citric acid using a rapid mechanochemical ligand exchange process, which makes CoFe 2 O 4 nanoparticles stable colloidal solution in water. The synthesized citric acid coated CoFe 2 O 4 (CA-CoFe 2 O 4 ) nanoparticles show a high enough and stable zeta potential over 120 days. CA-CoFe 2 O 4 nanoparticles exhibited high biocompatibility under in vitro cell studies. The specific absorption rate (SAR) of the CA-CoFe 2 O 4 nanoparticles was measured by induction heating studies. Upon the exposure of AC external magnetic field, the viability of cancer cells was reduced considerably, suggesting efficient potentiality of these CA-CoFe 2 O 4 nanoparticles for Magnetic Hyperthermia Applications. Present mechanochemical ligand exchange method is proposed as an efficient method for large scale production of biocompatible and water dispersible magnetic oxide nanoparticles for Magnetic Hyperthermia Applications.

Published
2019

40. Heat Shock Protein 90 (Hsp90)-Inhibitor-Luminespib-Loaded-Protein-Based Nanoformulation for Cancer Therapy

Author

Rochani, Ankit K., Balasubramanian, Sivakumar, Ravindran Girija, Aswathy, Maekawa, Toru, Kaushal, PhD, Gagan, Kumar, D Sakthi, Rochani, Ankit K., Balasubramanian, Sivakumar, Ravindran Girija, Aswathy, Maekawa, Toru, Kaushal, PhD, Gagan, and Kumar, D Sakthi

Abstract

Drugs targeting heat shock protein 90 (Hsp90) have been extensively explored for their anticancer potential in advanced clinical trials. Nanoformulations have been an important drug delivery platform for the anticancer molecules like Hsp90 inhibitors. It has been reported that bovine serum albumin (BSA) nanoparticles (NPs) serve as carriers for anticancer drugs, which have been extensively explored for their therapeutic efficacy against cancers. Luminespib (also known as NVP-AUY922) is a new generation Hsp90 inhibitor that was introduced recently. It is one of the most studied Hsp90 inhibitors for a variety of cancers in Phase I and II clinical trials and is similar to its predecessors such as the ansamycin class of molecules. To our knowledge, nanoformulations for luminespib remain unexplored for their anticancer potential. In the present study, we developed aqueous dispensable BSA NPs for controlled delivery of luminespib. The luminespib-loaded BSA NPs were characterized by SEM, TEM, FTIR, XPS, UV-visible spectroscopy and fluorescence spectroscopy. The results suggest that luminespib interacts by non-covalent reversible interactions with BSA to form drug-loaded BSA NPs (DNPs). Our in vitro evaluations suggest that DNP-based aqueous nanoformulations can be used in both pancreatic (MIA PaCa-2) and breast (MCF-7) cancer therapy.

Published
2020

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