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24 results on '"Balasco, Luigi"'

5. Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral, and transcriptomic levels.

Author

Montani, Caterina, Balasco, Luigi, Pagani, Marco, Alvino, Filomena Grazia, Barsotti, Noemi, de Guzman, A. Elizabeth, Galbusera, Alberto, de Felice, Alessia, Nickl-Jockschat, Thomas K., Migliarini, Sara, Casarosa, Simona, Lau, Pierre, Mattioni, Lorenzo, Pasqualetti, Massimo, Provenzano, Giovanni, Bozzi, Yuri, Lombardo, Michael V., and Gozzi, Alessandro

Subjects
*STEROID receptors, *X chromosome, *SEX hormones, *TRANSCRIPTOMES, *AUTISTIC people
Abstract

Genomic mechanisms enhancing risk in males may contribute to sex bias in autism. The ubiquitin protein ligase E3A gene (Ube3a) affects cellular homeostasis via control of protein turnover and by acting as transcriptional coactivator with steroid hormone receptors. Overdosage of Ube3a via duplication or triplication of chromosomal region 15q11-13 causes 1 to 2% of autistic cases. Here, we test the hypothesis that increased dosage of Ube3a may influence autism-relevant phenotypes in a sex-biased manner. We show that mice with extra copies of Ube3a exhibit sex-biasing effects on brain connectomics and autism-relevant behaviors. These effects are associated with transcriptional dysregulation of autism-associated genes, as well as genes differentially expressed in 15q duplication and in autistic people. Increased Ube3a dosage also affects expression of genes on the X chromosome, genes influenced by sex steroid hormone, and genes sex-differentially regulated by transcription factors. These results suggest that Ube3a overdosage can contribute to sex bias in neurodevelopmental conditions via influence on sexdifferential mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The interplay between oxidative stress and inflammation supports autistic-related behaviors in mice

Author

Pangrazzi, Luca, primary, Cerilli, Enrica, additional, Balasco, Luigi, additional, Tobia, Caterina, additional, Dall'O', Ginevra Matilde, additional, Chelini, Gabriele, additional, Perini, Samuel, additional, Filosi, Michele, additional, Ravizza, Teresa, additional, Vezzani, Annamaria, additional, Provenzano, Giovanni, additional, Pastore, Anna, additional, Weinberger, Birgit, additional, Domenici, Enrico, additional, and Bozzi, Yuri, additional

Published
2023
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8. Focal Clusters of Peri-Synaptic Matrix Contribute to Activity-Dependent Plasticity and Memory

Author

Chelini, Gabriele, primary, Mirzapourdelavar, Hadi, additional, Durning, Peter, additional, Baidoe-Ansah, David, additional, O’Donovan, Sinead M., additional, Klengel, Torsten, additional, Balasco, Luigi, additional, Berciu, Cristina, additional, Boyer-Boiteau, Anne, additional, Smith, Robert, additional, Ressler, Kerry J., additional, Bozzi, Yuri, additional, Dityatev, Alexander, additional, and Berretta, Sabina, additional

Published
2023
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10. Sex-biasing influence of autism-associatedUbe3agene overdosage at connectomic, behavioral and transcriptomic levels

Author

Montani, Caterina, primary, Pagani, Marco, additional, De Guzman, Elizabeth, additional, Balasco, Luigi, additional, Alvino, Filomena Grazia, additional, de Felice, Alessia, additional, Galbusera, Alberto, additional, Nickl-Jockschat, Thomas K., additional, Lau, Pierre, additional, Borsotti, Noemi, additional, Mattioni, Lorenzo, additional, Pasqualetti, Massimo, additional, Provenzano, Giovanni, additional, Bozzi, Yuri, additional, Lombardo, Michael V., additional, and Gozzi, Alessandro, additional

Published
2022
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14. Editorial: Toward an understanding of neurodevelopmental disorders: novel insights from molecular, behavioural and neuroinflammatory mechanisms.

Author

Pangrazzi, Luca, Provenzano, Giovanni, Treccani, Giulia, and Balasco, Luigi

Subjects
NEURAL development, COMPUTATIONAL biology, MEDICAL research, ACADEMIC medical centers, AUTISM spectrum disorders
Abstract

This article, published in Frontiers in Psychiatry, discusses the need for further research into neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disabilities. The article highlights recent studies that have identified gene variants associated with NDDs, indicating the genetic complexity of these disorders. Additionally, the article explores the role of neuroinflammatory mechanisms and environmental factors, such as early life adversities, in the development of NDDs. The authors emphasize the importance of a multidisciplinary approach to understanding NDDs and suggest that this knowledge could lead to novel therapeutic strategies. [Extracted from the article]

Published
2024
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15. Abnormal whisker-dependent behaviors and altered cortico-hippocampal connectivity in Shank3b−/− mice

Author

Balasco, Luigi, primary, Pagani, Marco, additional, Pangrazzi, Luca, additional, Chelini, Gabriele, additional, Ciancone Chama, Alessandra Georgette, additional, Shlosman, Evgenia, additional, Mattioni, Lorenzo, additional, Galbusera, Alberto, additional, Iurilli, Giuliano, additional, Provenzano, Giovanni, additional, Gozzi, Alessandro, additional, and Bozzi, Yuri, additional

Published
2021
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16. Proteoglycan Clusters as a Site of Coordinated, Multi-Dendritic Plasticity

Author

Chelini, Gabriele, primary, Durning, Peter, additional, O’Donovan, Sinead, additional, Klengel, Torsten, additional, Balasco, Luigi, additional, Berciu, Cristina, additional, Boyer-Boiteau, Anne, additional, Bozzi, Yuri, additional, McCullumsmith, Robert, additional, Ressler, Kerry J., additional, and Berretta, Sabina, additional

Published
2021
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