323 results on '"Balaram, Hemalatha"'
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2. Enantioselectivity in the enzymatic dehydration of malate and tartrate: Mirror image specificities of structurally similar dehydratases
3. GMP Synthetase: Allostery, Structure, and Function
4. Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
5. Revisiting the Burden Borne by Fumarase: Enzymatic Hydration of an Olefin
6. Revisiting the burden borne by fumarase: enzymatic hydration of an olefin
7. Mechanistic Insights into the Functioning of a Two-Subunit GMP Synthetase, an Allosterically Regulated, Ammonia Channeling Enzyme
8. A Histidine Aspartate Ionic Lock Gates the Iron Passage in Miniferritins from Mycobacterium smegmatis
9. Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis
10. Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC
11. Crosstalk between purine nucleotide metabolism and mitochondrial pathways in Plasmodium falciparum
12. Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase
13. Mechanistic insights into the functioning of GMP synthetase: a two-subunit, allosterically regulated, ammonia tunnelling enzyme
14. Role of loop dynamics in thermal stability of mesophilic and thermophilic adenylosuccinate synthetase: A molecular dynamics and normal mode analysis study
15. Probing the role of highly conserved residues in triosephosphate isomerase – analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme
16. Studies on active site mutants of P. falciparum adenylosuccinate synthetase: Insights into enzyme catalysis and activation
17. Reversible binding of zinc in Plasmodium falciparum Sir2: Structure and activity of the apoenzyme
18. Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation
19. Cloning and characterization of the Plasmodium falciparum adenylosuccinate synthetase gene
20. Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum
21. Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity
22. α -Helix and Mixed 310/α -helix in Cocrystallized Conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe
23. 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii
24. Methanocaldococcus jannaschii adenylosuccinate synthetase: Studies on temperature dependence of catalytic activity and structural stability
25. Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila
26. Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
27. Structural basis for the hyperthermostability of an archaeal glutaminase induced by post-translational succinimide formation
28. Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase—an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line
29. Leptospira interrogans triosephosphate isomerase: exploring the structural determinants of stability, high reaction rate and specificity.
30. Toward Developing Intuitive Rules for Protein Variant Effect Prediction Using Deep Mutational Scanning Data
31. Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state
32. Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase
33. Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis − distal effects on dimer stability
34. Engineered dimer interface mutants of triosephosphate isomerase: the role of inter-subunit interactions in enzyme function and stability
35. Helices on Interdomain Interface Couple Catalysis in the ATPPase Domain with Allostery in Plasmodium falciparum GMP Synthetase
36. Correction: Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei.
37. Helices on interdomain interface couple catalysis in the ATPPase domain with allostery inPlasmodium falciparumGMP synthetase
38. Unfolding of Plasmodium falciparum triosephosphate isomerase in urea and guanidinium chloride: evidence for a novel disulfide exchange reaction in a covalently cross-linked mutant
39. Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase
40. Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase: Stability studies on the product-activated enzyme
41. Unusual fluorescence of W168 in Plasmodium falciparum triosephosphate isomerase, probed by single-tryptophan mutants
42. Subunit interface mutation disrupting an aromatic cluster in Plasmodium falciparum triosephosphate isomerase: effect on dimer stability
43. How a purine salvage enzyme singles out the right base
44. Biochemical and physiological investigations on adenosine 5ʹ monophosphate deaminase fromPlasmodium spp.
45. Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei
46. Metabolic proof-reading in Plasmodium berghei: essentiality of phosphoglycolate phosphatase
47. Biochemical and physiological investigations on adenosine 5’ monophosphate deaminase from Plasmodium spp.
48. Visualizing Deep Mutational Scan Data
49. Biochemical characterization and essentiality of fumarate hydratase
50. Mechanism of allostery and catalysis in P. falciparum GMP Synthetase
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