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The rapid advancement of computational infrastructure has led to unprecedented growth in machine learning, deep learning, and computer vision, fundamentally transforming the analysis of retinal images. By utilizing a wide array of visual cues extracted from retinal fundus images, sophisticated artificial intelligence models have been developed to diagnose various retinal disorders. This paper concentrates on the detection of Age-Related Macular Degeneration (AMD), a significant retinal condition, by offering an exhaustive examination of recent machine learning and deep learning methodologies. Additionally, it discusses potential obstacles and constraints associated with implementing this technology in the field of ophthalmology. Through a systematic review, this research aims to assess the efficacy of machine learning and deep learning techniques in discerning AMD from different modalities as they have shown promise in the field of AMD and retinal disorders diagnosis. Organized around prevalent datasets and imaging techniques, the paper initially outlines assessment criteria, image preprocessing methodologies, and learning frameworks before conducting a thorough investigation of diverse approaches for AMD detection. Drawing insights from the analysis of more than 30 selected studies, the conclusion underscores current research trajectories, major challenges, and future prospects in AMD diagnosis, providing a valuable resource for both scholars and practitioners in the domain. [ABSTRACT FROM AUTHOR]

Wilms tumor (WT), or nephroblastoma, is the predominant renal malignancy in the pediatric population. This narrative review explores the evolution of personalized care strategies for WT, synthesizing critical developments in molecular diagnostics and treatment approaches to enhance patient-specific outcomes. We surveyed recent literature from the last five years, focusing on high-impact research across major databases such as PubMed, Scopus, and Web of Science. Diagnostic advancements, including liquid biopsies and diffusion-weighted MRI, have improved early detection precision. The prognostic significance of genetic markers, particularly WT1 mutations and miRNA profiles, is discussed. Novel predictive tools integrating genetic and clinical data to anticipate disease trajectory and therapy response are explored. Progressive treatment strategies, particularly immunotherapy and targeted agents such as HIF-2α inhibitors and GD2-targeted immunotherapy, are highlighted for their role in personalized treatment protocols, especially for refractory or recurrent WT. This review underscores the necessity for personalized management supported by genetic insights, with improved survival rates for localized disease exceeding 90%. However, knowledge gaps persist in therapies for high-risk patients and strategies to reduce long-term treatment-related morbidity. In conclusion, this narrative review highlights the need for ongoing research, particularly on the long-term outcomes of emerging therapies and integrating multi-omic data to inform clinical decision-making, paving the way for more individualized treatment pathways. [ABSTRACT FROM AUTHOR]

Prostate cancer is a significant health concern with high mortality rates and substantial economic impact. Early detection plays a crucial role in improving patient outcomes. This study introduces a non-invasive computer-aided diagnosis (CAD) system that leverages intravoxel incoherent motion (IVIM) parameters for the detection and diagnosis of prostate cancer (PCa). IVIM imaging enables the differentiation of water molecule diffusion within capillaries and outside vessels, offering valuable insights into tumor characteristics. The proposed approach utilizes a two-step segmentation approach through the use of three U-Net architectures for extracting tumor-containing regions of interest (ROIs) from the segmented images. The performance of the CAD system is thoroughly evaluated, considering the optimal classifier and IVIM parameters for differentiation and comparing the diagnostic value of IVIM parameters with the commonly used apparent diffusion coefficient (ADC). The results demonstrate that the combination of central zone (CZ) and peripheral zone (PZ) features with the Random Forest Classifier (RFC) yields the best performance. The CAD system achieves an accuracy of 84.08% and a balanced accuracy of 82.60%. This combination showcases high sensitivity (93.24%) and reasonable specificity (71.96%), along with good precision (81.48%) and F1 score (86.96%). These findings highlight the effectiveness of the proposed CAD system in accurately segmenting and diagnosing PCa. This study represents a significant advancement in non-invasive methods for early detection and diagnosis of PCa, showcasing the potential of IVIM parameters in combination with machine learning techniques. This developed solution has the potential to revolutionize PCa diagnosis, leading to improved patient outcomes and reduced healthcare costs. [ABSTRACT FROM AUTHOR]

Feature selection (FS) is vital in improving the performance of machine learning (ML) algorithms. Despite its importance, identifying the most important features remains challenging, highlighting the need for advanced optimization techniques. In this study, we propose a novel hybrid feature ranking technique called the Hybrid Feature Ranking Weighted Majority Model (HFRWM2). HFRWM2 combines ML models with the Harris Hawks Optimizer (HHO) metaheuristic. HHO is known for its versatility in addressing various optimization challenges, thanks to its ability to handle continuous, discrete, and combinatorial optimization problems. It achieves a balance between exploration and exploitation by mimicking the cooperative hunting behavior of Harris's hawks, thus thoroughly exploring the search space and converging toward optimal solutions. Our approach operates in two phases. First, an odd number of ML models, in conjunction with HHO, generate feature encodings along with performance metrics. These encodings are then weighted based on their metrics and vertically aggregated. This process produces feature rankings, facilitating the extraction of the top- K features. The motivation behind our research is 2-fold: to enhance the precision of ML algorithms through optimized FS and to improve the overall efficiency of predictive models. To evaluate the effectiveness of HFRWM2, we conducted rigorous tests on two datasets: "Australian" and "Fertility." Our findings demonstrate the effectiveness of HFRWM2 in navigating the search space and identifying optimal solutions. We compared HFRWM2 with 12 other feature ranking techniques and found it to outperform them. This superiority was particularly evident in the graphical comparison of the "Australian" dataset, where HFRWM2 showed significant advancements in feature ranking. [ABSTRACT FROM AUTHOR]

Credit scoring models serve as pivotal instruments for lenders and financial institutions, facilitating the assessment of creditworthiness. Traditional models, while instrumental, grapple with challenges related to efficiency and subjectivity. The advent of machine learning heralds a transformative era, offering data-driven solutions that transcend these limitations. This research delves into a comprehensive analysis of various machine learning algorithms, emphasizing their mathematical underpinnings and their applicability in credit score classification. A comprehensive evaluation is conducted on a range of algorithms, including logistic regression, decision trees, support vector machines, and neural networks, using publicly available credit datasets. Within the research, a unified mathematical framework is introduced, which encompasses preprocessing techniques and critical algorithms such as Particle Swarm Optimization (PSO), the Light Gradient Boosting Model, and Extreme Gradient Boosting (XGB), among others. The focal point of the investigation is the LIME (Local Interpretable Model-agnostic Explanations) explainer. This study offers a comprehensive mathematical model using the LIME explainer, shedding light on its pivotal role in elucidating the intricacies of complex machine learning models. This study's empirical findings offer compelling evidence of the efficacy of these methodologies in credit scoring, with notable accuracies of 88.84%, 78.30%, and 77.80% for the Australian, German, and South German datasets, respectively. In summation, this research not only amplifies the significance of machine learning in credit scoring but also accentuates the importance of mathematical modeling and the LIME explainer, providing a roadmap for practitioners to navigate the evolving landscape of credit assessment. [ABSTRACT FROM AUTHOR]

Nurse educators are often burnt out and suffer from depression due to their demanding job settings. Biochemical markers of burnout can provide insights into the physiological changes that lead to burnout and may help us prevent burnout symptoms. Research was conducted using a descriptive cross-sectional survey design and a multi-stage sampling method. The ministry of education website provides a list of Saudi Arabian nursing education programs that offer bachelor of science in nursing programs (BSN). The study consisted of 299 qualified participants. Malsach Burnout Inventory (MBI) was used to measure burnout as the dependent variable. The MBI is a 22-item scale that measures depersonalization, accomplishment, and emotional exhaustion during work. Bootstrapping with 5000 replicas was used to address potential non-normality. During this framework, four deep neural networks are created. They all have the same number of layers but differ in the number of neurons they have in the hidden layers. The number of female nurse educators experiencing burnout is moderate (mean = 1.92 ± 0.63). Burnout is also moderately observed in terms of emotional exhaustion (mean = 2.13 ± 0.63), depersonalization (mean = 2.12 ± 0.50), and personal achievement scores (mean = 12 2.38 ± 1.13). It has been shown that stacking the clusters at the end of a column increases their accuracy, which can be considered an important feature when classifying. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a chronic disease that affects the elderly. There are many different types of dementia, but Alzheimer's disease is one of the leading causes of death. AD is a chronic brain disorder that leads to problems with language, disorientation, mood swings, bodily functions, memory loss, cognitive decline, mood or personality changes, and ultimately death due to dementia. Unfortunately, no cure has yet been developed for it, and it has no known causes. Clinically, imaging tools can aid in the diagnosis, and deep learning has recently emerged as an important component of these tools. Deep learning requires little or no image preprocessing and can infer an optimal data representation from raw images without prior feature selection. As a result, they produce a more objective and less biased process. The performance of a convolutional neural network (CNN) is primarily affected by the hyperparameters chosen and the dataset used. A deep learning model for classifying Alzheimer's patients has been developed using transfer learning and optimized by Gorilla Troops for early diagnosis. This study proposes the A 3 C-TL-GTO framework for MRI image classification and AD detection. The A 3 C-TL-GTO is an empirical quantitative framework for accurate and automatic AD classification, developed and evaluated with the Alzheimer's Dataset (four classes of images) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The proposed framework reduces the bias and variability of preprocessing steps and hyperparameters optimization to the classifier model and dataset used. Our strategy, evaluated on MRIs, is easily adaptable to other imaging methods. According to our findings, the proposed framework was an excellent instrument for this task, with a significant potential advantage for patient care. The ADNI dataset, an online dataset on Alzheimer's disease, was used to obtain magnetic resonance imaging (MR) brain images. The experimental results demonstrate that the proposed framework achieves 96.65% accuracy for the Alzheimer's Dataset and 96.25% accuracy for the ADNI dataset. Moreover, a better performance in terms of accuracy is demonstrated over other state-of-the-art approaches. [ABSTRACT FROM AUTHOR]

The increase in eye disorders among older individuals has raised concerns, necessitating early detection through regular eye examinations. Age-related macular degeneration (AMD), a prevalent condition in individuals over 45, is a leading cause of vision impairment in the elderly. This paper presents a comprehensive computer-aided diagnosis (CAD) framework to categorize fundus images into geographic atrophy (GA), intermediate AMD, normal, and wet AMD categories. This is crucial for early detection and precise diagnosis of age-related macular degeneration (AMD), enabling timely intervention and personalized treatment strategies. We have developed a novel system that extracts both local and global appearance markers from fundus images. These markers are obtained from the entire retina and iso-regions aligned with the optical disc. Applying weighted majority voting on the best classifiers improves performance, resulting in an accuracy of 96.85%, sensitivity of 93.72%, specificity of 97.89%, precision of 93.86%, F1 of 93.72%, ROC of 95.85%, balanced accuracy of 95.81%, and weighted sum of 95.38%. This system not only achieves high accuracy but also provides a detailed assessment of the severity of each retinal region. This approach ensures that the final diagnosis aligns with the physician's understanding of AMD, aiding them in ongoing treatment and follow-up for AMD patients., (© 2024. The Author(s).)