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30 results on '"Balachandran, Kanarath"'

3. Invasive Versus Medical Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: A Pilot Randomized Controlled Trial

Author

Lee, Matthew M.Y., Petrie, Mark C., Rocchiccioli, Paul, Simpson, Joanne, Jackson, Colette E., Corcoran, David S., Mangion, Kenneth, Brown, Ammani, Cialdella, Pio, Sidik, Novalia P., McEntegart, Margaret B., Shaukat, Aadil, Rae, Alan P., Hood, Stuart H.M., Peat, Eileen E., Findlay, Iain N., Murphy, Clare L., Cormack, Alistair J., Bukov, Nikolay B., Balachandran, Kanarath P., Oldroyd, Keith G., Ford, Ian, Wu, Olivia, McConnachie, Alex, Barry, Sarah J.E., and Berry, Colin

Published
2019
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4. Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS–NSTEMI randomized trial

Author

Layland, Jamie, Oldroyd, Keith G., Curzen, Nick, Sood, Arvind, Balachandran, Kanarath, Das, Raj, Junejo, Shahid, Ahmed, Nadeem, Lee, Matthew M.Y., Shaukat, Aadil, OʼDonnell, Anna, Nam, Julian, Briggs, Andrew, Henderson, Robert, McConnachie, Alex, Berry, Colin, Hannah, Andrew, Stewart, Andrew, Metcalfe, Malcolm, Norrie, John, Chowdhary, Saqib, Clark, Andrew, Henderson, Robert, Balachandran, Kanarath, Berry, Colin, Baird, Gordon, OʼDonnell, Anna, Sood, Arvind, Curzen, Nick, Das, Raj, Ford, Ian, Layland, Jamie, Junejo, Shahid, and Oldroyd, Keith

Published
2015
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8. Invasive versus medically managed acute coronary syndromes with prior bypass (CABG-ACS): insights into the registry versus randomised trial populations

Author

Lee, Matthew M Y, primary, Petrie, Mark C, additional, Rocchiccioli, Paul, additional, Simpson, Joanne, additional, Jackson, Colette E, additional, Corcoran, David S, additional, Mangion, Kenneth, additional, Brown, Ammani, additional, Cialdella, Pio, additional, Sidik, Novalia P, additional, McEntegart, Margaret B, additional, Shaukat, Aadil, additional, Rae, Alan P, additional, Hood, Stuart H M, additional, Peat, Eileen E, additional, Findlay, Iain N, additional, Murphy, Clare L, additional, Cormack, Alistair J, additional, Bukov, Nikolay B, additional, Balachandran, Kanarath P, additional, Ford, Ian, additional, Wu, Olivia, additional, McConnachie, Alex, additional, Barry, Sarah J E, additional, and Berry, Colin, additional

Published
2021
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12. NON-INVASIVE VERSUS INVASIVE MANAGEMENT IN PATIENTS WITH PRIOR CORONARY ARTERY BYPASS SURGERY WITH A NON-ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME: COMPARISONS BETWEEN THE RANDOMIZED CONTROLLED PILOT TRIAL AND REGISTRY

Author

Lee, Matthew M.Y., primary, Petrie, Mark, additional, Rocchiccioli, Paul, additional, Simpson, Joanne, additional, Jackson, Colette, additional, Brown, Ammani, additional, Corcoran, David, additional, Mangion, Kenneth, additional, Cialdella, Pio, additional, Sidik, Novalia, additional, McEntegart, Margaret, additional, Shaukat, Aadil, additional, Rae, Alan, additional, Hood, Stuart, additional, Peat, Eileen, additional, Findlay, Iain, additional, Murphy, Clare, additional, Cormack, Alistair, additional, Bukov, Nikolay, additional, Balachandran, Kanarath, additional, Ford, Ian, additional, Wu, Olivia, additional, McConnachie, Alex, additional, Barry, Sarah, additional, and Berry, Colin, additional

Published
2018
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13. DECISION MAKING USING FRACTIONAL FLOW RESERVE IS ASSOCIATED WITH LOWER RATES OF INCOMPLETE REVASCULARIZATION COMPARED WITH ANGIOGRAPHIC GUIDED DECISION MAKING AMONGST PATIENTS WITH NSTEMI

Author

Layland, Jamie John, primary, Carberry, Jaclyn, additional, May, Vanessa T.Y., additional, Lee, Matthew, additional, Eteiba, Hany, additional, Lindsay, Mitchell, additional, Petrie, Mark, additional, McEntegart, Margaret, additional, Watkins, Stuart, additional, Shaukat, Aadil, additional, Oldroyd, Keith, additional, Curzen, Nick, additional, Sood, Arvind, additional, Balachandran, Kanarath, additional, Das, Rajiv, additional, Junejo, Shahid, additional, Hannah, Andrew, additional, Stewart, Andrew, additional, Henderson, Robert, additional, McConnachie, Alex, additional, and Berry, Colin, additional

Published
2017
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14. Non-invasive versus invasive management in patients with prior coronary artery bypass surgery with a non-ST segment elevation acute coronary syndrome: study design of the pilot randomised controlled trial and registry (CABG-ACS)

Author

Lee, Matthew M Y, primary, Petrie, Mark C, additional, Rocchiccioli, Paul, additional, Simpson, Joanne, additional, Jackson, Colette, additional, Brown, Ammani, additional, Corcoran, David, additional, Mangion, Kenneth, additional, McEntegart, Margaret, additional, Shaukat, Aadil, additional, Rae, Alan, additional, Hood, Stuart, additional, Peat, Eileen, additional, Findlay, Iain, additional, Murphy, Clare, additional, Cormack, Alistair, additional, Bukov, Nikolay, additional, Balachandran, Kanarath, additional, Papworth, Richard, additional, Ford, Ian, additional, Briggs, Andrew, additional, and Berry, Colin, additional

Published
2016
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17. Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST segment elevation myocardial infarction (FAMOUS-NSTEMI) developmental trial: cost-effectiveness using a mixed trial- and model-based methods

Author

Nam, Julian, primary, Briggs, Andrew, additional, Layland, Jamie, additional, Oldroyd, Keith G., additional, Curzen, Nick, additional, Sood, Arvind, additional, Balachandran, Kanarath, additional, Das, Raj, additional, Junejo, Shahid, additional, Eteiba, Hany, additional, Petrie, Mark C., additional, Lindsay, Mitchell, additional, Watkins, Stuart, additional, Corbett, Simon, additional, O’Rourke, Brian, additional, O’Donnell, Anna, additional, Stewart, Andrew, additional, Hannah, Andrew, additional, McConnachie, Alex, additional, Henderson, Robert, additional, and Berry, Colin, additional

Published
2015
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18. Outcomes of Percutaneous Coronary Intervention Performed at Offsite Versus Onsite Surgical Centers in the United Kingdom

Author

Garg, Scot, primary, Anderson, Simon G., additional, Oldroyd, Keith, additional, Berry, Colin, additional, Emdin, Connor A., additional, Peters, Sanne A.E., additional, West, Nick E.J., additional, Kelly, Damian, additional, Balachandran, Kanarath, additional, McDonald, John, additional, Singh, Ravi, additional, Devadathan, Sen, additional, Redwood, Simon, additional, Ludman, Peter F., additional, Rahimi, Kazem, additional, and Woodward, Mark, additional

Published
2015
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19. FRACTIONAL FLOW RESERVE (FFR) VERSUS ANGIOGRAPHY IN GUIDING MANAGEMENT TO OPTIMIZE OUTCOMES IN NON-ST ELEVATION MYOCARDIAL INFARCTION (FAMOUS - NSTEMI) HEALTH ECONOMIC ANALYSIS

Author

Nam, Julian, primary, Briggs, Andrew, additional, Layland, Jamie, additional, Oldroyd, Keith, additional, Curzen, Nick, additional, Sood, Arvind, additional, Balachandran, Kanarath, additional, Das, Rajiv, additional, Junejo, Shahid, additional, Eteiba, Hany, additional, Petrie, Mark, additional, Watkins, Stuart, additional, Corbett, Simon, additional, O’Rourke, Brian, additional, O’Donnell, Anna, additional, McConnachie, Alex, additional, Henderson, Robert, additional, Lindsay, Mitchell, additional, and Berry, Colin, additional

Published
2015
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20. TCT-84 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Study Design and Baseline Characteristics of Randomized Participants.

Author

Layland, Jamie, primary, Sood, Arvind, additional, Curzen, Nick, additional, Balachandran, Kanarath, additional, Das, Rajiv, additional, Junejo, Shahid, additional, Lee, Matthew M., additional, Ahmed, Nadeem, additional, Mahrous, Ahmed M., additional, Beck, Andrew, additional, Eteiba, Hany, additional, Petrie, Mark C., additional, Lindsay, Martin M., additional, Hood, Stuart, additional, Watkins, Stuart, additional, McEntegart, Margaret B., additional, Owens, Colum, additional, Davie, Andrew, additional, Peat, Eileen, additional, Henderson, Robert A., additional, Briggs, Andrew, additional, Ford, Ian, additional, Oldroyd, Keith G., additional, and Berry, Colin, additional

Published
2013
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21. TCT-82 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Relationships Between FFR and Angiographic Stenosis Severity at Baseline.

Author

Layland, Jamie, primary, Curzen, Nick, additional, Sood, Arvind, additional, Das, Rajiv, additional, Balachandran, Kanarath, additional, Junejo, Shahid, additional, Lee, Matthew M., additional, Ahmed, Nadeem, additional, Mahrous, Ahmed M., additional, Petrie, Mark C., additional, Eteiba, Hany, additional, Watkins, Stuart, additional, Lindsay, Martin M., additional, McEntegart, Margaret B., additional, Davie, Andrew, additional, Henderson, Robert A., additional, Ford, Ian, additional, Oldroyd, Keith G., additional, and Berry, Colin, additional

Published
2013
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23. The role of LV in the autograft complication after ROSS operation.

Author

Kai Ma, Qiuming Chen, Shoujun Li, Hamid, Tahir, Macdonald, John E., Balachandran, Kanarath P., Mudawi, Telal, and Battista, Giovanni

Subjects
CARDIAC surgery, LEFT heart ventricle, AUTOGRAFTS
Abstract

A letter to the editor is presented related to the role of left ventricle (LV) in the autograft complication after ROSS cardiac surgery in infants and children.

Published
2014
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25. 9 Routine non-invasive vs invasive management in patients with prior CABG with a NSTE-ACS: a randomised controlled trial

Author

Lee, Matthew MY, Petrie, Mark C, Rocchiccioli, Paul, Simpson, Joanne, Jackson, Colette, Brown, Ammani, Corcoran, David, Mangion, Kenneth, Cialdella, Pio, Sidik, Novalia, McEntegart, Margaret, Shaukat, Aadil, Rae, Alan, Hood, Stuart, Peat, Eileen, Findlay, Iain, Murphy, Clare, Cormack, Alistair, Bukov, Nikolay, Balachandran, Kanarath, Ford, Ian, Wu, Olivia, McConnachie, Alex, Barry, Sarah, and Berry, Colin

Abstract

BackgroundThere is an evidence-gap about how to best treat patients with a history of prior CABG presenting with a NSTE-ACS because these patients were excluded from key randomised trials.MethodsThe CABG-ACS pilot trial (NCT01895751) randomised patients with a NSTE-ACS and prior CABG to routine invasive or non-invasive management. The primary efficacy outcome was a composite of all-cause death, rehospitalisation for refractory ischaemia/angina, MI and HF hospitalisation. The primary safety outcome was a composite of bleeding, stroke, procedure-related MI and worsening renal function. A CEC assessed events.Results60 patients (mean ±SD age 71±9 years, 28% female) were randomised to invasive (n=31) or non-invasive (n=29) management. The invasive group had worse NYHA class (p=0.044) and less valve disease (17% vs 27%; p=0.035). Other comorbidities, age, sex, CCS grade, frailty score and medications were similar. Baseline LIMA grafts were similar (p=0.720). All invasive group patients had invasive management (mean BCIS-1 Jeopardy Score 7±4) and 6 (19%) had PCI. 6 non-invasive group patients ended up having invasive management and 3 (50%) had PCI. No patients had redo CABG. The primary efficacy outcome occurred in 42% invasive vs 45% non-invasive groups (RR (95% CI) 0.94 (0.52, 1.67); p=1.000). The primary safety outcome occurred in 26% invasive vs 31% non-invasive groups (RR 0.83 (0.37, 1.86); p=0.777). EQ-5D was similar at 1 year.ConclusionCompared with routine non-invasive management, a strategy of routine invasive management was not associated with patient benefits.

Published
2018
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26. CORRESPONDENCE.

Author

Marchetti, Pennie, Pechlaner, Christoph, Wiedermann, Christian J, Melandri, Giovanni, Moller, Bengt Hjalmar, Dronfield, Michael W, Morice, Alyn H, Fox, K A A, Poole-Wilson, P A, Henderson, R A, Berry, Colin, Balachandran, Kanarath P, Oldroyd, Keith G, Farley, Tim, Gaillard, Philippe, de Vincenzi, Isabelle, Osborne, Connie, de Zoysa, Isabelle, Graham, J, and Potts, H.W.W.

Subjects
*LETTERS to the editor, *CANCER research, *HIV infections, *PSYCHOLOGICAL burnout, *MALARIA
Abstract

Presents letters to the editor. Topic of keeping scientific advice non-partisan; The RITA 3 trial; Mother-to-child transmission of HIV-1 infection; Stress and burnout in doctors; Performance-based partnership agreements in Afghanistan; Anti-body response to Staphylococcal slime and lipoteichoic acid; Goosebumps and the insula; Glucose homoeostasis in young adults without diagnosis of diabetes mellitus; Nicorandil-associated anal ulceration; Tobacco money and cancer research; Antitoxin approach to malaria.

Published
2002

27. Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS – NSTEMI) Clinical Trial: Study Design and Baseline Characteristics of Randomized Participants.

Author

Layland, Jamie, Sood, Arvind, Curzen, Nick, Balachandran, Kanarath, Das, Rajiv, Junejo, Shahid, Lee, Matthew M., Ahmed, Nadeem, Mahrous, Ahmed M., Beck, Andrew, Eteiba, Hany, Petrie, Mark C., Lindsay, Martin M., Hood, Stuart, Watkins, Stuart, McEntegart, Margaret B., Owens, Colum, Davie, Andrew, Peat, Eileen, and Henderson, Robert A.

Published
2013
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28. Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS – NSTEMI) Clinical Trial: Relationships Between FFR and Angiographic Stenosis Severity at Baseline.

Author

Layland, Jamie, Curzen, Nick, Sood, Arvind, Das, Rajiv, Balachandran, Kanarath, Junejo, Shahid, Lee, Matthew M., Ahmed, Nadeem, Mahrous, Ahmed M., Petrie, Mark C., Eteiba, Hany, Watkins, Stuart, Lindsay, Martin M., McEntegart, Margaret B., Davie, Andrew, Henderson, Robert A., Ford, Ian, Oldroyd, Keith G., and Berry, Colin

Published
2013
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29. Successful reintroduction of previously failed ACE inhibitor therapy following stenting of atherosclerotic renovascular disease.

Author

Balachandran KP and Oldroyd KG

Subjects
Aged, Atherosclerosis complications, Cohort Studies, Coronary Artery Disease complications, Female, Humans, Renal Artery Obstruction complications, Retreatment, Angioplasty, Balloon, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Atherosclerosis therapy, Coronary Artery Disease therapy, Renal Artery Obstruction therapy, Stents
Abstract

Background: Angiotensin Converting Enzyme (ACE) inhibitors improve outcomes in patients with coronary artery disease irrespective of the status of the left ventricle. In the presence of functionally significant renovascular disease, ACE inhibitors often cause deterioration of renal function leading to their withdrawal., Design: Observational study with 6 months prospective follow-up., Methods and Results: Six patients with coronary artery disease and previous ACE inhibitor induced deterioration in renal function underwent renal artery stenting for angiographically-confirmed unilateral renal artery stenosis. Pre-existing significant renal dysfunction was present in 4 patients. Immediate technical success was achieved in all patients. ACE inhibitors were successfully reintroduced and titrated to maximum-tolerated in all 6 patients. At 6 months, one patient died due to progressive heart failure. The other patients remained tolerant of ACE inhibitor treatment with stable or improved renal function., Conclusion: Renal angiography should be considered in patients with coronary artery disease and ACE inhibitor induced renal dysfunction. Successful renal artery stenting permits reintroduction of ACE inhibitor with satisfactory maintenance of renal function at 6 months.

Published
2008

30. Improvement in left ventricular function following successful rescue percutaneous coronary intervention is independent of time-to-reperfusion.

Author

Balachandran KP, Berry C, Pell AC, Vance BD, and Oldroyd KG

Subjects
Aged, Coronary Angiography, Female, Humans, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction drug therapy, Stents, Stroke Volume physiology, Thrombolytic Therapy methods, Time Factors, Angioplasty, Balloon, Coronary, Cardiac Catheterization methods, Myocardial Infarction physiopathology, Myocardial Infarction therapy, Myocardial Reperfusion methods, Ventricular Function, Left physiology
Abstract

Objective: To study the influence of clinical and angiographic factors on global and regional left ventricular (LV) function after rescue percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI)., Methods: We performed repeat cardiac catheterization in 102 patients who underwent rescue PCI at our centre. Eighty-two patients had suitable baseline and follow-up ventriculograms, which were analyzed offline by an automated edge detection technique., Results: The mean (standard deviation [SD]) follow-up period was 22 (15) months. PCI was completed in all patients between 3 to 24 hours following the onset of pain. Improved global and regional LV systolic function was observed in 55 (67%) patients, and deterioration in 27 (33%). On univariate analysis, baseline ejection fraction (p = 0.005) and coronary stenting (p = 0.05) were associated with improved LV systolic function. Preprocedure TIMI flow, postprocedure TMP grade, time-to-reperfusion, and use of glycoprotein (GP) IIb/IIIa inhibitors did not influence LV systolic function. On multivariate analysis, ejection fraction at the time of rescue PCI (odds ratio [95% confidence interval]: 0.427 [0.234, 0.780]; p = 0.006) and stenting 3.944 (1.182, 13.156; p = 0.026) were predictors of improved LV systolic function., Conclusion: Successful rescue PCI was associated with improved LV function at follow up in the majority of patients. Stenting, but not GP IIb/IIIa inhibitor therapy, predicted improved LV function in the area supplied by the infarct-related artery. These improvements in regional wall motion were independent of the time taken to establish reperfusion, provided the intervention was carried out between 3 to 24 hours from the onset of pain.

Published
2006

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