116 results on '"Balaban S"'
Search Results
2. Bipolaron Binding in Quantum Wires
- Author
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Pokatilov, E. P., Fomin, V. M., Devreese, J. T., Balaban, S. N., and Klimin, S. N.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Statistical Mechanics - Abstract
A theory of bipolaron states in quantum wires with a parabolic potential well is developed applying the Feynman variational principle. The basic parameters of the bipolaron ground state (the binding energy, the number of phonons in the bipolaron cloud, the effective mass, and the bipolaron radius) are studied as a function of sizes of the potential well. Two cases are considered in detail: a cylindrical quantum wire and a planar quantum wire. Analytical expressions for the bipolaron parameters are obtained at large and small sizes of the quantum well. It is shown that at $R\gg 1$ [where $R$ means the radius (halfwidth) of a cylindrical (planar) quantum wire, expressed in Feynman units], the influence of confinement on the bipolaron binding energy is described by the function $\sim 1/R^{2}$ for both cases, while at small sizes this influence is different in each case. In quantum wires, the bipolaron binding energy $W(R) $ increases logarithmically with decreasing radius. The shapes and the sizes of a nanostructure, which are favorable for observation of stable bipolaron states, are determined., Comment: 17 pages, 6 figures, E-mail addresses: devreese@uia.ua.ac.be; fomin@uia.ua.ac.be
- Published
- 2000
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3. Quantum transport in the cylindrical nanosize silicon-based MOSFET
- Author
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Balaban, S. N., Pokatilov, E. P., Fomin, V. M., Gladilin, V. N., Devreese, J. T., Magnus, W., Schoenmaker, W., Van Rossum, M., and Soree, B.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
A model is developed for a detailed investigation of the current flowing through a cylindrical nanosize MOSFET with a close gate electrode. The quantum mechanical features of the lateral charge transport are described by Wigner distribution function which is explicitly dealing with electron scattering due to acoustic phonons and acceptor impurities. A numerical simulation is carried out to obtain a set of I-V characteristics for various channel lengths. It is demonstrated that inclusion of the collision term in the numerical simulation is important for low values of the source-drain voltage. The calculations have further shown that the scattering leads to an increase of the electron density in the channel thereby smoothing out the threshold kink in I-V characteristics. An analysis of the electron phase-space distribution shows that scattering does not prevent electrons from flowing through the channel as a narrow stream, and that features of both ballistic and diffusive transport may be observed simultaneously., Comment: 24 pages, 8 figures, E-mail addresses: devreese@uia.ua.ac.be, fomin@uia.ua.ac.be
- Published
- 2000
4. Relationship between exhaled leukotriene and 8-isoprostane levels and asthma severity, asthma control level, and asthma control test score
- Author
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Keskin, O., Balaban, S., Keskin, M., Kucukosmanoglu, E., Gogebakan, B., Ozkars, M.Y., Kul, S., Bayram, H., and Coskun, Y.
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- 2014
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5. Glutamine addiction promotes glucose oxidation in triple-negative breast cancer
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Quek, L-E, van Geldermalsen, M, Guan, YF, Wahi, K, Mayoh, C, Balaban, S, Pang, A, Wang, Q, Cowley, MJ, Brown, KK, Turner, N, Hoy, AJ, Holst, J, Quek, L-E, van Geldermalsen, M, Guan, YF, Wahi, K, Mayoh, C, Balaban, S, Pang, A, Wang, Q, Cowley, MJ, Brown, KK, Turner, N, Hoy, AJ, and Holst, J
- Abstract
Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth requirements confers greater fitness to glutamine-addicted cancers. By contrasting two breast cancer subtypes with distinct glutamine dependencies, we show that glutamine-indispensable triple-negative breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, with glutamine carbon routed once through the TCA cycle. Importantly, this single-pass glutaminolysis increases TCA cycle fluxes and replenishes TCA cycle intermediates in TNBC cells, a process that achieves net oxidation of glucose but not glutamine. The coupling of glucose and glutamine catabolism appears hard-wired via a distinct TNBC gene expression profile biased to strip and then sequester glutamine nitrogen, but hampers the ability of TNBC cells to oxidise glucose when glutamine is limiting. Our results provide a new understanding of how metabolically rigid TNBC cells are sensitive to glutamine deprivation and a way to select vulnerable TNBC subtypes that may be responsive to metabolic-targeted therapies.
- Published
- 2022
6. Захворюваність серцево-судинної системи працівників залізничного транспорту «шумонебезпечних» професій та контингенту поза дією виробничих факторів
- Author
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Balaban, S. V., Panov, B. V., Svirsky, A. A., and Savitsky, I. V.
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“noise-dangerous professions” ,«шумонебезпечні» професії ,«шумоопасные профессии» ,профессиональный стаж ,професійний стаж ,вегетативно-судинна дистонія ,vegetovascular dystonia ,professional length of service ,ишемическая болезнь сердца ,гіпертонічна хвороба ,ischemic heart disease ,ішемічна хвороба серця ,вегетативно-сосудистая дистония - Abstract
The authors have investigated the cardio-vascular morbidity rate of “noise-related hazardous” professions and the employees of the managerial personnel not connected with the influence of hazardous production factors in 246 patients of the cardiological department of the “Road Hospital of the State Enterprise “Odessa railroad” during the period from 2009 to 2011. Pathology of the cardio-vascular system (hypertensive disease, ischemic heart disease and others) develops in a relatively early age (18-30 years) and job seniority up to 10 years, that is, connected with a negative effect on the organism of industrial noise, vibration, infra- and ultrasound, unfavorable microclimate, psycho-emotional and physical overstrain etc. The similar incidence in the employees of the managerial personnel develops significantly later., У 246 пациентов кардиологического отделения Дорожной больницы Государственного Предприятия «Одесская железная дорога» в 2009-2011 гг. исследована сердечно-сосудистая заболеваемость «шумоопасных» профессий и работников руководящего состава, не связанных с влиянием вредных производственных факторов.В относительно раннем возрасте (18-30 лет) и стаже до 10 лет развивается патология сердечно-сосудистой системы (гипертоническая болезнь, ишемическая болезнь сердца и др.), что связано с отрицательным влиянием на организм производственного шума, вибрации, инфра- и ультразвука, неблагоприятного микроклимата, психоэмоционального и физического перенапряжения и др. У работников руководящего состава аналогичная заболеваемость развивается значительно позже., У 246 пацієнтів кардіологічного відділення Дорожньої лікарні ДП «Одеська залізниця» у 2009-2011рр. досліджена серцево-судинна захворюваність «шумонебезпечних» професій і працівників керівного складу, не пов’язаних із впливом шкідливих виробничих факторів.У відносно ранньому віці (18-30 років) і стажі до 10 років розвивається патологія серцево-судинної системи (гіпертонічна хвороба, ішемічна хвороба серця та ін.), що пов’язано з негативним впливом на організм виробничого шуму, вібрації, інфра- й ультразвуку, несприятливого мікроклімату, психоемоційного й фізичного перенапруження та ін. У працівників керівного складу аналогічна захворюваність розвивається значно пізніше.
- Published
- 2021
7. Assessment of economic expediency of heat utilization technology use at food industry enterprises
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Stadnyk, I., primary, Balaban, S., additional, Kaspruk, V., additional, and Derkach, A., additional
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- 2022
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8. Trend of green growth indicators in EU countries after accession
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Stojkov-Pavlović Aleksandra, Balaban Suzana, Simić Milica, and Jovanović Larisa
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green growth ,production ,renewable energy ,green economy ,sustainable development ,ecological economics ,Business ,HF5001-6182 - Abstract
This paper examines the latest advancements in green growth among EU member countries, with a focus on Serbia. It aims to compare green growth indicators across different countries by employing two defined hypotheses. This analysis utilizes data from the OECD statistics database, specifically focusing on annual data related to CO2 emissions and renewable energy. The choice of these indicators is based on their causal relationship to green growth. The research is based on the methodology of comparative analysis for selected indicators. The first section applies to CO2 emission indicators with trends, while the second section analyses the renewable energy situation. All considerations were made by creating groups of EU member countries by year of accession: 2004 (for 10 countries), 2007 (for 2 countries), and 2013 (for Croatia) for selected indicators. The utilization of combined datasets facilitated the evaluation of positive trend outcomes in Serbia.
- Published
- 2024
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9. Theta- and Gamma-Band Activity Discriminates Face, Body and Object Perception
- Author
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Bossi, F, Premoli, I, Pizzamiglio, S, Balaban, S, Ricciardelli, P, Rivolta, D, Bossi, Francesco, Premoli, Isabella, Pizzamiglio, Sara, Balaban, Sema, Ricciardelli, Paola, Rivolta, Davide, Bossi, F, Premoli, I, Pizzamiglio, S, Balaban, S, Ricciardelli, P, Rivolta, D, Bossi, Francesco, Premoli, Isabella, Pizzamiglio, Sara, Balaban, Sema, Ricciardelli, Paola, and Rivolta, Davide
- Abstract
Face and body perception is mediated by configural mechanisms, which allow the perception of these stimuli as a whole, rather than the sum of individual parts. Indirect measures of configural processing in visual cognition are the face and body inversion effects (FIE and BIE), which refer to the drop in performance when these stimuli are perceived upside-down. Albeit FIE and BIE have been well characterized at the behavioral level, much still needs to be understood in terms of the neurophysiological correlates of these effects. Thus, in the current study, the brain's electrical activity has been recorded by a 128 channel electroencephalogram (EEG) in 24 healthy participants while perceiving (upright and inverted) faces, bodies and houses. EEG data were analyzed in both the time domain (i.e., event-related potentials-ERPs) and the frequency domain [i.e., induced theta (5-7 Hz) and gamma (28-45 Hz) oscillations]. ERPs amplitude results showed increased N170 amplitude for inverted faces and bodies (compared to the same stimuli presented in canonical position) but not for houses. ERPs latency results showed delayed N170 components for inverted (vs. upright) faces, houses, but not bodies. Spectral analysis of induced oscillations indicated physiological FIE and BIE; that is decreased gamma-band synchronization over right occipito-temporal electrodes for inverted (vs. upright) faces, and increased bilateral frontoparietal theta-band synchronization for inverted (vs. upright) faces. Furthermore, increased left occipito-temporal and right frontal theta-band synchronization for upright (vs. inverted) bodies was found. Our findings, thus, demonstrate clear differences in the neurophysiological correlates of face and body perception. The neurophysiological FIE suggests disruption of feature binding processes (decrease in occipital gamma oscillations for inverted faces), together with enhanced feature-based attention (increase in frontoparietal theta oscillations for inverted f
- Published
- 2020
10. Neural oscillations involved in Face and Body Inversion Effects
- Author
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BOSSI, FRANCESCO, GALLUCCI, MARCELLO, RICCIARDELLI, PAOLA, Rivolta, D, Premoli, I, Pizzamiglio, S, Balaban, S, Bossi, F, Rivolta, D, Premoli, I, Pizzamiglio, S, Balaban, S, Gallucci, M, and Ricciardelli, P
- Subjects
neural oscillations, face-inversion effect, body-inversion effect, gamma activity, theta activity ,M-PSI/01 - PSICOLOGIA GENERALE - Published
- 2017
11. Harvesting light energy with optical rectennas
- Author
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Reynaud, C., Duche, D., Palanchoke, U., F-X, Dang, Patrone, L., Le Rouzo, J., Ludovic Escoubas, Gourgon, C., Charai, A., Claude Alfonso, Margeat, O., JÖRG ACKERMANN, Balaban, S., J-J, Simon, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire des technologies de la microélectronique (LTM ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Clot, Marielle
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[PHYS]Physics [physics] ,ComputingMilieux_MISCELLANEOUS ,[PHYS] Physics [physics] - Abstract
International audience
- Published
- 2017
12. The influence of liquidity on the profitability of companies in the processing sector in the rural Serbia
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Stoiljković Bojan, Balaban Suzana, and Simić Milica
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profitability ,roa ,liquidity ,panel analysis ,Commerce ,HF1-6182 ,Finance ,HG1-9999 - Abstract
The subject of this paper is the examination of the impact of liquidity on the profitability of 100 companies in the processing sector of the Republic of Serbia with the highest level of business income in the period from 2016 to 2020. A regression with fixed effects was applied to the panel data. Based on the obtained results, it can be argued that there is no direct relationship between indicators of accelerated liquidity and net return on assets when it comes to the observed companies, which implies that the optimal amount of cash and cash equivalents that would enable the maximization of net return on assets cannot be determined either.. There is no direct connection between profitability and the length of the business cycle of the observed companies. On the other hand, a faster turnover of capital results in a higher level of profitability, as well as the growth of company assets, while higher indebtedness has negative implications for the profitability of companies in the processing sector. The obtained results have significant implications for the decisions of financial managers, for the financial sector, as well as for competent state institutions.
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- 2023
13. Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
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Hardie, R-A, van Dam, E, Cowley, M, Han, T-L, Balaban, S, Pajic, M, Pinese, M, Iconomou, M, Shearer, RF, McKenna, J, Miller, D, Waddell, N, Pearson, JV, Grimmond, SM, Australian Pancreatic Cancer Genome Initiative, Sazanov, L, Biankin, AV, Villas-Boas, S, Hoy, AJ, Turner, N, Saunders, DN, Hardie, R-A, van Dam, E, Cowley, M, Han, T-L, Balaban, S, Pajic, M, Pinese, M, Iconomou, M, Shearer, RF, McKenna, J, Miller, D, Waddell, N, Pearson, JV, Grimmond, SM, Australian Pancreatic Cancer Genome Initiative, Sazanov, L, Biankin, AV, Villas-Boas, S, Hoy, AJ, Turner, N, and Saunders, DN
- Abstract
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as pancreatic cancer, which are driven by genetic alterations that are not tractable drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been observed in various tumors types, understanding of metabolic genotype-phenotype relationships is limited. METHODS: We deployed an integrated approach combining genomics, metabolomics, and phenotypic analysis on a unique cohort of patient-derived pancreatic cancer cell lines (PDCLs). Genome analysis was performed via targeted sequencing of the mitochondrial genome (mtDNA) and nuclear genes encoding mitochondrial components and metabolic genes. Phenotypic characterization of PDCLs included measurement of cellular oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) using a Seahorse XF extracellular flux analyser, targeted metabolomics and pathway profiling, and radiolabelled glutamine tracing. RESULTS: We identified 24 somatic mutations in the mtDNA of 12 patient-derived pancreatic cancer cell lines (PDCLs). A further 18 mutations were identified in a targeted study of ~1000 nuclear genes important for mitochondrial function and metabolism. Comparison with reference datasets indicated a strong selection bias for non-synonymous mutants with predicted functional effects. Phenotypic analysis showed metabolic changes consistent with mitochondrial dysfunction, including reduced oxygen consumption and increased glycolysis. Metabolomics and radiolabeled substrate tracing indicated the initiation of reductive glutamine metabolism and lipid synthesis in tumours. CONCLUSIONS: The heterogeneous genomic landscape of pancreatic tumours may converge on a common metabolic phenotype, with individual tumours adapting to increased anabolic demands via different ge
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- 2017
14. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.
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Balaban, S, Shearer, RF, Lee, LS, van Geldermalsen, M, Schreuder, M, Shtein, HC, Cairns, R, Thomas, KC, Fazakerley, DJ, Grewal, T, Holst, J, Saunders, DN, Hoy, AJ, Balaban, S, Shearer, RF, Lee, LS, van Geldermalsen, M, Schreuder, M, Shtein, HC, Cairns, R, Thomas, KC, Fazakerley, DJ, Grewal, T, Holst, J, Saunders, DN, and Hoy, AJ
- Abstract
BACKGROUND: Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to support breast cancer progression is poorly understood. RESULTS: Here, we show that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of adipocyte triacylglycerol. Adipocyte-derived free fatty acids were transferred to breast cancer cells, driving fatty acid metabolism via increased CPT1A and electron transport chain complex protein levels, resulting in increased proliferation and migration. Notably, fatty acid transfer to breast cancer cells was enhanced from "obese" adipocytes, concomitant with increased stimulation of cancer cell proliferation and migration. This adipocyte-stimulated breast cancer cell proliferation was dependent on lipolytic processes since HSL/ATGL knockdown attenuated cancer cell responses. CONCLUSIONS: These findings highlight a novel and potentially important role for adipocyte lipolysis in the provision of metabolic substrates to breast cancer cells, thereby supporting cancer progression.
- Published
- 2017
15. Neural oscillations involved in Face and Body Inversion Effects
- Author
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Bossi, F, Rivolta, D, Premoli, I, Pizzamiglio, S, Balaban, S, Gallucci, M, Ricciardelli, P, BOSSI, FRANCESCO, GALLUCCI, MARCELLO, RICCIARDELLI, PAOLA, Bossi, F, Rivolta, D, Premoli, I, Pizzamiglio, S, Balaban, S, Gallucci, M, Ricciardelli, P, BOSSI, FRANCESCO, GALLUCCI, MARCELLO, and RICCIARDELLI, PAOLA
- Published
- 2017
16. The determinants of growing agri-food export: The case of CEE countries
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Balaban Suzana, Joksimović Marijana, and Stoiljković Bojan
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economy ,agri-food sector ,eu accession and trade liberalization ,Agriculture - Abstract
The aim of this study is to analyse the determinants of the growing agri-food export in the CEE countries. Using the SYS-GMM estimation, we control for the endogeneity problem. As the explanatory variables we use the variable that have been empirically proven as determinants of the agri-food export and available for observed countries. The obtained results show that the trade liberalisation increases the agri-food exports, while the EU enlargement indirectly affects the agri-food exports which is an important statement for policy-makers.
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- 2022
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17. In vitro susceptibility of Candida species isolated from clinical specimens against some antifungal agents
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Özçelik, Berrin, Çayırlı, A, Aksaray, S, Balaban, S, and Cesur, Salih
- Published
- 2004
18. Radio Controls and Automatic Identification Systems
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Balaban, S. Gene, primary and Andersson, Edmund P., additional
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19. Role of pelvic sensory signalling during delivery in postpartum mental health
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Hayes, U.L., primary, Balaban, S., additional, Smith, J.Z., additional, Perry‐Jenkins, M., additional, and Powers, S.I., additional
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- 2010
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20. What's ahead for materials handling equipment
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Goosman, Robert, McDonald, Richard A., Berg, E. Kurt, Boldrin, Bruce, Horrey, Raymond J., Balaban, S. Gene, Reisinger, Robert, Miller, Donald E., Azzi, Victor, Leong, David S., Jespersen, Herbert A., Saigh, Robert W., Raymond, George G., Schrader, D.E., Nafsinger, John, and Ryder, John F.
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Industrial equipment and supplies industry -- Forecasts and trends ,Business ,Business, general ,Engineering and manufacturing industries - Published
- 1986
21. AB0050 Minor salivary gland biopsy findings in patients with rheumatoid arthritis
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Dalkilic, E, primary, Karakoc, Y, additional, Ozturk, E, additional, Balaban, S, additional, Dogru, M, additional, Ozkan, A, additional, and Gullulu, M, additional
- Published
- 2001
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22. Electron states in rectangular quantum well wires (single wires, finite and infinite lattices)
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Pokatilov, E P, primary, Fonoberov, V A, additional, Balaban, S N, additional, and Fomin, V M, additional
- Published
- 2000
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23. Bipolaron binding in quantum wires
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Pokatilov, E. P., primary, Fomin, V. M., additional, Devreese, J. T., additional, Balaban, S. N., additional, and Klimin, S. N., additional
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- 2000
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24. A bipolaron in a spherical quantum dot with parabolic confinement
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Pokatilov, E P, primary, Fomin, V M, additional, Devreese, J T, additional, Balaban, S N, additional, and Klimin, S N, additional
- Published
- 1999
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25. Distribution of fields and charge carriers in cylindrical nanosize silicon-based metal–oxide–semiconductor structures
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Pokatilov, E. P., primary, Fomin, V. M., additional, Balaban, S. N., additional, Gladilin, V. N., additional, Klimin, S. N., additional, Devreese, J. T., additional, Magnus, W., additional, Schoenmaker, W., additional, Collaert, N., additional, Van Rossum, M., additional, and De Meyer, K., additional
- Published
- 1999
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26. Photoluminescence of spherical quantum dots
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Fomin, V. M., primary, Gladilin, V. N., additional, Devreese, J. T., additional, Pokatilov, E. P., additional, Balaban, S. N., additional, and Klimin, S. N., additional
- Published
- 1998
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27. Multiquantum Optical Processes in Semiconductor Quantum Dots
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Fomin, V. M., primary, Pokatilov, E. P., additional, Devreese, J. T., additional, Klimin, S. N., additional, Gladilin, V. N., additional, and Balaban, S. N., additional
- Published
- 1997
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28. Spironolactone therapy in hypertrichosis
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Darendeliler, F, primary, Baş, F, additional, Balaban, S, additional, Bundak, R, additional, Demirkol, D, additional, Saka, N, additional, and Günöz, H, additional
- Published
- 1996
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29. Measurement of the Unsteady Flow at the Entrance to an Axial Gas Turbine Rotor
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Adler, D., primary, Kleiner, Μ., additional, and Balaban, S., additional
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- 1996
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30. Measurement of the Flow Inside the Tip Clearance of a Rotating Gas Turbine Rotor
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Adler, D., primary, Kleiner, Μ., additional, and Balaban, S., additional
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- 1996
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31. Polarons in a Cylindrical Quantum Wire with Finite‐Barrier Well
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Pokatilov, E. P., primary, Klimin, S. N., additional, Balaban, S. N., additional, and Fomin, V. M., additional
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- 1995
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32. Magnetopolaron in a Cylindrical Quantum Wire
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Pokatilov, E. P., primary, Klimin, S. N., additional, Balaban, S. N., additional, and Fomin, V. M., additional
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- 1995
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33. Three-Dimensional LDA Measurements of the Flow Field Inside an Axial Gas Turbine Rotor
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Adler, D., primary, Kleiner, Μ., additional, and Balaban, S., additional
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- 1995
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34. Monoclonal antibody to native P39 protein from Borrelia burgdorferi
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Sullivan, T J, primary, Hechemy, K E, additional, Harris, H L, additional, Rudofsky, U H, additional, Samsonoff, W A, additional, Peterson, A J, additional, Evans, B D, additional, and Balaban, S L, additional
- Published
- 1994
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35. Polarons in an ellipsoidal potential well
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Pokatilov, E. P., Fomin, V. M., Devreese, J. T., Balaban, S. N., and Klimin, S. N.
- Published
- 1999
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36. Electron-phonon interaction in cylindrical and planar quantum wires
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Pokatilov, E. P., Fomin, V. M., Balaban, S. N., Klimin, S. N., Fai, L. C., and Devreese, J. T.
- Abstract
Within the framework of the Feynman variational method the bipolaron binding energy and the bipolaron effective mass in cylindrical and planar quantum wires with parabolic confinement are calculated. An analogy is found between the effects due to strong confinement and those due to the application of a strong magnetic field. Strengthening the confinement leads to an enlargement of the bipolaron stability region. Copyright 1998 Academic Press Limited
- Published
- 1998
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37. Characterization of nanostructures by virtue of the phenomena due to the electron-phonon interaction
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Pokatilov, E. P., Fomin, V. M., Klimin, S. N., and Balaban, S. N.
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- 1996
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38. Gm Allotype Preference in Erythrocyte IgG Antibodies of Patients With Autoimmune Hemolytic Anemia
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Litwin, S.D., Balaban, S., and Eyster, M.E.
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IgG antibodies were isolated from erythrocytes of five patients with autoimmune hemolytic anemia (AHA) and one case of hemolytic anemia of unknown etiology. All six persons were heterozygous for human IgG1 allotypes, and thus their serum immunoglobulins were Gm (a + f +). Quantitative analysis of the antibody preparations disclosed that three patients contained only the Gm(a) allotype; the remaining samples showed a predominance of Gm(a) in comparison to the Gm(f) allele. It was concluded that erythrocyte antibodies of patients with AHA are often restricted in respect to their Gm genetic characters with a preference for the Gm(a) allotype. In a second group of experiments, serums from three cases of hemolytic anemia were incubated with Rh+ erythrocytes from a healthy donor. Subsequently, the red cell IgG coat was eluted and analyzed. One sample had only Gm(a +) antibody; a second case showed Gm(a) predominance. The last antibody preparation varied from a disproportionately high Gm(a) concentration to equal allotype concentrations, depending on the antibody/antigen ratio used during the sensitization of the erythrocytes. The latter data suggested that allelic expression was influenced by the immunologic characteristics of the antibody subpopulation tested. No association could be demonstrated between the Ig allotypes and either the Rh specificity of the eluate, or the presence of complement coating on erythrocytes. These findings are similar to a previous report from this laboratory that noted a preference for the Gm(a) allotype in many isoantibodies with Rh specificity. The data suggest an association between certain erythrocyte antibodies and Ig allotypes.
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- 1973
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39. A Quantitative Method for Determining Human γG Allotype Antigens (Gm)
- Author
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Litwin, S. D., primary and Balaban, S., additional
- Published
- 1972
- Full Text
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40. Effect of Pressure on Heat Capacity. Nitrogen-Trifluoromethane System
- Author
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Balaban, S. M., primary and Wenzel, L. A., additional
- Published
- 1970
- Full Text
- View/download PDF
41. Theta- and Gamma-Band Activity Discriminates Face, Body and Object Perception
- Author
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Francesco Bossi, Isabella Premoli, Sara Pizzamiglio, Sema Balaban, Paola Ricciardelli, Davide Rivolta, Bossi, F, Premoli, I, Pizzamiglio, S, Balaban, S, Ricciardelli, P, and Rivolta, D
- Subjects
media_common.quotation_subject ,neural oscillations ,Electroencephalography ,050105 experimental psychology ,configural processing ,lcsh:RC321-571 ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,neural oscillation ,Perception ,gamma activity ,medicine ,face-inversion effect ,Contrast (vision) ,0501 psychology and cognitive sciences ,Object perception ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Biological Psychiatry ,Original Research ,media_common ,medicine.diagnostic_test ,05 social sciences ,Human Neuroscience ,Neurophysiology ,theta activity ,Inversion (music) ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Neurology ,Face (geometry) ,body-inversion effect ,Psychology ,Gamma band ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Face and body perception is mediated by configural mechanisms, which allow the perception of these stimuli as a whole, rather than the sum of individual parts. Indirect measures of configural processing in visual cognition are the face and body inversion effects (FIE and BIE), which refer to the drop in performance when these stimuli are perceived upside-down. Albeit FIE and BIE have been well characterized at the behavioral level, much still needs to be understood in terms of the neurophysiological correlates of these effects. Thus, in the current study, the brain’s electrical activity has been recorded by a 128 channel electroencephalogram (EEG) in 24 healthy participants while perceiving (upright and inverted) faces, bodies and houses. EEG data were analyzed in both the time domain (i.e., event-related potentials—ERPs) and the frequency domain [i.e., induced theta (5–7 Hz) and gamma (28–45 Hz) oscillations]. ERPs amplitude results showed increased N170 amplitude for inverted faces and bodies (compared to the same stimuli presented in canonical position) but not for houses. ERPs latency results showed delayed N170 components for inverted (vs. upright) faces, houses, but not bodies. Spectral analysis of induced oscillations indicated physiological FIE and BIE; that is decreased gamma-band synchronization over right occipito-temporal electrodes for inverted (vs. upright) faces, and increased bilateral frontoparietal theta-band synchronization for inverted (vs. upright) faces. Furthermore, increased left occipito-temporal and right frontal theta-band synchronization for upright (vs. inverted) bodies was found. Our findings, thus, demonstrate clear differences in the neurophysiological correlates of face and body perception. The neurophysiological FIE suggests disruption of feature binding processes (decrease in occipital gamma oscillations for inverted faces), together with enhanced feature-based attention (increase in frontoparietal theta oscillations for inverted faces). In contrast, the BIE may suggest that structural encoding for bodies is mediated by the first stages of configural processing (decrease in occipital theta oscillations for inverted bodies).
- Published
- 2020
42. Evaluation of the Relationship between Cognitive Impairment and Atria Score Systems in Patients with Atrial Fibrillation.
- Author
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Özdemir E, Ekinci AS, Emren SV, Balaban S, Tiryaki MM, Karaca M, Tiryaki ENÖ, and Nazlı C
- Abstract
Background: Atrial fibrillation (AF) is the main arrhythmia associated with thromboembolic complications and cognitive impairment. In this study, we aimed to evaluate the relationship between cognitive impairment and different scoring systems developed for AF to improve the medical follow-up of cognitive impairment., Methods: Between January 2019 and December 2020, 124 patients between the age of 30 and 80 years, diagnosed with AF for at least 5 years and complaining about memory impairment during cardiological follow-up, were included in the study. The patients were divided into two groups based on their cognitive status as assessed by the Mini-Mental State Examination group 1 consisted of 52 patients with cognitive impairment and group 2 comprised 72 patients without cognitive impairment., Results: The ATRIA bleeding score had a positive moderate correlation ( r = 0.454, P < 0.001), the ATRIA stroke score had a strong correlation ( r = 0.738, P < 0.001), and the SAMe-TT
2 R2 score had a strong correlation ( r = 0.688, P < 0.001) with cognitive impairment. However, CHADS2 and CHA2 DS2 VASc scores were not statistically correlated with cognitive impairment. According to the receiver operating characteristic (ROC) curve, the area under the curve (AUC) of the ATRIA bleeding score was 0.761 with a 95% confidence interval (CI) of 0.678-0.844 and P < 0.001; also, for the ATRIA stroke score, AUC was 0.930 with a 95% CI of 0.886-0.974 and P < 0.001. In addition, for the SAMe-TT2 R2 score, AUC was 0.895 with a 95% CI of 0.838-0.952 and P < 0.001. In the pairwise comparison of AUC on ROC curves, the ATRIA stroke score and the SAMe-TT2 R2 score were statistically similar ( P = 0.324). ATRIA bleeding, ATRIA stroke, and SAMe-TT2 R2 scores were greater than CHADS2 stroke score ( P : 0.0004, P < 0.0001, and P < 0.0001, respectively), but CHA2 DS2 -VASc and CHADS2 stroke scores were statistically similar ( P : 0.402)., Conclusion: Both ATRIA stroke and SAMe-TT2 R2 scoring systems can provide a better correlation than CHADS2 and CHA2 DS2 -VASc scores in patients with AF to evaluate their cognitive status. These two scores can be more useful to monitor the patients with AF for medical follow-up of cognitive status., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Annals of Indian Academy of Neurology.)- Published
- 2024
- Full Text
- View/download PDF
43. Glutamine addiction promotes glucose oxidation in triple-negative breast cancer.
- Author
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Quek LE, van Geldermalsen M, Guan YF, Wahi K, Mayoh C, Balaban S, Pang A, Wang Q, Cowley MJ, Brown KK, Turner N, Hoy AJ, and Holst J
- Subjects
- Cell Line, Tumor, Citric Acid Cycle, Glucose metabolism, Glutamic Acid metabolism, Humans, Glutamine metabolism, Triple Negative Breast Neoplasms genetics, Triple Negative Breast Neoplasms metabolism
- Abstract
Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth requirements confers greater fitness to glutamine-addicted cancers. By contrasting two breast cancer subtypes with distinct glutamine dependencies, we show that glutamine-indispensable triple-negative breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, with glutamine carbon routed once through the TCA cycle. Importantly, this single-pass glutaminolysis increases TCA cycle fluxes and replenishes TCA cycle intermediates in TNBC cells, a process that achieves net oxidation of glucose but not glutamine. The coupling of glucose and glutamine catabolism appears hard-wired via a distinct TNBC gene expression profile biased to strip and then sequester glutamine nitrogen, but hampers the ability of TNBC cells to oxidise glucose when glutamine is limiting. Our results provide a new understanding of how metabolically rigid TNBC cells are sensitive to glutamine deprivation and a way to select vulnerable TNBC subtypes that may be responsive to metabolic-targeted therapies., (© 2022. The Author(s).)
- Published
- 2022
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- View/download PDF
44. Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game.
- Author
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Fernandes C, Garcez H, Balaban S, Barbosa F, Pereira MR, Silveira C, Marques-Teixeira J, and Gonçalves AR
- Abstract
Benzodiazepines and antidepressants have been shown to change responses to unfairness; however, the effects of their combined use on unfairness evaluation are unknown. This study examines the effects of concomitant benzodiazepines and antidepressants long-term use on the evaluation of fair and unfair offers. To analyze behavioral changes on responses to unfairness, we compared the performance of medicated participants and healthy controls in the Ultimatum Game (UG), both in the proposer and in the respondent role. The results showed that long-term psychotropic users had the worse economic strategy by accepting less offers than control subjects. However, in the proposer role, the unfair offers made by participants were similar between groups. The present results suggest that long-term use of psychotropic medication, specifically the combination of benzodiazepines and antidepressants, may increase the sensitivity to unfairness, resulting in higher rejection rates in conditions where this strategy is the most disadvantageous., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Fernandes, Garcez, Balaban, Barbosa, Pereira, Silveira, Marques-Teixeira and Gonçalves.)
- Published
- 2022
- Full Text
- View/download PDF
45. The effects of diet-induced weight loss on asthma control and quality of life in obese adults with asthma: a randomized controlled trial.
- Author
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Özbey Ü, Balaban S, Sözener ZÇ, Uçar A, Mungan D, and Mısırlıgil Z
- Subjects
- Adult, Diet, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Obesity physiopathology, Vital Capacity, Asthma physiopathology, Obesity diet therapy, Quality of Life, Weight Loss
- Abstract
Objective: While the effects of obesity on asthma are yet to be fully clarified, increased fat tissue is known to increase the severity of asthma and to impair asthma control. This study evaluated the effects of diet-induced weight loss on the characteristics of asthma in obese adults with asthma. Methods: A total of 55 obese individuals (BMI ≥ 30.0) with asthma were enrolled in the study and randomized into the diet or control groups. The anthropometric measurements, asthma control test (ACT) scores, asthma quality of life questionnaire (AQLQ) scores, pulmonary function tests (PFT) and daily food consumption of the participants were recorded and compared at the baseline and at study completion. Results: The changes recorded in body weight (diet -5.2 (4, 5); control, -0.1 (1.3)), ACT score (diet 2.0 (2.0); control 0.0 (1.7)) and AQLQ score (diet 0.8 ± 0.1; control -0.02 ± 0.5) of the participants in the diet group were significantly higher than in the control group ( p = 0.00). The increases in forced expiratory volume in one second (FEV
1 ) and the forced vital capacity (FVC) measurements of the participants with weight loss of ≥5.0 percent were significant when compared to those with weight loss of <5.0 percent ( p < 0.05). While total energy uptake and carbohydrate consumption at the end of study were found to be decreased in the diet group, they had increased in the control group ( p < 0.05). Conclusion: Diet intervention improved asthma control and quality of life in obese patients with controlled asthma in this study. However to generalize this finding to all asthma patients, further studies including uncontrolled asthmatics are needed.- Published
- 2020
- Full Text
- View/download PDF
46. Theta- and Gamma-Band Activity Discriminates Face, Body and Object Perception.
- Author
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Bossi F, Premoli I, Pizzamiglio S, Balaban S, Ricciardelli P, and Rivolta D
- Abstract
Face and body perception is mediated by configural mechanisms, which allow the perception of these stimuli as a whole, rather than the sum of individual parts. Indirect measures of configural processing in visual cognition are the face and body inversion effects (FIE and BIE), which refer to the drop in performance when these stimuli are perceived upside-down. Albeit FIE and BIE have been well characterized at the behavioral level, much still needs to be understood in terms of the neurophysiological correlates of these effects. Thus, in the current study, the brain's electrical activity has been recorded by a 128 channel electroencephalogram (EEG) in 24 healthy participants while perceiving (upright and inverted) faces, bodies and houses. EEG data were analyzed in both the time domain (i.e., event-related potentials-ERPs) and the frequency domain [i.e., induced theta (5-7 Hz) and gamma (28-45 Hz) oscillations]. ERPs amplitude results showed increased N170 amplitude for inverted faces and bodies (compared to the same stimuli presented in canonical position) but not for houses. ERPs latency results showed delayed N170 components for inverted (vs. upright) faces, houses, but not bodies. Spectral analysis of induced oscillations indicated physiological FIE and BIE; that is decreased gamma-band synchronization over right occipito-temporal electrodes for inverted (vs. upright) faces, and increased bilateral frontoparietal theta-band synchronization for inverted (vs. upright) faces. Furthermore, increased left occipito-temporal and right frontal theta-band synchronization for upright (vs. inverted) bodies was found. Our findings, thus, demonstrate clear differences in the neurophysiological correlates of face and body perception. The neurophysiological FIE suggests disruption of feature binding processes (decrease in occipital gamma oscillations for inverted faces), together with enhanced feature-based attention (increase in frontoparietal theta oscillations for inverted faces). In contrast, the BIE may suggest that structural encoding for bodies is mediated by the first stages of configural processing (decrease in occipital theta oscillations for inverted bodies)., (Copyright © 2020 Bossi, Premoli, Pizzamiglio, Balaban, Ricciardelli and Rivolta.)
- Published
- 2020
- Full Text
- View/download PDF
47. A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics.
- Author
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Celikbas E, Balaban S, Evran S, Coskunol H, and Timur S
- Subjects
- Colorimetry, Electrochemical Techniques, Point-of-Care Systems, SELEX Aptamer Technique, Aptamers, Nucleotide chemistry, Biosensing Techniques, Forensic Sciences methods, Illicit Drugs chemistry, Substance Abuse Detection methods
- Abstract
Aptamer-based point-of-care (POC) diagnostics platforms may be of substantial benefit in forensic analysis as they provide rapid, sensitive, user-friendly, and selective analysis tools for detection. Aptasensors have not yet been adapted commercially. However, the significance of the applications of aptasensors in the literature exceeded their potential. Herein, in this review, a bottom-up approach is followed to describe the aptasensor development and application procedure, starting from the synthesis of the corresponding aptamer sequence for the selected analyte to creating a smart surface for the sensitive detection of the molecule of interest. Optical and electrochemical biosensing platforms, which are designed with aptamers as recognition molecules, detecting abused drugs are critically reviewed, and existing and possible applications of different designs are discussed. Several potential disciplines in which aptamer-based biosensing technology can be of greatest value, including forensic drug analysis and biological evidence, are then highlighted to encourage researchers to focus on developing aptasensors in these specific areas., Competing Interests: The authors declare no conflict of interest.
- Published
- 2019
- Full Text
- View/download PDF
48. A cross sectional survey of smoking characteristics and quitting behaviour from a sample of homeless adults in Great Britain.
- Author
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Dawkins L, Ford A, Bauld L, Balaban S, Tyler A, and Cox S
- Subjects
- Adult, Attitude to Health, Cigarette Smoking therapy, Costs and Cost Analysis, Electronic Nicotine Delivery Systems economics, Female, Friends, Humans, Male, Middle Aged, Smoking Cessation methods, Smoking Cessation Agents therapeutic use, Surveys and Questionnaires, Tobacco Use Cessation Devices, United Kingdom epidemiology, Cigarette Smoking epidemiology, Ill-Housed Persons statistics & numerical data, Smoking Cessation statistics & numerical data, Tobacco Use Disorder epidemiology
- Abstract
Background: Smoking is a key contributor to health and social inequalities and homeless smoking prevalence rates are 4 times higher than the general population. Research on homelessness and smoking to date has been concentrated predominantly in the US and Australia. This study aimed to describe smoking and quitting behaviour in homeless adult smokers in Great Britain. Data on perceptions of, and willingness to try, e-cigarettes were also gathered., Methods: Cross sectional survey of 283 adult smokers accessing homeless support services in Kent, the Midlands, London and Edinburgh. Participants answered a four-part survey: i) demographics; ii) current smoking behaviour and dependence (including the Fagerström Test of Cigarette Dependence [FTCD]); iii) previous quit attempts; and iv) e-cigarettes perceptions., Results: High levels of cigarette dependence were observed (FTCD: M = 7.78, sd ± 0.98). Although desire to quit was high, most had made fewer than 5 quit attempts and 90% of these lasted less than 24 h. 91.5% reported that others around them also smoked. Previous quit methods used included cold turkey (29.7%), NRT (24.7%), varenicline (22.3%) and bupropion (14.5%). 34% were willing or able to spend £20 or more for an e-cigarette and 82% had tried one in the past although 54% reported that they preferred smoking., Conclusion: We observed high nicotine dependence, few long-term quit attempts, strong desire to quit and amenability to both traditional cessation methods and e-cigarettes. Community embedded and non-routine approaches to cessation may be promising avenues promoting engagement with the homeless community. Likely barriers to uptake include low affordability, preference for cigarettes and high numbers of smoking acquaintances., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
49. Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.
- Author
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Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, and Hoy AJ
- Subjects
- Cell Line, Tumor, Extracellular Fluid metabolism, Humans, Lipid Metabolism, Male, Palmitates metabolism, Triglycerides metabolism, Fatty Acids metabolism, Lipids biosynthesis, Prostatic Neoplasms metabolism
- Abstract
Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased de novo synthesis of fatty acids (FA); however, little is known about how extracellular FAs, such as those in the circulation, may support prostate cancer progression. Here, we show that increasing FA availability increased intracellular triacylglycerol content in cultured patient-derived tumor explants, LNCaP and C4-2B spheroids, a range of prostate cancer cells (LNCaP, C4-2B, 22Rv1, PC-3), and prostate epithelial cells (PNT1). Extracellular FAs are the major source (∼83%) of carbons to the total lipid pool in all cell lines, compared with glucose (∼13%) and glutamine (∼4%), and FA oxidation rates are greater in prostate cancer cells compared with PNT1 cells, which preferentially partitioned extracellular FAs into triacylglycerols. Because of the higher rates of FA oxidation in C4-2B cells, cells remained viable when challenged by the addition of palmitate to culture media and inhibition of mitochondrial FA oxidation sensitized C4-2B cells to palmitate-induced apoptosis. Whereas in PC-3 cells, palmitate induced apoptosis, which was prevented by pretreatment of PC-3 cells with FAs, and this protective effect required DGAT-1-mediated triacylglycerol synthesis. These outcomes highlight for the first-time heterogeneity of lipid metabolism in prostate cancer cells and the potential influence that obesity-associated dyslipidemia or host circulating has on prostate cancer progression. IMPLICATIONS: Extracellular-derived FAs are primary building blocks for complex lipids and heterogeneity in FA metabolism exists in prostate cancer that can influence tumor cell behavior., (©2019 American Association for Cancer Research.)
- Published
- 2019
- Full Text
- View/download PDF
50. Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis.
- Author
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Balaban S, Lee LS, Varney B, Aishah A, Gao Q, Shearer RF, Saunders DN, Grewal T, and Hoy AJ
- Subjects
- Breast Neoplasms etiology, Carnitine O-Palmitoyltransferase metabolism, Cell Proliferation drug effects, Estrogen Receptor alpha metabolism, Female, Humans, Lipase biosynthesis, Lipolysis, MCF-7 Cells, Mitochondria metabolism, Obesity complications, Oleic Acid pharmacology, Oxidative Phosphorylation, Signal Transduction drug effects, Apoptosis drug effects, Breast Neoplasms metabolism, Fatty Acids metabolism, Obesity metabolism, Palmitates pharmacology, Triglycerides biosynthesis
- Abstract
Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alters MCF-7 and MDA-MB-231 cell metabolism and promotes proliferation and migration. Since adipocytes are FA-rich, and these FAs are transferred to BrCa cells, we sought to elucidate the FA metabolism of BrCa cells and their response to FA-rich environments. MCF-7 and MDA-MB-231 cells incubated in serum-containing media supplemented with FAs accumulate extracellular FAs as intracellular triacylglycerols (TAG) in a dose-dependent manner, with MDA-MB-231 cells accumulating more TAG. The differences in TAG levels were a consequence of distinct differences in intracellular partitioning of FAs, and not due to differences in the rate of FA uptake. Specifically, MCF-7 cells preferentially partition FAs into mitochondrial oxidation, whereas MDA-MB-231 cells partition FAs into TAG synthesis. These differences in intracellular FA handling underpin differences in the sensitivity to palmitate-induced lipotoxicity, with MDA-MB-231 cells being highly sensitive, whereas MCF-7 cells are partially protected. The attenuation of palmitate-induced lipotoxicity in MCF-7 cells was reversed by inhibition of FA oxidation. Pretreatment of MDA-MB-231 cells with FAs increased TAG synthesis and reduced palmitate-induced apoptosis. Our results provide novel insight into the potential influences of obesity on BrCa biology, highlighting distinct differences in FA metabolism in MCF-7 and MDA-MB-231 cells and how lipid-rich environments modulate these effects., (© 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
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