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2. Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia

Author

Bakker-Arkema, Rebecca G., Davidson, Michael H., Goldstein, Robert J., Davignon, Jean, Isaccsohn, Jonathan L., Weiss, Stuart R., Keilson, Leonard M., Brown, W. Virgil, Miller, Valery T., Shurzinske, Linda J., and Black, Donald M.

Subjects
Hydroxymethylglutaryl coenzyme A reductases -- Physiological aspects, Enzyme inhibitors -- Evaluation, Hyperlipidemia -- Drug therapy
Abstract

The new HMG-CoA reductase inhibitor, atorvastatin, appears to reduce elevated blood levels of triglycerides. Elevated triglyceride levels are associated with an increased risk of coronary artery disease. Researchers randomized 55 people with elevated triglycerides into one of four groups: groups that would take 5 milligrams (mg), 20 mg or 80 mg of atorvastatin and a group that would take a placebo. All of the volunteers were on a low-cholesterol diet. After two weeks, atorvastatin had lowered triglyceride levels from 26.5% to 45.8% on average, depending on the dose. Higher doses led to greater reductions. In addition, the drug lowered total cholesterol and LDL and VLDL cholesterol, all of which are risk factors for coronary artery disease when elevated. Ten percent of the people taking the drug experienced an adverse effect, which included headache, pain, diarrhea and flatulence. HMG-CoA reductase inhibitors are usually used to reduce elevated cholesterol levels.

Published
1996

7. Treating patients with documented atherosclerosis to national cholesterol education program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin

Author

Brown, Alan S, primary, Bakker-Arkema, Rebecca G, additional, Yellen, Laurence, additional, Henley, Robert W, additional, Guthrie, Richard, additional, Campbell, Cam F, additional, Koren, Michael, additional, Woo, William, additional, McLain, Richard, additional, and Black, Donald M, additional

Published
1998
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