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462 results on '"Bakker, Astrid"'

10. Correlation of clinical manifestations and condylar morphology of patients with temporomandibular degenerative joint diseases.

Author

Yuan, ShanShan, Liu, YaRui, Deng, KaiTong, Li, XingYang, Bakker, Astrid D., Klein-Nulend, Jenneke, Pathak, Janak L., Zhang, QingBin, and Wang, ZhaoJian

Subjects
CONE beam computed tomography, OSTEOARTHRITIS, SYMPTOMS, TEMPOROMANDIBULAR joint, ANATOMICAL planes
Abstract

Objective: To study the correlation between condylar morphology and clinical manifestations in patients with degenerative joint disease (DJD) of the temporomandibular joint (TMJ). Methods: A total of 175 joints of 131 patients with DJD were included. Data on patients' basic information and symptoms were collected and analyzed. Condylar morphology was evaluated using cone beam computed tomography (CBCT). The correlation between the condylar morphology and clinical manifestations was analyzed. Results: The prevalence of joint noises, clicks, and crepitus was 93/175 (53%), 73/175 (42%), and 20/175 (11%), respectively. Condylar anteroposterior diameter and condylar height were correlated with pain. There was a correlation between the shape of the condyle in the sagittal plane and joint noise. Conclusion: Condylar morphology and clinical features of DJD were correlated to some extent. [ABSTRACT FROM AUTHOR]

Published
2024
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13. In Vivo Models of Mechanical Loading

Author

Javaheri, Behzad, primary, Bravenboer, Nathalie, additional, Bakker, Astrid D., additional, van der Veen, Albert, additional, de Souza, Roberto Lopes, additional, Saxon, Leanne, additional, and Pitsillides, Andrew A., additional

Published
2019
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15. Compressed Prostate Cancer Cells Decrease Osteoclast Activity While Enhancing Osteoblast Activity In Vitro

Author

van Santen, Victor J. B., Zandieh Doulabi, Behrouz, Semeins, Cornelis M., Hogervorst, Jolanda M. A., Bratengeier, Cornelia, Bakker, Astrid D., van Santen, Victor J. B., Zandieh Doulabi, Behrouz, Semeins, Cornelis M., Hogervorst, Jolanda M. A., Bratengeier, Cornelia, and Bakker, Astrid D.

Abstract

Once prostate cancer cells metastasize to bone, they perceive approximately 2 kPa compression. We hypothesize that 2 kPa compression stimulates the epithelial-to-mesenchymal transition (EMT) of prostate cancer cells and alters their production of paracrine signals to affect osteoclast and osteoblast behavior. Human DU145 prostate cancer cells were subjected to 2 kPa compression for 2 days. Compression decreased expression of 2 epithelial genes, 5 out of 13 mesenchymal genes, and increased 2 mesenchymal genes by DU145 cells, as quantified by qPCR. Conditioned medium (CM) of DU145 cells was added to human monocytes that were stimulated to differentiate into osteoclasts for 21 days. CM from compressed DU145 cells decreased osteoclast resorptive activity by 38% but did not affect osteoclast size and number compared to CM from non-compressed cells. CM was also added to human adipose stromal cells, grown in osteogenic medium. CM of compressed DU145 cells increased bone nodule production (Alizarin Red) by osteoblasts from four out of six donors. Compression did not affect IL6 or TNF-alpha production by PC DU145 cells. Our data suggest that compression affects EMT-related gene expression in DU145 cells, and alters their production of paracrine signals to decrease osteoclast resorptive activity while increasing mineralization by osteoblasts is donor dependent. This observation gives further insight in the altered behavior of PC cells upon mechanical stimuli, which could provide novel leads for therapies, preventing bone metastases., Funding Agencies|MechanoCHIP

Published
2023
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17. Osteocytes: Mechanosensors of Bone and Orchestrators of Mechanical Adaptation

Author

Klein-Nulend, Jenneke and Bakker, Astrid

Abstract

Abstract: Significant progress has been made in the field of mechanotransduction in bone cells. The knowledge about the role of osteocytes as the professional mechanosensor cells of bone as well as the lacuno-canalicular porosity as the structure that mediates mechanosensing is increasing. New insights might result in a paradigm for understanding the bone formation response to mechanical loading, and the bone resorption response to disuse. Under physiological loading conditions the strain-derived flow of interstitial fluid through the lacuno-canalicular porosity seems to mechanically activate the osteocytes, which subsequently alter the bone remodeling activity of osteoblasts and/or osteoclasts. Fatigue loading results in local microdamage, disruption of normal flow patterns, and osteocyte apoptosis. Apoptotic osteocytes likely attract osteoclasts to resorb the damaged bone. This concept allows explanation of local bone gain and loss, as well as remodeling in response to fatigue damage, as processes supervised by mechanosensitive osteocytes. Uncovering the cellular and mechanical basis of the osteocyte’s response to loading would greatly contribute to our understanding of the cellular basis for bone remodeling, and could contribute to the discovery of new treatment modalities for bone mass disorders, such as osteoporosis.

Published
2024
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30. Fluid shear stress-induced mechanotransduction in myoblasts: Does it depend on the glycocalyx?

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Haroon, Mohammad, Bloks, Niek G C, Deldicque, Louise, Koppo, Katrien, Seddiqi, Hadi, Bakker, Astrid D, Klein-Nulend, Jenneke, Jaspers, Richard T, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Haroon, Mohammad, Bloks, Niek G C, Deldicque, Louise, Koppo, Katrien, Seddiqi, Hadi, Bakker, Astrid D, Klein-Nulend, Jenneke, and Jaspers, Richard T

Abstract

Muscle stem cells (MuSCs) are involved in muscle maintenance and regeneration. Mechanically loaded MuSCs within their native niche undergo tensile and shear deformations, but how MuSCs sense mechanical stimuli and translate these into biochemical signals regulating function and fate is still poorly understood. We aimed to investigate whether the glycocalyx is involved in the MuSC mechanoresponse, and whether MuSC morphology affects mechanical loading-induced pressure, shear stress, and fluid velocity distribution. FSS-induced deformation of active proliferating MuSCs (myoblasts) with intact or degraded glycocalyx was assessed by live-cell imaging. Glycocalyx-degradation did not significantly affect nitric oxide production, but reduced FSS-induced myoblast deformation and modulated gene expression. Finite-element analysis revealed that the distribution of FSS-induced pressure, shear stress, and fluid velocity on myoblasts was non-uniform, and the magnitude depended on myoblast morphology and apex-height. In conclusion, our results suggest that the glycocalyx does not play a role in NO production in myoblasts but might impact mechanotransduction and gene expression, which needs further investigation. Future studies will unravel the underlying mechanism by which the glycocalyx affects FSS-induced myoblast deformation, which might be related to increased drag forces. Moreover, MuSCs with varying apex-height experience different levels of FSS-induced pressure, shear stress, and fluid velocity, suggesting differential responsiveness to fluid shear forces.

Published
2022

35. sj-docx-1-sci-10.1177_00368504221115232 - Supplemental material for Temporomandibular joint synovial chondromatosis: An analysis of 7 cases and literature review

Author

Song, Zhiqiang, Yuan, Shanshan, Liu, Junjie, Bakker, Astrid D., Klein-Nulend, Jenneke, Pathak, Janak L., and Zhang, Qingbin

Subjects
FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-sci-10.1177_00368504221115232 for Temporomandibular joint synovial chondromatosis: An analysis of 7 cases and literature review by Zhiqiang Song, Shanshan Yuan, Junjie Liu, Astrid D. Bakker, Jenneke Klein-Nulend, Janak L. Pathak and Qingbin Zhang in Science Progress

Published
2022
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37. Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity

Author

Haroon, Mohammad, primary, Boers, Heleen E., additional, Bakker, Astrid D., additional, Bloks, Niek G.C., additional, Hoogaars, Willem M.H., additional, Giordani, Lorenzo, additional, Musters, René J.P., additional, Deldicque, Louise, additional, Koppo, Katrien, additional, Le Grand, Fabien, additional, Klein-Nulend, Jenneke, additional, and Jaspers, Richard T., additional

Published
2022
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48. Pulsating fluid flow affects pre‐osteoblast behavior and osteogenic differentiation through production of soluble factors

Author

Jin, Jianfeng, primary, Seddiqi, Hadi, additional, Bakker, Astrid D., additional, Wu, Gang, additional, Verstappen, Johanna F. M., additional, Haroon, Mohammad, additional, Korfage, Joannes A. M., additional, Zandieh‐Doulabi, Behrouz, additional, Werner, Arie, additional, Klein‐Nulend, Jenneke, additional, and Jaspers, Richard T., additional

Published
2021
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49. Temporomandibular joint synovial chondromatosis: An analysis of 7 cases and literature review.

Author

Zhiqiang Song, Shanshan Yuan, Junjie Liu, Bakker, Astrid D., Klein-Nulend, Jenneke, Pathak, Janak L., and Qingbin Zhang

Abstract

Objective: To investigate the diagnosis and treatment procedure of synovial chondromatosis (SC) of the temporomandibular joint (TMJ). Methods: Clinical features, imaging features, surgical methods, and prognosis of 7 patients with SC of the TMJ were analyzed. We also reviewed and analyzed surgery-relevant literature included in the Pubmed database in the past decade using the search terms “synovial chondromatosis” and “temporomandibular joint”, and found 181 cases. Results: There was no specific difference in the symptoms of SC in the TMJ in different Milgram’s stages in our cases and the cases mentioned in the literature. The main symptoms of SC in the TMJ were pain (100%, 7/7; 64.64%, 117/181), limited mouth opening (57.14%, 4/7; 53.59%, 97/181), swelling (14.29%, 1/7; 28.18%, 51/181), crepitus (28.57%, 2/7; 19.34%, 35/181), and clicking (14.29%, 1/7; 9.94%, 18/181) in our cases and cases from literature separately. The imaging features of SC were occupying lesions (including loose bodies or masses) (71.42%, 5/7; 37.57%, 68/181), bone change in condyle or glenoid fossa (1/7, 14.29%; 34.81%, 63/181), effusion (42.86%, 3/7; 20.99%, 38/181), joint space changes (42.86%, 3/7; 11.05%, 20/181) in our cases and cases from literature separately. The surgical procedures seem to depend mainly on the involved structures and the extension of the lesion rather than the Milgram’s stage. Conclusions: The clinical features of SC in the TMJ are nonspecific and easy to be misdiagnosed. MRI is helpful in the diagnosis of SC in the TMJ. The surgical procedures mainly depend on the involved structures and the extension of the lesion. [ABSTRACT FROM AUTHOR]

Published
2022
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