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Your search keyword '"Bakken, Russel R."' showing total 4 results
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4 results on '"Bakken, Russel R."'

1. SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets

Author

Zumbrun, Elizabeth E., primary, Zak, Samantha E., additional, Lee, Eric D., additional, Bowling, Philip A., additional, Ruiz, Sara I., additional, Zeng, Xiankun, additional, Koehler, Jeffrey W., additional, Delp, Korey L., additional, Bakken, Russel R., additional, Hentschel, Shannon S., additional, Bloomfield, Holly A., additional, Ricks, Keersten M., additional, Clements, Tamara L., additional, Babka, April M., additional, Dye, John M., additional, and Herbert, Andrew S., additional

Published
2023
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2. Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

Author

Mittler, Eva, Serris, Alexandra, Esterman, Emma S., Florez, Catalina, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M., Wec, Anna Z., Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R., Jangra, Rohit K., Dye, John M., Ahlm, Clas, Rappazzo, C. Garrett, Ulrich, Rainer G., Zeitlin, Larry, Geoghegan, James C., Bradfute, Steven B., Sidoli, Simone, Forsell, Mattias N. E., Strandin, Tomas, Rey, Felix A., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, Guardado-Calvo, Pablo, Mittler, Eva, Serris, Alexandra, Esterman, Emma S., Florez, Catalina, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M., Wec, Anna Z., Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R., Jangra, Rohit K., Dye, John M., Ahlm, Clas, Rappazzo, C. Garrett, Ulrich, Rainer G., Zeitlin, Larry, Geoghegan, James C., Bradfute, Steven B., Sidoli, Simone, Forsell, Mattias N. E., Strandin, Tomas, Rey, Felix A., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, and Guardado-Calvo, Pablo

Abstract

Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.

Published
2023
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3. Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19

Author

Zumbrun, Elizabeth E., primary, Kaku, Chengzi I., additional, Dillinger, Lukas, additional, Zak, Samantha E., additional, Kuehne, Ana I., additional, Bakken, Russel R., additional, Koehler, Jeffrey W., additional, Delp, Korey L., additional, Stefan, Christopher P., additional, Kumar, Raina, additional, Kugelman, Jeffrey R., additional, Moreau, Alicia M., additional, Zeng, Xiankun, additional, Dye, John M., additional, Herbert, Andrew S., additional, Narayan, Kristin, additional, and Walker, Laura M., additional

Published
2023
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4. Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.

Author

Mittler E, Serris A, Esterman ES, Florez C, Polanco LC, O'Brien CM, Slough MM, Tynell J, Gröning R, Sun Y, Abelson DM, Wec AZ, Haslwanter D, Keller M, Ye C, Bakken RR, Jangra RK, Dye JM, Ahlm C, Rappazzo CG, Ulrich RG, Zeitlin L, Geoghegan JC, Bradfute SB, Sidoli S, Forsell MNE, Strandin T, Rey FA, Herbert AS, Walker LM, Chandran K, and Guardado-Calvo P

Subjects
Humans, Benchmarking, Broadly Neutralizing Antibodies, Conserved Sequence, Antibodies, Viral, Orthohantavirus
Abstract

Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.

Published
2023
Full Text
View/download PDF

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