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6. Modifiable and non-modifiable risk factors for obstetric anal sphincter injury in a Norwegian Region: A case-control study

Author

Markestad T, Holten-Andersen M, Bakken K, and Klokk R

Subjects
medicine.medical_specialty, Obstetrics, business.industry, Case-control study, medicine, language, Norwegian, Anal sphincter, business, language.human_language
Abstract

Objective To identify modifiable and non-modifiable risk factors for severe obstetric anal sphincter injury (OASI) following vaginal delivery. Design Retrospective case-control study. Setting Single center maternity clinic in South-Eastern Norway Population Women diagnosed with OASI following singleton vaginal birth after 30 weeks’ gestation (n = 421) and matched controls (n = 421) during 1990-2002. Methods Data were extracted retrospectively from an institutional birth registry. For each woman with OASI the first subsequent vaginal singleton delivery matched for parity was elected as control. Potential determinants for OASI were assessed by conditional logistic regression analyses. Main outcome measure OASI, defined as 3rd or 4th degree obstetric anal sphincter lesions. Results Among modifiable factors amniotomy was the strongest independent determinant for OASI in both primi- (adjusted odds ratio [aOR] 4.84; 95% CI 2.60–9.02) and multiparous (aOR 3.76; 95% CI 1.45–9.76) women, followed by augmentation with oxytocin (primiparous: aOR 1.63; 95% CI 1.08–2.46, multiparous: aOR 3.70; 95% CI 1.79–7.67). Vacuum extraction and forceps delivery were independently associated with OASI in primiparous women (vacuum: aOR 1.91; 95% CI 1.03–3.57, forceps: aOR 2.37; 95% CI 1.14–4.92), and episiotomy for OASI in multiparous women (aOR 2.64; 95% CI 1.36–5.14). Conclusions Amniotomy may be a hitherto unrecognized independent modifiable risk factor for OASI and should be further investigated for its potential role in preventive strategies for OASI. Funding Innlandet Hospital Trust research fund, grant number 150434. Keywords Obstetric anal sphincter injury; OASI; Birth; Birth injury; Modifiable risk factor; Amniotomy.

Published
2021

8. Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

Author

González, C. A., Megraud, F., Buissonniere, A., Lujan Barroso, L., Agudo, A., Duell, E. J., Boutron-Ruault, M. C., Clavel-Chapelon, F., Palli, D., Krogh, V., Mattiello, A., Tumino, R., Sacerdote, C., Quirós, J. R., Sanchez-Cantalejo, E., Navarro, C., Barricarte, A., Dorronsoro, M., Khaw, K.-T., Wareham, N., Allen, N. E., Tsilidis, K. K., Bas Bueno-de-Mesquita, H., Jeurnink, S. M., Numans, M. E., Peeters, P. H. M., Lagiou, P., Valanou, E., Trichopoulou, A., Kaaks, R., Lukanova-McGregor, A., Bergman, M. M., Boeing, H., Manjer, J., Lindkvist, B., Stenling, R., Hallmans, G., Mortensen, L. M., Overvad, K., Olsen, A., Tjonneland, A., Bakken, K., Dumeaux, V., Lund, E., Jenab, M., Romieu, I., Michaud, D., Mouw, T., Carneiro, F., Fenge, C., and Riboli, E.

Published
2012
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16. Dietary total antioxidant capacity and gastriccancer risk in the European prospective investigation into cancer and nutritionstudy

Author

Serafini M, Jakszyn P, Luján L, Agudo A, Bas Bueno de Mesquita H, van Duijnhoven FJ, Jenab M, Navarro C, Palli D, Boeing H, Wallström P, Regnér S, Numans ME, Carneiro F, Boutron Ruault MC, Clavel Chapelon F, Morois S, Grioni S, Tumino R, Sacerdote C, Ramon Quirós J, Molina Montes E, Huerta Castaño JM, Barricarte A, Amiano P, Khaw KT, Wareham N, Allen NE, Key TJ, Jeurnink SM, Peeters PH, Bamia C, Valanou E, Trichopoulou A, Kaaks R, Lukanova A, Bergmann MM, Lindkvist B, Stenling R, Johansson I, Dahm CC, Overvad K, Jensen M, Olsen A, Tjonneland A, Bakken K, Dumeaux V, Lund E, McCormack V, Rinaldi S, Michaud D, Mouw T, Riboli E, González C.A., PANICO, SALVATORE, Serafini, M, Jakszyn, P, Luján, L, Agudo, A, Bas Bueno de Mesquita, H, van Duijnhoven, Fj, Jenab, M, Navarro, C, Palli, D, Boeing, H, Wallström, P, Regnér, S, Numans, Me, Carneiro, F, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Grioni, S, Panico, Salvatore, Tumino, R, Sacerdote, C, Ramon Quirós, J, Molina Montes, E, Huerta Castaño, Jm, Barricarte, A, Amiano, P, Khaw, Kt, Wareham, N, Allen, Ne, Key, Tj, Jeurnink, Sm, Peeters, Ph, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, Mm, Lindkvist, B, Stenling, R, Johansson, I, Dahm, Cc, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Bakken, K, Dumeaux, V, Lund, E, Mccormack, V, Rinaldi, S, Michaud, D, Mouw, T, Riboli, E, and González, C. A.

Published
2012

17. Endogenoussex steroids and risk of cervical carcinoma: results from the EPIC study

Author

Rinaldi S, Plummer M, Biessy C, Castellsagué X, Overvad K, Krüger Kjær S, Tjønneland A, Clavel Chapelon F, Chabbert Buffet N, Mesrine S, Lukanova A, Kaaks R, Weikert C, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Agnoli C, Tumino R, Vineis P, Bueno de Mesquita B, van Kranen HJ, Peeters PH, Bakken K, Lund E, Gram IT, Rodríguez L, Bosch FX, Sánchez MJ, Dorronsoro M, Navarro C, Gurrea AB, Kjellberg L, Dillner J, Manjer J, Butt S, Khaw KT, Wareham N, Allen NE, Travis R, Romieu I, Ferrari P, Riboli E, Franceschi S., PANICO, SALVATORE, Rinaldi, S, Plummer, M, Biessy, C, Castellsagué, X, Overvad, K, Krüger Kjær, S, Tjønneland, A, Clavel Chapelon, F, Chabbert Buffet, N, Mesrine, S, Lukanova, A, Kaaks, R, Weikert, C, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, Salvatore, Bueno de Mesquita, B, van Kranen, Hj, Peeters, Ph, Bakken, K, Lund, E, Gram, It, Rodríguez, L, Bosch, Fx, Sánchez, Mj, Dorronsoro, M, Navarro, C, Gurrea, Ab, Kjellberg, L, Dillner, J, Manjer, J, Butt, S, Khaw, Kt, Wareham, N, Allen, Ne, Travis, R, Romieu, I, Ferrari, P, Riboli, E, and Franceschi, S.

Published
2011

19. Enhanced in-plane ferroelectricity in BaTiO3 thin films fabricated by aqueous chemical solution deposition.

Author

Raeder, T. M., Bakken, K., Glaum, J., Einarsrud, M. A., and Grande, T.

Subjects
*BARIUM titanate films, *CHEMICAL solution deposition, *FERROELECTRICITY
Abstract

Ferroelectric BaTiO3 is widely used in capacitors, but the low Curie temperature limits a further use of BaTiO3. In this work we present an aqueous chemical solution deposition (CSD) route for BaTiO3 thin films, demonstrating that organic solvents are not required for CSD. Textured BaTiO3 thin films were deposited on SrTiO3 substrates. The in-plane dielectric properties were investigated using interdigitated electrodes and ferroelectric switching was observed up to 160±5 °C. The increased Curie temperature is proposed to result from thermal strain due to a mismatch in thermal expansion coefficient between the film and the substrate, and is in good agreement with the theory of strain engineering in BaTiO3. Finally, the decomposition and crystallization of BaTiO3 during thermal treatment were determined by the combination of thermal analysis, IR spectroscopy and X-ray diffraction of powder prepared from the solution. [ABSTRACT FROM AUTHOR]

Published
2018
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20. Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Tsilidis, K. K. Allen, N. E. Key, T. J. Dossus, L. and Lukanova, A. Bakken, K. Lund, E. Fournier, A. Overvad, K. Hansen, L. Tjonneland, A. Fedirko, V. Rinaldi, S. and Romieu, I. Clavel-Chapelon, F. Engel, P. Kaaks, R. and Schuetze, M. Steffen, A. Bamia, C. Trichopoulou, A. and Zylis, D. Masala, G. Pala, V. Galasso, R. Tumino, R. and Sacerdote, C. Bueno-de-Mesquita, H. B. van Duijnhoven, F. J. B. and Braem, M. G. M. Onland-Moret, N. C. Gram, I. T. and Rodriguez, L. Travier, N. Sanchez, M-J Huerta, J. M. and Ardanaz, E. Larranaga, N. Jirstrom, K. Manjer, J. Idahl, A. Ohlson, N. Khaw, K-T Wareham, N. Mouw, T. Norat, T. Riboli, E.

Abstract

BACKGROUND: It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear. METHODS: We examined the associations of oral contraceptive use and reproductive factors with ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 327 396 eligible women, 878 developed ovarian cancer over an average of 9 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre and age, and adjusted for smoking status, body mass index, unilateral ovariectomy, simple hysterectomy, menopausal hormone therapy, and mutually adjusted for age at menarche, age at menopause, number of full-term pregnancies and duration of oral contraceptive use. RESULTS: Women who used oral contraceptives for 10 or more years had a significant 45% (HR, 0.55; 95% CI, 0.41-0.75) lower risk compared with users of 1 year or less (P-trend, 52 vs

Published
2011

21. Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Tsilidis, K. K. Allen, N. E. Key, T. J. Bakken, K. Lund, E. Berrino, F. Fournier, A. Olsen, A. Tjonneland, A. and Overvad, K. Boutron-Ruault, M-C Clavel-Chapelon, F. Byrnes, G. Chajes, V. Rinaldi, S. Chang-Claude, J. Kaaks, R. and Bergmann, M. Boeing, H. Koumantaki, Y. Stasinopoulou, G. and Trichopoulou, A. Palli, D. Tagliabue, G. Panico, S. and Tumino, R. Vineis, P. Bueno-de-Mesquita, H. B. van Duijnhoven, F. J. B. van Gils, C. H. Peeters, P. H. M. and Rodriguez, L. Gonzalez, C. A. Sanchez, M-J Chirlaque, M-D and Barricarte, A. Dorronsoro, M. Borgquist, S. Manjer, J. and van Guelpen, B. Hallmans, G. Rodwell, S. A. Khaw, K-T and Norat, T. Romaguera, D. Riboli, E.

Abstract

BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK

Published
2010

22. Laser Doppler Flowmetar u oralnoj kirurgiji - prikaz slučaja

Author

Zajc, Ivan, Macan, Darko, Siber, Stjepan, Brajdić, Davor, Bakken, B, and Bakken, K

Subjects
oralna kirurgija, laser dopler flowmetar
Abstract

Laser doppler flowmetar (LDF) je uređaj za procjenu dinamičkog protoka krvi u tijelu putem mjerenja kretanja eritrocita unutar tkiva. Laserska zraka određene valne duljine udara u putujući eritrocit što stvara dopplerski pomak frekvencije odbijenog svjetla kojeg registrira receptor. LDF u oralnoj kirurgiji se koristi za mjerenje perfuzije zuba, gingive, sluznice usne šupljine, kosti i žvačnih mišića. Rađena su istraživanja LDF-om s ciljem određivanja vitaliteta zuba nakon traume zuba ili autotransplantacije ; proučavanja utjecaja lokalnih i sistemskih lijekova ; gledanja pulpnog odgovora na ortognatske zahvate ; pratila se vaskularizacija koštanih transplantata prilikom podizanja dna maksilarnog sinusa. Prikazan je slučaj autotransplantacije zuba koji pokazuje kliničku primjenu i vrijednost LDF-a (PeriFux System 5000, Perimed AB, Stockholm, Švedska) kao ključne metode prilikom dijagnosticiranja vitalnosti zuba. Procjena vitalnosti zuba LDF- om je osjetljivija i bezbolna za pacijenta za razliku od dostupnih metoda električnog ili toplinskog ispitivanja senzibiliteta zuba. Naime zubi koji ne reagiraju na električni ili termički podražaj se smatraju avitalnima te se često nepotrebno endodontski liječe. Senzibilitet pulpe ne odražava uvijek i vitalitet pulpe, on uvijek odražava samo očuvanost senzoričkih živaca. Stoga pojmovi vitalitet i senzibilitet ne bi se smjeli koristiti kao istoznačnice.

Published
2009

27. Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Tsilidis, K. K., Allen, N. E., Key, T. J., Dossus, L., Lukanova, A., Bakken, K., Lund, E., Fournier, A., Overvad, K., Hansen, L., Tjonneland, A., Fedirko, V., Rinaldi, S., Romieu, I., Clavel-Chapelon, F., Engel, P., Kaaks, R., Schuetze, M., Steffen, A., Bamia, C., Trichopoulou, A., Zylis, D., Masala, G., Pala, V., Galasso, R., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H. B., van Duijnhoven, F. J. B., Braem, M. G. M., Onland-Moret, N. C., Gram, I. T., Rodriguez, L., Travier, N., Sanchez, M-J, Huerta, J. M., Ardanaz, E., Larranaga, N., Jirstrom, K., Manjer, J., Idahl, Annika, Ohlson, Nina, Khaw, K-T, Wareham, N., Mouw, T., Norat, T., Riboli, E., Tsilidis, K. K., Allen, N. E., Key, T. J., Dossus, L., Lukanova, A., Bakken, K., Lund, E., Fournier, A., Overvad, K., Hansen, L., Tjonneland, A., Fedirko, V., Rinaldi, S., Romieu, I., Clavel-Chapelon, F., Engel, P., Kaaks, R., Schuetze, M., Steffen, A., Bamia, C., Trichopoulou, A., Zylis, D., Masala, G., Pala, V., Galasso, R., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H. B., van Duijnhoven, F. J. B., Braem, M. G. M., Onland-Moret, N. C., Gram, I. T., Rodriguez, L., Travier, N., Sanchez, M-J, Huerta, J. M., Ardanaz, E., Larranaga, N., Jirstrom, K., Manjer, J., Idahl, Annika, Ohlson, Nina, Khaw, K-T, Wareham, N., Mouw, T., Norat, T., and Riboli, E.

Abstract

BACKGROUND: It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear. METHODS: We examined the associations of oral contraceptive use and reproductive factors with ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 327 396 eligible women, 878 developed ovarian cancer over an average of 9 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre and age, and adjusted for smoking status, body mass index, unilateral ovariectomy, simple hysterectomy, menopausal hormone therapy, and mutually adjusted for age at menarche, age at menopause, number of full-term pregnancies and duration of oral contraceptive use. RESULTS: Women who used oral contraceptives for 10 or more years had a significant 45% (HR, 0.55; 95% CI, 0.41-0.75) lower risk compared with users of 1 year or less (P-trend, <0.01). Compared with nulliparous women, parous women had a 29% (HR, 0.71; 95% CI, 0.59-0.87) lower risk, with an 8% reduction in risk for each additional pregnancy. A high age at menopause was associated with a higher risk of ovarian cancer (>52 vs <= 45 years: HR, 1.46; 95% CI, 1.06-1.99; P-trend, 0.02). Age at menarche, age at first full-term pregnancy, incomplete pregnancies and breastfeeding were not associated with risk. CONCLUSION: This study shows a strong protective association of oral contraceptives and parity with ovarian cancer risk, a higher risk with a late age at menopause, and no association with other reproductive factors. British Journal of Cancer (2011) 105, 1436-1442. doi:10.1038/bjc.2011.371 www.bjcancer.com Published online 13 September 2011 (C) 2011 Cancer Research UK

Published
2011
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28. Oral contraceptives, reproductive history and risk of colorectal cancer in the European prospective investigation into cancer and nutrition

Author

Tsilidis, K K, Allen, N E, Key, T J, Bakken, K, Lund, E, Berrino, F, Fournier, A, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Byrnes, G, Chajes, V, Rinaldi, S, Chang-Claude, J, Kaaks, R, Bergmann, M, Boeing, H, Koumantaki, Y, Stasinopoulou, G, Trichopoulou, A, Palli, D, Tagliabue, G, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, van Gils, C H, Peeters, P H M, Rodríguez, L, González, C A, Sánchez, M-J, Chirlaque, M-D, Barricarte, A, Dorronsoro, M, Borgquist, S, Manjer, J, van Guelpen, Bethany, Hallmans, Göran, Rodwell, S A, Khaw, K-T, Norat, T, Romaguera, D, Riboli, E, Tsilidis, K K, Allen, N E, Key, T J, Bakken, K, Lund, E, Berrino, F, Fournier, A, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Byrnes, G, Chajes, V, Rinaldi, S, Chang-Claude, J, Kaaks, R, Bergmann, M, Boeing, H, Koumantaki, Y, Stasinopoulou, G, Trichopoulou, A, Palli, D, Tagliabue, G, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, van Gils, C H, Peeters, P H M, Rodríguez, L, González, C A, Sánchez, M-J, Chirlaque, M-D, Barricarte, A, Dorronsoro, M, Borgquist, S, Manjer, J, van Guelpen, Bethany, Hallmans, Göran, Rodwell, S A, Khaw, K-T, Norat, T, Romaguera, D, and Riboli, E

Abstract

Background:Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. Methods:We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. Results:After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. Conclusion:Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk.

Published
2010
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29. Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study.

Author

Michaud, D.S., Gallo, V., Schlehofer, B., Tjonneland, A., Olsen, A., Overvad, K., Dahm, C.C., Kaaks, R., Lukanova, A., Boeing, H., Schutze, M., Trichopoulou, A., Bamia, C., Kyrozis, A., Sacerdote, C., Agnoli, C., Palli, D., Tumino, R., Mattiello, A., Bueno-De-Mesquita, H.B., Ros, M.M., Peeters, P.H.M., Gils, C.H. van, Lund, E., Bakken, K., Gram, I.T., Barricarte, A., Navarro, C, Dorronsoro, M., Sanchez, M.J., Rodriguez, L., Duell, E.J., Hallmans, G., Melin, B.S., Manjer, J., Borgquist, S., Khaw, K.T., Wareham, N., Allen, N.E., Tsilidis, K.K., Romieu, I., Rinaldi, S., Vineis, P., Riboli, E., Michaud, D.S., Gallo, V., Schlehofer, B., Tjonneland, A., Olsen, A., Overvad, K., Dahm, C.C., Kaaks, R., Lukanova, A., Boeing, H., Schutze, M., Trichopoulou, A., Bamia, C., Kyrozis, A., Sacerdote, C., Agnoli, C., Palli, D., Tumino, R., Mattiello, A., Bueno-De-Mesquita, H.B., Ros, M.M., Peeters, P.H.M., Gils, C.H. van, Lund, E., Bakken, K., Gram, I.T., Barricarte, A., Navarro, C, Dorronsoro, M., Sanchez, M.J., Rodriguez, L., Duell, E.J., Hallmans, G., Melin, B.S., Manjer, J., Borgquist, S., Khaw, K.T., Wareham, N., Allen, N.E., Tsilidis, K.K., Romieu, I., Rinaldi, S., Vineis, P., and Riboli, E.

Abstract

1 oktober 2010, Contains fulltext : 89404.pdf (publisher's version ) (Closed access), BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.

Published
2010

30. EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Author

Aaberg-Jessen, C., primary, Fogh, L., additional, Halle, B., additional, Jensen, V., additional, Brunner, N., additional, Kristensen, B. W., additional, Abe, T., additional, Momii, Y., additional, Watanabe, J., additional, Morisaki, I., additional, Natsume, A., additional, Wakabayashi, T., additional, Fujiki, M., additional, Aldaz, B., additional, Fabius, A. W. M., additional, Silber, J., additional, Harinath, G., additional, Chan, T. A., additional, Huse, J. T., additional, Anai, S., additional, Hide, T., additional, Nakamura, H., additional, Makino, K., additional, Yano, S., additional, Kuratsu, J.-i., additional, Balyasnikova, I. V., additional, Prasol, M. S., additional, Kanoija, D. K., additional, Aboody, K. S., additional, Lesniak, M. S., additional, Barone, T., additional, Burkhart, C., additional, Purmal, A., additional, Gudkov, A., additional, Gurova, K., additional, Plunkett, R., additional, Barton, K., additional, Misuraca, K., additional, Cordero, F., additional, Dobrikova, E., additional, Min, H., additional, Gromeier, M., additional, Kirsch, D., additional, Becher, O., additional, Pont, L. B., additional, Kloezeman, J., additional, van den Bent, M., additional, Kanaar, R., additional, Kremer, A., additional, Swagemakers, S., additional, French, P., additional, Dirven, C., additional, Lamfers, M., additional, Leenstra, S., additional, Balvers, R., additional, Kleijn, A., additional, Lawler, S., additional, Gong, X., additional, Andres, A., additional, Hanson, J., additional, Delashaw, J., additional, Bota, D., additional, Chen, C.-C., additional, Yao, N.-W., additional, Chuang, W.-J., additional, Chang, C., additional, Chen, P.-Y., additional, Huang, C.-Y., additional, Wei, K.-C., additional, Cheng, Y., additional, Dai, Q., additional, Morshed, R., additional, Han, Y., additional, Auffinger, B., additional, Wainwright, D., additional, Zhang, L., additional, Tobias, A., additional, Rincon, E., additional, Thaci, B., additional, Ahmed, A., additional, He, C., additional, Lesniak, M., additional, Choi, Y. A., additional, Pandya, H., additional, Gibo, D. M., additional, Fokt, I., additional, Priebe, W., additional, Debinski, W., additional, Chornenkyy, Y., additional, Agnihotri, S., additional, Buczkowicz, P., additional, Rakopoulos, P., additional, Morrison, A., additional, Barszczyk, M., additional, Hawkins, C., additional, Chung, S., additional, Decollogne, S., additional, Luk, P., additional, Shen, H., additional, Ha, W., additional, Day, B., additional, Stringer, B., additional, Hogg, P., additional, Dilda, P., additional, McDonald, K., additional, Moore, S., additional, Hayden-Gephart, M., additional, Bergen, J., additional, Su, Y., additional, Rayburn, H., additional, Edwards, M., additional, Scott, M., additional, Cochran, J., additional, Das, A., additional, Varma, A. K., additional, Wallace, G. C., additional, Dixon-Mah, Y. N., additional, Vandergrift, W. A., additional, Giglio, P., additional, Ray, S. K., additional, Patel, S. J., additional, Banik, N. L., additional, Dasgupta, T., additional, Olow, A., additional, Yang, X., additional, Mueller, S., additional, Prados, M., additional, James, C. D., additional, Haas-Kogan, D., additional, Dave, N. D., additional, Desai, P. B., additional, Gudelsky, G. A., additional, Chow, L. M. L., additional, LaSance, K., additional, Qi, X., additional, Driscoll, J., additional, Ebsworth, K., additional, Walters, M. J., additional, Ertl, L. S., additional, Wang, Y., additional, Berahovic, R. D., additional, McMahon, J., additional, Powers, J. P., additional, Jaen, J. C., additional, Schall, T. J., additional, Eroglu, Z., additional, Portnow, J., additional, Sacramento, A., additional, Garcia, E., additional, Raubitschek, A., additional, Synold, T., additional, Esaki, S., additional, Rabkin, S., additional, Martuza, R., additional, Wakimoto, H., additional, Ferluga, S., additional, Tome, C. L., additional, Forde, H. E., additional, Netland, I. A., additional, Sleire, L., additional, Skeie, B., additional, Enger, P. O., additional, Goplen, D., additional, Giladi, M., additional, Tichon, A., additional, Schneiderman, R., additional, Porat, Y., additional, Munster, M., additional, Dishon, M., additional, Weinberg, U., additional, Kirson, E., additional, Wasserman, Y., additional, Palti, Y., additional, Gramatzki, D., additional, Staudinger, M., additional, Frei, K., additional, Peipp, M., additional, Weller, M., additional, Grasso, C., additional, Liu, L., additional, Berlow, N., additional, Davis, L., additional, Fouladi, M., additional, Gajjar, A., additional, Huang, E., additional, Hulleman, E., additional, Hutt, M., additional, Keller, C., additional, Li, X.-N., additional, Meltzer, P., additional, Quezado, M., additional, Quist, M., additional, Raabe, E., additional, Spellman, P., additional, Truffaux, N., additional, van Vurden, D., additional, Wang, N., additional, Warren, K., additional, Pal, R., additional, Grill, J., additional, Monje, M., additional, Green, A. L., additional, Ramkissoon, S., additional, McCauley, D., additional, Jones, K., additional, Perry, J. A., additional, Ramkissoon, L., additional, Maire, C., additional, Shacham, S., additional, Ligon, K. L., additional, Kung, A. L., additional, Zielinska-Chomej, K., additional, Grozman, V., additional, Tu, J., additional, Viktorsson, K., additional, Lewensohn, R., additional, Gupta, S., additional, Mladek, A., additional, Bakken, K., additional, Carlson, B., additional, Boakye-Agyeman, F., additional, Kizilbash, S., additional, Schroeder, M., additional, Reid, J., additional, Sarkaria, J., additional, Hadaczek, P., additional, Ozawa, T., additional, Soroceanu, L., additional, Yoshida, Y., additional, Matlaf, L., additional, Singer, E., additional, Fiallos, E., additional, Cobbs, C. S., additional, Hashizume, R., additional, Tom, M., additional, Ihara, Y., additional, Santos, R., additional, Torre, J. D. L., additional, Lepe, E., additional, Waldman, T., additional, James, D., additional, Huang, X., additional, Yu-Jen, L., additional, Gupta, N., additional, Solomon, D., additional, Zhang, Z., additional, Hayashi, T., additional, Adachi, K., additional, Nagahisa, S., additional, Hasegawa, M., additional, Hirose, Y., additional, Gephart, M. H., additional, Su, Y. S., additional, Hingtgen, S., additional, Kasmieh, R., additional, Nesterenko, I., additional, Figueiredo, J.-L., additional, Dash, R., additional, Sarkar, D., additional, Fisher, P., additional, Shah, K., additional, Horne, E., additional, Diaz, P., additional, Stella, N., additional, Huang, C., additional, Yang, H., additional, Wei, K., additional, Huang, T., additional, Hlavaty, J., additional, Ostertag, D., additional, Espinoza, F. L., additional, Martin, B., additional, Petznek, H., additional, Rodriguez-Aguirre, M., additional, Ibanez, C., additional, Kasahara, N., additional, Gunzburg, W., additional, Gruber, H., additional, Pertschuk, D., additional, Jolly, D., additional, Robbins, J., additional, Hurwitz, B., additional, Yoo, J. Y., additional, Bolyard, C., additional, Yu, J.-G., additional, Wojton, J., additional, Zhang, J., additional, Bailey, Z., additional, Eaves, D., additional, Cripe, T., additional, Old, M., additional, Kaur, B., additional, Serwer, L., additional, Le Moan, N., additional, Ng, S., additional, Butowski, N., additional, Krtolica, A., additional, Cary, S. P. L., additional, Johns, T., additional, Greenall, S., additional, Donoghue, J., additional, Adams, T., additional, Karpel-Massler, G., additional, Westhoff, M.-A., additional, Kast, R. E., additional, Dwucet, A., additional, Wirtz, C. R., additional, Debatin, K.-M., additional, Halatsch, M.-E., additional, Merkur, N., additional, Kievit, F., additional, Stephen, Z., additional, Wang, K., additional, Kolstoe, D., additional, Ellenbogen, R., additional, Zhang, M., additional, Kitange, G., additional, Haefner, E., additional, Knubel, K., additional, Pernu, B. M., additional, Sufit, A., additional, Pierce, A. M., additional, Nelson, S. K., additional, Keating, A. K., additional, Jensen, S. S., additional, Lachowicz, J., additional, Demeule, M., additional, Regina, A., additional, Tripathy, S., additional, Curry, J.-C., additional, Nguyen, T., additional, Castaigne, J.-P., additional, Davis, T., additional, Davis, A., additional, Tanaka, K., additional, Keating, T., additional, Getz, J., additional, Kapp, G. T., additional, Romero, J. M., additional, Lee, S., additional, Ramisetti, S., additional, Slagle-Webb, B., additional, Sharma, A., additional, Connor, J., additional, Lee, W.-S., additional, Kluk, M., additional, Aster, J. C., additional, Ligon, K., additional, Sun, S., additional, Lee, D., additional, Ho, A. S. W., additional, Pu, J. K. S., additional, Zhang, Z.-q., additional, Lee, N. P., additional, Day, P. J. R., additional, Leung, G. K. K., additional, Liu, Z., additional, Liu, X., additional, Madhankumar, A. B., additional, Miller, P., additional, Webb, B., additional, Connor, J. R., additional, Yang, Q. X., additional, Lobo, M., additional, Green, S., additional, Schabel, M., additional, Gillespie, Y., additional, Woltjer, R., additional, Pike, M., additional, Lu, Y.-J., additional, Luchman, H. A., additional, Stechishin, O., additional, Nguyen, S., additional, Cairncross, J. G., additional, Weiss, S., additional, Lun, X., additional, Wells, J. C., additional, Hao, X., additional, Grinshtein, N., additional, Kaplan, D., additional, Luchman, A., additional, Senger, D., additional, Robbins, S., additional, Madhankumar, A., additional, Rizk, E., additional, Payne, R., additional, Park, A., additional, Pang, M., additional, Harbaugh, K., additional, Wilisch-Neumann, A., additional, Pachow, D., additional, Kirches, E., additional, Mawrin, C., additional, McDonell, S., additional, Liang, J., additional, Piao, Y., additional, Nguyen, N., additional, Yung, A., additional, Verhaak, R., additional, Sulman, E., additional, Stephan, C., additional, Lang, F., additional, de Groot, J., additional, Mizobuchi, Y., additional, Okazaki, T., additional, Kageji, T., additional, Kuwayama, K., additional, Kitazato, K. T., additional, Mure, H., additional, Hara, K., additional, Morigaki, R., additional, Matsuzaki, K., additional, Nakajima, K., additional, Nagahiro, S., additional, Kumala, S., additional, Heravi, M., additional, Devic, S., additional, Muanza, T., additional, Knubel, K. H., additional, Neuwelt, A., additional, Wu, Y. J., additional, Donson, A., additional, Vibhakar, R., additional, Venkatamaran, S., additional, Amani, V., additional, Neuwelt, E., additional, Rapkin, L., additional, Foreman, N., additional, Ibrahim, F., additional, New, P., additional, Cui, K., additional, Zhao, H., additional, Chow, D., additional, Stephen, W., additional, Nozue-Okada, K., additional, Nagane, M., additional, McDonald, K. L., additional, Ogawa, D., additional, Chiocca, E., additional, Godlewski, J., additional, Patel, A., additional, Pasupuleti, N., additional, Gorin, F., additional, Valenzuela, A., additional, Leon, L., additional, Carraway, K., additional, Ramachandran, C., additional, Nair, S., additional, Quirrin, K.-W., additional, Khatib, Z., additional, Escalon, E., additional, Melnick, S., additional, Phillips, A., additional, Boghaert, E., additional, Vaidya, K., additional, Ansell, P., additional, Shalinsky, D., additional, Zhang, Y., additional, Voorbach, M., additional, Mudd, S., additional, Holen, K., additional, Humerickhouse, R., additional, Reilly, E., additional, Parab, S., additional, Diago, O., additional, Ryken, T., additional, Agarwal, S., additional, Al-Keilani, M., additional, Alqudah, M., additional, Sibenaller, Z., additional, Assemolt, M., additional, Sai, K., additional, Li, W.-y., additional, Li, W.-p., additional, Chen, Z.-p., additional, Saito, R., additional, Sonoda, Y., additional, Kanamori, M., additional, Yamashita, Y., additional, Kumabe, T., additional, Tominaga, T., additional, Sarkar, G., additional, Curran, G., additional, Jenkins, R., additional, Scharnweber, R., additional, Kato, Y., additional, Lin, J., additional, Everson, R., additional, Soto, H., additional, Kruse, C., additional, Liau, L., additional, Prins, R., additional, Semenkow, S., additional, Chu, Q., additional, Eberhart, C., additional, Sengupta, R., additional, Marassa, J., additional, Piwnica-Worms, D., additional, Rubin, J., additional, Shai, R., additional, Pismenyuk, T., additional, Moshe, I., additional, Fisher, T., additional, Freedman, S., additional, Simon, A., additional, Amariglio, N., additional, Rechavi, G., additional, Toren, A., additional, Yalon, M., additional, Shimazu, Y., additional, Kurozumi, K., additional, Ichikawa, T., additional, Fujii, K., additional, Onishi, M., additional, Ishida, J., additional, Oka, T., additional, Watanabe, M., additional, Nasu, Y., additional, Kumon, H., additional, Date, I., additional, Sirianni, R. W., additional, McCall, R. L., additional, Spoor, J., additional, van der Kaaij, M., additional, Geurtjens, M., additional, Veiseh, O., additional, Fang, C., additional, Leung, M., additional, Strohbehn, G., additional, Atsina, K.-K., additional, Patel, T., additional, Piepmeier, J., additional, Zhou, J., additional, Saltzman, W. M., additional, Takahashi, M., additional, Valdes, G., additional, Inagaki, A., additional, Kamijima, S., additional, Hiraoka, K., additional, Micewicz, E., additional, McBride, W. H., additional, Iwamoto, K. S., additional, Gruber, H. E., additional, Robbins, J. M., additional, Jolly, D. J., additional, McCully, C., additional, Bacher, J., additional, Thomas, T., additional, Murphy, R., additional, Steffen-Smith, E., additional, McAllister, R., additional, Pastakia, D., additional, Widemann, B., additional, Chen, P., additional, Hua, M., additional, Liu, H., additional, Woolf, E. C., additional, Abdelwahab, M. G., additional, Fenton, K. E., additional, Liu, Q., additional, Turner, G., additional, Preul, M. C., additional, Scheck, A. C., additional, Shen, W., additional, Brown, D., additional, Pedersen, H., additional, Hariono, S., additional, Yao, T.-W., additional, Sidhu, A., additional, Weiss, W. A., additional, Nicolaides, T. P., additional, and Olusanya, T., additional

Published
2013
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31. LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY

Author

Yang, F. H., primary, Zhang, B., additional, Zhou, D. J., additional, Bie, L., additional, Tom, M. W., additional, Drummond, D. C., additional, Nicolaides, T., additional, Mueller, S., additional, Banerjee, A., additional, Park, J. W., additional, Prados, M. D., additional, James, D. C., additional, Gupta, N., additional, Hashizume, R., additional, Strohbehn, G. W., additional, Zhou, J., additional, Fu, M., additional, Patel, T. R., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Xie, Q., additional, Johnson, J., additional, Bradley, R., additional, Ascierto, M. L., additional, Kang, L., additional, Koeman, J., additional, Marincola, F. M., additional, Briggs, M., additional, Tanner, K., additional, Vande Woude, G. F., additional, Tanaka, S., additional, Klofas, L. K., additional, Wakimoto, H., additional, Borger, D. R., additional, Iafrate, A. J., additional, Batchelor, T. T., additional, Chi, A. S., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Rizk, E., additional, Harbaugh, K., additional, Connor, J. R., additional, Sarkar, G., additional, Curran, G. L., additional, Jenkins, R. B., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Fujii, K., additional, Ishida, J., additional, Shimazu, Y., additional, Date, I., additional, Ebsworth, K., additional, Walters, M. J., additional, Ertl, L. S., additional, Wang, Y., additional, Berahovich, R. D., additional, Zhang, P., additional, Powers, J. P., additional, Liu, S.-C., additional, Al Omran, R., additional, Sullivan, T. J., additional, Jaen, J. C., additional, Brown, M., additional, Schall, T. J., additional, Yusuke, N., additional, Shimizu, S., additional, Shishido-Hara, Y., additional, Shiokawa, Y., additional, Nagane, M., additional, Wang, J., additional, Sai, K., additional, Chen, F.-R., additional, Chen, Z.-P., additional, Shi, Z., additional, Zhang, J., additional, Zhang, K., additional, Han, L., additional, Chen, L., additional, Qian, X., additional, Zhang, A., additional, Wang, G., additional, Jia, Z., additional, Pu, P., additional, Kang, C., additional, Kong, L.-Y., additional, Doucette, T. A., additional, Ferguson, S. D., additional, Hachem, J., additional, Yang, Y., additional, Wei, J., additional, Priebe, W., additional, Fuller, G. N., additional, Qiao, W., additional, Rao, G., additional, Heimberger, A. B., additional, Chen, P.-Y., additional, Ozawa, T., additional, Drummond, D., additional, Santos, R., additional, Torre, J. D., additional, Ng, C., additional, Lepe, E. L., additional, Butowski, N., additional, Prados, M., additional, Bankiewicz, K., additional, James, C. D., additional, Cheng, Z., additional, Gong, Y., additional, Ma, Y., additional, Muller-Knapp, S., additional, Knapp, S., additional, Antonio Chiocca, E., additional, Kaur, B., additional, Yu, J. S., additional, Judkowski, V., additional, Bunying, A., additional, Ji, J., additional, Li, Z., additional, Bender, J., additional, Pinilla, C., additional, Srinivasan, V., additional, Dombovy-Johnson, M., additional, Carson-Walter, E., additional, Walter, K., additional, Xu, Z., additional, Popp, B., additional, Schlesinger, D., additional, Gray, L., additional, Sheehan, J., additional, Keir, S. T., additional, Friedman, H. S., additional, Bigner, D. D., additional, Kut, C., additional, Tyler, B., additional, McVeigh, E., additional, Li, X., additional, Herzka, D., additional, Grossman, S., additional, Lasky, J. L., additional, Panosyan, E., additional, Meisen, W. H., additional, Hardcastle, J., additional, Wojton, J., additional, Wohleb, E., additional, Alvarez-Breckenridge, C., additional, Nowicki, M., additional, Godbout, J., additional, Lee, S. Y., additional, Sheehan, J. M., additional, Yin, S., additional, Kaluz, S., additional, Devi, S. N., additional, de Noronha, R., additional, Nicolaou, K. C., additional, Van Meir, E. G., additional, Lachowicz, J. E., additional, Demeule, M., additional, Che, C., additional, Tripathy, S., additional, Jarvis, S., additional, Currie, J.-C., additional, Regina, A., additional, Nguyen, T., additional, Castaigne, J.-P., additional, Zielinska-Chomej, K., additional, Mohanty, C., additional, Viktorsson, K., additional, Lewensohn, R., additional, Driscoll, J. J., additional, Alsidawi, S., additional, Warnick, R. E., additional, Rixe, O., additional, deCarvalho, A. C., additional, Irtenkauf, S., additional, Hasselbach, L., additional, Xin, H., additional, Mikkelsen, T., additional, Sherman, J. H., additional, Siu, A., additional, Volotskova, O., additional, Keidar, M., additional, Gibo, D. M., additional, Dickinson, P., additional, Robertson, J., additional, Rossmeisl, J., additional, Debinski, W., additional, Nair, S., additional, Schmittling, R., additional, Boczkowski, D., additional, Archer, G., additional, Sampson, J. H., additional, Mitchell, D. A., additional, Miller, I. S., additional, Didier, S., additional, Murray, D. W., additional, Issaivanan, M., additional, Coniglio, S. J., additional, Segall, J. E., additional, Al-Abed, Y., additional, Symons, M., additional, Fotovati, A., additional, Hu, K., additional, Triscott, J., additional, Bacha, J., additional, Brown, D. M., additional, Dunn, S. E., additional, Daniels, D. J., additional, Peterson, T. E., additional, Dietz, A. B., additional, Knutson, G. J., additional, Parney, I. F., additional, Diaz, R. J., additional, Golbourn, B., additional, Picard, D., additional, Smith, C., additional, Huang, A., additional, Rutka, J., additional, Saito, N., additional, Fu, J., additional, Yao, J., additional, Wang, S., additional, Koul, D., additional, Yung, W. K. A., additional, Yuan, Y., additional, Sulman, E. P., additional, Colman, H., additional, Lang, F. F., additional, Slat, E. A., additional, Herzog, E. D., additional, Rubin, J. B., additional, Carminucci, A. S., additional, Amendolara, B., additional, Leung, R., additional, Lei, L., additional, Canoll, P., additional, Bruce, J. N., additional, Wojton, J. A., additional, Chu, Z., additional, Kwon, C.-H., additional, Chow, L. M., additional, Palascak, M., additional, Franco, R., additional, Bourdeau, T., additional, Thornton, S., additional, Qi, X., additional, Kitange, G. J., additional, Mladek, A. C., additional, Su, D., additional, Carlson, B. L., additional, Schroeder, M. A., additional, Pokorny, J. L., additional, Bakken, K. K., additional, Gupta, S. K., additional, Decker, P. A., additional, Wu, W., additional, Sarkaria, J. N., additional, Oddou, M. P., additional, Mollard, A., additional, Call, L. T., additional, Vakayalapati, H., additional, Warner, S. L., additional, Sharma, S., additional, Bearss, D. J., additional, Chen, T. C., additional, Cho, H., additional, Wang, W., additional, Hofman, F. M., additional, Flores, C. T., additional, Snyder, D., additional, Sanchez-Perez, L., additional, Pham, C., additional, Friedman, H., additional, Woolf, E., additional, Abdelwahab, M. G., additional, Turner, G., additional, Preul, M. C., additional, Lynch, A., additional, Rho, J. M., additional, Scheck, A. C., additional, Salphati, L., additional, Heffron, T. P., additional, Alicke, B., additional, Barck, K., additional, Carano, R. A., additional, Cheong, J., additional, Greve, J., additional, Lee, L. B., additional, Nishimura, M., additional, Pang, J., additional, Plise, E. G., additional, Reslan, H. B., additional, Zhang, X., additional, GOuld, S. G., additional, Olivero, A. G., additional, Phillips, H. S., additional, Zadeh, G., additional, Jalali, S., additional, Voce, D., additional, Wei, Z., additional, Shijun, K., additional, Nikolai, K., additional, Josh, W., additional, Clayton, C., additional, Bakhtiar, Y., additional, Alkins, R., additional, Burgess, A., additional, Ganguly, M., additional, Wels, W., additional, Hynynen, K., additional, Li, Y. M., additional, Jun, H., additional, Daniel, V., additional, Walter, H. A., additional, Nakashima, H., additional, Nguyen, T. T., additional, Shalkh, I., additional, Goins, W. F., additional, Chiocca, E. A., additional, Pyko, I. V., additional, Nakada, M., additional, Furuyama, N., additional, Lei, T., additional, Hayashi, Y., additional, Kawakami, K., additional, Minamoto, T., additional, Fedulau, A. S., additional, and Hamada, J.-i., additional

Published
2012
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33. Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Tsilidis, K K, primary, Allen, N E, additional, Key, T J, additional, Dossus, L, additional, Lukanova, A, additional, Bakken, K, additional, Lund, E, additional, Fournier, A, additional, Overvad, K, additional, Hansen, L, additional, Tjønneland, A, additional, Fedirko, V, additional, Rinaldi, S, additional, Romieu, I, additional, Clavel-Chapelon, F, additional, Engel, P, additional, Kaaks, R, additional, Schütze, M, additional, Steffen, A, additional, Bamia, C, additional, Trichopoulou, A, additional, Zylis, D, additional, Masala, G, additional, Pala, V, additional, Galasso, R, additional, Tumino, R, additional, Sacerdote, C, additional, Bueno-de-Mesquita, H B, additional, van Duijnhoven, F J B, additional, Braem, M G M, additional, Onland-Moret, N C, additional, Gram, I T, additional, Rodríguez, L, additional, Travier, N, additional, Sánchez, M-J, additional, Huerta, J M, additional, Ardanaz, E, additional, Larrañaga, N, additional, Jirström, K, additional, Manjer, J, additional, Idahl, A, additional, Ohlson, N, additional, Khaw, K-T, additional, Wareham, N, additional, Mouw, T, additional, Norat, T, additional, and Riboli, E, additional

Published
2011
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34. Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Tsilidis, K K, primary, Allen, N E, additional, Key, T J, additional, Bakken, K, additional, Lund, E, additional, Berrino, F, additional, Fournier, A, additional, Olsen, A, additional, Tjønneland, A, additional, Overvad, K, additional, Boutron-Ruault, M-C, additional, Clavel-Chapelon, F, additional, Byrnes, G, additional, Chajes, V, additional, Rinaldi, S, additional, Chang-Claude, J, additional, Kaaks, R, additional, Bergmann, M, additional, Boeing, H, additional, Koumantaki, Y, additional, Stasinopoulou, G, additional, Trichopoulou, A, additional, Palli, D, additional, Tagliabue, G, additional, Panico, S, additional, Tumino, R, additional, Vineis, P, additional, Bueno-de-Mesquita, H B, additional, van Duijnhoven, F J B, additional, van Gils, C H, additional, Peeters, P H M, additional, Rodríguez, L, additional, González, C A, additional, Sánchez, M-J, additional, Chirlaque, M-D, additional, Barricarte, A, additional, Dorronsoro, M, additional, Borgquist, S, additional, Manjer, J, additional, van Guelpen, B, additional, Hallmans, G, additional, Rodwell, S A, additional, Khaw, K-T, additional, Norat, T, additional, Romaguera, D, additional, and Riboli, E, additional

Published
2010
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35. Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition

Author

Allen, N. E., primary, Tsilidis, K. K., additional, Key, T. J., additional, Dossus, L., additional, Kaaks, R., additional, Lund, E., additional, Bakken, K., additional, Gavrilyuk, O., additional, Overvad, K., additional, Tjonneland, A., additional, Olsen, A., additional, Fournier, A., additional, Fabre, A., additional, Clavel-Chapelon, F., additional, Chabbert-Buffet, N., additional, Sacerdote, C., additional, Krogh, V., additional, Bendinelli, B., additional, Tumino, R., additional, Panico, S., additional, Bergmann, M., additional, Schuetze, M., additional, van Duijnhoven, F. J. B., additional, Bas Bueno-de-Mesquita, H., additional, Charlotte Onland-Moret, N., additional, van Gils, C. H., additional, Amiano, P., additional, Barricarte, A., additional, Chirlaque, M.-D., additional, Molina-Montes, M.-E., additional, Redondo, M.-L., additional, Duell, E. J., additional, Khaw, K.-T., additional, Wareham, N., additional, Rinaldi, S., additional, Fedirko, V., additional, Mouw, T., additional, Michaud, D. S., additional, and Riboli, E., additional

Published
2010
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46. In situX-ray diffraction studies of the crystallization of K0.5Na0.5NbO3powders and thin films from an aqueous synthesis route

Author

Bakken, K., Gaukås, N.H., Grendal, O.G., Blichfeld, A.B., Tominaka, S., Ohara, K., Chernyshov, D., Glaum, J., Grande, T., and Einarsrud, M.-A.

Abstract

Aqueous chemical solution deposition is a promising route for ferroelectric K0.5Na0.5NbO3(KNN) thin films, requiring a stable precursor solution with complexed Nb5+. Here, we report on the local structure of Nb-complexes forming during synthesis of KNN using Nb5+complexed with either oxalic or malic acid. In situtotal X-ray scattering during the decomposition, pyrolysis and crystallization of KNN precursor powders using the two routes revealed information of the changes in the atomic bond distances during the thermal processing, and a reaction scheme was presented. The structures of the Nb-complexes were proposed based on cluster modelling. In situX-ray diffraction demonstrated the crystallization of KNN thin films from the precursor solutions, revealing how the complexing agents affect the formation of crystalline KNN films. The structure of the Nb-complexes was found to influence the kinetics of the combustion of the organic part of the deposited films, which further determined the crystallization temperature.

Published
2021
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50. Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma

Author

Michael S. Regan, Jeanette E. Eckel-Passow, Jennifer R. Cochran, Sonia Jain, Gaspar J. Kitange, Katrina K. Bakken, William F. Elmquist, Paul A. Decker, Minjee Kim, Caterina Giannini, Ian F. Parney, Rachael A. Vaubel, Ann C. Mladek, Brett L. Carlson, Terence C. Burns, Bianca-Maria Marin, Caitlyn L. Miller, Madison H McMinn, Sylwia A. Stopka, Jann N. Sarkaria, Nathalie Y. R. Agar, Danielle M. Burgenske, Forest M. White, Kendra A Porath, Jason E Conage-Pough, Juhee Oh, Surabhi Talele, Shulan Tian, Shiv K. Gupta, Lihong He, Marin B.-M., Porath K.A., Jain S., Kim M., Conage-Pough J.E., Oh J.-H., Miller C.L., Talele S., Kitange G.J., Tian S., Burgenske D.M., Mladek A.C., Gupta S.K., Decker P.A., McMinn M.H., Stopka S.A., Regan M.S., He L., Carlson B.L., Bakken K., Burns T.C., Parney I.F., Giannini C., Agar N.Y.R., Eckel-Passow J.E., Cochran J.R., Elmquist W.F., Vaubel R.A., White F.M., and Sarkaria J.N.

Subjects
0301 basic medicine, Drug, Cancer Research, Antibody-drug conjugate, Immunoconjugates, media_common.quotation_subject, EGFR, Brain tumor, Blood–brain barrier, Antibodies, Monoclonal, Humanized, Depatux-M, Depatuxizumab mafodotin, Brain Neoplasm, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Antibody drug conjugate, Cell Line, Tumor, medicine, Humans, Distribution (pharmacology), Epidermal growth factor receptor, ErbB Receptor, media_common, biology, Brain Neoplasms, business.industry, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, Immunoconjugate, Pharmaceutical Preparations, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Basic and Translational Investigations, Drug delivery, Cancer research, biology.protein, Neurology (clinical), business, Glioblastoma, Human
Abstract

Background Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. Understanding the mechanisms of failure for this promising strategy is critically important. Methods PDX models were employed to study efficacy of systemic vs intracranial delivery of Depatux-M. Immunofluorescence and MALDI-MSI were performed to detect drug levels in the brain. EGFR levels and compensatory pathways were studied using quantitative flow cytometry, Western blots, RNAseq, FISH, and phosphoproteomics. Results Systemic delivery of Depatux-M was highly effective in nine of 10 EGFR-amplified heterotopic PDXs with survival extending beyond one year in eight PDXs. Acquired resistance in two PDXs (GBM12 and GBM46) was driven by suppression of EGFR expression or emergence of a novel short-variant of EGFR lacking the epitope for the Depatux-M antibody. In contrast to the profound benefit observed in heterotopic tumors, only two of seven intrinsically sensitive PDXs were responsive to Depatux-M as intracranial tumors. Poor efficacy in orthotopic PDXs was associated with limited and heterogeneous distribution of Depatux-M into tumor tissues, and artificial disruption of the BBB or bypass of the BBB by direct intracranial injection of Depatux-M into orthotopic tumors markedly enhanced the efficacy of drug treatment. Conclusions Despite profound intrinsic sensitivity to Depatux-M, limited drug delivery into brain tumor may have been a key contributor to lack of efficacy in recently failed clinical trials.

Published
2021

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