40 results on '"Bakirci, EM"'
Search Results
2. Circumflex Artery Lesion Originating from Right Sinus Valsalva Presenting with Acute Inferoposterior Myocardial Infarction
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Degirmenci H, Dogan Mo, Olmez H, and Bakirci Em
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medicine.medical_specialty ,business.industry ,medicine.disease ,Lesion ,medicine.anatomical_structure ,Internal medicine ,medicine ,Cardiology ,Sinus valsalva ,Circumflex ,Myocardial infarction ,medicine.symptom ,business ,Artery - Published
- 2020
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3. Tips and Tricks in Aortailiac Lesions
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Hamur H, Bakirci Em, Degirmenci H, and Yurt S
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- 2020
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4. Resistant Hypertension
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Degirmenci H, Bakirci EM, and Hamur H
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- 2020
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5. Relationship of the total atrial conduction time to subclinical atherosclerosis, inflammation and echocardiographic parameters in patients with type 2 diabetes mellitus
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Bakirci, EM, primary, Demirtas, L, additional, Degirmenci, H, additional, Topcu, S, additional, Demirelli, S, additional, Hamur, H, additional, Buyuklu, M, additional, Akbas, EM, additional, Ozcicek, A, additional, Ozcicek, F, additional, Ceyhun, G, additional, and Topal, E, additional
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- 2015
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6. Benefical effects of lycopene against contrast medium-induced oxidative stress, inflammation, autophagy, and apoptosis in rat kidney
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Buyuklu, M, primary, Kandemir, FM, additional, Ozkaraca, M, additional, Set, T, additional, Bakirci, EM, additional, Topal, E, additional, Ileriturk, M, additional, and Turkmen, K, additional
- Published
- 2014
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7. Benefical effects of lycopene against contrast medium-induced oxidative stress, inflammation, autophagy, and apoptosis in rat kidney.
- Author
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Buyuklu, M, Kandemir, FM, Ozkaraca, M, Set, T, Bakirci, EM, Topal, E, Ileriturk, M, and Turkmen, K
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LYCOPENE ,KIDNEY diseases ,CONTRAST media ,SUPEROXIDE dismutase ,OXIDATIVE stress ,AUTOPHAGY ,LABORATORY rats - Abstract
Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Contrast-induced nephropathy (CIN) is the most important CA-related complication. Oxidative stress plays a significant role in its pathophysiology. Lycopene (LPN) is a natural substance with strong antioxidant capacity. The present study aimed to investigate the potential preventive effects of LPN against CIN. In total, 28 male Wistar albino rats were divided into 4 groups with 7 rats in each group; the groups include normal control group, LPN only group at a dose of 4 mg/kg/day for 10 days, CIN group by administering 10 mg/kg furosemide IM + 10 mg/kg indomethacin IP + 10 ml/kg iomeprol IV following 24-h dehydration, and CIN + LPN group. There were statistically significant increase in urea, creatinine, and malondialdehyde levels (p < 0.001, for all) but a significant decrease in glutathione, superoxide dismutase, catalase, and glutathione peroxidase levels (p < 0.001, for all) in the CIN group compared with the control group. On histological examination, a significant increase of infiltrated inflammatory cells and necrotic degenerative changes were observed in the CIN group and the immunohistochemical examination revealed a significant increase in inflammation (inducible nitric oxide synthase), autophagy (LC3/B), and apoptosis (cleaved caspase 3) in the CIN group compared with the control group (p < 0.05, for all). Significant improvements in these unfavorable parameters were observed with CIN + LPN group compared with the CIN only group. In conclusion, the favorable effects of LPN as an anti-inflammatory, antiautophagic, and antiapoptotic agent in an experimental model of CIN have been demonstrated. [ABSTRACT FROM PUBLISHER]
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- 2015
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8. "Broken heart" syndrome complicated by acute severe mitral regurgitation.
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Demirelli S, Arslan S, Bakirci EM, Demir O, Demirelli, Selami, Arslan, Sakir, Bakırcı, Eftal Murat, and Demir, Orhan
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- 2011
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9. The Association Between C-Reactive Protein/Albumin Ratio and Severity of Carotid Artery Stenosis.
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Bakirci EM, Degirmenci H, and Hamur H
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- Humans, Risk Factors, Albumins, Severity of Illness Index, C-Reactive Protein analysis, Carotid Stenosis diagnostic imaging
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- 2023
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10. Aortic propagation velocity in the prediction of coronary artery disease severity.
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Bakirci EM, Degirmenci H, Duman H, Demirelli S, Hamur H, Buyuklu M, Ceyhun G, and Kutlusoy E
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- Carotid Intima-Media Thickness, Coronary Angiography, Humans, Predictive Value of Tests, Severity of Illness Index, Coronary Artery Disease complications, Coronary Artery Disease diagnostic imaging
- Abstract
Aims: To investigate the association of the aortic propagation velocity (APV) with coronary artery disease (CAD) in patients with stable angina pectoris (SAP) through SYNTAX scores (SS)., Methods: The study population comprised 214 SAP subjects who received a coronary angiography. The APV and carotid intima-media thickness (CIMT) were examined and SS was calculated. Subjects were grouped following specific SS criteria: SS less than 22 (low) and SS greater than or equal to 22 (high)., Results: High SS subjects had lower APV compared to low SS [39.0 (32.0-51.7) vs. 55.0 (45.0-62.0) cm/s, respectively; P<0.001] and higher CIMT (0.86 ± 0.24 vs. 0.74 ± 0.21 mm, respectively; P<0.001). APV demonstrated a negative correlation with the CIMT (r=-0.239, P<0.001), age (r=-0.188, P=0.006) , and SS (r=-0.561, P<0.001) and showed a positive association with LV ejection fraction (r=0.163, P=0.017). APV, CIMT, diabetes, low-density lipoprotein cholesterol (LDL-C), and age were determined to be markers independently of a high SS., Conclusion: APV, CIMT, diabetes, LDL-C and age are independently linked to the CAD severity of SAP subjects. Decreased APV, an indicator of subclinical atherosclerosis, may independently help determine the severity of atherosclerotic CAD in SAP patients.
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- 2022
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11. Predictors of left atrial remodeling in newly diagnosed hypertensive patients: a speckle-tracking echocardiographic study.
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Bakirci EM, Degirmenci H, Hamur H, Cosgun MS, Coskun R, Gunduz T, Tan M, Dogan MO, Tanriseven HI, Cakir M, and Buyuklu M
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- Atrial Function, Left, Echocardiography, Heart Atria diagnostic imaging, Humans, Predictive Value of Tests, Atrial Remodeling, Hypertension diagnostic imaging
- Abstract
Endothelial dysfunction, oxidative stress, and increased inflammatory activity are the main pathophysiological mechanisms responsible for cardiac remodeling secondary to hypertension. Bilirubin has anti-oxidant, anti-inflammatory, and anti-fibrotic functions. This report's objectives are to determine whether Query identifiers of left atrial (LA) remodeling, total atrial conduction time (TACT) and LA reservoir strain (LARS), are associated with serum total bilirubin levels, and to identify the possible predictors of LA remodeling in newly diagnosed hypertensive subjects. One hundred thirty-four subjects were enrolled in this study. TACT was evaluated by tissue Doppler imaging, and LARS was calculated by speckle-tracking echocardiography. Laboratory parameters were recorded. The subjects were classified into two separate groups according to the median value of TACT and LARS. In patients with supramedian TACT, LA volume index (LAVI) and epicardial adipose tissue (EAT) thickness were higher, while LARS and LVGLS were lower. In subjects with inframedian LARS, TACT was longer, LAVI and EAT thickness were higher, and LVGLS was lower. Patients with supramedian TACT and inframedian LARS were older and had lower total bilirubin. Total bilirubin, EAT thickness, and age were predictors of TACT and LARS. Serum bilirubin levels may have a protective effect on the LA remodeling process in newly diagnosed hypertensive subjects., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2021
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12. The CHA2DS2-VASc Score and Acute Stent Thrombosis After Primary Percutaneous Coronary Intervention.
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Degirmenci H and Bakirci EM
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- Humans, Stents adverse effects, Percutaneous Coronary Intervention adverse effects, Thrombosis diagnosis, Thrombosis etiology
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- 2021
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13. Determinants of Chronic Total Occlusion in Patients With Peripheral Arterial Occlusive Disease.
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Hamur H, Onk OA, Vuruskan E, Duman H, Bakirci EM, Kucuksu Z, Degirmenci H, Buyuklu M, and Topal E
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- Adult, Aged, Aged, 80 and over, Bilirubin blood, Biomarkers blood, C-Reactive Protein metabolism, Chronic Disease, Erythrocyte Indices, Female, Humans, Lymphocyte Count, Male, Middle Aged, Neutrophils, Predictive Value of Tests, Risk Factors, Uric Acid blood, Arterial Occlusive Diseases blood, Arterial Occlusive Diseases pathology, Peripheral Arterial Disease blood, Peripheral Arterial Disease pathology
- Abstract
Chronic total occlusion (CTO) is a common finding in 40% of the patients with peripheral arterial disease (PAD). The aim of this study was to investigate the determinants of CTO in patients with PAD. The study included a total of 211 nonanemic patients with PAD. All patients were categorized according to the Fontaine classification. In lower extremity angiography cohorts, CTO
- patients were designated as group 1 and CTO+ patients were designated as group 2. Patients with CTO had significantly higher red cell distribution width (RDW), neutrophil-lymphocyte ratio, uric acid, and high-sensitivity C-reactive protein compared to patients without CTO ( P ≤ .001, P = .036, P ≤ .001, and P = .015, respectively). Albumin, total bilirubin, and direct bilirubin were significantly lower in the patients with CTO compared to patients without CTO ( P = .023, P ≤ .001, and P = .049, respectively). Multivariate logistic regression analysis showed that RDW, uric acid, and total bilirubin were independent predictors of CTO in patients with PAD. We demonstrated that increased RDW and uric acid levels and lower total bilirubin values were independently associated with CTO in patients with PAD.- Published
- 2017
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14. Total Bilirubin Levels Predict Subclinical Atherosclerosis in Patients With Prediabetes.
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Hamur H, Duman H, Demirtas L, Bakirci EM, Durakoglugil ME, Degirmenci H, Kalkan K, Yildirim E, and Vuruskan E
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- Asymptomatic Diseases, Blood Pressure physiology, Carotid Intima-Media Thickness, Female, Humans, Leukocyte Count, Lymphocyte Count, Male, Middle Aged, Multivariate Analysis, Neutrophils immunology, Predictive Value of Tests, Risk, Atherosclerosis blood, Bilirubin blood, Diabetes Complications blood, Prediabetic State blood
- Abstract
Bilirubin may have important antiatherosclerotic effects. Prediabetes (PD), the intermediate stage before diabetes mellitus, is associated with increased cardiovascular morbidity and mortality. We evaluated the relationship between serum bilirubin levels and carotid intima-media thickness (cIMT), as a surrogate marker of subclinical atherosclerosis, in patients with PD. We enrolled 170 consecutive patients with PD. The patients underwent ultrasonography to evaluate cIMT. The patients were divided into groups according to cIMT values (<0.9 vs ≥0.9 mm). The patients with cIMT ≥ 0.9 mm had significantly higher diastolic blood pressure, neutrophil-lymphocyte ratio (NLR), and glycated hemoglobin values compared with patients having cIMT < 0.9 mm, whereas total and direct bilirubin values were significantly lower in this group. Multivariate regression analyses revealed NLR and total bilirubin as the independent predictors of subclinical atherosclerosis. The present study demonstrated that NLR and lower total bilirubin levels were independent predictors of subclinical atherosclerosis in patients with PD. Simple measures such as NRL and total bilirubin may provide predictive information regarding the risk of cardiovascular disease in patients with PD.
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- 2016
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15. Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction.
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Hamur H, Duman H, Bakirci EM, Kucuksu Z, Demirelli S, Kalkan K, and Degirmenci H
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- Adult, Aged, Aged, 80 and over, Biomarkers blood, Chi-Square Distribution, Coronary Thrombosis complications, Coronary Thrombosis diagnostic imaging, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction etiology, Severity of Illness Index, Bilirubin blood, Coronary Thrombosis blood, ST Elevation Myocardial Infarction blood
- Abstract
We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 ± 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3-22.9] vs 7.7 [2.4-20.3] µmol/L, P ≤ .001), (0.84 [0.25-1.34] vs 0.45 [0.14-1.19] mg/dL P ≤ .001) and direct bilirubin levels (3.1 [2.1-8.4] vs 1.7 [0.5-6.5] µmol/L, P ≤ .001), (0.18 [0.03-0.49] vs 0.10 [0.03-0.38] mg/dL, P ≤ .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03-1.08, P ≤ .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI., (© The Author(s) 2015.)
- Published
- 2016
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16. The retrieval of atrial septal defect closure device embolized into aortic arch.
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Hamur H, Onk OA, Degirmenci H, Kahraman U, Bakirci EM, and Tuncer ON
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Percutaneous atrial septal defect (ASD) closure has become an increasingly simplified procedure over the past decade. The device embolization is seen rarely but it can be fatal. Although percutaneous retrieval is feasible, surgical removal might be preferred when the endothelialization status of the device is unknown. We report a comlication of such closure in a 43-year-old woman: embolization of the ASD occluder device into aortic arch 12 months after implantation. We removed the device surgically and closed the ASD.
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- 2016
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17. The preventive role of levosimendan against bleomycin-induced pulmonary fibrosis in rats.
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Gürbüzel M, Sayar I, Cankaya M, Gürbüzel A, Demirtas L, Bakirci EM, and Capoglu I
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- Animals, Catalase metabolism, Erythrocytes drug effects, Erythrocytes metabolism, Glutathione Reductase metabolism, Inflammation chemically induced, Inflammation drug therapy, Inflammation metabolism, Lung metabolism, Male, Phosphogluconate Dehydrogenase metabolism, Pulmonary Fibrosis metabolism, Rats, Rats, Sprague-Dawley, Simendan, Bleomycin pharmacology, Hydrazones pharmacology, Lung drug effects, Pulmonary Fibrosis chemically induced, Pulmonary Fibrosis drug therapy, Pyridazines pharmacology
- Abstract
Background: In this study, the effects of levosimendan used in the treatment of acute congestive heart failure upon pulmonary fibrosis in rats induced with bleomycin (BL) were analyzed., Methods: A total of 33 male Sprague-Dawley type rats were categorized into five groups randomly. About 2.5U/kg BL was intratracheally administered to the rats in the BL, BL+L1, BL+L2, and BL+L3 groups, and 0.9% saline was intratracheally administered at the same rate to the control group. 0.3, 1, and 3mg/kg levosimendan was intraperitoneally administered to the BL+L1, BL+L2, and BL+L3 groups, respectively. Blood and tissue samples were taken from the rats euthanized to determine the changes in erythrocyte enzyme activities and to conduct histopathological evaluations after 14 days. With values between 0 and 3, histopathological scoring damage was assessed by the presence of inflammation and fibrosis in a semiquantitative manner., Results: Compared with those in the C group, glutathione reductase (GR) and Catalase (CAT) enzymes decreased in the BL group; compared with that in the BL group, GR increased in the BL+L1 and BL+L3 groups, 6-phosphogluconate dehydrogenase (6PGD) increased in the BL+L3 group, and CAT increased in the BL+L2 and BL+L3 groups (p<0.05). In the histopathological evaluation, fibrosis occurred in all rats in the BL group, and tissue damage was noticed to be generally less in the BL+L1, BL+L2, and BL+L3 groups (p<0.001)., Conclusions: The results obtained from biochemical and histopathological evaluations indicate that levosimendan had an anti-fibrotic effect without a dose-dependent response on pulmonary fibrosis., (Copyright © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
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- 2016
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18. The safety and efficacy of 12 versus 24 hours of tirofiban infusion in patients undergoing primary percutaneous coronary intervention.
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Topcu S, Karal H, Kaya A, Bakirci EM, Tanboga IH, Kurt M, Aksakal E, Acikel M, and Sevimli S
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- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Time Factors, Tirofiban, Tyrosine administration & dosage, Tyrosine adverse effects, Myocardial Infarction surgery, Percutaneous Coronary Intervention, Postoperative Care methods, Tyrosine analogs & derivatives
- Abstract
Aim: We aimed to investigate the 6-month efficacy and safety of postprocedural 12-hour tirofiban administration versus 24-hour tirofiban administration in patients with ST-segment elevated myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI)., Methods: This retrospective study enrolled 349 patients with STEMI who underwent primary PCI. Following the administration of bolus tirofiban after primary PCI, those receiving a 12-hour tirofiban infusion as the maintenance dose were classified as group 1 (n = 123) while those receiving a 24-hour infusion were classified as group 2 (n = 226). In-hospital and 6-month major adverse cardiac events were recorded., Results: There were no statistically significant differences between the 2 groups regarding in-hospital efficacy (in-hospital death: 4.4% vs 5.7%, P = .600 and stent thrombosis 1.8% vs 1.6%, P = .921) and in-hospital safety (2.6% vs 1.6% for major bleeding and 5.3% vs 4.1% for minor bleeding, P = .562). During the 6-month follow-up period, the incidence of the recurrent revascularization (16.1% vs 15.5%, odds ratio [OR] = 1.05 [0.47-3.67]), the repeated nonfatal acute coronary syndrome and/or stent thrombosis (27% vs 24.4%, P = .598, OR = 1.02 [0.42-2.48]), and the cardiovascular deaths (6.6% vs 6.5%, P = .943, OR = 1.03 [0.43-2.43]) were comparable between group 1 and group 2., Conclusion: Our study revealed that 12-hour tirofiban administration versus 24-hour tirofiban administration in STEMI who underwent primary PCI was similar with respect to in-hospital efficacy and safety and major adverse cardiac events during 6-month follow-up., (© The Author(s) 2014.)
- Published
- 2015
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19. Increased Epicardial Adipose Tissue Thickness is Associated With Angiographic Thrombus Burden in the Patients With Non-ST-Segment Elevation Myocardial Infarction.
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Bakirci EM, Degirmenci H, Duman H, Inci S, Hamur H, Buyuklu M, Ceyhun G, and Topal E
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- Adult, Female, Humans, Male, Middle Aged, Ultrasonography, Adipose Tissue diagnostic imaging, Myocardial Infarction diagnostic imaging, Myocardial Infarction surgery, Percutaneous Coronary Intervention, Pericardium diagnostic imaging, Thrombosis diagnostic imaging, Thrombosis surgery
- Abstract
We aimed to evaluate the relation among epicardial adipose tissue (EAT) thickness, angiographic presence of thrombus, and the no-reflow in the patients with non-ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The study population consisted of 229 patients. The EAT thickness and neutrophil to lymphocyte ratio (NLR) were significantly higher in the patients with coronary thrombus than in those without coronary thrombus (6.1 ± 1.1 vs 5.1 ± 1.3 mm, P < .001 and 3.4 ± 0.9 vs 2.5 ± 0.7, P < .001, respectively) and in the patients with no-reflow compared to patients with reflow. The EAT thickness was found to be correlated positively with the degree of the thrombus burden, NLR, and waist circumference and negatively with high-density lipoprotein cholesterol. Multivariate logistic regression analysis demonstrated that EAT thickness and NLR independently predicted coronary thrombus formation and no-reflow. We have suggested that EAT can play an important role in the pathophysiology of coronary thrombus formation and the no-reflow., (© The Author(s) 2014.)
- Published
- 2015
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20. Surgical removal of guidewire entrapped within stent struts during percutaneous coronary angioplasty.
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Oruc OA, Aksüt M, Bakirci EM, Ekren H, and Erkut B
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- Coronary Artery Bypass, Humans, Male, Middle Aged, Acute Coronary Syndrome surgery, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary instrumentation, Device Removal, Stents
- Abstract
There has been a growing trend toward percutaneous coronary angioplasty for complex coronary artery lesions. Stent or guidewire break off or trapping within the coronary artery lumen is a rare complication, but it may have fatal consequences. In such cases, the entrapped device may be removed by either percutaneous route or surgical exploration. Here, we report a patient with guidewire entrapment within the struts of the intracoronary stent during primary percutaneous coronary angioplasty, which necessitated surgical removal and subsequent coronary artery bypass grafting (CABG).
- Published
- 2015
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21. Terminal QRS distortion and severity of coronary artery disease in ST-elevation myocardial infarction.
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Bakirci EM, Kalkan K, Hamur H, Buyuklu M, Cetin M, Degirmenci H, Duman H, Kucuksu Z, Tanboga IH, and Topal E
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- Coronary Artery Disease etiology, Female, Humans, Male, Middle Aged, Myocardial Infarction complications, Percutaneous Coronary Intervention, Prognosis, Reproducibility of Results, Retrospective Studies, Risk Assessment methods, Sensitivity and Specificity, Treatment Outcome, Coronary Artery Disease diagnosis, Coronary Artery Disease surgery, Electrocardiography methods, Myocardial Infarction diagnosis, Myocardial Infarction surgery
- Abstract
Background: Grade 3 ischemia (G3I) is defined as ST elevation with distortion of the terminal portion of the QRS complex on electrocardiograms (ECGs) of patients with ST-segment elevation myocardial infarction (STEMI). Although the association between G3I and short- and long-term cardiovascular events is well established, its mechanism is unclear. We assessed the association between G3I on the admission ECG and SYNTAX score (SS) in patients with STEMI undergoing primary percutaneous coronary intervention., Patients and Methods: The study population consisted of 312 patients with STEMI. Baseline ECGs of the patients were analyzed for grade of ischemia; the online latest updated version (2.11) of the SS calculator was used to determine the SS (http://www.syntaxscore.com). Patients were divided into two groups according to their grade of ischemia: grade 2 ischemia (G2I) or G3I. Also, patients were classified according to their SS as SS < 22 (low) or SS ≥ 22 (high)., Results: There were 211 patients in the low SS group and 101 patients in the high SS group. G3I was present in 31.1 % (n = 97) of the study population. SS was significantly higher in patients with G3I than in patients with G2I (20.1 ± 8.8 vs. 13.7 ± 7.1, p < 0.001). G3I was significantly higher in patients with high SS (50.5 % vs. 21.8 %, p < 0.001). Multivariate logistic regression analysis revealed that G3I (p < 0.001), diabetes (p = 0.013), age (p = 0.016), and anterior MI (p = 0.011), were independent predictors of high SS., Conclusion: In conclusion, G3I was independently related to high SS. We suggest that elevated SS in patients with G3I may explain the relationship between G3I and the poor outcome observed in these patients. Furthermore, the prediction of high SS by means of G3I in patients with STEMI may help determine the most appropriate revascularization method and prevent procedure failure.
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- 2015
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22. The role of the nonspecific inflammatory markers in determining the anatomic extent of venous thromboembolism.
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Bakirci EM, Topcu S, Kalkan K, Tanboga IH, Borekci A, Sevimli S, and Acikel M
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- Adult, Biomarkers blood, Female, Humans, Lymphocyte Count, Male, Middle Aged, Pulmonary Embolism pathology, Retrospective Studies, Venous Thromboembolism pathology, Venous Thrombosis pathology, C-Reactive Protein metabolism, Lymphocytes, Neutrophils, Pulmonary Embolism blood, Venous Thromboembolism blood, Venous Thrombosis blood
- Abstract
We aimed to investigate the relationship between the extent of venous thromboembolism (VTE) and nonspecific inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hs-CRP). We retrospectively enrolled 77 patients with VTE (distal deep vein thrombosis [DVT], n = 19; proximal DVT, n = 32; and pulmonary thromboembolism [PTE], n = 26) and 34 healthy controls. In the performed analysis of variance, the levels of white blood cell, NLR, and hs-CRP were clearly different among the groups (control, distal and proximal DVT, and PTE) (P < .001). Especially, a significant increase from the control group to the DVT and PTE was observed in the analysis made for NLR. In the performed receiver-operating characteristic curve analysis, area under curve (AUC) = 0.849 and P < .001 were detected for NLR > 1.84. For this value, the sensitivity and specificity were determined as 88.2% and 67.6%, respectively. The NLR is an inexpensive and a readily available marker that may be effective in determining the extent of VTE, and it is useful for risk stratification in patients with VTE., (© The Author(s) 2013.)
- Published
- 2015
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23. New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness.
- Author
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Bakirci EM, Degirmenci H, Hamur H, Gunay M, Gulhan B, Aydin M, Kucuksu Z, Ceyhun G, and Topal E
- Subjects
- Biomarkers blood, C-Reactive Protein metabolism, Chitinase-3-Like Protein 1, Cross-Sectional Studies, Essential Hypertension, Female, Glycoproteins, Humans, Hypertension diagnostic imaging, Hypertension physiopathology, Male, Middle Aged, Adipokines blood, Adipose Tissue diagnostic imaging, Blood Pressure physiology, Echocardiography methods, Hypertension blood, Lectins blood, Pericardium diagnostic imaging
- Abstract
The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.
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- 2015
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24. Increased platelet indices in acute stent thrombosis--response letter.
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Cetin M, Balli M, Tasolar H, Cakici M, and Bakirci EM
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- Female, Humans, Male, Blood Platelets pathology, Myocardial Infarction therapy, Thrombolytic Therapy
- Published
- 2014
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25. Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure.
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Cetin M, Bakirci EM, Baysal E, Tasolar H, Balli M, Cakici M, Abus S, Akturk E, and Ozgul S
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- Aged, Aged, 80 and over, Blood Platelets metabolism, Coronary Artery Disease therapy, Female, Humans, Male, Mean Platelet Volume methods, Middle Aged, Myocardial Infarction etiology, Platelet Activation physiology, Blood Platelets pathology, Myocardial Infarction therapy, Thrombolytic Therapy
- Abstract
We investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both < .001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P = .021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P < .001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI., (© The Author(s) 2013.)
- Published
- 2014
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26. Left ventricular mechanics in Behcet's disease: a speckle tracking echocardiographic study.
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Demirelli S, Degirmenci H, Bilen H, Ermis E, Duman H, Arisoy A, Bakirci EM, Ipek E, and Askin L
- Subjects
- Adult, Echocardiography, Doppler, Female, Heart Rate, Humans, Male, Observer Variation, Rotation, Sensitivity and Specificity, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology, Ventricular Function, Left, Young Adult, Behcet Syndrome diagnostic imaging, Behcet Syndrome physiopathology, Echocardiography methods, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology
- Abstract
Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of subclinical LV dysfunction in patients with BD. 30 patients diagnosed as BD due to International Study Group Behcet's diagnostic criteria and 25 control subjects underwent Doppler echocardiography including pulsed tissue Doppler of the mitral annulus and speckle-tracking echocardiography. LV peak longitudinal strain and strain rate (SR) was calculated in four-chamber (4C), apical long-axis (LAX), and two-chamber (2C) views, and values of the three views were averaged LV global longitudinal strain (LV-GLS) and SR. LV torsion was determined as the net difference in the mean rotation between the apical and basal levels. There was not any significant difference in age and gender between groups. Patients with BD had significantly lower LV longitudinal strain and Sr measurements than the control group. Although LV basal rotation (LVR) basal values were similar in both groups, LVR-apical and LV torsion (LVTR) values were significantly higher in patient group. LVR-apical and LV-GLS were found to have a good positive corelation (r:0.44, p<0.001) (r: -0.56, r: -0.65,respectively. p<0.001). There was a weak positive correlation between LVTR and LV-GLS (r: 0.29, p<0.05). We demonstrated that combined assessment of LV-GLS, LV-GLSR, LVTR and LVR-apical values detected by STE can be useful in determination of subclinical left ventricular dysfunction in BD.
- Published
- 2014
- Full Text
- View/download PDF
27. Relationship between obstructive sleep apnea-specific symptoms and cardiac function before and after adenotonsillectomy in children with adenotonsillar hypertrophy.
- Author
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Cincin A, Sakalli E, Bakirci EM, and Dizman R
- Subjects
- Adenoids pathology, Adenoids surgery, Case-Control Studies, Child, Echocardiography, Doppler, Female, Humans, Hypertrophy, Male, Palatine Tonsil pathology, Palatine Tonsil surgery, Sleep Apnea, Obstructive surgery, Ventricular Dysfunction, Left physiopathology, Adenoidectomy, Blood Pressure physiology, Pulmonary Artery physiopathology, Sleep Apnea, Obstructive physiopathology, Tonsillectomy, Ventricular Dysfunction, Right physiopathology
- Abstract
Objective: The aim of our study was to investigate subclinical cardiac disturbances in patients with symptoms due to adenotonsillar hypertrophy (ATH) and the impact of adenotonsillectomy (AT) using conventional and novel echocardiographic measures., Material and Methods: Thirty patients with grade 3 or 4 ATH (mean age: 7.86 ± 3.83 years; 10 females) and 30 healthy, age- and sex-matched volunteers (mean age, 8 ± 2.77; 14 females) were enrolled in the study. In addition to conventional two-dimensional and Doppler echocardiographic parameters, tissue Doppler parameters, including myocardial performance indices (MPIs) of both the right (RV) and left ventricle (LV), were studied. The severity of obstructive sleep apnea (OSA) was determined using the OSA-18 health quality questionnaire. The OSA-18 questionnaire and echocardiographic examination were repeated after AT in patients with ATH., Results: The total OSA-18 scores for the control, preoperative, and postoperative groups were 39.56 ± 19.98, 80.63 ± 22.32, and 44.10 ± 20.31, respectively. Conventional parameters were not different among the groups. The mean pulmonary artery pressure estimated using the Mahan formula was increased in the ATH group compared with that in the control group (21.72 ± 4.25 vs. 12.43 ± 3.83, respectively; p<0.001) and significantly improved after AT (21.72 ± 4.25 vs. 16.09 ± 4.53; p<0.001). The RV MPI was significantly different between the control and ATH groups (0.322 ± 0.052 vs. 0.383 ± 0.079, respectively; p=0.001). Both the LV and RV MPI significantly improved (0.515 ± 0.066 vs. 0.434 ± 0.052, p<0.001; and 0.383 ± 0.079 vs. 0.316 ± 0.058, p=0.018, respectively) after surgery for ATH., Conclusions: Our study revealed that the patients with OSA-specific symptoms due to ATH had higher pulmonary artery pressure and impaired RV function according to novel echocardiographic parameters. Surgery for ATH seems to have an important effect on both LV and RV function., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
28. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy.
- Author
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Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, Ozcicek F, and Turkmen K
- Abstract
Background: The relationship between diabetic nephropathy, visceral adipose tissue (VAT), and inflammation has been shown. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, inexpensive, and useful markers to determine inflammation. However, to date, in the literature, there have been no studies demonstrating the relationship between epicardial adipose tissue (EAT), inflammation, and albuminuria., Aims: We aimed to investigate the association between diabetic nephropathy, NLR, and PLR as inflammatory markers and EAT thickness., Methods: This was a cross-sectional study involving 200 diabetic patients. The patients were separated into three groups according to their albuminuria levels. The NLR and PLR were calculated from a complete blood count. EAT was measured by transthoracic echocardiography. The estimated glomerular filtration rate (eGFR) was calculated by the modification of diet in renal disease (MDRD) equation., Results: Disease duration, EAT, creatinine, NLR, PLR, absolute neutrophil, lymphocyte, and platelet count tended to increase with increasing albuminuria while the eGFR decreased. When patients were separated into two groups according to NLR and PLR medians, albuminuria levels increased with an increase of the NLR (p = 0.003) and PLR (p = 0.009). A correlation analysis showed that albuminuria was significantly correlated with EAT, disease duration, creatinine, eGFR, PLR, and NLR levels. Additionally, in a binary logistic regression analysis, EAT, NLR, and PLR were found to be independently associated with albuminuria., Conclusions: Determining various inflammatory cytokines and measuring abdominal VAT in diabetic patients is complex and expensive. Simply measuring EAT and calculating NLR and PLR can predict inflammation and albuminuria in patients with diabetes.
- Published
- 2014
29. Spontaneous lingual and sublingual haematoma: a rare complication of warfarin use.
- Author
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Buyuklu M, Bakirci EM, Topal E, and Ceyhun G
- Subjects
- Aged, Anticoagulants administration & dosage, Diagnosis, Differential, Female, Follow-Up Studies, Hematoma pathology, Hematoma therapy, Humans, Mouth Floor blood supply, Plasma, Rare Diseases, Tongue blood supply, Treatment Outcome, Warfarin administration & dosage, Anticoagulants adverse effects, Antifibrinolytic Agents therapeutic use, Hematoma chemically induced, Mouth Floor drug effects, Tongue drug effects, Vitamin K therapeutic use, Warfarin adverse effects
- Abstract
Warfarin is commonly used for prevention of embolic events. Bleeding is the main side effect of warfarin. Lingual and sublingual haematoma are rare. In the literature, nine cases have so far been reported. We report the case of a 70-year-old Caucasian woman who developed spontaneous lingual and sublingual haematomas while on warfarin therapy. Spontaneous lingual and sublingual haematoma are rare, but can be potentially life-threatening complications as they cause airway obstruction. To the best of our knowledge, this is the first reported case of earliest haematoma after warfarin use., (2014 BMJ Publishing Group Ltd.)
- Published
- 2014
- Full Text
- View/download PDF
30. Predictors of epicardial adipose tissue in patients with type 2 diabetes mellitus.
- Author
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Akbas EM, Hamur H, Demirtas L, Bakirci EM, Ozcicek A, Ozcicek F, Kuyrukluyildiz U, and Turkmen K
- Abstract
Background: Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were introduced as potential markers to determine inflammation in various disorders. Recently, atherogenic index of plasma (AIP) was found to be closely associated with atherosclerosis in general population. Waist circumference is commonly used to assess the risk factors in various metabolic disorders. There has been a well known relation between inflammation and peripheral adipose tissue in diabetes mellitus. However, the data regarding EAT and inflammation is scant in this population. Hence, we aimed to determine the relationship between PLR, NLR, AIP, waist circumference and EAT in diabetic patients., Methods: This was a cross-sectional study involving 156 patients with type 2 diabetes mellitus (87 females, 69 males; mean age, 53.62 ± 9.33 years) and 50 control subjects (35 females, 15 males; mean age, 51.06 ± 8.74 years). EAT was measured by using a trans-thoracic echocardiogram. Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum triglyceride to high density lipoprotein (HDL)cholesterol. NLR and PLR were calculated as the ratio of the neutrophils and platelets to lymphocytes, respectively., Results: Waist circumference, PLR, NLR, AIP and EAT measurements were significantly higher in diabetic patients when compared to control subjects. When diabetic patients were separated into two groups according to their median value of EAT (Group 1, EAT < 4.53 (n = 78) and group 2, EAT ≥4.53 (n = 78)), group 2 patients had significantly higher Body mass index (BMI), waist circumference, AIP, NLR and PLR levels. In the bivariate correlation analysis, EAT was positively correlated with PLR, NLR, AIP, BMI and waist circumference (r = 0.197, p = 0.014; r = 0.229, p = 0.004; r = 0.161, p = 0.044; r = 0.248, p = 0.002; r = 0.306, p < 0.001, respectively). Waist circumference was found to be independent variables of EAT., Conclusions: Simple calculation of PLR and measurement of waist circumference were found to be associated with increased EAT in diabetic patients.
- Published
- 2014
- Full Text
- View/download PDF
31. Impact of -455G/a polymorphism of the β-fibrinogen gene on platelet aggregation in patients with acute coronary syndrome.
- Author
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Sevimli S, Karakoyun S, Bakirci EM, Topcu S, Kalkan K, Borekci A, and Vançelik S
- Subjects
- Acute Coronary Syndrome blood, Clopidogrel, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors administration & dosage, Polymorphism, Genetic, Risk Assessment, Ticlopidine administration & dosage, Acute Coronary Syndrome drug therapy, Acute Coronary Syndrome genetics, Aspirin administration & dosage, Fibrinogen genetics, Platelet Aggregation drug effects, Platelet Aggregation genetics, Ticlopidine analogs & derivatives
- Abstract
We aimed to investigate the association of aspirin and/or clopidogrel low response with -455G/A polymorphism of β-fibrinogen in patients with acute coronary syndrome (ACS). We enrolled 114 consecutive patients (mean age 61 ± 7, 31 female [27.2%], 83 male [72.8%]) with a first ACS. The diagnostic criteria for ACS were based on current guidelines. The -455 G/A β-fibrinogen polymorphism genotype distribution in the patient group was determined as the following: 54.4% GG homozygote, 39.5% GA, and 6.1% AA homozygote. Clopidogrel low response was present in 25 (21.9%) patients, aspirin low response in 21 (18.4%) patients, and dual antiplatelet low response in 9 (7.9%) patients. In our study, no difference was observed in terms of the distribution of -455 G/A β-fibrinogen polymorphism between the groups with and without aspirin and/or clopidogrel or dual antiplatelet low response in the patient group who underwent aspirin and clopidogrel treatment for ACS (P > .05).
- Published
- 2014
- Full Text
- View/download PDF
32. Assessment of effect of irbesartan and nebivolol on the left atrium volume and deformation in the patients with mild-moderate hypertension.
- Author
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Degirmenci H, Duman H, Demirelli S, Bakirci EM, Hamur H, Inci S, Simsek Z, Askın L, Arısoy A, and Lazoglu Z
- Subjects
- Blood Pressure drug effects, Diastole drug effects, Echocardiography methods, Female, Humans, Irbesartan, Male, Middle Aged, Nebivolol, Prospective Studies, Systole drug effects, Antihypertensive Agents therapeutic use, Benzopyrans therapeutic use, Biphenyl Compounds therapeutic use, Ethanolamines therapeutic use, Heart Atria drug effects, Hypertension drug therapy, Tetrazoles therapeutic use
- Abstract
Background: We aimed to assess the effects of irbesartan and nebivolol on the left atrium (LA) volume and deformation in the patients with mild-moderate hypertension., Patients and Methods: The study comprised of 160 patients (mean age: 55.6±9.6 years), who had Stage 1 or 2 hypertension according to the European Society of Cardiology (ESC) and have not been receiving antihypertensive therapy. The patients were assigned to treatment groups; irbesartan (n=80) and nebivolol (n=80). The patients were clinically and echocardiographically reevaluated on the 6th and 12th months after the onset of treatment., Results: There was no difference between the two treatment groups in terms of baseline demographic, clinical and echocardiographic characteristics. Moreover, no difference was observed between the treatment groups on the 6th and 12th months. Intragroup analyses revealed that systolic blood pressure (SBP) and diastolic blood pressure (DBP) significantly decreased in time and diastolic function parameters were improved. However, whilst significant increase was observed in conduit volume, decrease was observed in other volumes of the LA in the irbesartan and nebivolol groups. This significant change was observed on the 6th month in both treatment groups. LA global peak systolic strain (LAGLSs), LA global peak systolic strain rate (LAGLSRs), LA global peak strain rate during early ventricular diastole (LAGLSRe) and LA global peak strain rate (LAGLSRa) during late ventricular diastole (LAGLSRa) values began to be significantly increased after 6 months of treatment in both treatment groups., Conclusions: We found that nebivolol, which is a new generation beta blocker, is effective as irbesartan with proven efficacy in improving LA volume and LA myocardial performance in patients with mild-moderate hypertension. Moreover, we determined that strain and strain rate, which are the new echocardiographic parameters, are effective as LA volumes in assessing LA functions.
- Published
- 2014
33. Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.
- Author
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Degirmenci H, Açikel M, Bakirci EM, Duman H, Demirelli S, Tas H, Simsek Z, Karakelleoglu S, Aksakal E, and Erol MK
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Adult, Aged, Antihypertensive Agents therapeutic use, Biphenyl Compounds, Carvedilol, Cohort Studies, Female, Humans, Hypertension epidemiology, Hypertrophy, Left Ventricular epidemiology, Irbesartan, Male, Middle Aged, Prospective Studies, Tetrazoles, Treatment Outcome, Ultrasonography, Carbazoles therapeutic use, Hypertension diagnostic imaging, Hypertension drug therapy, Hypertrophy, Left Ventricular diagnostic imaging, Hypertrophy, Left Ventricular drug therapy, Nebivolol therapeutic use, Propanolamines therapeutic use
- Abstract
Objectives: The aim of this study was to investigate if the new generation beta-blockers are as effective as irbesartan, which is an angiotensin receptor blocker (ARB), on left ventricular hypertrophy (LVH)., Patients and Methods: The study included 85 patients (average age: 56.6±9.6 year) with stage 1 and 2 hypertension, who previously didn't receive an antihypertensive treatment, but diagnosed with LVH echocardiographically. The patients were divided into three different treatment groups: irbesartan (n=28), nebivolol (n=25) and carvedilol (n=32). The patients were reassessed clinically and echocardiographically at 3, 6 and 12 months after the treatments., Results: There was no statistically significant difference in baseline left ventricular mass index (LVMI) and other parameters among the three treatment groups (p > 0.05). Although there was no significant decrease in LVMI in irbesartan and carvedilol groups at 3 months after the treatment (p > 0.05), the values measured at 6 and 12 months (p < 0.0001) were significant. The decrease in LVMI in the nebivolol group was significant at 3, 6 and 12 months (p < 0.0001). There was a significant difference in measurements at 12 months (p < 0.05)., Conclusions: Both of the new generation beta-blockers were more effective than irbesartan in the regression of LVH. A significant regression in LVH was observed 3 months after nebivolol treatment and 6 months after irbesartan and carvedilol treatments.
- Published
- 2014
34. Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis?
- Author
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Buyuklu M, Kandemir FM, Ozkaraca M, Set T, Bakirci EM, and Topal E
- Subjects
- Animals, Biomarkers metabolism, Cytoprotection, Disease Models, Animal, Kidney metabolism, Kidney pathology, Kidney Diseases chemically induced, Kidney Diseases metabolism, Kidney Diseases pathology, Male, Nephritis chemically induced, Nephritis metabolism, Nephritis pathology, Rats, Wistar, Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Apoptosis drug effects, Autophagy drug effects, Contrast Media, Curcumin pharmacology, Iopamidol analogs & derivatives, Kidney drug effects, Kidney Diseases prevention & control, Nephritis prevention & control, Oxidative Stress drug effects
- Abstract
Background: Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Curcumin (CC) is a natural substance with strong antioxidant efficacy., Materials and Methods: In total, 24 male Wistar-albino rats were divided into four groups with seven rats in each group., Results: Biochemical measurements showed a significant increase (p < 0.001) in urea, creatinine and malondialdehyde (MDA) but a significant decrease (p < 0.001) in glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels in the contrast-induced nephropathy (CIN) group compared with the control group. The immunohistochemical examination revealed a significant increase in autophagic and apoptotic cell death ratios and in the inflammatory signal (p < 0.05). Compared with the CIN group, a significant improvement in these unfavorable parameters was observed with CC therapy., Conclusions: The preventive efficacy of CC against an experimental model of CIN has been demonstrated.
- Published
- 2014
35. Predictors of reintervention after coronary artery bypass grafting.
- Author
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Inci S, Arslan S, Bakirci EM, Tas MH, Gundogdu F, and Karakelleoglu S
- Subjects
- Aged, Diabetes Mellitus epidemiology, Electrocardiography, Female, Humans, Hypertension epidemiology, Male, Middle Aged, Odds Ratio, Reoperation, Risk Factors, Smoking epidemiology, Stroke Volume, Acute Coronary Syndrome epidemiology, Acute Coronary Syndrome surgery, Angina, Stable epidemiology, Angina, Stable surgery, Coronary Artery Bypass, Percutaneous Coronary Intervention
- Abstract
Aim: Percutaneous and surgical reintervention after coronary artery bypass grafting (CABG) is frequent. The purpose of this study was to determine the predictors of reintervention in patients with symptoms of recurrent ischemia after coronary artery bypass graft surgery (CABG)., Patients and Methods: The data of 20000 patients who had coronary angiography (CAG) from 2003 to 2010 in our centre were retrospectively analysed. 485 of these patients with CABG who had CAG were included in this study. Demographic characteristics, the presence of coronary artery disease (CAD), risk factors for CAD, electrocardiographic (ECG) changes, troponin and CKMB levels, and left ventricular function were evaluated in terms of time elapsed after CABG., Results: Reintervention was performed significantly more frequent in patients with acute coronary syndrome, diabetes mellitus (DM), hypertension (HT), family history of CAD, ECG changes, positive troponin level, elevated CKMB, ejection fraction (EF) > 50% and in smoker patients (p < 0.05). Multivariate backward logistic regression analysis revealed that DM, smoking, family history of CAD, HT, ECG changes and patients with EF > 50% were found the independent predictors of reintervention., Conclusions: Reintervention after CABG is especially higher in patients with risk factors for atherosclerosis and those who have ECG changes and normal EF. Knowledge of these risk factors is useful in the determination of CAG requirement and modification of risk factors for atherosclerosis may play an important role in reducing reintervention.
- Published
- 2014
36. Assesment of myocardial ischemia by combination of tissue synchronisation imaging and dobutamine stress echocardiography.
- Author
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Tas MH, Aksakal E, Gurlertop Y, Simsek Z, Gundogdu F, Sevimli S, Bakirci EM, and Karakelleoglu S
- Abstract
Background and Objectives: Dobutamine stress echocardiography (DSE) is an important non-invasive imaging method for evaluating ischemia. However, wall motion interpretation can be impaired by the experience level of the interpreter and the subjectivity of the visual assessment. In our study we aimed to combine DSE and tissue syncronisation imaging to increase sensitivity for detecting ischemia., Subjects and Methods: 50 patients with indications for DSE were included in the study. In 25 patients we found DSE positive for ischemia and in the other 25 patients we found it to be negative. The negative group was accepted as the control group. There was no significant difference in terms of risk factors and echocardiographic parameters between the two groups, except for wall motion scores. In both groups, left ventricular dyssychrony was accepted as the difference between time to peak systolic velocity (Ts) in the reciprocal four couple of non-apical segments at rest and during peak stress. Timings were corrected for heart rate. We compared the differences of the dyssynchronisation value at rest and during peak stress to determine the distinctions within the groups and between the groups of DSE positive and negative patients., Results: We found that stress and ischemia did not create any significant difference over the left intraventricular dyssynchrony with DSE, although at the segmenter level it prolonged the time to peak systolic velocity (p<0.05). These alterations did not show any significant difference between positive and negative DSE groups., Conclusion: As a result, this segmenter dyssynchrony and the time to peak systolic velocity, which is corrected for heart rate, did not enhance any new value over DSE for detecting ischemia.
- Published
- 2013
- Full Text
- View/download PDF
37. Complete atrioventricular block due to overdose of pregabalin.
- Author
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Aksakal E, Bakirci EM, Emet M, and Uzkeser M
- Subjects
- Aged, Analgesics therapeutic use, Atrioventricular Block physiopathology, Back Pain drug therapy, Diabetic Neuropathies drug therapy, Electrocardiography, Female, Humans, Pregabalin, Prescription Drug Misuse, gamma-Aminobutyric Acid poisoning, gamma-Aminobutyric Acid therapeutic use, Analgesics poisoning, Atrioventricular Block chemically induced, gamma-Aminobutyric Acid analogs & derivatives
- Abstract
Pregabalin, a synthetic derivate of the inhibitory neurotransmitter γ-aminobutyric acid, shows antiepileptic, analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. The major advantage of pregabalin is its relative reliability, easy use, high tolerance, and lack of negative interaction with other drugs. A 65-year-old woman with medical histories of diabetes mellitus, lumbar spondylosis, diabetic nephropathy, chronic renal failure, and anemia of chronic disease was admitted with the complaint of dizziness and syncope. She had been taking pregabalin 300 mg daily for 8 months. Electrocardiogram revealed complete atrioventricular (AV) block and right bundle-brunch block with a heart rate of 39 per minute. Her creatinine was 1.8 mg/dL, and creatinine clearance was 50 mL/min. Pregabalin treatment was discontinued. Four days later, the complete AV block resolved spontaneously to Mobitz type II block and to sinus rhythm with right bundle-brunch block on the seventh day. To our knowledge, this is the first case of complete AV block associated with pregabalin. We believe that AV block occurred as a result of pregabalin's effect on L-type Ca++ channels in the heart. Pregabalin's different effects on electrocardiogram and on the heart in different individuals may have an association with the patterns of distribution of the L-type calcium channels in myocardium.
- Published
- 2012
- Full Text
- View/download PDF
38. A quadricuspid aortic valve causing moderate aortic regurgitation.
- Author
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Bakirci EM, Arslan S, Degirmenci H, and Sevimli S
- Subjects
- Aged, Aortic Valve diagnostic imaging, Aortic Valve Insufficiency complications, Aortic Valve Insufficiency diagnostic imaging, Dyspnea etiology, Echocardiography, Three-Dimensional, Echocardiography, Transesophageal, Humans, Male, Mitral Valve Insufficiency complications, Mitral Valve Insufficiency diagnostic imaging, Treatment Refusal, Aortic Valve abnormalities, Aortic Valve Insufficiency diagnosis, Aortic Valve Insufficiency etiology, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency etiology
- Abstract
Quadricuspid aortic valve (QAV) is a rare cause of aortic regurgitation. Most cases are detected incidentally during echocardiography, angiography, autopsy or surgery. It may also be associated with other congenital anomalies of the heart. A 70 year-old man was admitted to our hospital with a five-month history of dyspnea. Echocardiographic examination showed a QAV leading to moderate aortic regurgitation, severe mitral regurgitation, left ventricular dysfunction and aortic root dilatation. Surgical treatment was considered, but the patient refused. We describe a case of QAV leading to aortic regurgitation.
- Published
- 2012
- Full Text
- View/download PDF
39. Coexistence of idiopathic left ventricular aneurysm and aneurysm of right coronary artery.
- Author
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Gundogdu F, Bakirci EM, Arslan S, Kantarci M, and Acikel M
- Subjects
- Adult, Cardiovascular Agents therapeutic use, Coronary Aneurysm diagnosis, Coronary Aneurysm drug therapy, Coronary Angiography, Echocardiography, Heart Aneurysm diagnosis, Heart Aneurysm drug therapy, Humans, Male, Tomography, X-Ray Computed, Coronary Aneurysm complications, Heart Aneurysm complications, Heart Ventricles diagnostic imaging
- Abstract
A 40-year-old man was admitted to our hospital with dyspnea and atypical chest pain. Left ventricle (LV) apico-lateral wall aneurysm and right coronary artery aneurysm were found. We could find no etiological reason for this condition. Surgical treatment was considered but the patient refused. In this report, we describe an interesting and rare case of idiopathic LV aneurysm accompanied by coronary artery aneurysm.
- Published
- 2011
- Full Text
- View/download PDF
40. The role of oxidative stress in diabetic cardiomyopathy: an experimental study.
- Author
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Aksakal E, Akaras N, Kurt M, Tanboga IH, Halici Z, Odabasoglu F, Bakirci EM, and Unal B
- Subjects
- Animals, Antioxidants metabolism, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental metabolism, Female, Immunohistochemistry, Myocardium metabolism, Rats, Rats, Sprague-Dawley, Diabetic Cardiomyopathies metabolism, Oxidative Stress physiology
- Abstract
Background: Diabetes mellitus (DM) has a negative effect on cardiovascular functions. Little, however, is known of the overall effect of DM on the cardiac histology or the pathophysiological basis of this., Aim: We aimed to investigate the role of oxidative stress on the pathogenesis of diabetic cardiomyopathy in an experimental model., Materials and Methods: 12 week-old female Sprague Dawley rats were randomly allocated into a healthy control group (n=6) and an DM group (n=6). After 12 weeks of alloxan induced DM, the groups' cardiac tissues were histopathologically analyzed and examined for determination of oxidant and antioxidant enzymes [activities of catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) and amount of reduced glutathione (GSH) and lipid peroxidation (LPO)]., Results: When compared to the control group, the DM group showed cardiomyopathic changes. In the DM group, activities of CAT (144 +/- 0.9 vs. 112 +/- 1.4, p < 0.05) and LPO amount (27.0 +/- 0.74 vs. 14.4 +/- 0, 20, p < 0.05) were significantly increased whereas activities of SOD (142 +/- 0.2 vs. 146 +/- 0.7, p < 0.05) and amount of GSH (3.48 +/- 0.01 vs. 3.73 +/- 0.01, p < 0.05) were significantly decreased when compared to the control group. Besides, activities of MPO (7.3 +/- 0.02 vs. 8.6 +/- 0.11, p < 0.05) were comparable between groups., Conclusions: Using the experimental animal model, we were able to demonstrate that DM causes cardiomyopathic changes, and we propose that these changes could be mediated by an oxidative stress.
- Published
- 2011
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