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45 results on '"Bakhiet, Sahar Mubarak"'

1. Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial

Author

Fahal, Ahmed H, Ahmed, Eiman Siddig, Bakhiet, Sahar Mubarak, Bakhiet, Osama Elhadi, Fahal, Lamis Ahmed, Mohamed, Abubakar Ahmed, Mohamedelamin, El Semani Widaa, Bahar, Mustafa El Nour, Attalla, Hadil Yassir, Siddig, Emmanuel Edwar, Mhmoud, Najwa A, Musa, Ahmed Mudawi, van de Sande, Wendy W J, Scherrer, Bruno, Oyieko, Peelen, Egondi, Thaddaeus W, Onyango, Kevin O, Hata, Katsura, Chu, Wan-Yu, Dorlo, Thomas P C, Brüggemann, Roger J, Nyaoke, Borna A, Strub-Wourgaft, Nathalie, and Zijlstra, Eduard E

Published
2024
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4. Comparing the performance of the common used eumycetoma diagnostic tests

Author

Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Mhmoud, Najwa Adam, Abdallah, Omnia Babekir, Bahar, Mustafa El Nour, Ahmed, Eiman Siddig, Nyaoke, Borna, Zijlstra, Eduard E., Verbon, Annelies, Bakhiet, Sahar Mubarak, Fahal, Ahmed Hassan, van de Sande, Wendy W.J., Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Mhmoud, Najwa Adam, Abdallah, Omnia Babekir, Bahar, Mustafa El Nour, Ahmed, Eiman Siddig, Nyaoke, Borna, Zijlstra, Eduard E., Verbon, Annelies, Bakhiet, Sahar Mubarak, Fahal, Ahmed Hassan, and van de Sande, Wendy W.J.

Abstract

Objectives: Mycetoma is a neglected tropical implantation disease caused by 70 different infectious agents. Identifying the causative organism to the species level is essential for appropriate patient management. Ultrasound, histopathology, culture and two species-specific PCRs are most the commonly used methods for species identification in endemic regions. The aim of this study was to compare the diagnostic performance of these commonly used assays using sequencing of barcoding genes as the gold standard. Methods: This descriptive cross-sectional study was conducted at the Mycetoma Research Centre, University of Khartoum, Sudan. It included 222 patients suspected of fungal mycetoma caused by Madurella mycetomatis. Results: 154 (69.3%) were correctly identified by ultrasound, histology, culture and both species-specific PCRs. In 60 patients, at least one of the diagnostic tests failed to identify M. mycetomatis. Five patients had no evidence of eumycetoma, and for three, only the ultrasound was indicative of mycetoma. The two species-specific PCRs were the most sensitive and specific methods, followed by culture and histology. Ultrasound was the least specific as it only allowed differentiation between actinomycetoma and eumycetoma. The time to result was 9.38 minutes for ultrasound, 3.76 hours for PCR, 8.5 days for histopathology and 21 days for grain culturing. Conclusion: Currently, PCR directly on DNA isolated from grains is the most rapid and reliable diagnostic tool to identify M. mycetomatis eumycetoma.

Published
2023

6. Comparing the performance of the common used eumycetoma diagnostic tests

Author

Siddig, Emmanuel Edwar, primary, Nyuykonge, Bertrand, additional, Mhmoud, Najwa Adam, additional, Abdallah, Omnia Babekir, additional, Bahar, Mustafa El Nour, additional, Ahmed, Eiman Siddig, additional, Nyaoke, Borna, additional, Zijlstra, Eduard E., additional, Verbon, Annelies, additional, Bakhiet, Sahar Mubarak, additional, Fahal, Ahmed Hassan, additional, and van de Sande, Wendy W. J., additional

Published
2023
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10. S4.5a A randomized, double blind phase II proof-of-concept superiority trial of fosravuconazole 200 mg or 300 mg weekly dose versus itraconazole 400 mg daily, all three arms in combination with surgery, in patients with eumycetoma in Sudan—top line results

Author

Fahal, Ahmed Hassan, primary, Bakhiet, Sahar Mubarak, additional, Mohamed, El Samani Wadaa, additional, Ahmed, Eiman Siddig, additional, Bakhiet, Osama El Hadi, additional, Yousif, Abu Bakar Ahmed, additional, Fahal, Lamis Ahmed, additional, Alla, Hadel Yassir Atta, additional, Razig, A Razig Osman A, additional, Siddig, Emmanuel Edwar, additional, Hassan, Omnia Babekir, additional, Abdulla, Sahar A Rahman, additional, Mohaemd, Amir Faroug, additional, Jodda, Nagwa Adam, additional, Bahar, Mustafa El Nour, additional, Nyaoke, Borna A., additional, Egondi, Thaddaeus, additional, Oyieko, Peelen, additional, Zijlstra, Eduard E., additional, and Strub-Wourgaft, Nathalie, additional

Published
2022
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11. S4.5b A randomized, double blind phase II proof-of-concept superiority trial of fosravuconazole 200 mg or 300 mg weekly dose versus itraconazole 400 mg daily, all three arms in combination with surgery, in patients with eumycetoma in Sudan—pharmacokinetic results

Author

Brüggemann, Roger, primary, Nyaoke, Borna, additional, Ahmed, Eiman Siddig, additional, Siddig, Emanwell Edwar, additional, Egondi, Thaddaeus, additional, Oyieko, Peelen, additional, Bakhiet, Sahar Mubarak, additional, Zijlstra, Eduard E, additional, and Fahal, Ahmed H, additional

Published
2022
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14. Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities

Author

Watson, Andrew Keith, primary, Kepplinger, Bernhard, additional, Bakhiet, Sahar Mubarak, additional, Mhmoud, Najwa Adam, additional, Chapman, Jonathan, additional, Allenby, Nick EE, additional, Mickiewicz, Katarzyna, additional, Goodfellow, Michael, additional, Fahal, Ahmed Hassan, additional, and Errington, Jeff, additional

Published
2022
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15. Staphylococcus aureus causing primary foot botryomycosis mimicking actinomycetoma:a case report from Sudan

Author

Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Bakheit, Osama E. L. Hadi, Hassan, Omnia Babekir, Ahmed, Eiman Siddig, Osman, Asma Adam, Bakhiet, Sahar Mubarak, van de Sande, Wendy W. J., Fahal, Ahmed Hassan, Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Bakheit, Osama E. L. Hadi, Hassan, Omnia Babekir, Ahmed, Eiman Siddig, Osman, Asma Adam, Bakhiet, Sahar Mubarak, van de Sande, Wendy W. J., and Fahal, Ahmed Hassan

Abstract

Objectives: Botryomycosis is a rare chronic granulomatous inflammatory disease of bacterial origin. Two forms of the disease exist; the cutaneous and the visceral form. The subcutaneous form mimics actino-mycetoma clinically and histologically; however, the treatment is different. In this communication, we report on a Sudanese male patient who presented with foot botryomycosis. Design: Case report. Results: The patient was initially diagnosed with actinomycetoma by the presence of Streptomyces soma-liensis like-grains in the histological slides. The patient was treated with a combination of co-trimoxazole and amikacin sulfate and shifted after 1 year to co-trimoxazole, amoxicillin, and clavulanic acid. Despite treatment, the infection progressed, and the bone was invaded. The infected limb was amputated. The histopathological report of the surgical biopsy showed gram-positive cocci inside the grain. The 16S se-quence identified these cocci as Staphylococcus aureus. Conclusion: This is the first reported botryomycosis case from Sudan, and it highlights why molecular identification is vital in diagnosis.

Published
2022

17. Mycetoma management and clinical outcomes: the Mycetoma Research Center experience.

Author

Musa, Esraa Abdelgadir, Abdoon, Iman Hassan, Bakhiet, Sahar Mubarak, Osman, Bashier, Abdalla, Safa A, and Fahal, Ahmed Hassan

Subjects
CHRONIC granulomatous disease, TREATMENT effectiveness, RESEARCH institutes, SURGICAL excision, THERAPEUTICS
Abstract

Background Mycetoma is a chronic granulomatous inflammatory disease that affects the cutaneous and subcutaneous tissues, leading to gruesome complications if not treated early. As a neglected disease, it has received scant attention in developing curable drugs. Mycetoma treatment is still based on expert opinions in the absence of guidelines. Methods This descriptive, cross-sectional, hospital-based study aimed to determine and assess the disease treatment outcomes observed at Mycetoma Research Center, Sudan. Results In this study, 75% of patients had eumycetoma, all of whom were treated with itraconazole and 37.4% underwent surgical excision, while 25% of the patients had actinomycetoma, 99.2% of whom were treated with a combination of cotrimoxazole and amoxicillin-clavulanate. The cure rate was 12.7% and 14.3% for patients with eumycetoma and actinomycetoma, respectively. Only 6.1% of eumycetoma patients underwent amputation. Remarkably, no patient with actinomycetoma underwent an amputation. Small lesions (OR=10.09, p < 0.001) and good follow-up (OR=6.81, p=0.002) were positive predictors of complete cure. In terms of amputation, history of surgical recurrence at presentation (OR=3.67, p=0.020) and presence of grains (OR=7.13, p=0.012) were positive predictors, whereas small lesions were negative predictors (OR=0.06, p=0.009). Conclusions Treatment of mycetoma was suboptimal, with a low cure rate despite a long treatment duration. Complete cure has a significant association with small lesions and good follow-up. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Human actinomycetoma caused by Actinomadura mexicana in Sudan:the first report

Author

Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Ahmed, Mohammed Tayfour, Hassan, Rowa, Saad, Eiman Siddig Ahmed, Mhmoud, Najwa Adam, Bakhiet, Sahar Mubarak, van de Sande, Wendy W.J., Fahal, Ahmed Hassan, Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Ahmed, Mohammed Tayfour, Hassan, Rowa, Saad, Eiman Siddig Ahmed, Mhmoud, Najwa Adam, Bakhiet, Sahar Mubarak, van de Sande, Wendy W.J., and Fahal, Ahmed Hassan

Abstract

Mycetoma is a localized, chronic, granulomatous disease that can be caused by fungi (eumycetoma) or bacteria (actinomycetoma). Of the 70 different causative agents implicated in mycetoma worldwide, Actinomadura madurae is the only one that causes multiple cases on all continents. Recently, new Actinomadura species were described as causative agents of human mycetoma. One of these new causative agents was Actinomadura mexicana, which was identified in Latin America. Here we demonstrate that this causative agent is not confined to Latin America and that it is also a causative agent of actinomycetoma in Sudan. The disease was managed by antibiotic treatment alone and resulted in complete cure after 6 months of treatment, which is quick when compared with actinomycetoma cases caused by other Actinomadura species.

Published
2021

24. Mycetoma caused by Microascus gracilis:a novel agent of human eumycetoma in Sudan

Author

Mhmoud, Najwa A., Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Bakhiet, Sahar Mubarak, van de Sande, Wendy W.J., Fahal, Ahmed Hassan, Mhmoud, Najwa A., Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Bakhiet, Sahar Mubarak, van de Sande, Wendy W.J., and Fahal, Ahmed Hassan

Abstract

Species of the genus Microascus are uncommon agents of human diseases despite their ubiquitous presence in the environment. In this communication, the first case of white grain eumycetoma caused by the fungus Microascus gracilis is reported. The patient was initially misdiagnosed as having actinomycetoma based on the grains morphological and cytological features and was treated with antimicrobial therapy with no clinical improvement. She underwent wide local surgical excision to improve the response to medical treatment and further grain cultural, molecular and taxonomy techniques were conducted and the diagnosis of mycetoma due to M. gracilis was established. The antifungal susceptibilities of this isolate to nine drugs were tested in vitro and they showed poor activity. Combination therapy with surgery and itraconazole led to complete recovery. A medical literature search revealed no previous report on M. gracilis as a causative agent of eumycetoma and hence we are reporting this new causative agent of human eumycetoma. Also, the difficulty in the management of this patient emphasizes the need for accurate and appropriate diagnostic tests for the identification of mycetoma-causative organisms and thus proper management.

Published
2021

25. MRC Poster

Author

Fahal, Ahmed Hassan, Bakhiet, Sahar Mubarak, Rayan Ali, and Roa Fath EL Rahman

Published
2020
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40. Mycetoma caused by Microascus gracilis: a novel agent of human eumycetoma in Sudan.

Author

Mhmoud, Najwa A, Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Bakhiet, Sahar Mubarak, Sande, Wendy W J van de, and Fahal, Ahmed Hassan

Subjects
MEDICAL literature, SURGICAL excision, THERAPEUTICS, DIAGNOSIS
Abstract

Species of the genus Microascus are uncommon agents of human diseases despite their ubiquitous presence in the environment. In this communication, the first case of white grain eumycetoma caused by the fungus Microascus gracilis is reported. The patient was initially misdiagnosed as having actinomycetoma based on the grains morphological and cytological features and was treated with antimicrobial therapy with no clinical improvement. She underwent wide local surgical excision to improve the response to medical treatment and further grain cultural, molecular and taxonomy techniques were conducted and the diagnosis of mycetoma due to M. gracilis was established. The antifungal susceptibilities of this isolate to nine drugs were tested in vitro and they showed poor activity. Combination therapy with surgery and itraconazole led to complete recovery. A medical literature search revealed no previous report on M. gracilis as a causative agent of eumycetoma and hence we are reporting this new causative agent of human eumycetoma. Also, the difficulty in the management of this patient emphasizes the need for accurate and appropriate diagnostic tests for the identification of mycetoma-causative organisms and thus proper management. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Human actinomycetoma caused by Actinomadura mexicana in Sudan: the first report.

Author

Siddig, Emmanuel Edwar, Nyuykonge, Bertrand, Ahmed, Mohammed Tayfour, Hassan, Rowa, Saad, Eiman Siddig Ahmed, Mhmoud, Najwa Adam, Bakhiet, Sahar Mubarak, Sande, Wendy W J van de, and Fahal, Ahmed Hassan

Subjects
HUMAN beings, ANTIBIOTICS, SPECIES, CONTINENTS, BACTERIA
Abstract

Mycetoma is a localized, chronic, granulomatous disease that can be caused by fungi (eumycetoma) or bacteria (actinomycetoma). Of the 70 different causative agents implicated in mycetoma worldwide, Actinomadura madurae is the only one that causes multiple cases on all continents. Recently, new Actinomadura species were described as causative agents of human mycetoma. One of these new causative agents was Actinomadura mexicana , which was identified in Latin America. Here we demonstrate that this causative agent is not confined to Latin America and that it is also a causative agent of actinomycetoma in Sudan. The disease was managed by antibiotic treatment alone and resulted in complete cure after 6 months of treatment, which is quick when compared with actinomycetoma cases caused by other Actinomadura species. [ABSTRACT FROM AUTHOR]

Published
2021
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44. A holistic approach to the mycetoma management

Author

Bakhiet, Sahar Mubarak, primary, Fahal, Ahmed Hassan, additional, Musa, Ahmed Mudawi, additional, Mohamed, El Samani Wadaa, additional, Omer, Rowa Fathelrahman, additional, Ahmed, Eiman Siddig, additional, El Nour, Mustafa, additional, Mustafa, El Rayah Mohamed, additional, Sheikh A. Rahman, Manar El, additional, Suliman, Suliman Hussein, additional, El Mamoun, Mohamed A. Gadir, additional, and El Amin, Hajo Mohamed, additional

Published
2018
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