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1. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context

Author

Gemini Team, Georgiev, Petko, Lei, Ving Ian, Burnell, Ryan, Bai, Libin, Gulati, Anmol, Tanzer, Garrett, Vincent, Damien, Pan, Zhufeng, Wang, Shibo, Mariooryad, Soroosh, Ding, Yifan, Geng, Xinyang, Alcober, Fred, Frostig, Roy, Omernick, Mark, Walker, Lexi, Paduraru, Cosmin, Sorokin, Christina, Tacchetti, Andrea, Gaffney, Colin, Daruki, Samira, Sercinoglu, Olcan, Gleicher, Zach, Love, Juliette, Voigtlaender, Paul, Jain, Rohan, Surita, Gabriela, Mohamed, Kareem, Blevins, Rory, Ahn, Junwhan, Zhu, Tao, Kawintiranon, Kornraphop, Firat, Orhan, Gu, Yiming, Zhang, Yujing, Rahtz, Matthew, Faruqui, Manaal, Clay, Natalie, Gilmer, Justin, Co-Reyes, JD, Penchev, Ivo, Zhu, Rui, Morioka, Nobuyuki, Hui, Kevin, Haridasan, Krishna, Campos, Victor, Mahdieh, Mahdis, Guo, Mandy, Hassan, Samer, Kilgour, Kevin, Vezer, Arpi, Cheng, Heng-Tze, de Liedekerke, Raoul, Goyal, Siddharth, Barham, Paul, Strouse, DJ, Noury, Seb, Adler, Jonas, Sundararajan, Mukund, Vikram, Sharad, Lepikhin, Dmitry, Paganini, Michela, Garcia, Xavier, Yang, Fan, Valter, Dasha, Trebacz, Maja, Vodrahalli, Kiran, Asawaroengchai, Chulayuth, Ring, Roman, Kalb, Norbert, Soares, Livio Baldini, Brahma, Siddhartha, Steiner, David, Yu, Tianhe, Mentzer, Fabian, He, Antoine, Gonzalez, Lucas, Xu, Bibo, Kaufman, Raphael Lopez, Shafey, Laurent El, Oh, Junhyuk, Hennigan, Tom, Driessche, George van den, Odoom, Seth, Lucic, Mario, Roelofs, Becca, Lall, Sid, Marathe, Amit, Chan, Betty, Ontanon, Santiago, He, Luheng, Teplyashin, Denis, Lai, Jonathan, Crone, Phil, Damoc, Bogdan, Ho, Lewis, Riedel, Sebastian, Lenc, Karel, Yeh, Chih-Kuan, Chowdhery, Aakanksha, Xu, Yang, Kazemi, Mehran, Amid, Ehsan, Petrushkina, Anastasia, Swersky, Kevin, Khodaei, Ali, Chen, Gowoon, Larkin, Chris, Pinto, Mario, Yan, Geng, Badia, Adria Puigdomenech, Patil, Piyush, Hansen, Steven, Orr, Dave, Arnold, Sebastien M. R., Grimstad, Jordan, Dai, Andrew, Douglas, Sholto, Sinha, Rishika, Yadav, Vikas, Chen, Xi, Gribovskaya, Elena, Austin, Jacob, Zhao, Jeffrey, Patel, Kaushal, Komarek, Paul, Austin, Sophia, Borgeaud, Sebastian, Friso, Linda, Goyal, Abhimanyu, Caine, Ben, Cao, Kris, Chung, Da-Woon, Lamm, Matthew, Barth-Maron, Gabe, Kagohara, Thais, Olszewska, Kate, Chen, Mia, Shivakumar, Kaushik, Agarwal, Rishabh, Godhia, Harshal, Rajwar, Ravi, Snaider, Javier, Dotiwalla, Xerxes, Liu, Yuan, Barua, Aditya, Ungureanu, Victor, Zhang, Yuan, Batsaikhan, Bat-Orgil, Wirth, Mateo, Qin, James, Danihelka, Ivo, Doshi, Tulsee, Chadwick, Martin, Chen, Jilin, Jain, Sanil, Le, Quoc, Kar, Arjun, Gurumurthy, Madhu, Li, Cheng, Sang, Ruoxin, Liu, Fangyu, Lamprou, Lampros, Munoz, Rich, Lintz, Nathan, Mehta, Harsh, Howard, Heidi, Reynolds, Malcolm, Aroyo, Lora, Wang, Quan, Blanco, Lorenzo, Cassirer, Albin, Griffith, Jordan, Das, Dipanjan, Lee, Stephan, Sygnowski, Jakub, Fisher, Zach, Besley, James, Powell, Richard, Ahmed, Zafarali, Paulus, Dominik, Reitter, David, Borsos, Zalan, Joshi, Rishabh, Pope, Aedan, Hand, Steven, Selo, Vittorio, Jain, Vihan, Sethi, Nikhil, Goel, Megha, Makino, Takaki, May, Rhys, Yang, Zhen, Schalkwyk, Johan, Butterfield, Christina, Hauth, Anja, Goldin, Alex, Hawkins, Will, Senter, Evan, Brin, Sergey, Woodman, Oliver, Ritter, Marvin, Noland, Eric, Giang, Minh, Bolina, Vijay, Lee, Lisa, Blyth, Tim, Mackinnon, Ian, Reid, Machel, Sarvana, Obaid, Silver, David, Chen, Alexander, Wang, Lily, Maggiore, Loren, Chang, Oscar, Attaluri, Nithya, Thornton, Gregory, Chiu, Chung-Cheng, Bunyan, Oskar, Levine, Nir, Chung, Timothy, Eltyshev, Evgenii, Si, Xiance, Lillicrap, Timothy, Brady, Demetra, Aggarwal, Vaibhav, Wu, Boxi, Xu, Yuanzhong, McIlroy, Ross, Badola, Kartikeya, Sandhu, Paramjit, Moreira, Erica, Stokowiec, Wojciech, Hemsley, Ross, Li, Dong, Tudor, Alex, Shyam, Pranav, Rahimtoroghi, Elahe, Haykal, Salem, Sprechmann, Pablo, Zhou, Xiang, Mincu, Diana, Li, Yujia, Addanki, Ravi, Krishna, Kalpesh, Wu, Xiao, Frechette, Alexandre, Eyal, Matan, Dafoe, Allan, Lacey, Dave, Whang, Jay, Avrahami, Thi, Zhang, Ye, Taropa, Emanuel, Lin, Hanzhao, Toyama, Daniel, Rutherford, Eliza, Sano, Motoki, Choe, HyunJeong, Tomala, Alex, Safranek-Shrader, Chalence, Kassner, Nora, Pajarskas, Mantas, Harvey, Matt, Sechrist, Sean, Fortunato, Meire, Lyu, Christina, Elsayed, Gamaleldin, Kuang, Chenkai, Lottes, James, Chu, Eric, Jia, Chao, Chen, Chih-Wei, Humphreys, Peter, Baumli, Kate, Tao, Connie, Samuel, Rajkumar, Santos, Cicero Nogueira dos, Andreassen, Anders, Rakićević, Nemanja, Grewe, Dominik, Kumar, Aviral, Winkler, Stephanie, Caton, Jonathan, Brock, Andrew, Dalmia, Sid, Sheahan, Hannah, Barr, Iain, Miao, Yingjie, Natsev, Paul, Devlin, Jacob, Behbahani, Feryal, Prost, Flavien, Sun, Yanhua, Myaskovsky, Artiom, Pillai, Thanumalayan Sankaranarayana, Hurt, Dan, Lazaridou, Angeliki, Xiong, Xi, Zheng, Ce, Pardo, Fabio, Li, Xiaowei, Horgan, Dan, Stanton, Joe, Ambar, Moran, Xia, Fei, Lince, Alejandro, Wang, Mingqiu, Mustafa, Basil, Webson, Albert, Lee, Hyo, Anil, Rohan, Wicke, Martin, Dozat, Timothy, Sinha, Abhishek, Piqueras, Enrique, Dabir, Elahe, Upadhyay, Shyam, Boral, Anudhyan, Hendricks, Lisa Anne, Fry, Corey, Djolonga, Josip, Su, Yi, Walker, Jake, Labanowski, Jane, Huang, Ronny, Misra, Vedant, Chen, Jeremy, Skerry-Ryan, RJ, Singh, Avi, Rijhwani, Shruti, Yu, Dian, Castro-Ros, Alex, Changpinyo, Beer, Datta, Romina, Bagri, Sumit, Hrafnkelsson, Arnar Mar, Maggioni, Marcello, Zheng, Daniel, Sulsky, Yury, Hou, Shaobo, Paine, Tom Le, Yang, Antoine, Riesa, Jason, Rogozinska, Dominika, Marcus, Dror, Badawy, Dalia El, Zhang, Qiao, Wang, Luyu, Miller, Helen, Greer, Jeremy, Sjos, Lars Lowe, Nova, Azade, Zen, Heiga, Chaabouni, Rahma, Rosca, Mihaela, Jiang, Jiepu, Chen, Charlie, Liu, Ruibo, Sainath, Tara, Krikun, Maxim, Polozov, Alex, Lespiau, Jean-Baptiste, Newlan, Josh, Cankara, Zeyncep, Kwak, Soo, Xu, Yunhan, Chen, Phil, Coenen, Andy, Meyer, Clemens, Tsihlas, Katerina, Ma, Ada, Gottweis, Juraj, Xing, Jinwei, Gu, Chenjie, Miao, Jin, Frank, Christian, Cankara, Zeynep, Ganapathy, Sanjay, Dasgupta, Ishita, Hughes-Fitt, Steph, Chen, Heng, Reid, David, Rong, Keran, Fan, Hongmin, van Amersfoort, Joost, Zhuang, Vincent, Cohen, Aaron, Gu, Shixiang Shane, Mohananey, Anhad, Ilic, Anastasija, Tobin, Taylor, Wieting, John, Bortsova, Anna, Thacker, Phoebe, Wang, Emma, Caveness, Emily, Chiu, Justin, Sezener, Eren, Kaskasoli, Alex, Baker, Steven, Millican, Katie, Elhawaty, Mohamed, Aisopos, Kostas, Lebsack, Carl, Byrd, Nathan, Dai, Hanjun, Jia, Wenhao, Wiethoff, Matthew, Davoodi, Elnaz, Weston, Albert, Yagati, Lakshman, Ahuja, Arun, Gao, Isabel, Pundak, Golan, Zhang, Susan, Azzam, Michael, Sim, Khe Chai, Caelles, Sergi, Keeling, James, Sharma, Abhanshu, Swing, Andy, Li, YaGuang, Liu, Chenxi, Bostock, Carrie Grimes, Bansal, Yamini, Nado, Zachary, Anand, Ankesh, Lipschultz, Josh, Karmarkar, Abhijit, Proleev, Lev, Ittycheriah, Abe, Yeganeh, Soheil Hassas, Polovets, George, Faust, Aleksandra, Sun, Jiao, Rrustemi, Alban, Li, Pen, Shivanna, Rakesh, Liu, Jeremiah, Welty, Chris, Lebron, Federico, Baddepudi, Anirudh, Krause, Sebastian, Parisotto, Emilio, Soricut, Radu, Xu, Zheng, Bloxwich, Dawn, Johnson, Melvin, Neyshabur, Behnam, Mao-Jones, Justin, Wang, Renshen, Ramasesh, Vinay, Abbas, Zaheer, Guez, Arthur, Segal, Constant, Nguyen, Duc Dung, Svensson, James, Hou, Le, York, Sarah, Milan, Kieran, Bridgers, Sophie, Gworek, Wiktor, Tagliasacchi, Marco, Lee-Thorp, James, Chang, Michael, Guseynov, Alexey, Hartman, Ale Jakse, Kwong, Michael, Zhao, Ruizhe, Kashem, Sheleem, Cole, Elizabeth, Miech, Antoine, Tanburn, Richard, Phuong, Mary, Pavetic, Filip, Cevey, Sebastien, Comanescu, Ramona, Ives, Richard, Yang, Sherry, Du, Cosmo, Li, Bo, Zhang, Zizhao, Iinuma, Mariko, Hu, Clara Huiyi, Roy, Aurko, Bijwadia, Shaan, Zhu, Zhenkai, Martins, Danilo, Saputro, Rachel, Gergely, Anita, Zheng, Steven, Jia, Dawei, Antonoglou, Ioannis, Sadovsky, Adam, Gu, Shane, Bi, Yingying, Andreev, Alek, Samangooei, Sina, Khan, Mina, Kocisky, Tomas, Filos, Angelos, Kumar, Chintu, Bishop, Colton, Yu, Adams, Hodkinson, Sarah, Mittal, Sid, Shah, Premal, Moufarek, Alexandre, Cheng, Yong, Bloniarz, Adam, Lee, Jaehoon, Pejman, Pedram, Michel, Paul, Spencer, Stephen, Feinberg, Vladimir, Xiong, Xuehan, Savinov, Nikolay, Smith, Charlotte, Shakeri, Siamak, Tran, Dustin, Chesus, Mary, Bohnet, Bernd, Tucker, George, von Glehn, Tamara, Muir, Carrie, Mao, Yiran, Kazawa, Hideto, Slone, Ambrose, Soparkar, Kedar, Shrivastava, Disha, Cobon-Kerr, James, Sharman, Michael, Pavagadhi, Jay, Araya, Carlos, Misiunas, Karolis, Ghelani, Nimesh, Laskin, Michael, Barker, David, Li, Qiujia, Briukhov, Anton, Houlsby, Neil, Glaese, Mia, Lakshminarayanan, Balaji, Schucher, Nathan, Tang, Yunhao, Collins, Eli, Lim, Hyeontaek, Feng, Fangxiaoyu, Recasens, Adria, Lai, Guangda, Magni, Alberto, De Cao, Nicola, Siddhant, Aditya, Ashwood, Zoe, Orbay, Jordi, Dehghani, Mostafa, Brennan, Jenny, He, Yifan, Xu, Kelvin, Gao, Yang, Saroufim, Carl, Molloy, James, Wu, Xinyi, Arnold, Seb, Chang, Solomon, Schrittwieser, Julian, Buchatskaya, Elena, Radpour, Soroush, Polacek, Martin, Giordano, Skye, Bapna, Ankur, Tokumine, Simon, Hellendoorn, Vincent, Sottiaux, Thibault, Cogan, Sarah, Severyn, Aliaksei, Saleh, Mohammad, Thakoor, Shantanu, Shefey, Laurent, Qiao, Siyuan, Gaba, Meenu, Chang, Shuo-yiin, Swanson, Craig, Zhang, Biao, Lee, Benjamin, Rubenstein, Paul Kishan, Song, Gan, Kwiatkowski, Tom, Koop, Anna, Kannan, Ajay, Kao, David, Schuh, Parker, Stjerngren, Axel, Ghiasi, Golnaz, Gibson, Gena, Vilnis, Luke, Yuan, Ye, Ferreira, Felipe Tiengo, Kamath, Aishwarya, Klimenko, Ted, Franko, Ken, Xiao, Kefan, Bhattacharya, Indro, Patel, Miteyan, Wang, Rui, Morris, Alex, Strudel, Robin, Sharma, Vivek, Choy, Peter, Hashemi, Sayed Hadi, Landon, Jessica, Finkelstein, Mara, Jhakra, Priya, Frye, Justin, Barnes, Megan, Mauger, Matthew, Daun, Dennis, Baatarsukh, Khuslen, Tung, Matthew, Farhan, Wael, Michalewski, Henryk, Viola, Fabio, Quitry, Felix de Chaumont, Lan, Charline Le, Hudson, Tom, Wang, Qingze, Fischer, Felix, Zheng, Ivy, White, Elspeth, Dragan, Anca, Alayrac, Jean-baptiste, Ni, Eric, Pritzel, Alexander, Iwanicki, Adam, Isard, Michael, Bulanova, Anna, Zilka, Lukas, Dyer, Ethan, Sachan, Devendra, Srinivasan, Srivatsan, Muckenhirn, Hannah, Cai, Honglong, Mandhane, Amol, Tariq, Mukarram, Rae, Jack W., Wang, Gary, Ayoub, Kareem, FitzGerald, Nicholas, Zhao, Yao, Han, Woohyun, Alberti, Chris, Garrette, Dan, Krishnakumar, Kashyap, Gimenez, Mai, Levskaya, Anselm, Sohn, Daniel, Matak, Josip, Iturrate, Inaki, Chang, Michael B., Xiang, Jackie, Cao, Yuan, Ranka, Nishant, Brown, Geoff, Hutter, Adrian, Mirrokni, Vahab, Chen, Nanxin, Yao, Kaisheng, Egyed, Zoltan, Galilee, Francois, Liechty, Tyler, Kallakuri, Praveen, Palmer, Evan, Ghemawat, Sanjay, Liu, Jasmine, Tao, David, Thornton, Chloe, Green, Tim, Jasarevic, Mimi, Lin, Sharon, Cotruta, Victor, Tan, Yi-Xuan, Fiedel, Noah, Yu, Hongkun, Chi, Ed, Neitz, Alexander, Heitkaemper, Jens, Sinha, Anu, Zhou, Denny, Sun, Yi, Kaed, Charbel, Hulse, Brice, Mishra, Swaroop, Georgaki, Maria, Kudugunta, Sneha, Farabet, Clement, Shafran, Izhak, Vlasic, Daniel, Tsitsulin, Anton, Ananthanarayanan, Rajagopal, Carin, Alen, Su, Guolong, Sun, Pei, V, Shashank, Carvajal, Gabriel, Broder, Josef, Comsa, Iulia, Repina, Alena, Wong, William, Chen, Warren Weilun, Hawkins, Peter, Filonov, Egor, Loher, Lucia, Hirnschall, Christoph, Wang, Weiyi, Ye, Jingchen, Burns, Andrea, Cate, Hardie, Wright, Diana Gage, Piccinini, Federico, Zhang, Lei, Lin, Chu-Cheng, Gog, Ionel, Kulizhskaya, Yana, Sreevatsa, Ashwin, Song, Shuang, Cobo, Luis C., Iyer, Anand, Tekur, Chetan, Garrido, Guillermo, Xiao, Zhuyun, Kemp, Rupert, Zheng, Huaixiu Steven, Li, Hui, Agarwal, Ananth, Ngani, Christel, Goshvadi, Kati, Santamaria-Fernandez, Rebeca, Fica, Wojciech, Chen, Xinyun, Gorgolewski, Chris, Sun, Sean, Garg, Roopal, Ye, Xinyu, Eslami, S. M. Ali, Hua, Nan, Simon, Jon, Joshi, Pratik, Kim, Yelin, Tenney, Ian, Potluri, Sahitya, Thiet, Lam Nguyen, Yuan, Quan, Luisier, Florian, Chronopoulou, Alexandra, Scellato, Salvatore, Srinivasan, Praveen, Chen, Minmin, Koverkathu, Vinod, Dalibard, Valentin, Xu, Yaming, Saeta, Brennan, Anderson, Keith, Sellam, Thibault, Fernando, Nick, Huot, Fantine, Jung, Junehyuk, Varadarajan, Mani, Quinn, Michael, Raul, Amit, Le, Maigo, Habalov, Ruslan, Clark, Jon, Jalan, Komal, Bullard, Kalesha, Singhal, Achintya, Luong, Thang, Wang, Boyu, Rajayogam, Sujeevan, Eisenschlos, Julian, Jia, Johnson, Finchelstein, Daniel, Yakubovich, Alex, Balle, Daniel, Fink, Michael, Agarwal, Sameer, Li, Jing, Dvijotham, Dj, Pal, Shalini, Kang, Kai, Konzelmann, Jaclyn, Beattie, Jennifer, Dousse, Olivier, Wu, Diane, Crocker, Remi, Elkind, Chen, Jonnalagadda, Siddhartha Reddy, Lee, Jong, Holtmann-Rice, Dan, Kallarackal, Krystal, Liu, Rosanne, Vnukov, Denis, Vats, Neera, Invernizzi, Luca, Jafari, Mohsen, Zhou, Huanjie, Taylor, Lilly, Prendki, Jennifer, Wu, Marcus, Eccles, Tom, Liu, Tianqi, Kopparapu, Kavya, Beaufays, Francoise, Angermueller, Christof, Marzoca, Andreea, Sarcar, Shourya, Dib, Hilal, Stanway, Jeff, Perbet, Frank, Trdin, Nejc, Sterneck, Rachel, Khorlin, Andrey, Li, Dinghua, Wu, Xihui, Goenka, Sonam, Madras, David, Goldshtein, Sasha, Gierke, Willi, Zhou, Tong, Liu, Yaxin, Liang, Yannie, White, Anais, Li, Yunjie, Singh, Shreya, Bahargam, Sanaz, Epstein, Mark, Basu, Sujoy, Lao, Li, Ozturel, Adnan, Crous, Carl, Zhai, Alex, Lu, Han, Tung, Zora, Gaur, Neeraj, Walton, Alanna, Dixon, Lucas, Zhang, Ming, Globerson, Amir, Uy, Grant, Bolt, Andrew, Wiles, Olivia, Nasr, Milad, Shumailov, Ilia, Selvi, Marco, Piccinno, Francesco, Aguilar, Ricardo, McCarthy, Sara, Khalman, Misha, Shukla, Mrinal, Galic, Vlado, Carpenter, John, Villela, Kevin, Zhang, Haibin, Richardson, Harry, Martens, James, Bosnjak, Matko, Belle, Shreyas Rammohan, Seibert, Jeff, Alnahlawi, Mahmoud, McWilliams, Brian, Singh, Sankalp, Louis, Annie, Ding, Wen, Popovici, Dan, Simicich, Lenin, Knight, Laura, Mehta, Pulkit, Gupta, Nishesh, Shi, Chongyang, Fatehi, Saaber, Mitrovic, Jovana, Grills, Alex, Pagadora, Joseph, Petrova, Dessie, Eisenbud, Danielle, Zhang, Zhishuai, Yates, Damion, Mittal, Bhavishya, Tripuraneni, Nilesh, Assael, Yannis, Brovelli, Thomas, Jain, Prateek, Velimirovic, Mihajlo, Akbulut, Canfer, Mu, Jiaqi, Macherey, Wolfgang, Kumar, Ravin, Xu, Jun, Qureshi, Haroon, Comanici, Gheorghe, Wiesner, Jeremy, Gong, Zhitao, Ruddock, Anton, Bauer, Matthias, Felt, Nick, GP, Anirudh, Arnab, Anurag, Zelle, Dustin, Rothfuss, Jonas, Rosgen, Bill, Shenoy, Ashish, Seybold, Bryan, Li, Xinjian, Mudigonda, Jayaram, Erdogan, Goker, Xia, Jiawei, Simsa, Jiri, Michi, Andrea, Yao, Yi, Yew, Christopher, Kan, Steven, Caswell, Isaac, Radebaugh, Carey, Elisseeff, Andre, Valenzuela, Pedro, McKinney, Kay, Paterson, Kim, Cui, Albert, Latorre-Chimoto, Eri, Kim, Solomon, Zeng, William, Durden, Ken, Ponnapalli, Priya, Sosea, Tiberiu, Choquette-Choo, Christopher A., Manyika, James, Robenek, Brona, Vashisht, Harsha, Pereira, Sebastien, Lam, Hoi, Velic, Marko, Owusu-Afriyie, Denese, Lee, Katherine, Bolukbasi, Tolga, Parrish, Alicia, Lu, Shawn, Park, Jane, Venkatraman, Balaji, Talbert, Alice, Rosique, Lambert, Cheng, Yuchung, Sozanschi, Andrei, Paszke, Adam, Kumar, Praveen, Austin, Jessica, Li, Lu, Salama, Khalid, Kim, Wooyeol, Dukkipati, Nandita, Baryshnikov, Anthony, Kaplanis, Christos, Sheng, XiangHai, Chervonyi, Yuri, Unlu, Caglar, Casas, Diego de Las, Askham, Harry, Tunyasuvunakool, Kathryn, Gimeno, Felix, Poder, Siim, Kwak, Chester, Miecnikowski, Matt, Dimitriev, Alek, Parisi, Aaron, Liu, Dangyi, Tsai, Tomy, Shevlane, Toby, Kouridi, Christina, Garmon, Drew, Goedeckemeyer, Adrian, Brown, Adam R., Vijayakumar, Anitha, Elqursh, Ali, Jazayeri, Sadegh, Huang, Jin, Carthy, Sara Mc, Hoover, Jay, Kim, Lucy, Kumar, Sandeep, Chen, Wei, Biles, Courtney, Bingham, Garrett, Rosen, Evan, Wang, Lisa, Tan, Qijun, Engel, David, Pongetti, Francesco, de Cesare, Dario, Hwang, Dongseong, Yu, Lily, Pullman, Jennifer, Narayanan, Srini, Levin, Kyle, Gopal, Siddharth, Li, Megan, Aharoni, Asaf, Trinh, Trieu, Lo, Jessica, Casagrande, Norman, Vij, Roopali, Matthey, Loic, Ramadhana, Bramandia, Matthews, Austin, Carey, CJ, Johnson, Matthew, Goranova, Kremena, Shah, Rohin, Ashraf, Shereen, Dasgupta, Kingshuk, Larsen, Rasmus, Wang, Yicheng, Vuyyuru, Manish Reddy, Jiang, Chong, Ijazi, Joana, Osawa, Kazuki, Smith, Celine, Boppana, Ramya Sree, Bilal, Taylan, Koizumi, Yuma, Xu, Ying, Altun, Yasemin, Shabat, Nir, Bariach, Ben, Korchemniy, Alex, Choo, Kiam, Ronneberger, Olaf, Iwuanyanwu, Chimezie, Zhao, Shubin, Soergel, David, Hsieh, Cho-Jui, Cai, Irene, Iqbal, Shariq, Sundermeyer, Martin, Chen, Zhe, Bursztein, Elie, Malaviya, Chaitanya, Biadsy, Fadi, Shroff, Prakash, Dhillon, Inderjit, Latkar, Tejasi, Dyer, Chris, Forbes, Hannah, Nicosia, Massimo, Nikolaev, Vitaly, Greene, Somer, Georgiev, Marin, Wang, Pidong, Martin, Nina, Sedghi, Hanie, Zhang, John, Banzal, Praseem, Fritz, Doug, Rao, Vikram, Wang, Xuezhi, Zhang, Jiageng, Patraucean, Viorica, Du, Dayou, Mordatch, Igor, Jurin, Ivan, Liu, Lewis, Dubey, Ayush, Mohan, Abhi, Nowakowski, Janek, Ion, Vlad-Doru, Wei, Nan, Tojo, Reiko, Raad, Maria Abi, Hudson, Drew A., Keshava, Vaishakh, Agrawal, Shubham, Ramirez, Kevin, Wu, Zhichun, Nguyen, Hoang, Liu, Ji, Sewak, Madhavi, Petrini, Bryce, Choi, DongHyun, Philips, Ivan, Wang, Ziyue, Bica, Ioana, Garg, Ankush, Wilkiewicz, Jarek, Agrawal, Priyanka, Guo, Danhao, Xue, Emily, Shaik, Naseer, Leach, Andrew, Khan, Sadh MNM, Wiesinger, Julia, Jerome, Sammy, Chakladar, Abhishek, Wang, Alek Wenjiao, Ornduff, Tina, Abu, Folake, Ghaffarkhah, Alireza, Wainwright, Marcus, Cortes, Mario, Liu, Frederick, Maynez, Joshua, Terzis, Andreas, Samangouei, Pouya, Mansour, Riham, Kępa, Tomasz, Aubet, François-Xavier, Algymr, Anton, Banica, Dan, Weisz, Agoston, Orban, Andras, Senges, Alexandre, Andrejczuk, Ewa, Geller, Mark, Santo, Niccolo Dal, Anklin, Valentin, Merey, Majd Al, Baeuml, Martin, Strohman, Trevor, Bai, Junwen, Petrov, Slav, Wu, Yonghui, Hassabis, Demis, Kavukcuoglu, Koray, Dean, Jeffrey, and Vinyals, Oriol

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.

Published
2024

5. RVS Spectra of Gaia Photometric Science Alerts

Author

Seabroke, George, Cropper, Mark, Baker, Steven, Benson, Kevin, Dolding, Chris, Smith, Mike, Delgado, Arancha, Hodgkin, Simon, Harrison, Diana, Rixon, Guy, and Wyrzykowski, Lukasz

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Gaia Photometric Science Alerts (GPSA) publishes Gaia G magnitudes and Blue Photometer (BP) and Red Photometer (RP) low-resolution epoch spectra of transient events. 27 high-resolution spectra from Gaia's Radial Velocity Spectrometer (RVS) of 12 GPSAs have also been published. These 27 RVS epoch spectra are presented next to their corresponding BP and RP epoch spectra in a single place for the first time. We also present one new RVS spectrum of a 13th GPSA that could not be published by the GPSA system. Of the 13 GPSA with RVS spectra, five are photometrically classified as unknown, five as supernovae (three as SN Ia, one as SN II, one as SN IIP), one as a cataclysmic variable, one as a binary microlensing event and one as a young stellar object. The five GPSAs classified as unknown are potential scientific opportunities, while all of them are a preview of the epoch RVS spectra that will be published in Gaia's fourth data release., Comment: 11 pages, 11 figures, invited proceedings from the Galactic Astronomy Workshop in Istanbul, 12-13 September 2019 (https://astronomi.istanbul.edu.tr/calistay2019/en/index.php?kod=2), to be published by Istanbul University

Published
2020

6. Altimetry for the future: Building on 25 years of progress

Author

Team, International Altimetry, Abdalla, Saleh, Kolahchi, Abdolnabi Abdeh, Ablain, Michaël, Adusumilli, Susheel, Bhowmick, Suchandra Aich, Alou-Font, Eva, Amarouche, Laiba, Andersen, Ole Baltazar, Antich, Helena, Aouf, Lotfi, Arbic, Brian, Armitage, Thomas, Arnault, Sabine, Artana, Camila, Aulicino, Giuseppe, Ayoub, Nadia, Badulin, Sergei, Baker, Steven, Banks, Chris, Bao, Lifeng, Barbetta, Silvia, Barceló-Llull, Bàrbara, Barlier, François, Basu, Sujit, Bauer-Gottwein, Peter, Becker, Matthias, Beckley, Brian, Bellefond, Nicole, Belonenko, Tatyana, Benkiran, Mounir, Benkouider, Touati, Bennartz, Ralf, Benveniste, Jérôme, Bercher, Nicolas, Berge-Nguyen, Muriel, Bettencourt, Joao, Blarel, Fabien, Blazquez, Alejandro, Blumstein, Denis, Bonnefond, Pascal, Borde, Franck, Bouffard, Jérôme, Boy, François, Boy, Jean-Paul, Brachet, Cédric, Brasseur, Pierre, Braun, Alexander, Brocca, Luca, Brockley, David, Brodeau, Laurent, Brown, Shannon, Bruinsma, Sean, Bulczak, Anna, Buzzard, Sammie, Cahill, Madeleine, Calmant, Stéphane, Calzas, Michel, Camici, Stefania, Cancet, Mathilde, Capdeville, Hugues, Carabajal, Claudia Cristina, Carrere, Loren, Cazenave, Anny, Chassignet, Eric P, Chauhan, Prakash, Cherchali, Selma, Chereskin, Teresa, Cheymol, Cecile, Ciani, Daniele, Cipollini, Paolo, Cirillo, Francesca, Cosme, Emmanuel, Coss, Steve, Cotroneo, Yuri, Cotton, David, Couhert, Alexandre, Coutin-Faye, Sophie, Crétaux, Jean-François, Cyr, Frederic, d’Ovidio, Francesco, Darrozes, José, David, Cedric, Dayoub, Nadim, De Staerke, Danielle, Deng, Xiaoli, Desai, Shailen, Desjonqueres, Jean-Damien, Dettmering, Denise, Di Bella, Alessandro, Díaz-Barroso, Lara, Dibarboure, Gerald, Dieng, Habib Boubacar, Dinardo, Salvatore, Dobslaw, Henryk, Dodet, Guillaume, Doglioli, Andrea, Domeneghetti, Alessio, Donahue, David, and Dong, Shenfu

Subjects
Life Below Water, Climate Action, Satellite altimetry, Oceanography, Sea level, Coastal oceanography, Cryospheric sciences, Hydrology, Astronomical and Space Sciences, Aerospace Engineering, Mechanical Engineering, Aerospace & Aeronautics
Abstract

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion.

Published
2021

9. Altimetry for the future: Building on 25 years of progress

Author

Abdalla, Saleh, Abdeh Kolahchi, Abdolnabi, Ablain, Michaël, Adusumilli, Susheel, Aich Bhowmick, Suchandra, Alou-Font, Eva, Amarouche, Laiba, Andersen, Ole Baltazar, Antich, Helena, Aouf, Lotfi, Arbic, Brian, Armitage, Thomas, Arnault, Sabine, Artana, Camila, Aulicino, Giuseppe, Ayoub, Nadia, Badulin, Sergei, Baker, Steven, Banks, Chris, Bao, Lifeng, Barbetta, Silvia, Barceló-Llull, Bàrbara, Barlier, François, Basu, Sujit, Bauer-Gottwein, Peter, Becker, Matthias, Beckley, Brian, Bellefond, Nicole, Belonenko, Tatyana, Benkiran, Mounir, Benkouider, Touati, Bennartz, Ralf, Benveniste, Jérôme, Bercher, Nicolas, Berge-Nguyen, Muriel, Bettencourt, Joao, Blarel, Fabien, Blazquez, Alejandro, Blumstein, Denis, Bonnefond, Pascal, Borde, Franck, Bouffard, Jérôme, Boy, François, Boy, Jean-Paul, Brachet, Cédric, Brasseur, Pierre, Braun, Alexander, Brocca, Luca, Brockley, David, Brodeau, Laurent, Brown, Shannon, Bruinsma, Sean, Bulczak, Anna, Buzzard, Sammie, Cahill, Madeleine, Calmant, Stéphane, Calzas, Michel, Camici, Stefania, Cancet, Mathilde, Capdeville, Hugues, Carabajal, Claudia Cristina, Carrere, Loren, Cazenave, Anny, Chassignet, Eric P., Chauhan, Prakash, Cherchali, Selma, Chereskin, Teresa, Cheymol, Cecile, Ciani, Daniele, Cipollini, Paolo, Cirillo, Francesca, Cosme, Emmanuel, Coss, Steve, Cotroneo, Yuri, Cotton, David, Couhert, Alexandre, Coutin-Faye, Sophie, Crétaux, Jean-François, Cyr, Frederic, d’Ovidio, Francesco, Darrozes, José, David, Cedric, Dayoub, Nadim, De Staerke, Danielle, Deng, Xiaoli, Desai, Shailen, Desjonqueres, Jean-Damien, Dettmering, Denise, Di Bella, Alessandro, Díaz-Barroso, Lara, Dibarboure, Gerald, Dieng, Habib Boubacar, Dinardo, Salvatore, Dobslaw, Henryk, Dodet, Guillaume, Doglioli, Andrea, Domeneghetti, Alessio, Donahue, David, Dong, Shenfu, Donlon, Craig, Dorandeu, Joël, Drezen, Christine, Drinkwater, Mark, Du Penhoat, Yves, Dushaw, Brian, Egido, Alejandro, Erofeeva, Svetlana, Escudier, Philippe, Esselborn, Saskia, Exertier, Pierre, Fablet, Ronan, Falco, Cédric, Farrell, Sinead Louise, Faugere, Yannice, Femenias, Pierre, Fenoglio, Luciana, Fernandes, Joana, Fernández, Juan Gabriel, Ferrage, Pascale, Ferrari, Ramiro, Fichen, Lionel, Filippucci, Paolo, Flampouris, Stylianos, Fleury, Sara, Fornari, Marco, Forsberg, Rene, Frappart, Frédéric, Frery, Marie-laure, Garcia, Pablo, Garcia-Mondejar, Albert, Gaudelli, Julia, Gaultier, Lucile, Getirana, Augusto, Gibert, Ferran, Gil, Artur, Gilbert, Lin, Gille, Sarah, Giulicchi, Luisella, Gómez-Enri, Jesús, Gómez-Navarro, Laura, Gommenginger, Christine, Gourdeau, Lionel, Griffin, David, Groh, Andreas, Guerin, Alexandre, Guerrero, Raul, Guinle, Thierry, Gupta, Praveen, Gutknecht, Benjamin D., Hamon, Mathieu, Han, Guoqi, Hauser, Danièle, Helm, Veit, Hendricks, Stefan, Hernandez, Fabrice, Hogg, Anna, Horwath, Martin, Idžanović, Martina, Janssen, Peter, Jeansou, Eric, Jia, Yongjun, Jia, Yuanyuan, Jiang, Liguang, Johannessen, Johnny A., Kamachi, Masafumi, Karimova, Svetlana, Kelly, Kathryn, Kim, Sung Yong, King, Robert, Kittel, Cecile M.M., Klein, Patrice, Klos, Anna, Knudsen, Per, Koenig, Rolf, Kostianoy, Andrey, Kouraev, Alexei, Kumar, Raj, Labroue, Sylvie, Lago, Loreley Selene, Lambin, Juliette, Lasson, Léa, Laurain, Olivier, Laxenaire, Rémi, Lázaro, Clara, Le Gac, Sophie, Le Sommer, Julien, Le Traon, Pierre-Yves, Lebedev, Sergey, Léger, Fabien, Legresy, Benoı̂t, Lemoine, Frank, Lenain, Luc, Leuliette, Eric, Levy, Marina, Lillibridge, John, Liu, Jianqiang, Llovel, William, Lyard, Florent, Macintosh, Claire, Makhoul Varona, Eduard, Manfredi, Cécile, Marin, Frédéric, Mason, Evan, Massari, Christian, Mavrocordatos, Constantin, Maximenko, Nikolai, McMillan, Malcolm, Medina, Thierry, Melet, Angelique, Meloni, Marco, Mertikas, Stelios, Metref, Sammy, Meyssignac, Benoit, Minster, Jean-François, Moreau, Thomas, Moreira, Daniel, Morel, Yves, Morrow, Rosemary, Moyard, John, Mulet, Sandrine, Naeije, Marc, Nerem, Robert Steven, Ngodock, Hans, Nielsen, Karina, Nilsen, Jan Even Øie, Niño, Fernando, Nogueira Loddo, Carolina, Noûs, Camille, Obligis, Estelle, Otosaka, Inès, Otten, Michiel, Oztunali Ozbahceci, Berguzar, P. Raj, Roshin, Paiva, Rodrigo, Paniagua, Guillermina, Paolo, Fernando, Paris, Adrien, Pascual, Ananda, Passaro, Marcello, Paul, Stephan, Pavelsky, Tamlin, Pearson, Christopher, Penduff, Thierry, Peng, Fukai, Perosanz, Felix, Picot, Nicolas, Piras, Fanny, Poggiali, Valerio, Poirier, Étienne, Ponce de León, Sonia, Prants, Sergey, Prigent, Catherine, Provost, Christine, Pujol, M-Isabelle, Qiu, Bo, Quilfen, Yves, Rami, Ali, Raney, R. Keith, Raynal, Matthias, Remy, Elisabeth, Rémy, Frédérique, Restano, Marco, Richardson, Annie, Richardson, Donald, Ricker, Robert, Ricko, Martina, Rinne, Eero, Rose, Stine Kildegaard, Rosmorduc, Vinca, Rudenko, Sergei, Ruiz, Simón, Ryan, Barbara J., Salaün, Corinne, Sanchez-Roman, Antonio, Sandberg Sørensen, Louise, Sandwell, David, Saraceno, Martin, Scagliola, Michele, Schaeffer, Philippe, Scharffenberg, Martin G., Scharroo, Remko, Schiller, Andreas, Schneider, Raphael, Schwatke, Christian, Scozzari, Andrea, Ser-giacomi, Enrico, Seyler, Frederique, Shah, Rashmi, Sharma, Rashmi, Shaw, Andrew, Shepherd, Andrew, Shriver, Jay, Shum, C.K., Simons, Wim, Simonsen, Sebatian B., Slater, Thomas, Smith, Walter, Soares, Saulo, Sokolovskiy, Mikhail, Soudarin, Laurent, Spatar, Ciprian, Speich, Sabrina, Srinivasan, Margaret, Srokosz, Meric, Stanev, Emil, Staneva, Joanna, Steunou, Nathalie, Stroeve, Julienne, Su, Bob, Sulistioadi, Yohanes Budi, Swain, Debadatta, Sylvestre-baron, Annick, Taburet, Nicolas, Tailleux, Rémi, Takayama, Katsumi, Tapley, Byron, Tarpanelli, Angelica, Tavernier, Gilles, Testut, Laurent, Thakur, Praveen K., Thibaut, Pierre, Thompson, LuAnne, Tintoré, Joaquín, Tison, Céline, Tourain, Cédric, Tournadre, Jean, Townsend, Bill, Tran, Ngan, Trilles, Sébastien, Tsamados, Michel, Tseng, Kuo-Hsin, Ubelmann, Clément, Uebbing, Bernd, Vergara, Oscar, Verron, Jacques, Vieira, Telmo, Vignudelli, Stefano, Vinogradova Shiffer, Nadya, Visser, Pieter, Vivier, Frederic, Volkov, Denis, von Schuckmann, Karina, Vuglinskii, Valerii, Vuilleumier, Pierrik, Walter, Blake, Wang, Jida, Wang, Chao, Watson, Christopher, Wilkin, John, Willis, Josh, Wilson, Hilary, Woodworth, Philip, Yang, Kehan, Yao, Fangfang, Zaharia, Raymond, Zakharova, Elena, Zaron, Edward D., Zhang, Yongsheng, Zhao, Zhongxiang, Zinchenko, Vadim, and Zlotnicki, Victor

Published
2021
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11. An RNA interference screen identifies druggable regulators of MeCP2 stability

Author

Lombardi, Laura M, Zaghlula, Manar, Sztainberg, Yehezkel, Baker, Steven A, Klisch, Tiemo J, Tang, Amy A, Huang, Eric J, and Zoghbi, Huda Y

Subjects
Neurodegenerative, Rare Diseases, Autism, Mental Health, Pediatric, Intellectual and Developmental Disabilities (IDD), Genetics, Brain Disorders, Neurosciences, Hematology, Rett Syndrome, Orphan Drug, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Mental health, Amino Acid Sequence, Animals, Carrier Proteins, Genetic Testing, HEK293 Cells, Humans, Methyl-CpG-Binding Protein 2, Mice, Protein Kinases, Protein Phosphatase 2, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases, Protein Stability, RNA Interference, Reproducibility of Results, Biological Sciences, Medical and Health Sciences
Abstract

Alterations in gene dosage due to copy number variation are associated with autism spectrum disorder, intellectual disability (ID), and other psychiatric disorders. The nervous system is so acutely sensitive to the dose of methyl-CpG-binding protein 2 (MeCP2) that even a twofold change in MeCP2 protein-either increased or decreased-results in distinct disorders with overlapping features including ID, autistic behavior, and severe motor dysfunction. Rett syndrome is caused by loss-of-function mutations in MECP2, whereas duplications spanning the MECP2 locus result in MECP2 duplication syndrome (MDS), which accounts for ~1% of X-linked ID. Despite evidence from mouse models that restoring MeCP2 can reverse the course of disease, there are currently no U.S. Food and Drug Administration-approved therapies available to clinically modulate MeCP2 abundance. We used a forward genetic screen against all known human kinases and phosphatases to identify druggable regulators of MeCP2 stability. Two putative modulators of MeCP2, HIPK2 (homeodomain-interacting protein kinase 2) and PP2A (protein phosphatase 2A), were validated as stabilizers of MeCP2 in vivo. Further, pharmacological inhibition of PP2A in vivo reduced MeCP2 in the nervous system and rescued both overexpression and motor abnormalities in a mouse model of MDS. Our findings reveal potential therapeutic targets for treating disorders of altered MECP2 dosage.

Published
2017

15. A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma

Author

Ozawa, Michael G, Bhaduri, Aparna, Chisholm, Karen M, Baker, Steven A, Ma, Lisa, Zehnder, James L, Luna-Fineman, Sandra, Link, Michael P, Merker, Jason D, Arber, Daniel A, and Ohgami, Robert S

Subjects
Genetics, Cancer, Hematology, Pediatric, Lymphoma, Human Genome, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Biomarkers, Tumor, Child, DNA Mutational Analysis, Female, Humans, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Follicular, Male, Mutation, Medical and Health Sciences, Pathology
Abstract

Pediatric-type follicular lymphoma and pediatric marginal zone lymphoma are two of the rarest B-cell lymphomas. These lymphomas occur predominantly in the pediatric population and show features distinct from their more common counterparts in adults: adult-type follicular lymphoma and adult-type nodal marginal zone lymphoma. Here we report a detailed whole-exome deep sequencing analysis of a cohort of pediatric-type follicular lymphomas and pediatric marginal zone lymphomas. This analysis revealed a recurrent somatic variant encoding p.Lys66Arg in the transcription factor interferon regulatory factor 8 (IRF8) in 3 of 6 cases (50%) of pediatric-type follicular lymphoma. This specific point mutation was not detected in pediatric marginal zone lymphoma or in adult-type follicular lymphoma. Additional somatic point mutations in pediatric-type follicular lymphoma were observed in genes involved in transcription, intracellular signaling, and cell proliferation. In pediatric marginal zone lymphoma, no recurrent mutation was identified; however, somatic point mutations were observed in genes involved in cellular adhesion, cytokine regulatory elements, and cellular proliferation. A somatic variant in AMOTL1, a recurrently mutated gene in splenic marginal zone lymphoma, was also identified in a case of pediatric marginal zone lymphoma. The overall non-synonymous mutational burden was low in both pediatric-type follicular lymphoma and pediatric marginal zone lymphoma (4.6 mutations per exome). Altogether, these findings support a distinctive genetic basis for pediatric-type follicular lymphoma and pediatric marginal zone lymphoma when compared with adult subtypes and to one another. Moreover, identification of a recurrent point mutation in IRF8 provides insight into a potential driver mutation in the pathogenesis of pediatric-type follicular lymphoma with implications for novel diagnostic or therapeutic strategies.

Published
2016

18. Transforming aged care with virtual reality: How organisational culture impacts technology adoption and sustained uptake.

Author

Miller, Evonne, Wilding, Raelene, Baker, Steven, Caldwell, Glenda A., Neves, Barbara B., and Waycott, Jenny

Subjects
CORPORATE culture, DIGITAL technology, ELDER care, HUMAN services programs, RESEARCH funding, INTERVIEWING, CONFIDENCE, VIRTUAL reality, HOSPITAL medical staff, THEMATIC analysis, COMPARATIVE studies, ADOPTION, LABOR supply
Abstract

Objectives: Virtual reality (VR) is not a common leisure activity in aged care, despite pilot studies demonstrating its value as a tool to combat inactivity and loneliness. This study investigated the organisational enablers and barriers to sustained uptake of VR among aged care staff and organisations, who may lack familiarity or confidence with the technology. Methods: Creative methods were adopted to co‐design and develop a VR implementation toolkit tailored specifically for aged care staff. Three aged care homes in South‐East Queensland participated, with 15 residents and seven staff engaging in up to four VR sessions facilitated by the research team. Participant observation of the VR sessions was complemented by interviews with aged care staff and residents. Results: Guided by Normalisation Process Theory, a reflexive thematic analysis identified four key themes: (1) Positively Appreciating the VR Experience, (2) Staff VR Champions and the Importance of Personal Use and Experimentation with VR, (3) Management Support and (4) Technical Challenges. Conclusions: Our results indicate benefits and challenges of VR use in aged care, offering valuable insights into the factors that can lead to the long‐term success of VR‐based leisure activities for aged care. Providing time and resources for a VR champion to experiment and learn about the technology is critical. The development of an online implementation toolkit, based on our learning from this project, also provides aged care stakeholders with the evidence‐based resources needed to ensure the successful implementation of VR‐based leisure programs. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Optimizing Military Airlift

Author

Baker, Steven F., Morton, David P., Rosenthal, Richard E., and Williams, Laura Melody

Published
2002

29. An Unusual Case of Hyperhemolysis Syndrome and Delayed Hemolytic Transfusion Reaction due to Anti-Jk(a) and Anti-P1 Antibodies.

Author

Montgomery, Hunter, Luo, Matthew X., Baker, Steven, and Lim, Ming Y.

Subjects
DIAGNOSIS of blood diseases, IMMUNOGLOBULINS, BIOPSY, HEMOLYSIS & hemolysins, BLOOD diseases, SARCOMA, BONE marrow examination
Abstract

Background. Hyperhemolysis syndrome (HS) is a severe hemolytic transfusion reaction that can cause hemoglobin and hematocrit levels to drop below pretransfusion levels, leading to severe anemia. HS most commonly occurs in patients with a pre-existing hemoglobinopathy such as sickle cell disease (SCD) or beta-thalassemia. Methods. We report a case of HS, occurring in the absence of hemoglobinopathy, making the diagnosis challenging. The patient reported was also affected by a CIC-rearranged sarcoma. As part of the workup, the patient received a bone marrow biopsy for suspected hemophagocytic lymphohistiocytosis. Results. This provided a rare biopsy specimen to correlate reticulocytopenia with marked erythroid hyperplasia in the marrow, supporting the hypothesis of reticulocyte destruction as a contributing cause of anemia in these patients. This patient had demonstrable alloantibodies to the Jk(a) and P1 antigens as potential triggers for HS. Conclusions. It is vital that a diagnosis of HS be correctly made in these patients with severe anemia, as blood transfusions generally lead to worsening of their conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Movement Asymmetries: From Their Molecular Origin to the Analysis of Movement Asymmetries in Athletes.

Author

Egoyan, Alexander, Parulava, Giorgi, Baker, Steven, Gilhen-Baker, Melinda, and Roviello, Giovanni N.

Subjects
ASYMMETRY (Chemistry), ATHLETES, MEDICAL rehabilitation, PSYCHOLOGICAL factors, MYOSIN, ROBOTIC exoskeletons
Abstract

Asymmetry plays a major role in biology at all scales. This can be seen in the helix of DNA, the fact that the human heart is on the left side, or that most people use their right hand. A single protein such as Myosin 1D can induce helical motion in another molecule. This causes cells, organs, and even entire bodies to twist in a domino effect, causing left–right behaviour. More generally, athlete movements are often asymmetric and, during the physical rehabilitation after injury, the asymmetry is visually discernible. Herein, we review the molecular basis of the movement asymmetries and report on the available knowledge on the few therapeutics investigated so far such as meloxicam. From a more rehabilitative perspective, it is very important to use effective methods to control the process of resolving the injury-related movement asymmetry through the complex use of specialised exercises, measurements, and gait analysis, which can all provide useful information on the effectiveness of the rehabilitation plans. If for each athlete, the normal range of asymmetry is known, the asymmetry can be individually treated and the evolution can be monitored over time. Appropriate measures should be taken if the movement asymmetry is outside this range. In addition, genetic, physiological, and psychological factors relevant to athlete health should be considered in the process of assessing and improving exercise asymmetry, which we also discuss in this review. The main proposal of this work is that the movement asymmetries in athletes should be individually treated, while taking into account the athlete's genetics, physical condition, and previous injuries. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Respiratory viruses: New frontiers—a Keystone Symposia report

Author

Cable, Jennifer, primary, Sun, Jie, additional, Cheon, In Su, additional, Vaughan, Andrew E., additional, Castro, Italo A., additional, Stein, Sydney R., additional, López, Carolina B., additional, Gostic, Katelyn M., additional, Openshaw, Peter J. M., additional, Ellebedy, Ali H., additional, Wack, Andreas, additional, Hutchinson, Edward, additional, Thomas, Mallory M., additional, Langlois, Ryan A., additional, Lingwood, Daniel, additional, Baker, Steven F., additional, Folkins, Melanie, additional, Foxman, Ellen F., additional, Ward, Andrew B., additional, Schwemmle, Martin, additional, Russell, Alistair B., additional, Chiu, Christopher, additional, Ganti, Ketaki, additional, Subbarao, Kanta, additional, Sheahan, Timothy P., additional, Penaloza‐MacMaster, Pablo, additional, and Eddens, Taylor, additional

Published
2023
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48. Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus

Author

Baker, Steven F., primary, Meistermann, Helene, additional, Tzouros, Manuel, additional, Baker, Aaron, additional, Golling, Sabrina, additional, Polster, Juliane Siebourg, additional, Ledwith, Mitchell P., additional, Gitter, Anthony, additional, Augustin, Angelique, additional, Javanbakht, Hassan, additional, and Mehle, Andrew, additional

Published
2022
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49. The Canadian Registry for Amyloidosis Research: A National Multi-Disciplinary Registry for Real-World Evidence

Author

Venner, Christopher P., primary, Reece, Donna E., additional, Baker, Steven, additional, Bril, Vera, additional, Delgado, Diego, additional, Carr, Mervyn, additional, Giraldeau, Geneviève, additional, Hodgkinson, Victoria, additional, Jimenez-Zepeda, Victor H, additional, Laidlaw, Liam A., additional, Massie, Rami, additional, McWhinnie, Marsha, additional, Paterson, Ian, additional, Fine, Nowell, additional, and Davis, Margot, additional

Published
2022
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