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1. Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

Author

Yu, Xiaoying, Lobo, Judith D, Sundermann, Erin, Baker, Darren J, Tracy, Russell P, Kuchel, George A, Stephenson, Kathryn E, Letendre, Scott L, Brew, Bruce, Cysique, Lucette A, Dale, Sannisha K, Wallen, Chelsie, Kunisaki, Ken M, Guaraldi, Giovanni, Milic, Jovana, Winston, Alan, Moore, David J, Margolick, Joseph B, and Erlandson, Kristine M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Aging, HIV/AIDS, Infection, Good Health and Well Being, Humans, Aged, HIV Infections, Pandemics, Quality of Life, COVID-19, HIV, aging, biological mechanism, quality of life, delivery of care, Virology, Clinical sciences
Abstract

People with HIV on combination antiretroviral therapy (ART) have longer life expectancy and are increasingly experiencing age-related comorbidities. Thus, aging with HIV has become a central issue in clinical care and research, which has been particularly challenging with the intersection of the ongoing coronavirus (COVID)-19 pandemic. Since 2009, the International Workshop on HIV and Aging has served as a multidisciplinary platform to share research findings from cross-disciplinary fields along with community advocates to address critical issues in HIV and aging. In this article, we summarize the key oral presentations from the 12th Annual International Workshop on HIV and Aging, held virtually on September 23rd and 24th, 2021. The topics ranged from basic science research on biological mechanisms of aging to quality of life and delivery of care under the COVID-19 pandemic. This workshop enriched our understanding of HIV and aging under the COVID-19 pandemic, identified challenges and opportunities to combat the impact of COVID-19 on HIV communities, and also provided updated research and future directions of the field to move HIV and aging research forward, with the ultimate goal of successful aging for older people with HIV.

Published
2023

2. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies

Author

Cherry, Christopher, Andorko, James I., Krishnan, Kavita, Mejías, Joscelyn C., Nguyen, Helen Hieu, Stivers, Katlin B., Gray-Gaillard, Elise F., Ruta, Anna, Han, Jin, Hamada, Naomi, Hamada, Masakazu, Sturmlechner, Ines, Trewartha, Shawn, Michel, John H., Davenport Huyer, Locke, Wolf, Matthew T., Tam, Ada J., Peña, Alexis N., Keerthivasan, Shilpa, Le Saux, Claude Jordan, Fertig, Elana J., Baker, Darren J., Housseau, Franck, van Deursen, Jan M., Pardoll, Drew M., and Elisseeff, Jennifer H.

Published
2023
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3. An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

Author

Riviere-Cazaux, Cecile, Carlstrom, Lucas P., Neth, Bryan J., Olson, Ian E., Rajani, Karishma, Rahman, Masum, Ikram, Samar, Mansour, Moustafa A., Mukherjee, Bipasha, Warrington, Arthur E., Short, Susan C., von Zglinicki, Thomas, Brown, Desmond A., Burma, Sandeep, Tchkonia, Tamar, Schafer, Marissa J., Baker, Darren J., Kizilbash, Sani H., Kirkland, James L., and Burns, Terry C.

Published
2023
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9. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Author

Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun, Poon, Yan, David, Nathaniel, Baker, Darren J, van Deursen, Jan M, Campisi, Judith, and Elisseeff, Jennifer H

Subjects
Musculoskeletal, Animals, Anterior Cruciate Ligament, Anterior Cruciate Ligament Injuries, Antiviral Agents, Cartilage, Articular, Cellular Senescence, Chondrocytes, Cyclin-Dependent Kinase Inhibitor p16, Extracellular Matrix Proteins, Fluorescent Antibody Technique, Ganciclovir, Glycosaminoglycans, Humans, Immunoblotting, Immunohistochemistry, In Vitro Techniques, Mice, Mice, Transgenic, Osteoarthritis, Knee, Real-Time Polymerase Chain Reaction, Regeneration, Reverse Transcriptase Polymerase Chain Reaction, Weight-Bearing, Medical and Health Sciences, Immunology
Abstract

Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP). Removal of SnCs delays several pathologies and increases healthy lifespan. Aging and trauma are risk factors for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent chondrocytes are found in cartilage tissue isolated from patients undergoing joint replacement surgery, yet their role in disease pathogenesis is unknown. To test the idea that SnCs might play a causative role in OA, we used the p16-3MR transgenic mouse, which harbors a p16INK4a (Cdkn2a) promoter driving the expression of a fusion protein containing synthetic Renilla luciferase and monomeric red fluorescent protein domains, as well as a truncated form of herpes simplex virus 1 thymidine kinase (HSV-TK). This mouse strain allowed us to selectively follow and remove SnCs after anterior cruciate ligament transection (ACLT). We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development. Intra-articular injection of a senolytic molecule that selectively killed SnCs validated these results in transgenic, non-transgenic and aged mice. Selective removal of the SnCs from in vitro cultures of chondrocytes isolated from patients with OA undergoing total knee replacement decreased expression of senescent and inflammatory markers while also increasing expression of cartilage tissue extracellular matrix proteins. Collectively, these findings support the use of SnCs as a therapeutic target for treating degenerative joint disease.

Published
2017

10. Oncogenic senescence: a multi-functional perspective

Author

Baker, Darren J, Alimirah, Fatouma, van Deursen, Jan M, Campisi, Judith, and Hildesheim, Jeffrey

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Aging, Animals, Cell Transformation, Neoplastic, Cellular Senescence, Humans, Neoplasms, Tumor Microenvironment, cellular senescence, microenvironment, tumorigenesis, Oncology and carcinogenesis
Abstract

Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development. The senescence response has also become increasingly recognized as an important contributor to aging and age-related diseases, including cancer. Although oncogenic mutations are capable of inducing a beneficial senescence response that prevents the growth of premalignant cells and promotes cancer immune-surveillance, the secretome of senescent cells also includes factors with pro-tumorigenic properties. On June 23rd and 24th, 2016, the Division of Cancer Biology of the National Cancer Institute sponsored a workshop to discuss the complex role of cellular senescence in tumorigenesis with the goal to define the major challenges and opportunities within this important field of cancer research. Additionally, it was noted how the development of novel tools and technologies are required to accelerate research into a mechanistic understanding of senescent cells in carcinogenesis in order to overcome the current limitations in this exciting, yet ill-defined area.

Published
2017

12. Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Author

Childs, Bennett G, Baker, Darren J, Wijshake, Tobias, Conover, Cheryl A, Campisi, Judith, and van Deursen, Jan M

Subjects
Aging, Cardiovascular, Atherosclerosis, Aetiology, 2.1 Biological and endogenous factors, Animals, Cellular Senescence, Chemokines, Cyclin-Dependent Kinase Inhibitor p16, Cytokines, Foam Cells, Mice, Mice, Transgenic, Plaque, Atherosclerotic, Receptors, LDL, Tunica Intima, General Science & Technology
Abstract

Advanced atherosclerotic lesions contain senescent cells, but the role of these cells in atherogenesis remains unclear. Using transgenic and pharmacological approaches to eliminate senescent cells in atherosclerosis-prone low-density lipoprotein receptor-deficient (Ldlr-/-) mice, we show that these cells are detrimental throughout disease pathogenesis. We find that foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis, where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. Together, these results demonstrate that senescent cells are key drivers of atheroma formation and maturation and suggest that selective clearance of these cells by senolytic agents holds promise for the treatment of atherosclerosis.

Published
2016

13. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Author

Chini, Claudia C. S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., and Chini, Eduardo N.

Published
2020
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15. IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling

Author

Otero, Dennis C, Fares-Frederickson, Nancy J, Xiao, Menghong, Baker, Darren P, and David, Michael

Subjects
Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Animals, Arenaviridae Infections, Cells, Cultured, Chromatin Assembly and Disassembly, Cyclic AMP Response Element Modulator, Histone Deacetylase Inhibitors, Histone Deacetylases, Histones, Humans, Interferon-beta, Interleukin-2, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Multiple Sclerosis, Promoter Regions, Genetic, RNA Interference, RNA, Small Interfering, Receptor, Interferon alpha-beta, Receptors, Antigen, T-Cell, T-Lymphocytes, Regulatory, Immunology
Abstract

IFN-β is widely used in the treatment of multiple sclerosis, yet the mechanism facilitating its efficacy remains unclear. IL-2 production by activated T cells, including those mediating autoimmunity, and subsequent autocrine stimulation is vital for T cell expansion and function. In this study, we demonstrate that in mouse and human T cells, IFN-β specifically inhibits the production of IL-2 upon TCR engagement without affecting other cytokines or activation markers. Rather than disrupting TCR signaling, IFN-β alters histone modifications in the IL-2 promoter to retain the locus in an inaccessible configuration. This in turn is mediated through the upregulation of the transcriptional suppressor CREM by IFN-β and consequent recruitment of histone deacetylases to the IL-2 promoter. In accordance, ablation of CREM expression or inhibition of histone deacetylases activity eliminates the suppressive effects of IFN-β on IL-2 production. Collectively, these findings provide a molecular basis by which IFN-β limits T cell responses.

Published
2015

18. SenNet recommendations for detecting senescent cells in different tissues

Author

Suryadevara, Vidyani, Hudgins, Adam D., Rajesh, Adarsh, Pappalardo, Alberto, Karpova, Alla, Dey, Amit K., Hertzel, Ann, Agudelo, Anthony, Rocha, Azucena, Soygur, Bikem, Schilling, Birgit, Carver, Chase M., Aguayo-Mazzucato, Cristina, Baker, Darren J., Bernlohr, David A., Jurk, Diana, Mangarova, Dilyana B., Quardokus, Ellen M., Enninga, Elizabeth Ann L., Schmidt, Elizabeth L., Chen, Feng, Duncan, Francesca E., Cambuli, Francesco, Kaur, Gagandeep, Kuchel, George A., Lee, Gung, Daldrup-Link, Heike E., Martini, Helene, Phatnani, Hemali, Al-Naggar, Iman M., Rahman, Irfan, Nie, Jia, Passos, João F., Silverstein, Jonathan C., Campisi, Judith, Wang, Julia, Iwasaki, Kanako, Barbosa, Karina, Metis, Kay, Nernekli, Kerem, Niedernhofer, Laura J., Ding, Li, Wang, Lichao, Adams, Lisa C., Ruiyang, Liu, Doolittle, Madison L., Teneche, Marcos G., Schafer, Marissa J., Xu, Ming, Hajipour, Mohammadjavad, Boroumand, Mozhgan, Basisty, Nathan, Sloan, Nicholas, Slavov, Nikolai, Kuksenko, Olena, Robson, Paul, Gomez, Paul T., Vasilikos, Periklis, Adams, Peter D., Carapeto, Priscila, Zhu, Quan, Ramasamy, Ramalakshmi, Perez-Lorenzo, Rolando, Fan, Rong, Dong, Runze, Montgomery, Ruth R., Shaikh, Sadiya, Vickovic, Sanja, Yin, Shanshan, Kang, Shoukai, Suvakov, Sonja, Khosla, Sundeep, Garovic, Vesna D., Menon, Vilas, Xu, Yanxin, Song, Yizhe, Suh, Yousin, Dou, Zhixun, and Neretti, Nicola

Abstract

Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field.

Published
2024
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19. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Author

Vandeveer, George H., primary, Arduini, Robert M., additional, Baker, Darren P., additional, Barry, Kevin, additional, Bohnert, Tonika, additional, Bowden-Verhoek, Jon K., additional, Conlon, Patrick, additional, Cullen, Patrick F., additional, Guan, Bing, additional, Jenkins, Tracy J., additional, Liao, Shu-Yu, additional, Lin, Lin, additional, Liu, Yu-Ting, additional, Marcotte, Douglas, additional, Mertsching, Elisabeth, additional, Metrick, Claire M., additional, Negrou, Ella, additional, Powell, Noel, additional, Scott, Daniel, additional, Silvian, Laura F., additional, and Hopkins, Brian T., additional

Published
2023
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20. Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies

Author

Dayan, Colin M., primary, Lecumberri, Beatriz, additional, Muller, Ilaria, additional, Ganesananthan, Sashiananthan, additional, Hunter, Samuel F., additional, Selmaj, Krzysztof W., additional, Hartung, Hans-Peter, additional, Havrdova, Eva K., additional, LaGanke, Christopher C., additional, Ziemssen, Tjalf, additional, Van Wijmeersch, Bart, additional, Meuth, Sven G., additional, Margolin, David H., additional, Poole, Elizabeth M., additional, Baker, Darren P., additional, and Senior, Peter A., additional

Published
2023
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21. sj-docx-1-mso-10.1177_20552173221142741 - Supplemental material for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies

Author

Dayan, Colin M., Lecumberri, Beatriz, Muller, Ilaria, Ganesananthan, Sashiananthan, Hunter, Samuel F., Selmaj, Krzysztof W., Hartung, Hans-Peter, Havrdova, Eva K., LaGanke, Christopher C., Ziemssen, Tjalf, Van Wijmeersch, Bart, Meuth, Sven G., Margolin, David H., Poole, Elizabeth M., Baker, Darren P., and Senior, Peter A.

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173221142741 for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies by Colin M. Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F. Hunter, Krzysztof W. Selmaj, Hans-Peter Hartung, Eva K. Havrdova, Christopher C. LaGanke, Tjalf Ziemssen, Bart Van Wijmeersch, Sven G. Meuth, David H. Margolin, Elizabeth M. Poole, Darren P. Baker and Peter A. Senior in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2023
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22. D(-)-mandelate dehydrogenase of the yeast Rhodotorula graminis

Author

Baker, Darren P.

Subjects
572
Abstract

The yeast Rhodotorula graminis strain KGX 39 can grow on D(--)- or L(+)-mandelate as a sole source of carbon and energy. The first step in the dissimilation of mandelate involves stereospecific oxidation to phenylgiyoxylate, and this is then degraded via benzaldehyde to benzoate. Preliminary evidence had indicated the presence of a dye-linked L(+)-mandelate dehydrogenase and an NAD+-dependent D(--)-mandelate dehydrogenase in this organism. This thesis is concerned with the purification and characterization of the NAD+-dependent D(--)-mandelate dehydrogenase.

Published
1990

23. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling

Author

Jarret, Abigail, McFarland, Adelle P, Horner, Stacy M, Kell, Alison, Schwerk, Johannes, Hong, MeeAe, Badil, Samantha, Joslyn, Rochelle C, Baker, Darren P, Carrington, Mary, Hagedorn, Curt H, Gale, Michael, Jr, and Savan, Ram

Subjects
MicroRNA -- Health aspects, Hepatitis C -- Genetic aspects -- Development and progression -- Care and treatment, Interferon -- Patient outcomes, Cellular signal transduction -- Genetic aspects -- Health aspects, Gene expression -- Health aspects, Biological sciences, Health
Abstract

Author(s): Abigail Jarret [1]; Adelle P McFarland [1]; Stacy M Horner [1]; Alison Kell [1]; Johannes Schwerk [1]; MeeAe Hong [1]; Samantha Badil [1]; Rochelle C Joslyn [1]; Darren P [...]

Published
2016
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26. Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Author

Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., and Guckian, Kevin M.

Published
2018
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32. Function of Mitochondrial Stat3 in Cellular Respiration

Author

Wegrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B. V., Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szelag, Magdalena, Gornicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Jozef, Baker, Darren P., Wolfman, Alan, Stuehr, Dennis, Hassar, Medhat O., Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I., Fawcett, Paul, Lesnefsky, Edward J., and Larner, Andrew C.

Published
2009
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36. Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

Author

Blank, Thomas, Detje, Claudia N., Spie, Alena, Hagemeyer, Nora, Brendecke, Stefanie M., Wolfart, Jakob, Staszewski, Ori, Zöller, Tanja, Papageorgiou, Ismini, Schneider, Justus, Paricio-Montesinos, Ricardo, Eisel, Ulrich L.M., Manahan-Vaughan, Denise, Jansen, Stephan, Lienenklaus, Stefan, Lu, Bao, Imai, Yumiko, Müller, Marcus, Goelz, Susan E., Baker, Darren P., Schwaninger, Markus, Kann, Oliver, Heikenwalder, Mathias, Kalinke, Ulrich, and Prinz, Marco

Published
2016
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40. A novel cell type negatively associated with secondary autoimmunity in alemtuzumab-treated patients is revealed through single-cell longitudinal analysis of clinical trial samples

Author

Hanamsagar, Richa, primary, Chamberlain, Mathew, additional, Shankara, Srinivas, additional, Marcus, Robert, additional, Baker, Darren P., additional, Havari, Evis, additional, Klinger, Katherine, additional, Nestle, Frank O., additional, de Rinaldis, Emanuele, additional, and Savova, Virginia, additional

Published
2021
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41. sj-pdf-1-cns-10.1177_11795735211028781 – Supplemental material for Efficacy and Safety of Teriflunomide in Multiple Sclerosis across Age Groups: Analysis from Pooled Pivotal and Real-world Studies

Author

Oh, Jiwon, Vukusic, Sandra, Tiel-Wilck, Klaus, Inshasi, Jihad Said, Rog, David, Baker, Darren P, Pyatkevich, Yelena, Poole, Elizabeth M, and Vermersch, Patrick

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-cns-10.1177_11795735211028781 for Efficacy and Safety of Teriflunomide in Multiple Sclerosis across Age Groups: Analysis from Pooled Pivotal and Real-world Studies by Jiwon Oh, Sandra Vukusic, Klaus Tiel-Wilck, Jihad Said Inshasi, David Rog, Darren P Baker, Yelena Pyatkevich, Elizabeth M Poole and Patrick Vermersch in Journal of Central Nervous System Disease

Published
2021
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42. Outcomes in Alemtuzumab-Treated Patients With Thyroid Adverse Events: 6-Year Pooled CARE-MS Data (1509)

Author

Dayan, Colin, primary, Lecumberri, Beatriz, additional, Muller, Ilaria, additional, Ganesananthan, Sashiananthan, additional, Hunter, Samuel F., additional, Selmaj, Krzysztof W., additional, Hartung, Hans-Peter, additional, Havrdova, Eva K., additional, LaGanke, Christopher C., additional, Ziemssen, Tjalf, additional, Van Wijmeersch, Bart, additional, Meuth, Sven G., additional, Margolin, David H., additional, Afsar, Salman, additional, Daizadeh, Nadia, additional, Poole, Elizabeth M., additional, Baker, Darren P., additional, and Senior, Peter A., additional

Published
2021
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43. Alemtuzumab outcomes by age: Post hoc analysis from the randomized CARE-MS studies over 8 years

Author

Bass, Ann D., primary, Arroyo, Rafael, additional, Boster, Aaron L., additional, Boyko, Alexey N., additional, Eichau, Sara, additional, Ionete, Carolina, additional, Limmroth, Volker, additional, Navas, Carlos, additional, Pelletier, Daniel, additional, Pozzilli, Carlo, additional, Ravenscroft, Jennifer, additional, Sousa, Livia, additional, Tintoré, Mar, additional, Uitdehaag, Bernard M.J., additional, Baker, Darren P., additional, Daizadeh, Nadia, additional, Choudhry, Zia, additional, and Rog, David, additional

Published
2021
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44. sj-pdf-1-mso-10.1177_2055217320972137 - Supplemental material for Proportion of alemtuzumab-treated patients converting from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis over 6 years

Author

Horáková, Dana, Boster, Aaron, Bertolotto, Antonio, Freedman, Mark S, Firmino*, Isabel, Cavalier, Steven J, Jacobs*, Alan K, Karthinathan Thangavelu, Daizadeh, Nadia, Poole*, Elizabeth M, Baker, Darren P, Margolin*, David H, and Tjalf Ziemssen

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-mso-10.1177_2055217320972137 for Proportion of alemtuzumab-treated patients converting from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis over 6 years by Dana Horáková, Aaron Boster, Antonio Bertolotto, Mark S Freedman, Isabel Firmino*, Steven J Cavalier, Alan K Jacobs*, Karthinathan Thangavelu*, Nadia Daizadeh, Elizabeth M Poole*, Darren P Baker, David H Margolin*, Tjalf Ziemssen and on behalf of the CARE-MS I, CARE-MS II, and CAMMS03409 Investigators in Multiple Sclerosis Journal—Experimental, Translational and Clinical

Published
2020
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